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Volumn 6, Issue 1, 2007, Pages 56-59

The role of VHL in the regulation of E-cadherin: A new connection in an old pathway

Author keywords

CC RCC; E cadherin; HIF; SIP1; Snail; VHL; catenin

Indexed keywords

ACTIN; ALPHA CATENIN; BETA CATENIN; CHEMOKINE RECEPTOR CXCR4; FIBRONECTIN; GELATINASE A; GELATINASE B; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 2ALPHA; PROTEIN P300; RNA POLYMERASE II; SMAD PROTEIN; STROMAL CELL DERIVED FACTOR 1ALPHA; UBIQUITIN PROTEIN LIGASE E3; UVOMORULIN; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

EID: 33846643931     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.1.3668     Document Type: Review
Times cited : (27)

References (38)
  • 1
    • 16644373473 scopus 로고    scopus 로고
    • Role of VHL gene mutation in human cancer
    • Kim WY, Kaelin WG. Role of VHL gene mutation in human cancer. J Clin Oncol 2004; 22:4991-5004.
    • (2004) J Clin Oncol , vol.22 , pp. 4991-5004
    • Kim, W.Y.1    Kaelin, W.G.2
  • 4
    • 33746886185 scopus 로고    scopus 로고
    • Primary cilium formation requires von hippel-lindau gene function in renal-derived cells
    • Lutz MS, Burk RD. Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Cancer Res 2006; 66:6903-7.
    • (2006) Cancer Res , vol.66 , pp. 6903-6907
    • Lutz, M.S.1    Burk, R.D.2
  • 5
    • 33745819269 scopus 로고    scopus 로고
    • Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein
    • Esteban MA, Harten SK, Tran MG, Maxwell PH. Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. J Am Soc Nephrol 2006; 17:1801-6.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1801-1806
    • Esteban, M.A.1    Harten, S.K.2    Tran, M.G.3    Maxwell, P.H.4
  • 6
    • 0037223823 scopus 로고    scopus 로고
    • Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
    • Hergovich A, Lisztwan J, Barry R, Ballschmieter P, Krek W. Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat Cell Biol 2003; 5:64-70.
    • (2003) Nat Cell Biol , vol.5 , pp. 64-70
    • Hergovich, A.1    Lisztwan, J.2    Barry, R.3    Ballschmieter, P.4    Krek, W.5
  • 7
    • 1842557655 scopus 로고    scopus 로고
    • pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development
    • Stickle NH, Chung J, Klco JM, Hill RP, Kaelin WG, Jr., Ohh M. pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development. Mol Cell Biol 2004; 24:3251-61.
    • (2004) Mol Cell Biol , vol.24 , pp. 3251-3261
    • Stickle, N.H.1    Chung, J.2    Klco, J.M.3    Hill, R.P.4    Kaelin Jr., W.G.5    Ohh, M.6
  • 8
    • 0030834249 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity
    • Mukhopadhyay D, Knebelmann B, Cohen H, Ananth S, Sukhatme V. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity. Mol Cell Biol 1997; 17:5629-39.
    • (1997) Mol Cell Biol , vol.17 , pp. 5629-5639
    • Mukhopadhyay, D.1    Knebelmann, B.2    Cohen, H.3    Ananth, S.4    Sukhatme, V.5
  • 10
    • 0037446951 scopus 로고    scopus 로고
    • The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity
    • Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. EMBO J 2003; 22:1857-67.
    • (2003) EMBO J , vol.22 , pp. 1857-1867
    • Li, Z.1    Wang, D.2    Na, X.3    Schoen, S.R.4    Messing, E.M.5    Wu, G.6
  • 11
    • 33749238874 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells
    • Peruzzi B, Athauda G, Bottaro DP. The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells. Proc Natl Acad Sci U S A 2006; 103:14531-6.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14531-14536
    • Peruzzi, B.1    Athauda, G.2    Bottaro, D.P.3
  • 12
    • 0242608613 scopus 로고    scopus 로고
    • The genetic basis of cancer of the kidney
    • Linehan WM, Walther MM, Zbar B. The genetic basis of cancer of the kidney. J Urol 2003; 170:2163-72.
    • (2003) J Urol , vol.170 , pp. 2163-2172
    • Linehan, W.M.1    Walther, M.M.2    Zbar, B.3
  • 13
    • 33845673263 scopus 로고    scopus 로고
    • Beta Catenin Signaling: Linking Renal Cell Carcinoma and Polycystic Kidney Disease
    • In press
    • Peruzzi B, Bottaro DP. Beta Catenin Signaling: Linking Renal Cell Carcinoma and Polycystic Kidney Disease. Cell Cycle 2006; 5:In press.
    • (2006) Cell Cycle , pp. 5
    • Peruzzi, B.1    Bottaro, D.P.2
  • 14
    • 0033587146 scopus 로고    scopus 로고
    • The von Hippel-Lindau gene product is necessary for oxgyen-dependent proteolysis of hypoxia-inducible factor α subunits
    • Maxwell P, Weisner M, Chang G-W, Clifford S, Vaux E, Pugh C, Maher E, Ratcliffe P. The von Hippel-Lindau gene product is necessary for oxgyen-dependent proteolysis of hypoxia-inducible factor α subunits. Nature 1999; 399:271-5.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.1    Weisner, M.2    Chang, G.-W.3    Clifford, S.4    Vaux, E.5    Pugh, C.6    Maher, E.7    Ratcliffe, P.8
