Differential expansion of T-cell receptor variable beta subsets after antigenic stimulation in patients with different outcomes of hepatitis C infection

Immunology

Volumn 106, Issue 3, 2002, Pages 419-427

  Woitas, Rainer P ^a   Sippel, Martin ^a   Althausen, Eva Maria ^a   Brackmann, Hans H ^a   Kochan, Bettina ^a   Matz, Bertfried ^a   Rockstroh, Jürgen K ^a   Sauerbruch, Tilman ^a   Spengler, Ulrich ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; CORE PROTEIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR;

ADULT; AGED; ARTICLE; CELLULAR DISTRIBUTION; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MEMORY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ADULT; AGED; CELL CULTURE TECHNIQUES; CELL DIVISION; CYTOKINES; FEMALE; HEPATITIS C ANTIGENS; HEPATITIS C, CHRONIC; HUMANS; IMMUNOLOGIC MEMORY; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS;

EID: 0036304385     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2002.01437.x     Document Type: Article

References (42)

1. T-cell antigen receptor genes and T-cell recognition
2. Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
3. Immunological memory
4. The role of antigen in maintaining T cell memory
5. Functional analysis of human T cell subsets defined by CD45 isoform expression
6. Lymphocyte life-span and memory
7. Influence of HLA genes on T cell receptor V segment frequencies and expression levels in peripheral blood lymphocytes
8. Variability in T cell receptor V beta gene usage in human peripheral blood lymphocytes. Studies of identical twins, siblings, and insulin-dependent diabetes mellitus patients
9. Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype
10. An immunoassay for specific amplified HCV sequences
11. Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): Use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3
12. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
13. Mapping of immunodominant CD4+ T lymphocyte epitopes of hepatitis C virus antigens and their relevance during the course of chronic infection
14. Detection of intracellular cytokines by flow cytometry
15. Intracellular cytokine production by human CD4+ and CD8+ T cells from normal and immunodeficient donors using directly conjugated anti-cytokine antibodies and three-colour flow cytometry
16. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry
17. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies
18. Perturbation of the structure and function of the Golgi complex by monovalent carboxylic ionophores
19. Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure
20. The influence of a maternal chronic hepatitis B virus infection on the repertoire of transcribed T-cell receptor beta chain variable region genes in human cord blood
21. Analysis of T cell receptor Vbeta gene usage during the course of disease in patients with chronic hepatitis B
22. Distinct patterns of T cell receptor distribution of peripheral blood CD8+ cells during different stages of chronic infection with hepatitis B virus
23. Attrition of T cell memory: Selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
24. Functional diversity of helper T lymphocytes
25. The expanding universe of T-cell subsets. Th1, Th2 and more
26. Analysis of T-cell receptor Vbeta repertoire in liver-infiltrating lymphocytes in chronic hepatitis C
27. Dynamics of intra-hepatic lymphocytes in chronic hepatitis C. Enrichment for Valpha24+ T cells and rapid elimination of effector cells by apoptosis
28. Unbiased usage of T-cell receptor beta variable region genes in peripheral blood cells of hepatitis C patients: No correlation with superantigen effect
29. No evidence for abnormal immune activation in peripheral blood T cells in patients with hepatitis C virus (HCV) infection with or without cryoglobulinaemia
30. Fine specificity of monoclonal antibodies directed at human T cell receptor variable regions: Comparison with oligonucleotide-driven amplification for evaluation of V beta expression
31. Antigen-independent in vitro expansion of T cells does not affect the T cell receptor V beta repertoire
32. Superantigens and endogenous retroviruses: A confluence of puzzles
33. Superantigens: Mechanism of T-cell stimulation and role in immune responses
34. Superantigen implicated in dependence of HIV-1 replication in T cells on TCR V beta expression
35. Restriction of V beta gene usage of liver-derived lymphocytes in chronic hepatitis B and C
36. Apparent lack of MHC restriction in binding of class I HLA molecules to solid-phase peptides
37. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles
38. Degenerate binding of immunogenic peptides to HLA-DR proteins on B cell surfaces
39. Universally immunogenic T cell epitopes: Promiscuous binding to human MHC class II and promiscuous recognition by T cells
40. The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes
41. A hepatitis C virus (HCV) core protein derived peptide inhibits HCV specific lymphocyte proliferation
42. Flow cytometric analysis of peptide binding to major histocompatibility complex class I for hepatitis C virus core T-cell epitopes