Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress

Biochemical Pharmacology

Volumn 73, Issue 6, 2007, Pages 760-772

  Lin, Z Ping ^a   Belcourt, Michael F ^b   Carbone, Rocco ^a   Eaton, Jana S ^c   Penketh, Philip G ^a   Shadel, Gerald S ^a   Cory, Joseph G ^d   Sartorelli, Alan C ^a  

^a YALE CANCER CENTER   (United States)

^b Vion Pharmaceuticals Incorporated   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d EAST CAROLINA UNIVERSITY   (United States)

Author keywords

H2Ax; Cisplatin; DNA damage checkpoint; DNA repair; Ribonucleotide reductase; siRNA

Indexed keywords

CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 25A; CHECKPOINT KINASE 1; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; DNA; HISTONE H2AX; PROTEIN P53; RIBONUCLEOTIDE REDUCTASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL PROLIFERATION; CHEMOSENSITIVITY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SUBUNIT; HUMAN; HUMAN CELL; KNOCKOUT GENE; NUCLEOTIDE METABOLISM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; CISPLATIN; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; HCT116 CELLS; HISTONES; HUMANS; PHOSPHORYLATION; RIBONUCLEOTIDE REDUCTASES; S PHASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33846891365     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.11.014     Document Type: Article

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