Oral tolerance to insulin and the insulin B-chain: Cell lines and cytokine patterns

Annals of the New York Academy of Sciences

Volumn 778, Issue , 1996, Pages 346-357

  Maron, Ruth ^a   Blogg, Nancy S ^a   Polanski, Malu ^a   Hancock, Wayne ^b   Weiner, Howard L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INSULIN; INTERLEUKIN 10; INTERLEUKIN 4; PROSTAGLANDIN E; TRANSFORMING GROWTH FACTOR BETA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELL PROLIFERATION; CONTROLLED STUDY; ETIOLOGY; FEMALE; HELPER CELL; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; LYMPH NODE CELL; MALE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PROTEIN EXPRESSION; T LYMPHOCYTE;

EID: 0029978236     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb21142.x     Document Type: Article

References (25)

1. CASTANO, L. & G. S. EISENBARTH. 1990. Type-1 diabetes: A chronic autoimmune disease of human, mouse and rat. Annu. Rev. Immunol., 8: 647-679.
2. BACH, J.-F. 1994. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 15(4): 516-542.
3. LEITER, E. H., D. V. SERREZE & K. A. M. PROCHAZ. 1990. The epidemiology of diabetes in NOD mice. Immunol. Today 11: 147-149.
4. SHIZURU, A., C. EDWARDS-TAYLOR, B. A. BANKS, A. K. GREGORY & C. G. FATHMAN. 1988. Immunotherapy of the NOD mouse: Treatment with an antibody to T-helper lymphocytes. Science 240: 659-662.
5. MORI, Y., M. SUKO, H. OKUDIARA, I. MATSUBA, S. TSURUOKA, A. SASAKI, H. YOKOYAMA, T. TANASE, T. SHIDA, M. NISHIMURA, E. TERADA & Y. IKEDA. 1986. Preventive effects of cyclosporin on diabetes in NOD mice. Diabetologia 29: 244-247.
6. OGAWA, M., T. MARUYAMA, T. HASEGAWA, T. KANAYA, F. KUBAYASHI, Y. TOCHINO & H. UDA. 1985. The inhibitory effect of neonatal thymectomy on the incidence of insulitis in non-obese diabetes (NOD) mice. Biomed. Res. 6: 103-105.
7. CHEN, Y., V. K. KUCHROO, J.-I. INOBE, D. A. HAFLER & H. L. WEINER. 1994. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis. Science 265: 1237-1240.
8. ZHANG, Z. J., C. S. Y. LEE, O. LIDER & H. L. WEINER. 1990. Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen. J. Immunol. 145: 2489-2493.
9. WEINER, H. L., A. FRIEDMAN, A. MILLER, S. J. KHOURY, A. AL-SABBAGH, L. M. B. SANTOS, M. SAYEGH, R. B. NUSSENBLATT, D. E. TRENTHAM & D. A. HAFLER. 1994. Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12: 809-837.
10. DAYNES, R., B. ARANEO, T. DOWELL, K. HUANG & D. DUDLEY. 1990. Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function. J. Exp. Med. 171: 979-996.
11. COFFMAN, R., D. LEBMAN & B. SHRADER. 1989. Transforming growth factor beta (TGFb) specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J. Exp. Med. 169: 170-177.
12. MILLER, A., O. LIDER & H. L. WEINER. 1991. Antigen-driven bystander suppression after oral administration of antigens. J. Exp. Med. 174: 791-798.
13. ATKINSON, M. A. & N. K. MACLAREN. 1993. Islet cell autoantigens in insulin-dependent diabetes. J. Clin. Invest. 92: 1608-1616.
14. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16: 34-38.
15. KAUFMAN, D. L., M. CLARE-SALZLER, J. TIAN, T. FORSTHUBER, G. S. P. TING, P. ROBINSON, M. A. ATKINSON, E. E. SERCARZ, A. J. TOBIN & P. V. LEHMANN. 1993. Spontaneous loss of T-cell tolerance to glutamate decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72.
16. TISCH, R., X.-D. YANG, S. M. SINGER, R. S. LIBLAU, L. FUGGER & H. O. MCDEVITT. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature. 366: 72-75.
17. DEBRAY-SACHS, M., C. CARNAUD, H. BOITARD, H. COHEN, P. GRESSER, P. BEDOSSA & J.-F. BACH. 1991. Prevention of diabetes in NOD mice treated with antibody to murine INF-γ. J. Autoimmunity 4: 237-248.
18. RAPOPORT, M. J., A. JARAMILLO, D. ZIPRIS, A. H. LAZARUS, D. V. SERREZE, E. H. LEITER, P. CYOPICK, J. S. DANSKA & T. L. DELOVITCH. 1993. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in non obese diabetic mice. J. Exp. Med., 178: 87-99.
19. SHEHADEH, N. N., F. LAROSA & K. J. LAFFERTY. 1993. Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J. Autoimmunity 6: 291-300.
20. ZHANG, Z. J. A., L. DAVIDSON, G. EISENBARTH & H. L. WEINER. 1991. Suppression of diabetes in NOD mice by oral administration of porcine insulin. Proc. Natl. Acad. Sci. USA 88: 10252-10256.
21. HANCOCK, W. W., M. POLANSKI, Z. J. ZHANG, N. BLOGG & H. L. WEINER. 1995. Suppression of insulitis in NOD mice by oral insulin administration is associated with selective expression of IL-4, IL-10, TGF-β and prostaglandin-E. Am. J. Path. 147: 1193-1199.
22. RABINOVITCH, A. 1994. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Diabetes 43: 613-622.
23. KATZ, J. D., C. BENOIST & D. MATHIS. 1995. T helper cell subsets in insulin-dependent diabetes. Science 268: 1185-1188.
24. + Th1 and Th2 cells derived from the spleens of diabetic NOD mice. J. Clin. Invest. 95: 2979-2985.
25. + T cells that suppress adoptive transfer of diabetes. J. Autoimmunity 7: 655-663.