  • 19
    • 1342301598 scopus 로고    scopus 로고
    • Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer
    • Maynard MA, Ohh M. Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer. Am J Nephrol 2004; 24:1-13.
    • (2004) Am J Nephrol , vol.24 , pp. 1-13
    • Maynard, M.A.1    Ohh, M.2
  • 20
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin Jr WG. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002; 1:237-46.
    • (2002) Cancer Cell , vol.1 , pp. 237-246
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin Jr, W.G.5
  • 21
    • 2342597973 scopus 로고    scopus 로고
    • Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
    • Kondo K, Kim WY, Lechpammer M, Kaelin WG, Jr. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 2003; 1:E83.
    • (2003) PLoS Biol , vol.1
    • Kondo, K.1    Kim, W.Y.2    Lechpammer, M.3    Kaelin Jr., W.G.4
  • 22
    • 30644458570 scopus 로고    scopus 로고
    • Balancing cell adhesion and Wnt signaling, the key role of beta-catenin
    • Brembeck FH, Rosario M, Birchmeier W. Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev 2006; 16:51-9.
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 51-59
    • Brembeck, F.H.1    Rosario, M.2    Birchmeier, W.3
  • 24
    • 0029160437 scopus 로고
    • Morphogenetic roles of classic cadherins
    • Takeichi M. Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 1995; 7:619-27.
    • (1995) Curr Opin Cell Biol , vol.7 , pp. 619-627
    • Takeichi, M.1
  • 25
    • 0036392129 scopus 로고    scopus 로고
    • Epigenetic versus genetic alterations in the inactivation of E-cadherin
    • Strathdee G. Epigenetic versus genetic alterations in the inactivation of E-cadherin. Semin Cancer Biol 2002; 12:373-9.
    • (2002) Semin Cancer Biol , vol.12 , pp. 373-379
    • Strathdee, G.1
  • 27
    • 0141760411 scopus 로고    scopus 로고
    • Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells
    • Imai T, Horiuchi A, Wang C, Oka K, Ohira S, Nikaido T, Konishi I. Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am J Pathol 2003; 163:1437-47.
    • (2003) Am J Pathol , vol.163 , pp. 1437-1447
    • Imai, T.1    Horiuchi, A.2    Wang, C.3    Oka, K.4    Ohira, S.5    Nikaido, T.6    Konishi, I.7
  • 29
    • 0036840363 scopus 로고    scopus 로고
    • Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer
    • Rosivatz E, Becker I, Specht K, Fricke E, Luber B, Busch R, Hofler H, Becker KF. Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol 2002; 161:1881-91.
    • (2002) Am J Pathol , vol.161 , pp. 1881-1891
    • Rosivatz, E.1    Becker, I.2    Specht, K.3    Fricke, E.4    Luber, B.5    Busch, R.6    Hofler, H.7    Becker, K.F.8
  • 33
    • 33645090169 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
    • Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Back JH, Semenza GL. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res 2006; 66:2725-31.
    • (2006) Cancer Res , vol.66 , pp. 2725-2731
    • Krishnamachary, B.1    Zagzag, D.2    Nagasawa, H.3    Rainey, K.4    Okuyama, H.5    Back, J.H.6    Semenza, G.L.7
  • 34
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003; 425:307-11.
    • (2003) Nature , vol.425 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3    Moch, H.4    Oakeley, E.J.5    Krek, W.6
  • 35
    • 22244470409 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: Von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor
    • Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res 2005; 65:6178-88.
    • (2005) Cancer Res , vol.65 , pp. 6178-6188
    • Zagzag, D.1    Krishnamachary, B.2    Yee, H.3    Okuyama, H.4    Chiriboga, L.5    Ali, M.A.6    Melamed, J.7    Semenza, G.L.8
  • 37
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-catenin, and cadherin pathways
    • Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004; 303:1483-7.
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 38
    • 33645731190 scopus 로고    scopus 로고
    • Inactivation of von Hippel-Lindau gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma
    • Nakaigawa N, Yao M, Baba M, Kato S, Kishida T, Hattori K, Nagashima Y, Kubota Y. Inactivation of von Hippel-Lindau gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma. Cancer Res 2006; 66:3699-705.
    • (2006) Cancer Res , vol.66 , pp. 3699-3705
    • Nakaigawa, N.1    Yao, M.2    Baba, M.3    Kato, S.4    Kishida, T.5    Hattori, K.6    Nagashima, Y.7    Kubota, Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.