Epigenetic versus genetic alterations in the inactivation of E-cadherin

Seminars in Cancer Biology

Volumn 12, Issue 5, 2002, Pages 373-379

  Strathdee, Gordon ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cell adhesion; DNA methylation; E cadherin; Epigenetics; Metastasis

Indexed keywords

UVOMORULIN;

ALLELE; ARTICLE; CARCINOGENESIS; DNA METHYLATION; EPITHELIUM TUMOR; GENE EXPRESSION; GENE FUNCTION; GENE INACTIVATION; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; MUTATION RATE; NONHUMAN; STOMACH CANCER;

EID: 0036392129     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1044-579X(02)00057-3     Document Type: Article

References (78)

1. Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumourigenesis. Cell 61:759-767
2. Costello JF, Plass C (2001) Methylation matters. J Med Genet 38:285-303
3. Bird A (1996) The relationship of DNA methylation to cancer. Cancer Surv 28:87-101
4. Bird A, Wolffe AP (1999) Methylation-induced repression - belts, braces and chromatin. Cell 99:451-454
5. Costello JF et al. (2000) Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet 25:132-138
6. Yan PS, Perry MR, Laux DE, Asare AL, Caldwell CW, Huang THM (2000) CpG island arrays: an application toward deciphering epigenetic signatures of breast cancer. Clin Cancer Res 6:1432-1438
7. Issa J-PJ (1999) Aging, DNA methylation and cancer. Crit Rev Oncol/Hemat 32:31-43
8. Birchmeier W, Behrens J (1994) Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Bioch Biophys Acta 1198:11-26
9. Hirohashi S (1998) Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol 153:333-339
10. Berx G, Becker KF, Hofler H, van Roy F (1998) Mutations of the human E-cadherin (CDH1) gene. Hum Mutat 12:226-237
11. Aberle H, Schwartz H, Kemler R (1996) Cadherin-catenin complex: protein interactions and their implications for cadherin function. J Cell Biochem 61:514-523
12. Christofori G, Semb H (1999) The role of the cell adhesion molecule E-cadherin as a tumour suppressor gene. Trends Biochem Sci 24:73-76
13. Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, Lochner D, Birchmeier W (1991) E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113:173-185
14. Vleminckx K, Vakaet L, Mareel M, Fiers W, van Roy F (1991) Genetic manipulation of E-cadherin expression by epithelial tumour cells reveals an invassion suppressor role. Cell 66:107-119
15. Guilford P et al. (1998) E-cadherin germline mutations in familial gastric cancer. Nature 392:402-405
16. Gayther SA et al. (1998) Identification of germ-line E-cadherin mutations in gastric cancer families of European origin. Cancer Res 58:4086-4089
17. Gumbiner BM (1997) A balance between B-catenin and APC. Curr Biol 7:R443-R446
18. Natt E, Magenis RE, Zimmer J, Mansouri A, Scherer G (1989) Regional assignment for the human loci for uvomorulin (UVO) and chymotrypsinogen B (CTRB) with the help of two overlapping deletions on the long arm of chromosome 16 Cytogenet. Cell Genet 50:145-148
19. Tsuda H, Zhang WD, Shimosato Y, Yokota J, Terada M, Sugimura T, Miyamura T, Hirohashi S (1990) Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc Am Assoc Cancer Res 87:6791-6794
20. Sato T, Tanigami A, Yamakawa K, Akjiyama F, Kasumi F, Sakamoto G, Nakamura Y (1990) Allelotype of breast cancer: cumulative allele losses promote tumour progression in primary breast cancer. Cancer Res 50:7184-7189
21. Risinger JI, Berchuck A, Kohler MF, Boyd J (1994) Mutations of the E-cadherin gene in gynecologic cancers. Nat Genet 7:98-102
22. Becker KF, Atkinson MJ, Reich U, Becker I, Nekarda H, Siewert JR, Hofler H (1994) E-cadherin gene mutations porovide clues to diffuse type gastric carcinoma. Cancer Res 54:3845-3852
23. Kanai Y, Oda T, Tsuda H, Ochiai A, Hirohashi S (1994) Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast. Jpn J Cancer Res 85:1035-1039
24. Berx G, Cleton-Jansen A-M, Nollet F, de Leeuw WJ, van de Vijver M, Cornelisse C, van Roy F (1995) E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J 14:6107-6115
25. Berx G, Cleton-Jansen A-M, Strumane G, de Leeuw WJ, Nollet F, van Roy F, Cornelisse C (1996) E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. Oncogene 13:1919-1925
26. Muta H, Noguchi M, Kanai Y, Ochiai A, Nawata H, Hirohashi S (1996) E-cadherin gene mutations in signet ring carcinoma of the stomach. Jpn J Cancer Res 87:843-848
27. Vos CB et al. (1997) E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumourigenesis. Br J Cancer 76:1131-1133
