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Volumn 55, Issue 1, 2007, Pages 13-18

Treatment of autoimmune disease: Time for a paradigm shift?

Author keywords

Autoimmune disease; Immune regulation; Immune suppression; Regulatory T cells

Indexed keywords

COLLAGEN TYPE 2; INSULIN; MYELIN BASIC PROTEIN;

EID: 33847123994     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-007-0002-1     Document Type: Review
Times cited : (1)

References (74)
  • 3
    • 33747341049 scopus 로고    scopus 로고
    • Multiple sclerosis, natalizumab therapy, and progressive multifocal leukoencephalopathy
    • Bartt R. E. (2006): Multiple sclerosis, natalizumab therapy, and progressive multifocal leukoencephalopathy. Curr. Opin. Neurol., 19, 341-349.
    • (2006) Curr. Opin. Neurol , vol.19 , pp. 341-349
    • Bartt, R.E.1
  • 5
    • 0026197347 scopus 로고
    • Trimolecular interactions in experimental autoimmune demyelinating disease and prospects for immunotherapy
    • Bell R. B. and Steinman L. (1991): Trimolecular interactions in experimental autoimmune demyelinating disease and prospects for immunotherapy. Semin. Immunol., 3, 237-345.
    • (1991) Semin. Immunol , vol.3 , pp. 237-345
    • Bell, R.B.1    Steinman, L.2
  • 6
    • 0019487117 scopus 로고
    • Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein
    • Ben-Nun A., Wekerle H. and Cohen I. R. (1981): Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein. Nature, 292, 60-61.
    • (1981) Nature , vol.292 , pp. 60-61
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.R.3
  • 7
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova B., Goodwin B., Richert N., Cortese I., Kondo T., Afshar G., Gran B., Eaton J., Antel J., Frank J. A., McFarland H. F. and Martin R. (2000): Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat. Med., 6, 1167-1175.
    • (2000) Nat. Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, I.4    Kondo, T.5    Afshar, G.6    Gran, B.7    Eaton, J.8    Antel, J.9    Frank, J.A.10    McFarland, H.F.11    Martin, R.12
  • 8
    • 0029807595 scopus 로고    scopus 로고
    • Induction of autoimmune diabetes by oral administration of autoantigen
    • Blanas E., Carbone F. R., Allison J., Miller J. F. and Heath W. R. (1996): Induction of autoimmune diabetes by oral administration of autoantigen. Science, 274, 1707-1709.
    • (1996) Science , vol.274 , pp. 1707-1709
    • Blanas, E.1    Carbone, F.R.2    Allison, J.3    Miller, J.F.4    Heath, W.R.5
  • 9
    • 5144222918 scopus 로고    scopus 로고
    • Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells
    • Bluestone J. A. and Tang Q.(2004): Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc. Natl. Acad. Sci. USA, 101 (suppl. 2), 14622-14626.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , Issue.SUPPL. 2 , pp. 14622-14626
    • Bluestone, J.A.1    Tang, Q.2
  • 10
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • Bongartz T., Sutton A. J., Sweeting M. J., Buchan I., Matteson E. L. and Montori V. (2006): Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA, 295, 2275-2285.
    • (2006) JAMA , vol.295 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 12
    • 33646392755 scopus 로고    scopus 로고
    • Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
    • Bresson D., Togher L., Rodrigo E., Chen Y., Bluestone J. A., Herold K. C. and von Herrath M. (2006): Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J. Clin. Invest., 116, 1371-1381.
    • (2006) J. Clin. Invest , vol.116 , pp. 1371-1381
    • Bresson, D.1    Togher, L.2    Rodrigo, E.3    Chen, Y.4    Bluestone, J.A.5    Herold, K.C.6    von Herrath, M.7
  • 13
    • 24144461172 scopus 로고    scopus 로고
    • Resetting the functional capacity of regulatory T cells: A novel immunotherapeutic strategy to promote immune tolerance
    • Chatenoud L. and Bach J. F. (2005): Resetting the functional capacity of regulatory T cells: a novel immunotherapeutic strategy to promote immune tolerance. Expert Opin. Biol. Ther., 5 (suppl. 1), S73-81.
