Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: Site-directed active site mutagenesis to a progesterone dihydroxylase

Archives of Biochemistry and Biophysics

Volumn 409, Issue 1, 2003, Pages 113-126

  Xue, Linlong ^a,c   Zgoda, Victor G ^a,d   Arison, Byron ^b   Correia, Maria Almira ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A9; IMIPRAMINE; MUTANT PROTEIN; PROGESTERONE; PROGESTERONE DERIVATIVE; PROGESTERONE DIHYDROXYLASE; TESTOSTERONE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE; MALE; MOLECULAR RECOGNITION; MUTATION; NONHUMAN; PRIORITY JOURNAL; RAT; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CATALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMIPRAMINE; KINETICS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE PROTEINS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDOREDUCTASES, N-DEMETHYLATING; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTONS; RATS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STEROID HYDROXYLASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 0037229516     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9861(02)00582-9     Document Type: Article

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