A novel diketo phosphonic acid that exhibits specific, strand-transfer inhibition of HIV integrase and anti-HIV activity

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 5, 2007, Pages 1266-1269

  Chi, Guochen ^a   Nair, Vasu ^a   Semenova, Elena ^b   Pommier, Yves ^b  

^a UNIVERSITY OF GEORGIA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Anti HIV activity; HIV integrase inhibitors; Mechanism of inhibition; Phosphonates; Synthesis

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BETA DIKETOPHOSPHONIC ACID DERIVATIVE; INTEGRASE; INTEGRASE INHIBITOR; L 708906; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS;

ACETOACETATES; ANTI-HIV AGENTS; CELL LINE; HIV INFECTIONS; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; KETONES; PHOSPHONIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846913023     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.009     Document Type: Article

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