    • (2005) Expert Opin. Biol. Ther , vol.5 , Issue.SUPPL. 1
    • Chatenoud, L.1    Bach, J.F.2
  • 14
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen Y., Kuchroo V. K., Inobe J., Hafler D. A. and Weiner H. L. (1994): Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science, 265, 1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 15
    • 15244363969 scopus 로고    scopus 로고
    • Tregs in T cell vaccination: Exploring the regulation of regulation
    • Cohen I. R., Quintana F. J. and Mimran A. (2004): Tregs in T cell vaccination: exploring the regulation of regulation. J. Clin. Invest., 114, 1227-1232.
    • (2004) J. Clin. Invest , vol.114 , pp. 1227-1232
    • Cohen, I.R.1    Quintana, F.J.2    Mimran, A.3
  • 17
    • 14044278784 scopus 로고    scopus 로고
    • Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function
    • Cong Y., Konrad A., Iqbal N., Hatton R. D., Weaver C. T. and Elson C. O. (2005): Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function. J. Immunol., 174, 2787-2795.
    • (2005) J. Immunol , vol.174 , pp. 2787-2795
    • Cong, Y.1    Konrad, A.2    Iqbal, N.3    Hatton, R.D.4    Weaver, C.T.5    Elson, C.O.6
  • 18
    • 4444290680 scopus 로고    scopus 로고
    • Macrophage brain infiltration in experimental autoimmune encephalomyelitis is not completely compromised by suppressed T-cell invasion: In vivo magnetic resonance imaging illustration in effective anti-VLA-4 antibody treatment
    • Deloire M. S., Touil T., Brochet B., Dousset V., Caille J. M. and Petry K. G. (2004): Macrophage brain infiltration in experimental autoimmune encephalomyelitis is not completely compromised by suppressed T-cell invasion: in vivo magnetic resonance imaging illustration in effective anti-VLA-4 antibody treatment. Mult. Scler., 10, 540-548.
    • (2004) Mult. Scler , vol.10 , pp. 540-548
    • Deloire, M.S.1    Touil, T.2    Brochet, B.3    Dousset, V.4    Caille, J.M.5    Petry, K.G.6
  • 19
    • 0025879955 scopus 로고
    • T-cell receptor peptide immunization leads to enhanced and chronic experimental allergic encephalomyelitis
    • Desquenne-Clark L., Esch T. R., Otvos L. Jr., Heber-Katz E. (1991): T-cell receptor peptide immunization leads to enhanced and chronic experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. USA, 88, 7219-7223.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7219-7223
    • Desquenne-Clark, L.1    Esch, T.R.2    Otvos Jr., L.3    Heber-Katz, E.4
  • 20
    • 0033168696 scopus 로고    scopus 로고
    • Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis
    • Dittel B. N., Visintin I., Merchant R. M. and Janeway C. A. Jr. (1999): Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis. J. Immunol., 163, 32-39.
    • (1999) J. Immunol , vol.163 , pp. 32-39
    • Dittel, B.N.1    Visintin, I.2    Merchant, R.M.3    Janeway Jr., C.A.4
  • 21
    • 10044243777 scopus 로고    scopus 로고
    • New insights into cell responses involved in experimental autoimmune encephalomyelitis and multiple sclerosis
    • El Behi M., Dubucquoi S., Lefranc D., Zephir H., De Seze J., Vermersch P. and Prin L. (2005): New insights into cell responses involved in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Lett., 96, 11-26.
    • (2005) Immunol. Lett , vol.96 , pp. 11-26
    • El Behi, M.1    Dubucquoi, S.2    Lefranc, D.3    Zephir, H.4    De Seze, J.5    Vermersch, P.6    Prin, L.7
  • 22
    • 0033081912 scopus 로고    scopus 로고
    • Diversity of the B cell repertoire to myelin basic protein in rat strains susceptible and resistant to EAE
    • Figueiredo A. C., Cohen I. R. and Mor F.(1999): Diversity of the B cell repertoire to myelin basic protein in rat strains susceptible and resistant to EAE. J. Autoimmun., 12, 13-25.
    • (1999) J. Autoimmun , vol.12 , pp. 13-25
    • Figueiredo, A.C.1    Cohen, I.R.2    Mor, F.3
  • 23
    • 28744452210 scopus 로고    scopus 로고
    • Antigen-specific induction of regulatory T cells for type 1 diabetes therapy
    • Filippi C., Bresson D. and Von Herrath M. (2005): Antigen-specific induction of regulatory T cells for type 1 diabetes therapy. Int. Rev. Immunol., 24, 341-360.