28. Guilford PJ et al. (1999) E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. Hum Mutat 14:249-255
29. Yoshiura K, Kanai Y, Ochiai A, Shimoyama Y, Sugimura T, Hirohashi S (1995) Silencing of the E-cadherin tumour suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci USA 92:7416-7419
30. Graff JR et al. (1995) E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 55:5195-5199
31. Nass SJ, Herman JG, Gabrielson E, Iversen PW, Parl FF, Davidson NE, Graff JR (2000) Aberrant methylation of the estrogen receptor and E-cadherin 5′ CpG islands increases with malignant progression in human breast cancer. Cancer Res 60:4346-4348
32. Grady WM et al. (2000) Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nat Genet 26:16-17
33. Bornman DM, Mathew S, Alsruhe J, Herman JG, Gabrielson E (2001) Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithilium from elderly individuals. Am J Pathol 159:831-835
34. Zochbauer-Muller S, Fong KM, Virmani AK, Gerardts J, Gazdar AF, Minna JD (2001) Aberrant promoter methylation of multiple genes in non-small cell lung cancer. Cancer Res 61:249-255
35. Dong SM, Kim HS, Rha SH, Sidransky D (2001) Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin Cancer Res 7:1982-1986
36. Corn PG, Heath EI, Heitmiller R, Fogt F, Forastiere AA, Herman JG, Wu TT (2001) Frequent hypermethylation of the 5′ CpG island of E-cadherin in esophageal adenocarcinoma. Clin Cancer Res 7:2765-2769
37. Kantak SS, Kramer RH (1998) E-cadherin regulates anchorage independent growth and survival in oral squamous cell carcinoma cells. J Biol Chem 273:16953-16961
38. Hsieh CL (1994) Dependence of transcriptional repression on CpG methylation density. Mol Cell Biol 14:5487-5494
39. Cheng C, Wu P, Yu J, Huang C, Yue C, Wu C, Shen C (2001) Mechanisms of inactivation of E-cadherin in breast carcinomas: modification of the two-hit hypothesis of tumour suppressor gene. Oncogene 20:3814-3823
40. Bukholm IK, Nesland JM, Borresen-Dale AL (2000) Re-expression of E-cadherin, alpha-catenin and beta-catenin, but not of gamma-catenin, in metastatic tissue from breast cancer patients. J Pathol 190:15-19
41. Graff JR, Gabrielson E, Fujii H, Baylin SB, Herman JG (2000) Methylation patterns of the E-cadherin CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J Biol Chem 275:2727-2732
42. Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F, Nieto MA (2000) The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2:76-83
43. Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, Garcia De Herreros A (2000) The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2:84-89
44. Tamura G et al. (2001) Molecular characterisation of undifferentiated-type gastric carcinoma. Lab Invest 81:593-598
45. Tamura G et al. (1996) Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines. Jpn J Cancer Res 87:1153-1159
46. Machado JC, Soares P, Carneiro F, Rocha A, Beck S, Blin N, Berx G, Sobrihho-Simoes M (1999) E-cadherin gene mutations provide a genetic basis for the phenotypic divergence of mixed gastric carcinomas. Lab Invest 79:459-465
47. Leung WK et al. (2001) Concurrent hypermethylation of multiple tumour-related genes in gastric carcinoma and adjacent normal tissues. Cancer 91:2294-2301
48. Tamura G et al. (2000) E-cadherin gene promoter hypermethylation in primary human gastric cancer. J Natl Cancer Inst 92:569-573
49. Kimura T, Sugihara H, Misufuji S, Kodama T, Hattori T (1998) Microsatellite analysis and DNA ploidy pattern in signet-ring cell carcinomas and well differentiated adenocarcinomas of the stomach. Cancer J 11:298-305
50. Droufakou S, Deshmane V, Roylance R, Hanby A, Tomlinson I, Hart IR (2001) Multiple ways of silencing E-cadherin gene expression in lobular carcinoma of the breast. Int J Cancer 92:404-408
51. Huiping C, Sigurgeirsdottir JR, Jonasson JG, Eiriksdottir G, Johannsdottir JT, Egilsson V, Ingvarsson S (1999) Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer. Br J Cancer 81:1103-1110
52. Asgeirsson KS, Jonasson JG, Tryggvadottir L, Olafsdottir K, Sigurgeirsdottir JR, Ingvarsson S, Ogmundsdottir HM (2000) Altered expression of E-cadherin in breast cancer: patterns, mechanisms and clinical significance. Eur J Cancer 36:1098-1106
53. Kashiwaba M, Tamura G, Suzuki Y, Maesawa C, Ogasawara S, Sakata K, Satodate R (1995) Epithelial-cadherin gene is not mutated in ductal carcinomas of the breast. Jpn J Cancer Res 86:1054-1059
