Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: A review and integration

Behavioural Brain Research

Volumn 94, Issue 1, 1998, Pages 127-152

  Solanto, Mary V ^a  

^a SCHNEIDER CHILDREN'S HOSPITAL   (United States)

Author keywords

2 Adrenoceptors; Activation; Arousal; Attention deficit hyperactivity disorder; Autoreceptors; Catecholamines; Caudate; Clonidine; D 1 receptors; D 2 receptors; D amphetamine; Dopamine; Dysfunction; Event related potential; Guanfacine; Learning; Locus coeruleus; Memory; Mesocorticolimbic dopamine system; Methylphenidate; Motor activation; Norepinephrine; Nucleus accumbens; P300; Information processing; Prefrontal cortex; Rate dependency; Reinforcement; Reward; Stimulus evaluation; Ventral tegmental area; Working memory

Indexed keywords

AUTORECEPTOR; DEXAMPHETAMINE; DOPAMINE; METHYLPHENIDATE; NORADRENALIN; PEMOLINE; PRESYNAPTIC RECEPTOR; PSYCHOSTIMULANT AGENT;

ARTICLE; ATTENTION DEFICIT DISORDER; DRUG EFFECT; DRUG MECHANISM; FACILITATION; HUMAN; LOCOMOTION; LOCUS CERULEUS; NONHUMAN; NORADRENERGIC SYSTEM; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RECEPTOR SENSITIVITY; REINFORCEMENT; WORKING MEMORY;

ADULT; ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAIN; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; DEXTROAMPHETAMINE; HUMANS; METHYLPHENIDATE;

EID: 0032127304     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(97)00175-7     Document Type: Article

References (290)