    • (2005) Int. Rev. Immunol , vol.24 , pp. 341-360
    • Filippi, C.1    Bresson, D.2    Von Herrath, M.3
  • 24
    • 32644486426 scopus 로고    scopus 로고
    • Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire
    • Fisson S., Djelti F., Trenado A., Billiard F., Liblau R., Klatzmann D., Cohen J. L. and Salomon B. L. (2006): Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire. Eur. J. Immunol., 36, 817-827.
    • (2006) Eur. J. Immunol , vol.36 , pp. 817-827
    • Fisson, S.1    Djelti, F.2    Trenado, A.3    Billiard, F.4    Liblau, R.5    Klatzmann, D.6    Cohen, J.L.7    Salomon, B.L.8
  • 25
    • 12344280009 scopus 로고    scopus 로고
    • Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis
    • Ford M. L. and Evavold B. D. (2005): Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis. Eur. J. Immunol., 35, 76-85.
    • (2005) Eur. J. Immunol , vol.35 , pp. 76-85
    • Ford, M.L.1    Evavold, B.D.2
  • 26
    • 0030178058 scopus 로고    scopus 로고
    • Mitoxantrone immunotherapy in multiple sclerosis
    • Gonsette R. E. (1996): Mitoxantrone immunotherapy in multiple sclerosis. Mult. Scler., 1, 329-332.
    • (1996) Mult. Scler , vol.1 , pp. 329-332
    • Gonsette, R.E.1
  • 28
    • 3042733559 scopus 로고    scopus 로고
    • T-cell vaccination in multiple sclerosis: Update on clinical application and mode of action
    • Hellings N., Raus J. and Stinissen P. (2004): T-cell vaccination in multiple sclerosis: update on clinical application and mode of action. Autoimmun. Rev., 3, 267-275.
    • (2004) Autoimmun. Rev , vol.3 , pp. 267-275
    • Hellings, N.1    Raus, J.2    Stinissen, P.3
  • 29
    • 0025981021 scopus 로고
    • T-lymphocyte entry into the central nervous system
    • Hickey W. F., Hsu B. L. and Kimura H. (1991): T-lymphocyte entry into the central nervous system. J. Neurosci. Res., 28, 254-260.
    • (1991) J. Neurosci. Res , vol.28 , pp. 254-260
    • Hickey, W.F.1    Hsu, B.L.2    Kimura, H.3
  • 30
    • 0036295472 scopus 로고    scopus 로고
    • Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats
    • Jee Y., Yoon W. K., Okura Y., Tanuma N. and Matsumoto Y. (2002): Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats. J. Neuroimmunol., 128, 49-57.
    • (2002) J. Neuroimmunol , vol.128 , pp. 49-57
    • Jee, Y.1    Yoon, W.K.2    Okura, Y.3    Tanuma, N.4    Matsumoto, Y.5
  • 31
    • 0026713026 scopus 로고
    • Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain
    • Khoury S. J., Hancock W. W. and Weiner H. L. (1992): Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J. Exp. Med., 176, 1355-1364.
    • (1992) J. Exp. Med , vol.176 , pp. 1355-1364
    • Khoury, S.J.1    Hancock, W.W.2    Weiner, H.L.3
  • 32
    • 0027255487 scopus 로고
    • Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide
    • Khoury S. J., Sayegh M. H., Hancock W. W., Gallon L., Carpenter C. B. and Weiner H. L. (1993): Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide. J. Exp. Med., 178, 559-566.
    • (1993) J. Exp. Med , vol.178 , pp. 559-566
    • Khoury, S.J.1    Sayegh, M.H.2    Hancock, W.W.3    Gallon, L.4    Carpenter, C.B.5    Weiner, H.L.6
  • 33
    • 85047690619 scopus 로고    scopus 로고
    • Homeostatic control of immunity by TCR peptide-specific Tregs
    • Kumar V. (2004): Homeostatic control of immunity by TCR peptide-specific Tregs. J. Clin. Invest., 114, 1222-1226.
