Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form

Journal of Biological Chemistry

Volumn 277, Issue 46, 2002, Pages 43942-43947

  Zou, Wen Quan ^a   Cashman, Neil R ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b CRND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CONFORMATIONS; DETERGENTS; PH EFFECTS; PROTEINS;

CONFORMATIONAL TRANSITION;

BIOCHEMISTRY;

DETERGENT; DODECYL SULFATE SODIUM; EPITOPE; GUANIDINE; MONOCLONAL ANTIBODY; PRION PROTEIN; PROTEINASE; PROTEINASE K; RECOMBINANT PROTEIN;

ACIDITY; ALPHA HELIX; ARTICLE; BETA SHEET; CONFORMATIONAL TRANSITION; CREUTZFELDT JAKOB DISEASE; HUMAN; IN VITRO STUDY; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN STRUCTURE;

ANTIBODIES, MONOCLONAL; BRAIN; CREUTZFELDT-JAKOB SYNDROME; DETERGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASE K; EPITOPES; GUANIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOBLOTTING; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PRPC PROTEINS; PRPSC PROTEINS;

EID: 0037113898     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M203611200     Document Type: Article

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