The atypical protein kinase Cs: Functional specificity mediated by specific protein adapters

EMBO Reports

Volumn 1, Issue 5, 2000, Pages 399-403

  Moscat, Jorge ^a   Diaz Meco, María T ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; CARRIER PROTEIN; PROSTATE APOPTOSIS RESPONSE 4 PROTEIN; PROSTATE APOPTOSIS RESPONSE-4 PROTEIN; PROTEIN KINASE C; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; GENETICS; HUMAN; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 0034328882     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvd098     Document Type: Article

References (8)

1. Akimoto, K. et al. (1996) EGF or PDGF receptors activate atypical PKCλ through phosphatidylinositol 3-kinase. EMBO J., 15, 788-798.
2. Barradas, M., Monjas, A., Diaz-Meco, M.T., Serrano, M. and Moscat, J. (1999) The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J., 18, 6362-6369.
3. Berra, E., Diaz-Meco, M.T., Dominguez, I., Municio, M.M., Sanz, L., Lozano, J., Chapkin, R.S. and Moscat, J. (1993) Protein kinase Cζ isoform is critical for mitogenic signal transduction. Cell, 74, 555-563.
4. Berra, E., Diaz-Meco, M.T., Lozano, J., Frutos, S., Municio, M.M., Sanchez, P., Sanz, L. and Moscat, J. (1995) Evidence for a role of MEK and MAPK during signal transduction by protein kinase Cζ. EMBO J., 14, 6157-6163.
5. Guo, Q., Fu, W., Xie, J., Luo, H., Sells, S.F., Geddes, J.W., Bondada, V., Rangnekar, V.M. and Mattson, M.P. (1998) Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Nature Med., 4, 957-962.
6. Izumi, Y., Hirose, T., Tamai, Y., Hirai, S., Nagashima, Y., Fujimoto, T., Tabuse, Y., Kemphues, K.J. and Ohno, S. (1998) An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J. Cell Biol., 143, 95-106.
7. Wooten, M.W. (1999) Function for NF-κB in neuronal survival: regulation by atypical protein kinase C. J. Neurosci. Res., 58, 607-611.
8. Woolen, M.W., Seibenhener, M.L., Neidigh, K.B. and Vandenplas, M.L. (2000) Mapping of atypical prolein kinase C wilhin the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells. Mol Cell. Biol., 20, 4494-4504.