1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association, 1994.
2. Arnsten A.F.T. Catecholamine regulation of the prefrontal cortex. J Psychopharmacol. 11:1997;151-162.
3. Arnsten A.F.T., Goldman-Rakic P.S. Alpha-2 adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science. 230:1985;1273-1276.
4. Aston-Jones G., Bloom F.E. Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli. J Neurosci. 1:1981;887-900.
5. Aston-Jones G., Chiang C., Alexinsky T. Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggest a role in vigilance. Prog Brain Res. 88:1991;501-520.
6. Aston-Jones G., Rajkowski J., Kubiak P., Alexinsky T., Akaoka H. Locus coeruleus neurons in the monkey are selectively activated by attended stimuli in a vigilance task. J Neurosci. 14:1994;4467-4480.
7. Bannon M.J., Granneman J.G., Kapatos G. The dopamine transporter: Potential involvement in neuropsychiatric disorders. Bloom F.E., Kupfer D.J. Psychopharmacology: The Fourth Generation of Progress. 1995;179-188 Raven Press, New York.
8. Barkley R.A. The problem of stimulus control and rule-governed behavior in attention deficit disorder with hyperactivity. Bloomingdale L.M., Swanson J. Attention Deficit Disorder: Current Concepts and Emerging Trends in Attentional and Behavioral Disorders of Childhood. 1989;203-232 Pergamon, Elmsford.
9. Barkley R.A. Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment. 1990;Guilford, New York.
10. Barkley RA. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 1997, in press.
11. Barnes N.J.G., Costall B., Domeny A.M., Naylor R.J. Behavioural consequences of the infusion of dopamine into the nucleus accumbens of the common marmoset (Callithrix Jacchus). Neuropharmacology. 26:1987;1327-1335.
12. Blier P., de Montigny C. Current advances and trends in the treatment of depression. Trends Pharm Sci. 15:1994;220-226.
13. Bonhomme N., Cador M., Stinus L., Le Moal M., Spampinato U. Short and long-term changes in dopamine and serotonin receptor binding sites in amphetamine-sensitized rats: a quantitative autoradiographic study. Brain Res. 675:1995;215-223.
14. Borcherding B.G., Keysor C.S., Cooper T.B., Rapoport J.L. Differential effects of methylphenidate and dextroamphetamine on the motor activity of hyperactive children. Neuropsychopharmacology. 2:1989;255-263.
15. Bradley C. The behavior of children receiving Benzedrine. Am J Psychiatry. 94:1937;577-585.
16. Brumaghim J.T., Klorman R., Strauss J., Lewine J.D., Goldstein M.G. Does methylphenidate affect information processing? Findings from two studies on performance and P3b latency. Psychophysiology. 24:1987;361-373.
17. Bunney B.S., Aghajanian G.K., Roth R.H. Comparison of effects of L-Dopa, amphetamine, and apomorphine on firing rate of rat dopaminergic neurons. Nature New Biol. 245:1973;123-125.
18. Bunney B.S., Walters J.R., Roth R.H., Aghajanian K. Dopaminergic neurons: Effect of antipsychotic drugs and amphetamine on single cell activity. J Pharmacol Exp Ther. 185:1973;560-571.
19. Burns J.T., House R.F., Fensch F.C., Miller J.G. Effects of magnesium pemoline and dextroamphetamine on human learning. Science. 155:1967;849-851.
20. Burns L.H., Robbins T.W., Everitt B.J. Differential effects of excitotoxic lesions of the basolateral amygdala, ventral subiculum and medial prefrontal cortex on responding with conditioned reinforcement and locomotor activity potentiated by intra-accumbens infusions of D-amphetamine. Behav Brain Res. 55:1993;167-183.
21. Bye C., Munro-Faure A.D., Peck A.W., Young P.A. A comparison of the effects of L-benzylpiperazine and dexamphetamine on human performance tests. Eur J Clin Pharmacol. 6:1973;163-169.
22. Callaway E. The pharmacology of human information processing. Psychophysiology. 20:1983;359-370.
23. Callaway E. Human information-processing: Some effects of methylphenidate, age, and scopolamine. Biol Psychiatry. 19:1984;649-662.
24. Camp-Bruno J.A., Herting R.L. Cognitive effects of milacemide and methylphenidate in healthy young adults. Psychopharmacology. 115:1994;46-52.
25. Carli M., Robbins T.W., Evenden J.L., Everitt B.J. Effects of lesions to ascending noradrenergic neurons on performance of a 5-choice serial reaction task in rats: implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behav Brain Res. 9:1983;361-380.
26. Carlsson A. Receptor-mediated control of dopamine metabolism. Usdin E., Bunney W.E. Jr. Pre- and Postsynaptic Receptors. 1975;49-65 Marcel Dekker, New York.
27. Carlson C.L., Pelham W.E. Jr., Swanson J.M., Wagner J.L. A divided attention analysis of the effects of methylphenidate on the arithmetic performance of children with attention deficit hyperactivity disorder. J Child Psychol Psychiatry. 32:1991;463-471.
