Mycophenolate Mofetil Impairs the Integrity of Colonic Anastomosis

Journal of Surgical Research

Volumn 134, Issue 2, 2006, Pages 168-172

  Sikas, Nicholas ^a   Imvrios, George ^a   Takoudas, Dimitrios ^a   Gakis, Dimitrios ^a   Papanikolaou, Vasilios ^a  

^a Aristotle University of Thessaloniki   (Greece)

Author keywords

bowel anastomosis; mycophenolate mofetil; TGF 1

Indexed keywords

COLLAGEN; GROWTH FACTOR; HYDROXYPROLINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CELL COUNT; COLON ANASTOMOSIS; COLON RESECTION; CONTROLLED STUDY; DRUG EFFECT; END TO END ANASTOMOSIS; FIBROBLAST; HEALING IMPAIRMENT; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; NONHUMAN; PRESSURE MEASUREMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STATISTICAL SIGNIFICANCE; WOUND HEALING;

ANASTOMOSIS, SURGICAL; ANIMALS; COLON; FIBROBLASTS; HYDROXYPROLINE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; MACROPHAGES; MALE; MYCOPHENOLIC ACID; PRESSURE; RATS; RATS, WISTAR; RUPTURE; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; WOUND HEALING;

EID: 33746253896     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2006.02.010     Document Type: Article

References (28)

1. Furst M.B., Stromberg B.V., Blatchford G.J., Christensen M.A., and Thorson A.G. Colonic anastomoses. bursting strength after corticosteroid treatment. Dis Colon Rectum 37 (1994) 12
2. Del Rio J.V., Beck D.E., and Opelka F.G. Chronic perioperative steroids and colonic anastomotic healing in rats. J Surg Res 66 (1996) 138
3. Fishel R., Barbul A., Wasserkrug H.L., Penberthy L.T., Rettura G., and Efron G. Cyclosporine A impairs wound healing in rats. J Surg Res 34 (1983) 572
4. Schaffer M.R., Fuchs N., Proksch B., Bongartz M., Beiter T., and Becker H.D. Tacrolimus impairs wound healing. a possible role of decreased nitric oxide synthesis. Transplantation 65 (1998) 813
5. Troppmann C., Pierce J.L., Gandhi M.M., Gallay B.J., McVicar J.P., and Perez R.V. Higher surgical wound complication rates with sirolimus immunosuppression after kidney transplantation. a matched-pair pilot study. Transplantation 76 (2003) 426
6. Eugui E.M., Mirkovich A., and Allison A.C. Lymphocyte-selective antiproliferative and immunosuppressive effects of mycophenolic acid in mice. Scand J Immunol 33 (1991) 175
7. Allison A.C., and Eugui E. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology 47 (2000) 85
8. Zeeh J., Inglin R., Baumann G., et al. Mycophenolate mofetil impairs healing of left-sided colon anastomoses. Transplantation 71 (2001) 1429
9. Helderman J.H., and Goral S. Gastrointestinal complications of transplant immunosuppression. J Am Soc Nephrol 13 (2002) 277
10. Buckmire M.A., Parquet G., Greenway S., and Rolandelli R.H. Temporal expression of TGF-β1, EGF, and PDGF-BB in a model of colonic healing. J Surg Res 80 (1998) 52
11. Gregory C.R., Huang H., Pratt R.E., et al. Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement. Transplantation 59 (1995) 655
12. van den Helder T.B., Benhaim P., Anthony J.P., McCalmont T.H., and Mathes S.J. Efficacy of RS-61443 in reversing acute rejection in a rat model of hindlimb allotransplantation. Transplantation 57 (1994) 427
13. Fraser-Smith E.B., Rosete J.D., and Schatzman R.C. Suppression by mycophenolate mofetil of the neointimal thickening caused by vascular injury in a rat arterial stenosis model. J Pharmacol Exp Ther 275 (1995) 1204
14. Hesp F.L., Hendriks T., Lubbers E.J., and de Boer H.H. Wound healing in the intestinal wall. A comparison between experimental ileal and colonic anastomoses. Dis Colon Rectum 27 (1984) 99
15. Pimentel J.L., Sundell C.L., Wang S., et al. Role of angiotensin II in the expression and regulation of TGF-β in obstructive nephropathy. Kidney Int 48 (1995) 1233
16. Shehata M., Cope G.H., Johnson T.S., Raftery A.T., and el Nahas A.M. Cyclosporine enhances the expression of TGF-β in the juxtaglomerular cells of the rat kidney. Kidney Int 48 (1995) 1487
17. Thornton F.J., and Barbul A. Healing in the gastrointestinal tract. Surg Clin North Am 77 (1997) 549
18. Barnard J.A., Warwick G.J., and Gold L.I. Localization of TGF-β isoforms in the normal murine small intestine and colon. Gastroenterology 105 (1993) 67
19. di Mola F.F., Friess H., Scheuren A., et al. TGF-βs and their signalling receptors are coexpressed in Crohn's disease. Ann Surg 229 (1999) 67
20. Reimund J.M., Wittersheim C., Dumont S., et al. Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease. J Clin Immunol 16 (1996) 144
21. Brasken P., Renvall S., and Sandberg M. Fibronectin and collagen gene expression in healing experimental colonic anastomoses. Br J Surg 78 (1991) 1048
22. Graham M.F., Drucker D.E., Diegelmann R.F., and Elson C.O. Collagen synthesis by human intestinal smooth muscle cells in culture. Gastroenterology 92 (1987) 400
23. Fraser-Smith E.B., Rosete J.D., and Schatzman R.C. Suppression by mycophenolate mofetil of the neointimal thickening caused by vascular injury in a rat arterial stenosis model. J Pharmacol Exp Ther 275 (1995) 1204
24. Graham M.F., Bryson G.R., and Diegelmann R.F. TGF-β1 selectively augments collagen synthesis by human intestinal smooth muscle cells. Gastroenterology 99 (1990) 447
25. Egger B., Inglin R., Zeeh J., Dirsch O., Huang Y., and Buchler M.W. Insulin-like growth factor I and truncated keratinocyte growth factor accelerate healing of left-sided colonic anastomoses. Br J Surg 88 (2001) 90
26. Eubanks T.R., Greenberg J.J., Dobrin P.B., Harford F.J., and Gamelli R.L. The effects of different corticosteroids on the healing colon anastomosis and cecum in a rat model. Am Surg 63 (1997) 266
27. Mastboom W.J., Hendriks T., de Man B.M., and de Boer H.H. Influence of methylprednisolone on the healing of intestinal anastomoses in rats. Br J Surg 78 (1991) 54
28. Guatelli R., Koh I.H., Neto A.B., Gallupo M.T., Goldenberg S., and Barone B. Effect of cyclosporine A on the healing process of ileal anastomosis in rats. Transplant Proc 28 (1996) 2589