54. Schumacher C et al. (1999) Loss of immunohistochemical E-cadherin expression in colon cancer is not due to structural gene alterations. Virchows Archiv 434:489-495
55. Wheeler JM, Kim HC, Efstathiou JA, Ilyas M, Mortensen MJ, Bodmer WF (2001) Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer. Gut 48:367-371
56. Tomlinson I, Ilyas M, Johnson V, Davies A, Clark G, Talbot I, Bodmer W (1998) A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer. J Pathol 184:148-152
57. Taddei I, Piazzini M, Bartoletti R, Dal Canto M, Sardi I (2000) Molecular alterations of E-cadherin gene: possible role in human bladder carcinogenesis. Int J Mol Med 6:201-208
58. Yoon DS et al. (2001) Genetic mapping and DNA sequence-based analysis of deleted regions on chromosome 16 involved in progression of bladder cancer from occult preneoplastic conditions to invasive disease. Oncogenesis 20:5005-5014
59. Corn PG, Smith BD, Ruckdeschel DS, Douglas D, Baylin SB, Herman JG (2000) E-cadherin expression is silenced by 5′ CpG island methylation in acute leukemia. Clin Cancer Res 6:4243-4248
60. Melki JRPCV, Brown RD, Clark SJ (2000) Hypermethylation of E-cadherin in leukemia. Blood 95:3208-3213
61. Sweetster DA et al. (2001) Loss of heterozygosity in childhood de novo acute myelogenous leukemia. Blood 98:1188-1194
62. Wijnhoven BPL, de Both NJ, van Dekken H, Tilanus HW, Dinjens WNM (1999) E-cadherin gene mutations are rare in adenocarcinoma of the oesophagus. Br J Cancer 80:1652-1657
63. Si HX, Tsao SW, Lam KY, Srivastava G, Liu Y, Wong YC, Shen ZY, Cheung AL (2001) E-cadherin expression is commonly down-regulated by CpG hypermethylation in esophageal carcinoma cells. Cancer Lett 173:71-78
64. Wang G et al. (2000) Genetic aberration in primary hepatocellualr carcinoma: correlation between p53 gene mutation and loss-of-heterozygosity on chromosome 16q21-q23 and p21-p23. Cell Res 10:311-323
65. Matsumura T, Makino R, Mitamura K (2001) Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas. Clin Cancer Res 7:594-599
66. Kanai YSU, Tsuda H, Sakamoto M, Hirohashi S (2000) Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis. Cancer Lett 148:73-80
67. Saito T et al. (2001) E-cadherin gene mutations frequently occur in synovial sarcoma as a determinant of hitological features. Am J Pathol 159:2117-2124
68. Rocha AS, Soares P, Seruca R, Maximo V, Matias-Guiu X, Cameselle-Teijeiro J, Sobrihho-Simoes M (2001) Abnormalities of the E-cadherin/catenin complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant. J Pathol 194:358-366
69. Soares P, Berx G, van Roy F, Sobrinho-Simoes M (1997) E-cadherin gene alterations are rare events in thyroid tumours. Int J Cancer 70:32-38
70. Graff JR et al. (1998) Distinct patterns of E-cadherin CpG island methylstion in papillary, follicular, Hurtlhe's cell, and poorly differentiated human thyroid carcinoma. Cancer Res 58:2063-2066
71. Krul EJT, Kersemaekers AJF, Zomerdijik-Nooyen YA, Cornelisse CJ, Peters LAW, Fleuren GJ (1999) Different profiles of allelic loss in cervical carcinoma cases in Surinam and The Netherlands. Cancer 86:997-1004
72. Saito YHT, Uzawa K, Tanzawa H, Sato K (1998) Reduced expression of E-cadherin in oral squamous cell carcinoma: relationship with DNA methylation of 5′ CpG island. Int J Oncol 12:293-298
73. Nakayama S, Sasaki A, Mese H, Alcalde RE, Tsuki T, Matsumura T (2001) The E-cadherin gene is silenced by CpG methylation in human oral squamous cell carcinomas. Br J Cancer 93:667-673
74. Li CD et al. (1999) Distinct deleted regions on chromosome segment 16q23-q24 associated with metastasis in prostate cancer. Genes Chromosomes & Cancer 24:175-182
75. Suzuki H, Komiya A, Emi M, Kuramochi H, Shiraishi T, Yatani R, Shimazaki J (1996) Three distinct commonly deleted regions of chromosome arm 16q in human primary and metastatic prostate carcinomas. Gen Chrom Cancer 17:225-233
76. Li LC, Zhao H, Nakajima K, Oh BR, Filho LA, Carroll P, Dahiya R (2001) Methylation of the E-cadherin gene promoter correlates with progression of prostate cancer. J Urol 166:705-709
77. Latil A, Cussenot O, Fournier G, Driouch K, Lidereau R (1997) Loss of heterozygosity of chromosome 16q in prostate adenocarcinoma: identification of three independent regions. Cancer Res 57:1058-1062
78. Elo JP, Harkonen P, Kyllonen AP, Lukkarinen O, Poutanen M, Vihko R, Vihko P (1997) Loss of heterozygosity at 16q24-q24.2 is significantly associated with metastatic and aggressive behaviour of prostate cancer. Cancer Res 57:3356-3359