28. Carte E.T., Nigg J.T., Hinshaw S.P. Neuropsychological functioning, motor speed, and language processing in boys with and without ADHD. J Abnorm Child Psychol. 24:1996;481-498.
29. Casey B.J., Castellanos F.X., Giedd J.N., Marsh W.L., Hamburger S.D., Schubert A.B., Vauss Y.C., Vaituzis A.C., Dickstein D.P., Sarfatti S.E., Rapoport J.L. Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 36:1997;374-383.
30. Castellanos F.X., Elia J., Kruesi M.J., Gulotta C.S., Mefford I.N., Potter W.Z., Ritchie G.F., Rapoport J.L. Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder. Psychiatry Res. 52:1994;305-316.
31. Castellanos F.X., Elia J., Kruesi M.J.P., Marsh W.L., Gulotta C.S., Potter W.Z., Ritchie G.F., Hamburger S.D., Rapoport J.L., Kruesi M.J. Cerebrospinal homovanillic acid predicts behavioral response to stimulants in 45 boys with attention-deficit/hyperactivity disorder. Neuropsychopharmacology. 14:1996;125-137.
32. Castellanos F.X., Giedd J.N., Marsh W.L., Hamburger S.D., Vaituzis A.C., Dickstein D.P., Sarfatti S.E., Vauss Y.C., Snell J.W., Lange N., Kaysen D., Krain A.L., Ritchie G.F., Rajapakse J.C., Rapoport J.L. Quantitative brain magnetic imaging in attention-deficit hyperactivity disorder. Arch Gen Psychiatry. 53:1996;607-616.
33. Chappell P.B., Riddle M.A., Scahill L., Lynch K., Schultz R., Arnsten A.F.T., Leckman J.F., Cohen D.L. Guanfacine treatment of comorbid attention deficit hyperactivity disorder and Tourette's syndrome: preliminary clinical experience. J Am Acad Child Adolesc Psychiatry. 34:1995;1140-1146.
34. Chiodo L.A., Freeman A.S., Bunney B.S. Dopamine autoreceptor signal transduction and regulation. Bloom F.E., Kupfer D.J. Psychopharmacology: The Fourth Generation of Progress. 1996;Raven Press, New York.
35. Civelli O. Molecular biology of the dopamine receptor subtypes. Bloom F., Kupfer D.J. Psychopharmacology: The Fourth Generation of Progress. 1996;155-161 Raven Press, New York.
36. Clark C.R., Geffen G.M., Geffen L.B. Role of monoamine pathways in the control of attention: Effects of droperidol and methylphenidate in normal adult humans. Psychopharmacology. 90:1986;28-34.
37. Clark C.R., Geffen C.M., Geffen L.B. Role of monoamine pathways in attention and effort: Effects of clonidine and methylphenidate in normal adult humans. Psychopharmacology. 90:1986;35-39.
38. Clemens J.A., Fuller R.W. Differences in the effects of amphetamine and methylphenidate on brain dopamine turnover and serum prolactin concentration in reserpine-treated rats. Life Sci. 24:1979;2077-2081.
39. Cochran J.C., Thorne D.R., Penetar D.M., Newhouse P.A. Parsing attentional components during a simple reaction time task using sleep deprivation and amphetamine intervention. Percept Mot Skills. 75:1992;675-689.
40. Cole B.J., Robbins T.W. Forebrain norepinephrine: role in controlled information processing in the rat. Neuropsychopharmacology. 7:1992;129-141.
41. Conners C.K., Eisenberg L., Sharpe L. Effects of methylphenidate (Ritalin) on paired associate learning and Porteus Maze performance in emotionally disturbed boys. J Consult Clin Psychol. 28:1964;14-22.
42. Cook E.H., Stein M.A., Krasowski M.D., Cox W., Olkon D.M., Kieffer J.E., Leventhal B.L. Association of attention-deficit disorder and the dopamine transporter gene. Am J Hum Genet. 56:1995;993-998.
43. Coons H.W., Klorman R., Borgstedt A.D. Effects of methylphenidate on adolescents with a childhood history of Attention Deficit Disorder: II. Information processing. J Am Acad Child Adolesc Psychiatry. 26:1987;368-374.
44. Coull J.T., Middleton H.C., Robbins T.W., Sahakian B.J. Contrasting effects of clonidine and diazepam on tests of working memory and planning. Psychopharmacology. 120:1995;311-321.
45. Coull J.T., Middleton H.C., Robbins T.W., Sahakian B.J. Clonidine and diazepam have differential effects on tests of attention and learning. Psychopharmacology. 120:1995;322-332.
46. Coull J.T., Sahakian B.J., Middleton H.C., Young A.H., Park S.B., McShane R.H., Cowen P.J., Robbins T.W. Differential effects of clonidine, haloperidol, diazepam and tryptophan depletion on focused attention and attentional search. Psychopharmacology. 121:1995;222-230.
47. Crider A., Solomon P.R., McMahon M.A. Disruption of selective attention in the rat following chronic D-amphetamine administration: relationship to schizophrenic attention disorder. Biol Psychiatry. 17:1982;351-361.
48. de Sonneville L.M.J., Njiokiktjien C., Hilhorst R.C. Methylphenidate-induced changes in ADDH information processors. J Child Psychol Psychiatry. 32:1991;285-295.
49. de Sonneville L.M.J., Njiokiktjien C., Bos H. Methylphenidate and information processing. Part I: Differentiation between responders and nonresponders; Part 2: Efficacy in responders. J Clin Exp Neuropsychol. 16:1994;877-897.
