The interaction of spider gating modifier peptides with voltage-gated potassium channels

Toxicon

Volumn 49, Issue 2, 2007, Pages 285-292

  Huang, Po Tsang ^a   Shiau, Yu Shuan ^a   Lou, Kuo Long ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Charge belt; Gating modifier peptides; Hydrophobic patch; Membrane partitioning; Peptide channel interaction; Voltage sensor; Voltage gated ion channels

Indexed keywords

GATING MODIFIER PEPTIDE; HANATOXIN; MEMBRANE PROTEIN; POTASSIUM CHANNEL KV2.1; SPIDER VENOM; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

CHANNEL GATING; CONFORMATIONAL TRANSITION; MEMBRANE BINDING; NONHUMAN; PEPTIDE ANALYSIS; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN TRANSPORT; REVIEW; SPIDER; TARANTULA; TOXIN ANALYSIS;

ANIMALS; HUMANS; ION CHANNEL GATING; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; SPIDER VENOMS;

ARANEAE; TARANTULA;

EID: 33846461157     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2006.09.015     Document Type: Review

References (49)

1. + channel. Neuron 16 (1996) 1169-1177
2. Ashcroft F.M. From molecule to malady. Nature 440 (2006) 440-447
3. + channel gating. Neuron 20 (1998) 1283-1294
4. Bosmans F., Rash L., Zhu S., Diochot S., Lazdunski M., Escoubas P., and Tytgat J. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol. Pharmacol. 69 (2006) 419-429
5. + channel with fluorescence. Neuron 19 (1997) 1127-1140
6. + channel fast inactivation. Neuron 22 (1999) 73-87
7. Escoubas P., Diochot S., Celerier M.L., Nakajima T., and Lazdunski M. Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol. Pharmacol. 62 (2002) 48-57
8. Gonzalez C., Rosenman E., Bezanilla F., Alvarez O., and Latorre R. Modulation of the Shaker K(+) channel gating kinetics by the S3-S4 linker. J. Gen. Physiol. 115 (2000) 193-208
9. Harvey A.L., Bradley K.N., Cochran S.A., Rowan E.G., Pratt J.A., Quillfeldt J.A., and Jerusalinsky D.A. What can toxins tell us for drug discovery?. Toxicon 36 (1998) 1635-1640
10. Hille B. Ion Channels of Excitable Membranes. third ed. (2001), Sinauer, Sunderland pp. 131-160, 611-614
11. Huang P.T., Chen T.Y., Tseng L.J., Lou K.L., Liou H.H., Lin T.B., Spatz H.C., and Shiau Y.Y. Structural influence of hanatoxin binding on the carboxyl terminus of S3 segment in voltage-gated K(+)-channel Kv2.1. Recept. Channel. 8 (2002) 79-85
12. + channel. Nature 423 (2003) 33-41
13. + channel. Nature 423 (2003) 42-48
14. Jung H.J., Lee J.Y., Kim S.H., Eu Y.J., Shin S.Y., Milescu M., Swartz K.J., and Kim J.I. Solution structure and lipid membrane partitioning of VSTx1, an Inhibitor of the KvAP potassium channel. Biochemistry 44 (2005) 6015-6023
15. Ledwell J.L., and Aldrich R.W. Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J. Gen. Physiol. 113 (1999) 389-414
16. Lee S.Y., and MacKinnon R. A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature 430 (2004) 232-235
17. Lee H.C., Wang J.M., and Swartz K.J. Interaction between extracellular Hanatoxin and the resting conformation of the voltage-sensor paddle in Kv channels. Neuron 40 (2003) 527-536
18. Li D., Xiao Y., Hu W., Xie J., Bosmans F., Tytgat J., and Liang S. Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana. FEBS Lett. 555 (2003) 616-622
19. + channels. Proc. Natl. Acad. Sci. USA 95 (1998) 8585-8589
20. Li-Smerin Y., and Swartz K.J. Localization and molecular determinants of the Hanatoxin receptors on the voltage-sensing domains of a K(+) channel. J. Gen. Physiol. 115 (2000) 673-684
