Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites

Molecular Biology and Evolution

Volumn 24, Issue 2, 2007, Pages 562-573

  Nair, Shalini ^a   Nash, Denae ^a   Sudimack, Daniel ^a   Jaidee, Anchalee ^b   Barends, Marion ^b,c   Uhlemann, Anne Catrin ^d   Krishna, Sanjeev ^d   Nosten, François ^b,c,e   Anderson, Tim J C ^a  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^b SHOKLO MALARIA RESEARCH UNIT   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

^d ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^e CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

Adaptation; Adaptive evolution; Amplicon break point; Antimalarial drug; Artemisinin combination therapy; Hitchhiking; Soft selective sweeps; Tandem duplication

Indexed keywords

MEFLOQUINE; MICROSATELLITE DNA;

AMPLICON; ARTICLE; CHROMOSOME 5; CONTROLLED STUDY; DNA FLANKING REGION; GENE AMPLIFICATION; GENE DUPLICATION; GENE REARRANGEMENT; GENETIC SELECTION; GENETIC VARIABILITY; GENOME; MOLECULAR EVOLUTION; MULTIDRUG RESISTANCE; MUTATION RATE; NONHUMAN; PLASMODIUM FALCIPARUM; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; ANTIMALARIALS; ATP-BINDING CASSETTE TRANSPORTERS; DRUG RESISTANCE, MULTIPLE; EVOLUTION, MOLECULAR; GENE AMPLIFICATION; GENE DOSAGE; GENOME, PROTOZOAN; MALARIA, FALCIPARUM; MEFLOQUINE; MICROSATELLITE REPEATS; MYANMAR; PLASMODIUM FALCIPARUM; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTOZOAN PROTEINS; THAILAND;

PLASMODIUM FALCIPARUM;

EID: 33846833887     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msl185     Document Type: Article

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