50. 3H]dopamine release from nucleus accumbens slices and monoamine levels in a rat model for attention-deficit hyperactivity disorder. Neurochem Res. 20:1995;427-433.
51. Dews P.B., Wenger G.R. Rate-dependency of the behavioral effects of amphetamine. Thompson T., Dews P.B. Advances in Behavioral Pharmacology. 1:1977;167-227 Academic Press, New York.
52. DiChiara G., Imperato A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA. 85:1988;5274-5276.
53. DiChiara G, Porceddu M.L., Vargiu L., Argiolas A., Gessa G.L. Evidence for dopamine receptors mediating sedation in the mouse brain. Nature. 264:1976;564-567.
54. Donnelly M., Rapoport J.L., Potter W.Z., Oliver J., Keysor C.S., Murphy D.L. Fenfluramine and dextroamphetamine treatment of childhood hyperactivity. Clinical and biochemical findings. Arch Gen Psychiatry. 46:1989;205-212.
55. Douglas V.I. Toward a clearer definition of the attentional deficit of hyperactive children. Hale G.A., Lewis M. Attention and the Development of Cognitive Skills. 1979;173-247 Plenum, New York.
56. Douglas V.I. Can Skinnerian theory explain attention deficit disorder? A reply to Barkley. Bloomingdale L.M., Swanson J. Attention Deficit Disorder: Current Concepts and Emerging Trends in Attentional and Behavioral Disorders of Childhood. 1989;235-254 Pergamon, Elmsford.
57. Douglas V.I., Barr R.G., Amin K., O'Neill M.E., Britton B.G. Dosage effects and individual responsivity to methylphenidate in attention deficit disorder. J Child Psychol Psychiatry. 29:1988;453-475.
58. Douglas V.I., Barr R.G., Desilets J., Sherman E. Do high doses of methylphenidate impair flexible thinking in attention-deficit hyperactivity disorder? J Am Acad Child Adolesc Psychiatry. 34:1995;877-885.
59. Druhan J.P., Fibiger H.D., Phillips A.G. Amphetamine-like stimulus properties produced by electrical stimulation of reward sites in the ventral tegmental area. Behav Brain Res. 38:1990;175-184.
60. DuPaul G.J., Barkley R.A., McMurray M.B. Response of children with ADHD to methylphenidate: interaction with internalizing symptoms. J Am Acad Child Adolesc Psychiatry. 33:1994;894-903.
61. Elia J., Borcherding B.G., Rapoport J.L., Keysor C.S. Methylphenidate and dextroamphetamine treatments of hyperactivity: are there true nonresponders. Psychiatry Res. 36:1991;141-155.
62. Elia J., Welsh P.A., Gullotta C.S., Rapoport J.L. Classroom academic performance: improvement with both methylphenidate and dextroamphetamine in ADHD boys. J Child Psychol Psychiatry. 34:1993;785-804.
63. Emson P.C., Lindvall O. Distribution of putative neurotransmitters in the cortex. Neuroscience. 4:1979;1-30.
64. Engberg G., Svensson T.H. Amphetamine-induced inhibition of central noradrenergic neurons: a pharmacological analysis. Life Sci. 24:1979;2245.
65. Ernst M., Zametkin A.J., Matochik J.A., Liebenauer L., Fitzgerald G.A., Cohen R.M. Effects of intravenous dextroamphetamine on brain metabolism in adults with attention-deficit hyperactivity disorder (ADHD). Preliminary findings. Psychopharmacol Bull. 30:1994;219-225.
66. Ernst M., Zametkin A.J., Matochik J.A., Pascualvaca D., Jons P.H., Cohen R.M. Presynaptic dopaminergic activity in ADHD adults and children. A [fluorine-18] fluorodopa positron emission tomographic study. 1997;International Society for Research in Child and Adolescent Psychopathology, Paris, France.
67. Evangelista A.M., Izquierdo I. The effect of pre- and post-trial amphetamine injections on avoidance responses of rats. Psychopharmacology. 20:1971;42-47.
68. Evans H.L., Ghiselli W.B., Patton R.A. Diurnal rhythm in behavioral effects of methamphetamine, p-chloromethamphetamine, and scopolamine. J Pharmacol Exp Ther. 186:1973;10-17.
69. Evans R.W., Gualtieri C.T., Amara I. Methylphenidate and memory: Dissociated effects in hyperactive children. Psychopharmacology. 90:1986;211-216.
70. Feldman RS, Meyer JS, Quenzer LF. Principles of Neuropsychopharmacology. 1997.
71. 2 receptors. Psychopharmacology. 114:1994;297-308.
72. Fessler R.G., Sturgeon R.D., Meltzer H.Y. Effects of phencyclidine and methylphenidate on D-amphetamine-induced behaviors in reserpine pretreated. Pharmacol Biochem Behav. 13:1980;835-842.
73. Fitzpatrick P., Klorman R., Brumaghim J.T., Keefover R.W. Effects of methylphenidate on stimulus evaluation and response processes: Evidence from performance and event-related potentials. Psychophysiology. 25:1988;292-304.
74. Fletcher P.J. Effects of D-fenfluramine and metergoline on responding for conditioned reward and the response potentiating effect of nucleus accumbens D-amphetamine. Psychopharmacology. 118:1995;155-163.