21. Li-Smerin Y., and Swartz K.J. Helical structure of the COOH terminus of S3 and its contribution to the gating modifier toxin receptor in voltage-gated ion channels. J. Gen. Physiol. 117 (2001) 205-218
22. + channel. Neuron 25 (2000) 411-423
23. + channel. Nature 353 (1991) 752-756
24. +-channel drk1. J. Mol. Recognit. 15 (2002) 175-179
25. + channels. J. Mol. Recognit. 16 (2003) 392-395
26. Mannuzzu L.M., Moronne M.M., and Isacoff E.Y. Direct physical measure of conformational rearrangement underlying potassium channel gating. Science 271 (1996) 213-216
27. Mouhat S., Jouirou B., Mosbah A., De Waard M., and Sabatier J.M. Diversity of folds in animal toxins acting on ion channels. Biochem. J. 378 (2004) 717-726
28. Nishizawa M., and Nishizawa K. Interaction between K(+) channel gate modifier hanatoxin and lipid bilayer membranes analyzed by molecular dynamics simulation. Eur. Biophys. J. 35 (2006) 373-381
29. + channels. Toxicon 36 (1998) 759-770
30. Phillips L.R., Milescu M., Li-Smerin Y., Mindell J.A., Kim J.I., and Swartz K.J. Voltage-sensor activation with a tarantula toxin as cargo. Nature 436 (2005) 857-860
31. + channel voltage sensor measured with luminescence energy transfer. Nature 436 (2005) 848-851
32. Ruta V., and MacKinnon R. Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry 43 (2004) 10071-10079
33. Sands Z.A., Grottesi A., and Sansom M.S. The intrinsic flexibility of the Kv voltage sensor and its implications for channel gating. Biophys. J. 90 (2006) 1598-1606
34. + channel. Neuron 16 (1996) 1159-1167
35. Shiau Y.S., Huang P.T., Liou H.H., Liaw Y.C., Shiau Y.Y., and Lou K.L. Structural basis of binding and inhibition of novel tarantula toxins in mammalian voltage-dependent potassium channels. Chem. Res. Toxicol. 16 (2003) 1217-1225
36. +-channels and toxins from spider venom. Thesis for M.S. Degree, Institute of Oral Biology, College of Medicine National Taiwan University, Taiwan, pp. 25-50.
37. Silverman W.R., Bannister J.P., and Papazian D.M. Binding site in eag voltage sensor accommodates a variety of ions and is accessible in closed channel. Biophys. J. 87 (2004) 3110-3121
38. Sollod B.L., Wilson D., Zhaxybayeva O., Gogarten J.P., and Drinkwater R. Were arachnids the first to use combinatorial peptide libraries?. Peptides 261 (2005) 131-139
39. + channel. J. Gen. Physiol. 117 (2001) 469-490
40. Swartz K.J., and MacKinnon R. An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron 15 (1995) 941-949
41. + channel through multiple binding sites. Neuron 18 (1997) 665-673
42. + channels. Neuron 18 (1997) 675-682
43. Takahashi H., Kim J.I., Min H.J., Sato K., Swartz K.J., and Shimada I. Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins. J. Mol. Biol. 297 (2000) 771-780
44. Takeuchi K., Park E., Lee C., Kim J., Takahashi H., Swartz K., and Shimada I. Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca(2+) channel. J. Mol. Biol. 321 (2002) 517-526
45. Treptow W., Maigret B., Chipot C., and Tarek M. Coupled motions between pore and voltage-sensor domains: a model for Shaker B, a voltage-gated potassium channel. Biophys. J. 87 (2004) 2365-2379
46. Wang J.M., Roh S.H., Kim S., Lee C.W., Kim J.I., and Swartz K.J. Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channels. J. Gen. Physiol. 123 (2004) 455-467
47. + channels in mouse skeletal muscle. Pflugers Arch. 415 (1990) 671-677
48. Winterfield J.R., and Swartz K.J. A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels. J. Gen. Physiol. 116 (2000) 637-644
49. Yarov-Yarovoy V., Baker D., and Catterall W.A. Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. Proc. Natl. Acad. Sci. USA 103 (2006) 7292-7297