    • (2004) J. Clin. Invest , vol.114 , pp. 1222-1226
    • Kumar, V.1
  • 34
    • 0024405828 scopus 로고
    • The T-cell receptor repertoire and autoimmune diseases
    • Kumar V., Kono D. H., Urban J. L. and Hood L. (1989): The T-cell receptor repertoire and autoimmune diseases. Annu. Rev. Immunol., 7, 657-682.
    • (1989) Annu. Rev. Immunol , vol.7 , pp. 657-682
    • Kumar, V.1    Kono, D.H.2    Urban, J.L.3    Hood, L.4
  • 35
    • 0027166935 scopus 로고
    • Determinant spreading and the dynamics of the autoimmune T-cell repertoire
    • Lehmann P. V., Sercarz E. E., Forsthuber T., Dayan C. M. and Gammon G. (1993): Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol. Today, 14, 203-208.
    • (1993) Immunol. Today , vol.14 , pp. 203-208
    • Lehmann, P.V.1    Sercarz, E.E.2    Forsthuber, T.3    Dayan, C.M.4    Gammon, G.5
  • 36
    • 0023864061 scopus 로고
    • Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis
    • Lider O., Reshef T., Beraud E., Ben-Nun A. and Cohen I. R. (1988): Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Science, 239, 181-183.
    • (1988) Science , vol.239 , pp. 181-183
    • Lider, O.1    Reshef, T.2    Beraud, E.3    Ben-Nun, A.4    Cohen, I.R.5
  • 39
    • 0024363480 scopus 로고
    • Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells
    • Lohse A. W., Mor F., Karin N. and Cohen I. R. (1989): Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells. Science, 244, 820-822.
    • (1989) Science , vol.244 , pp. 820-822
    • Lohse, A.W.1    Mor, F.2    Karin, N.3    Cohen, I.R.4
  • 42
    • 0029978236 scopus 로고    scopus 로고
    • Oral tolerance to insulin and the insulin B-chain: Cell lines and cytokine patterns
    • Maron R., Blogg N. S., Polanski M., Hancock W. and Weiner H. L. (1996): Oral tolerance to insulin and the insulin B-chain: cell lines and cytokine patterns. Ann. NY Acad. Sci., 778, 346-357.
    • (1996) Ann. NY Acad. Sci , vol.778 , pp. 346-357
    • Maron, R.1    Blogg, N.S.2    Polanski, M.3    Hancock, W.4    Weiner, H.L.5
  • 43
    • 23844455192 scopus 로고    scopus 로고
    • Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice
    • Masteller E. L., Warner M. R., Tang Q., Tarbell K. V., McDevitt H. and Bluestone J. A. (2005): Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice. J. Immunol., 175, 3053-3059.
    • (2005) J. Immunol , vol.175 , pp. 3053-3059
    • Masteller, E.L.1    Warner, M.R.2    Tang, Q.3    Tarbell, K.V.4    McDevitt, H.5    Bluestone, J.A.6
  • 46
    • 85047686640 scopus 로고    scopus 로고
    • Microarray-based expression profiling of normal and malignant immune cells
    • Medh R. D. (2002): Microarray-based expression profiling of normal and malignant immune cells. Endocr. Rev., 23, 393-400.
    • (2002) Endocr. Rev , vol.23 , pp. 393-400
    • Medh, R.D.1
  • 48
    • 0032532313 scopus 로고    scopus 로고
    • Expression of autoimmune disease-related antigens by cells of the immune system
    • Mor F., Boccaccio G. L. and Unger T. (1998): Expression of autoimmune disease-related antigens by cells of the immune system. J. Neurosci. Res., 54, 254-262.
    • (1998) J. Neurosci. Res , vol.54 , pp. 254-262
    • Mor, F.1    Boccaccio, G.L.2    Unger, T.3
  • 49
    • 0025360562 scopus 로고
    • Clinical modeling of T cell vaccination against autoimmune diseases in rats. Selection of antigen-specific T cells using a mitogen
    • Mor F., Lohse A. W., Karin N. and Cohen I. R. (1990): Clinical modeling of T cell vaccination against autoimmune diseases in rats. Selection of antigen-specific T cells using a mitogen. J. Clin. Invest., 85, 1594-1598.
