Synthetic human prion protein octapeptide repeat binds to the proteinase K active site

Biochemical and Biophysical Research Communications

Volumn 325, Issue 4, 2004, Pages 1406-1411

  Georgieva, Dessislava ^a,b   Rypniewski, Wojciech ^a,c   Echner, Hartmut ^d   Perbandt, Markus ^a,e   Koker, Mirjam ^f   Clos, Joachim ^f   Redecke, Lars ^a   Bredehorst, Reinhard ^e   Voelter, Wolfgang ^d   Genov, Nicolay ^b   Betzel, Christian ^a,e  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

^c INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

^d Physiologisch chemisches Inst Univ   (Germany)

^e UNIVERSITY OF HAMBURG   (Germany)

^f BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

Octapeptide repeats; Prion protein; Proteinase K; Scrapie isoform; Substrate recognition; X ray

Indexed keywords

ASPARAGINE; GLYCINE; GLYCYLGLYCYLGLYCYLTRYPTOPHYLGLYCYLGLUTAMINYLPROLYLHISTIDINE; HISTIDYLGLYCYLGLYCYLGLYCYLTRYPTOPHAN; MERCURY; OCTAPEPTIDE; PEPTIDE DERIVATIVE; PRION PROTEIN; PROTEINASE K; SERINE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTALLIZATION; HUMAN; HYDROGEN BOND; MOLECULE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; X RAY ANALYSIS;

BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENDOPEPTIDASE K; ENZYME ACTIVATION; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; PEPTIDES; PRIONS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 8844276881     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.10.184     Document Type: Article

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