CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling

Archives of Biochemistry and Biophysics

Volumn 459, Issue 1, 2007, Pages 59-69

  Collom, Samuel L ^a   Jamakhandi, Arvind P ^a   Tackett, Alan J ^a   Radominska Pandya, Anna ^a   Miller, Grover P ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Active site; Azido; CYP2E1; Cytochrome; Labeling; Modeling; P450 2E1; Photoaffinity

Indexed keywords

4 NITROPHENOL; 7 AZIDO 4 METHYLCOUMARIN; COUMARIN DERIVATIVE; CYTOCHROME P450 2E1; HEME; LEUCINE; PHENYLALANINE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MASS SPECTROMETRY; OXIDATION; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN MODIFICATION;

AMINO ACID SEQUENCE; AMINO ACIDS; BINDING SITES; COMPUTER SIMULATION; CYTOCHROME P-450 CYP2E1; ENZYME ACTIVATION; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOTOAFFINITY LABELS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 33847096845     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2006.10.028     Document Type: Article

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