    • (1990) J. Clin. Invest , vol.85 , pp. 1594-1598
    • Mor, F.1    Lohse, A.W.2    Karin, N.3    Cohen, I.R.4
  • 50
    • 0030473601 scopus 로고    scopus 로고
    • IL-2 and TNF receptors as targets of regulatory T-T interactions: Isolation and characterization of cytokine receptor-reactive T cell lines in the Lewis rat
    • Mor F., Reizis B., Cohen I. R. and Steinman L. (1996): IL-2 and TNF receptors as targets of regulatory T-T interactions: isolation and characterization of cytokine receptor-reactive T cell lines in the Lewis rat. J. Immunol., 157, 4855-4861.
    • (1996) J. Immunol , vol.157 , pp. 4855-4861
    • Mor, F.1    Reizis, B.2    Cohen, I.R.3    Steinman, L.4
  • 53
    • 0023126661 scopus 로고
    • Exacerbations of multiple sclerosis in patients treated with gamma interferon
    • Panitch H. S., Hirsch R. L., Haley A. S. and Johnson K. P. (1987): Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet, 1, 893-895.
    • (1987) Lancet , vol.1 , pp. 893-895
    • Panitch, H.S.1    Hirsch, R.L.2    Haley, A.S.3    Johnson, K.P.4
  • 54
    • 0029619838 scopus 로고
    • B7-mediated costimulation can either provoke or prevent clinical manifestations of experimental allergic encephalomyelitis
    • Perrin P. J., Scott D., June C. H. and Racke M. K. (1995): B7-mediated costimulation can either provoke or prevent clinical manifestations of experimental allergic encephalomyelitis. Immunol. Res., 14, 189-199.
    • (1995) Immunol. Res , vol.14 , pp. 189-199
    • Perrin, P.J.1    Scott, D.2    June, C.H.3    Racke, M.K.4
  • 55
    • 0029901881 scopus 로고    scopus 로고
    • A pathogenic role for gamma delta T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse
    • Rajan A. J., Gao Y. L., Raine C. S. and Brosnan C. F. (1996): A pathogenic role for gamma delta T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse. J. Immunol., 157, 941-949.
    • (1996) J. Immunol , vol.157 , pp. 941-949
    • Rajan, A.J.1    Gao, Y.L.2    Raine, C.S.3    Brosnan, C.F.4
  • 56
    • 27744500993 scopus 로고    scopus 로고
    • Natalizumab and PML
    • Ransohoff R. M. (2005): Natalizumab and PML. Nat. Neurosci., 8, 1275.
    • (2005) Nat. Neurosci , vol.8 , pp. 1275
    • Ransohoff, R.M.1
  • 59
    • 0027773017 scopus 로고
    • Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain
    • Schmied M., Breitschopf H., Gold R., Zischler H., Rothe G., Wekerle H. and Lassmann H. (1993): Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain. Am. J. Pathol., 143, 446-452.
    • (1993) Am. J. Pathol , vol.143 , pp. 446-452
    • Schmied, M.1    Breitschopf, H.2    Gold, R.3    Zischler, H.4    Rothe, G.5    Wekerle, H.6    Lassmann, H.7
  • 60
    • 0034936777 scopus 로고    scopus 로고
    • Glatiramer acetate in the treatment of multiple sclerosis
    • Sela M. and Teitelbaum D. (2001): Glatiramer acetate in the treatment of multiple sclerosis. Expert Opin. Pharmacother., 2, 1149-1165.
    • (2001) Expert Opin. Pharmacother , vol.2 , pp. 1149-1165
    • Sela, M.1    Teitelbaum, D.2
  • 62
    • 20844454381 scopus 로고    scopus 로고
    • Blocking adhesion molecules as therapy for multiple sclerosis: Natalizumab
    • Steinman L. (2005): Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab. Nat. Rev. Drug Discov., 4, 510-518.
    • (2005) Nat. Rev. Drug Discov , vol.4 , pp. 510-518
    • Steinman, L.1
  • 65
    • 0032923927 scopus 로고    scopus 로고
    • Modulation by cytokines of induction of oral tolerance to type II collagen
    • Thorbecke G. J., Schwarcz R., Leu J., Huang C. and Simmons W. J. (1999): Modulation by cytokines of induction of oral tolerance to type II collagen. Arthritis Rheum., 42, 110-118.
    • (1999) Arthritis Rheum , vol.42 , pp. 110-118
    • Thorbecke, G.J.1    Schwarcz, R.2    Leu, J.3    Huang, C.4    Simmons, W.J.5
  • 66
    • 0024425273 scopus 로고
    • Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis
    • Vandenbark A. A., Hashim G. and Offner H. (1989): Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature, 341, 541-544.
    • (1989) Nature , vol.341 , pp. 541-544
    • Vandenbark, A.A.1    Hashim, G.2    Offner, H.3
  • 67
    • 33646394713 scopus 로고    scopus 로고
    • Type I regulatory T cells in autoimmunity and inflammatory diseases
    • Veldman C., Nagel A. and Hertl M. (2006): Type I regulatory T cells in autoimmunity and inflammatory diseases. Int. Arch. Allergy Immunol., 140, 174-183.
    • (2006) Int. Arch. Allergy Immunol , vol.140 , pp. 174-183
    • Veldman, C.1    Nagel, A.2    Hertl, M.3
  • 68
    • 0024356749 scopus 로고
    • Cerebrospinal fluid autoantibodies to myelin basic protein in multiple sclerosis patients. Detection during first exacerbations and kinetics of acute relapses and subsequent convalescent phases
    • Warren K. G. and Catz I. (1989): Cerebrospinal fluid autoantibodies to myelin basic protein in multiple sclerosis patients. Detection during first exacerbations and kinetics of acute relapses and subsequent convalescent phases. J. Neurol. Sci., 91, 143-151.
    • (1989) J. Neurol. Sci , vol.91 , pp. 143-151
    • Warren, K.G.1    Catz, I.2
  • 69
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells
    • Weiner H. L. (2001): Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol. Rev., 182, 207-214.
    • (2001) Immunol. Rev , vol.182 , pp. 207-214
    • Weiner, H.L.1
  • 70
    • 0027467440 scopus 로고
    • Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis
    • Weiner H. L., Mackin G. A., Matsui M., Orav E. J., Khoury S. J., Dawson D. M. and Hafler D. A. (1993): Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science, 259, 1321-1324.
    • (1993) Science , vol.259 , pp. 1321-1324
    • Weiner, H.L.1    Mackin, G.A.2    Matsui, M.3    Orav, E.J.4    Khoury, S.J.5    Dawson, D.M.6    Hafler, D.A.7
  • 71
    • 0036773925 scopus 로고    scopus 로고
    • Mechanisms of transplant tolerance induction using costimulatory blockade
    • Wekerle T., Kurtz J., Bigenzahn S., Takeuchi Y. and Sykes M. (2002): Mechanisms of transplant tolerance induction using costimulatory blockade. Curr. Opin. Immunol., 14, 592-600.
    • (2002) Curr. Opin. Immunol , vol.14 , pp. 592-600
    • Wekerle, T.1    Kurtz, J.2    Bigenzahn, S.3    Takeuchi, Y.4    Sykes, M.5
  • 72
    • 0020604045 scopus 로고
    • Immunospecific inhibition of nerve conduction by T lymphocytes reactive to basic protein of myelin
    • Yarom Y., Naparstek Y., Lev-Ram V., Holoshitz J., Ben-Nun A. and Cohen I. R. (1983): Immunospecific inhibition of nerve conduction by T lymphocytes reactive to basic protein of myelin. Nature, 303, 246-247.
    • (1983) Nature , vol.303 , pp. 246-247
    • Yarom, Y.1    Naparstek, Y.2    Lev-Ram, V.3    Holoshitz, J.4    Ben-Nun, A.5    Cohen, I.R.6
  • 73
    • 0030178186 scopus 로고    scopus 로고
    • T cell vaccination in multiple sclerosis
    • Zhang I. and Raus J. (1996): T cell vaccination in multiple sclerosis. Mult. Scler., 1, 353-356.
    • (1996) Mult. Scler , vol.1 , pp. 353-356
    • Zhang, I.1    Raus, J.2
  • 74
    • 0027448708 scopus 로고
    • MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination
    • Zhang J., Medaer R., Stinissen P., Hafler D. and Raus J. (1993): MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science, 261, 1451-1454.
    • (1993) Science , vol.261 , pp. 1451-1454
    • Zhang, J.1    Medaer, R.2    Stinissen, P.3    Hafler, D.4    Raus, J.5


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