75. Foote S.L., Aston-Jones G.S. Pharmacology and physiology of central noradrenergic systems. Bloom F.E., Kupfer D.J. Psychopharmacology: The Fourth Generation of Progress. 1996;335-345 Raven Press, New York.
76. Frith C.D., Dowdy J., Ferrier N., Crow T.J. Selective impairment of paired associate learning after administration of a centrally-acting adrenergic agonist (clonidine). Psychopharmacology. 87:1985;490-493.
77. Gan J., Cantwell D.P. Dosage effects of methylphenidate on paired associate learning: Positive/negative placebo responders. J Am Acad Child Adolesc Psychiatry. 21:1982;237-242.
78. Gill M., Daly G., Heron S., Haaw Z., Fitzgerald M. Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry. 2:1997;311-313.
79. Giros B., Caron M. Molecular characterization of the dopamine transporter. Trends Pharmacol Sci. 14:1993;43-49.
80. Gittelman R., Klein D., Kartz S., Sarf K., Pollack E. Comparative effects of methylphenidate and thioridazine in hyperkinetic children. Arch Gen Psychiatry. 33:1976;1217-1231.
81. Glick S.D., Milloy S. Rate-dependent effects of D-amphetamine on locomotor activity in mice: possible relation to paradoxical sedation in minimal brain dysfunction. Eur J Pharmacol. 24:1973;266-268.
82. Gonzalez F.A., Byrd L.D. Mathematics underlying the rate-dependency hypothesis. Science. 195:1977;546-550.
83. Grace A.A. The tonic/phasic model of dopamine system regulation: its relevance for understanding how stimulant abuse can alter basal ganglia function. Drug Alcohol Depend. 37:1995;111-129.
84. Graham A.W., Aghajanian G.K. Effects of amphetamine on single cell activity in a catecholamine nucleus, the locus coeruleus. Nature. 234:1971;100.
85. Greenhill L.L., Osman B.B. Ritalin: Theory and Patient Management. 1991;Liebert, New York.
86. Grilly D.M. Rate dependent effects of amphetamine resulting from behavioral competition. Biobehav Rev. 1:1977;887-893.
87. Grilly D.M., Gowans G.C. Effects of naltrexone, and D-amphetamine, and their interaction on the stimulus control of choice behavior of rats. Psychopharmacology. 96:1988;73-80.
88. Grilly D.M., Simon B.B. Differential effects of D-amphetamine on vigilance in younger and older male rats. Pharmacol Biochem Behav. 49:1994;497-502.
89. Grilly D.M., Gowans G.C., McCann D.S., Grogan T.W. Effect of cocaine and D-amphetamine on sustained and selective attention in rats. Pharmacol Biochem Behav. 33:1989;733-739.
90. Groves P.M., Tepper J.M. Neuronal mechanisms of action of amphetamine. Creese I. Stimulants: Neurochemical, Behavioral, and Clinical Perspectives. 1983;81-129 Raven Press, New York.
91. Groves P.M., Ryan L.J., Diana M., Young S.J., Fisher L.J. Neuronal actions of amphetamine in the rat brain. NIDA Res Monogr Series. 94:1989;127-145.
92. Haenlein M., Caul W. Attention deficit disorder with hyperactivity: A specific hypothesis of reward dysfunction. J Am Acad Child Adolesc Psychiatry. 26:1987;356-362.
93. Halliday R., Callaway E., Naylor H., Gratzinger P., Prael R. The effects of stimulant drugs on information processing in elderly adults. J Gerontol. 41:1986;748-757.
94. Halliday R., Gregory K., Naylor H., Callaway H., Yano L. Beyond drug effects and dependent variables: The use of the Poisson-Erlang model to assess the effects of D-amphetamine on information processing. Acta Psychol. 73:1990;35-54.
95. Haracz J.L., Tschanz J.T., Wang Z., White I.M., Rebec G.V. Striatal single-unit responses to amphetamine and neuroleptics in freely moving rats. Neurosci Biobehav Rev. 17:1993;1-12.
96. Hardman J.G. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 1996;McGraw-Hill, New York.
97. Haycock J.W., van Buskirk R., Gold P.E. Effects on retention of post-training amphetamine injections in mice: Interaction with pre-training experience. Psychopharmacology. 54:1977;21-24.
98. Hernandez L., Hoebel B.G. Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. Life Sci. 42:1988;1705-1712.
99. Herrnstein R.J. Relative and absolute strength of response as a function of frequency of reinforcement. J Exp Anal Behav. 13:1961;242-266.
100. Heyman G.M. Effects of methylphenidate on response rate and measures of motor performance and reinforcement efficacy. Psychopharmacology. 109:1992;145-152.
101. Hink R.F., Fenton W.H.J., Tinklenberg J.R., Pfefferbaum A., Kopell B.S. Vigilance and human attention under conditions of methylphenidate and secobarbital intoxication: an assessment using brain potentials. Psychophysiology. 15:1978;116-125.
102. Hoebel B.G., Monaco A.P., Hernandez L., Aulissi E., Stanley B.G., Lenard L. Self-injection of amphetamine directly into the brain. Psychopharmacology. 81:1983;158-163.
103. Horrigan J.P., Barnhill L.J. