Expression of autoimmune disease-related antigens by cells of the immune system

Journal of Neuroscience Research

Volumn 54, Issue 2, 1998, Pages 254-262

  Mor, Felix ^a   Boccaccio, Graciela L ^a   Unger, Tamar ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Autoimmunity; Myelin basic protein; Myelin proteolipid protein; Repertoire selection; Thymus

Indexed keywords

MYELIN BASIC PROTEIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; CELL SPECIFICITY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; IMMUNOBLOTTING; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; THYMUS;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; BLOTTING, WESTERN; CELL LINE; CELL SEPARATION; FEMALE; FLOW CYTOMETRY; IMMUNE SYSTEM; MICE; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; ORGAN SPECIFICITY; RATS; RATS, INBRED LEW; RNA, MESSENGER; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0032532313     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19981015)54:2<254::AID-JNR13>3.0.CO;2-4     Document Type: Article

References (44)

1. Abbas AK, Lichtman AH, Pober JS (1994): Self tolerance and autoimmunity. In "Cellular and Molecular Immunology." 2nd ed. Philadelphia: WB Saunders, pp 376-392.
2. Anderson G, Moore NC, Owen JJ, Jenkinson EJ (1996): Cellular interactions in thymocyte development. Annu Rev Immunol 14:73-99.
3. Bevan MJ, Hogquist KA, Jameson SC (1994): Selecting the T cell receptor repertoire. Science 264:797-797.
4. Bhatia SK, Rose NR, Schofield B, Lafond Walker A, Kuppers RC (1996): Influence of diet on the induction of experimental autoimmune thyroid disease. Proc Soc Exp Biol Med 213:294-300.
5. Boccaccio GL, Colman DR (1995): Myelin basic protein mRNA localization and polypeptide targeting. J Neurosci Res 42:277-286.
6. Boggs JM, Yip PM, Rangaraj G, Jo E (1997): Effect of posttranslational modifications to myelin basic protein on its ability to aggregate acidic lipid vesicles. Biochemistry 36:5065-5071.
7. Brakenhoff RH, Gerretsen M, Knippels EM, van Dijk M, van Essen H, Weghuis DO, Sinke RJ, Snow GB, van Dongen GA (1995): The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. J Cell Biol 129:1677-1689.
8. Chan DS, Lees MB (1974): Gel electrophoresis studies of bovine brain white matter proteolipid and myelin proteins. Biochemistry 13:2704-2712.
9. Egwuagu CE, Charukamnoetkanok P, Gery I (1997): Thymic expression of autoantigens correlates with resistance to autoimmune disease. J Immunol 159:3109-3112.
10. Eichberg J, Iyer S (1996): Phosphorylation of myelin protein: Recent advances. Neurochem Res 21:527-35.
11. Elias D, Markovits D, Reshef T, van-der Zee R, Cohen IR (1990): Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci USA 87:1576-1580.
12. Fritz RB, and Kalvakolanu I (1995): Thymic expression of the golli-myelin basic protein gene in the SJL/J mouse. J Neuroimmunol 57:93-99.
13. Fritz RB, McFarlin DE (1989): Encephalitogenic epitopes of myelin basic protein. Chem Immunol 46:101-125.
14. Fritz RB, Zhao ML (1996): Thymic expression of myelin basic protein (MBP). Activation of MBP-specific T cells by thymic cells in the absence of exogenous MBP. J Immunol 157:5249-5253.
15. Grima B, Zelenika D, and Pessac B (1992): A novel transcript overlapping the myelin basic protein gene. J Neurochem 59:2318-2323.
16. Grima B, Zelenika D, Javoy Agid F, Pessac B (1994): Identification of new human myelin basic protein transcripts in the immune and central nervous systems. Neurobiol Dis 1:61-66.
17. Hagerty DT, and Alien PM (1993): Tolerance to self and the processing and presentation of self antigens. Int Rev Immunol 10:313-319.
18. Haskins K, Wegmann D (1996): Diabetogenic T-cell clones. Diabetes 45:1299-1305.
19. Jolicoeur C, Hanahan D, Smith KM (1994): T cell tolerance toward a transgenic beta cell antigen and transcription of endogenous pancreatic genes in thymus. Proc Natl Acad Sci USA 91: 6707-11.
20. Kalwy S, Marty MC, Bausero P, Pessac B (1998): Myelinc basic potein-related proteins in mouse brain and immune tissues. J Neurochem 70:435-438.
21. Kornstein MJ, Asher O, Fuchs S (1995): Acetylcholine receptor alpha-subunit and myogenin mRNAs in thymus and thymomas. Am J Pathol 146:1320-1324.
22. Krenacs T, Rosendaal M (1995): Immunohistological detection of gap junctions in human lymphoid tissue: Connexin43 in follicular dendritic and lymphoendothelial cells. J Histochem Cytochem 43:1125-1137.
23. Lepage P, Helynck G, Chu JY, Luu B, Sorokine O, Trifilieff E, Van Dorsselaer A (1986): Purification and characterization of minor brain proteolipids: Use of fast atom bombardment-mass spectrometry for peptide sequencing. Biochimie 68:669-686.
24. MacKenzie Graham AJ, Pribyl TM, Kim S, Porter VR, Campagnoni AT, Voskuhl RR (1997): Myelin protein expression is increased in lymph nodes of mice with relapsing experimental autoimmune enccphalomyelitis. J Immunol 159:4602-4610.
25. Mathisen PM, Pease S, Garvey J, Hood L, Readhead C (1993): Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo. Proc Natl Acad Sci USA 90:10125-10129.
26. Mihovilovic M, Roses AD (1993): Expression of alpha-3, alpha-5, and beta-4 neuronal acetylcholine receptor subunit transcripts in normal and myasthenia gravis thymus. Identification of thymocytes expressing the alpha-3 transcripts. J Immunol 151:6517-6524.
27. Mor F, Cohen IR (1993): Shifts in the epitopes of myelin basic protein recognized by Lewis rat T cells before, during, and after the induction of experimental autoimmune encephalomyelitis. J Clin Invest 92:2199-2206.
28. Mor F, Cohen IR (1996): IL-2 rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis. Correlation with induction of Bcl-2. J Immunol 156:515-522.
29. Mor F, Reizis B, Cohen IR, and Steinman L (1996): IL-2 and TNF receptors as targets of regulatory T-T interactions: Isolation and characterization of cytokine receptor-reactive T cell lines in the Lewis rat. J Immunol 157:4855-4861.
30. Pribyl TM, Campagnoni CW, Kampf K, Kashima T, Handley VW, McMachon J, Campagnoni AT (1993): The human myelin basic protein gene is included within a 179 kilobase transcription unit: Expression in the immune and central immune systems. Proc Natl Acad Sci USA 90:10695-9.
31. Pribyl, TM, Campagnoni C, Kampf K, Handley VW, Campagnoni AT (1996a): The major myelin protein genes are expressed in the human thymus. J Neurosci Res 45:812-819.
32. Pribyl TM, Campagnoni CW, Kampf K, Kashima T, Handley VW, McMahon J, Campagnoni AT (1996b): Expression of the myelin proteolipid protein gene in the human fetal thymus. J Neuroimmunol 67:125-130.
33. Pugliese A, Zeller M, Fernandez A Jr, Zalcberg LJ, Bartlett RJ, Ricordi C, Pietropaolo M, Eisenbarth GS, Bennett ST, Patel DD (1997): The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 15:293-297.
34. Reizis B, Schramm C, Cohen IR, and Mor F (1994): Expression of major histocompatibility complex class II molecules in rat T cells. Eur J Immunol 24:2796-2802.
35. Roberts AJ, Kasp E, Stanford M, Dumonde DC, Banga JP (1992): Induction of experimental autoimmune uveoretinitis in Lewis rats with purified recombinant human retinal S-antigen fusion protein. Eur J Immunol 22:951-956.
36. Rocha B, von Boehmer H (1991): Peripheral selection of the T cell repertoire. Science 251:1225-1228.
37. Steinman L (1995): Escape from "horror autotoxicus": Pathogenesis and treatment of autoimmune disease. Cell 80:7-10.
38. Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO (1993): Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366:72-75.
39. Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG, Wickramasinghe S, Colle E, Polychronakos C (1997): Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet 15:289-292.
40. Veis DJ, Sentman CL, Bach EA, Korsmeyer SJ (1993): Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J Immunol 151:2546-2554.
41. Wang J, Whetsell M, Klein JR (1997): Local hormone networks and intestinal T cell homeostasis. Science 275:1937-1939.
42. Wegmann KW, Zhao W, Griffin AC, Hickey WF (1994): Identification of myocarditogenic peptides derived from cardiac myosin capable of inducing experimental allergic myocarditis in the Lewis rat. The utility of a class II binding motif in selecting self-reactive peptides. J Immunol 153:892-900.
43. Wekerle H, Ketelsen UP, Zurn AD, Fulpius BW (1978): Intrathymic pathogenesis of myasthenia gravis: Transient expression of acetylcholine receptors on thymus-derived myogenic cells. Eur J Immunol 8:579-582.
44. Zelenika D, Grima B, Pessac B (1993): A new family of transcripts of the myelin basic protein gene: Expression in brain and in immune system. J Neurochem 60:1574-1577.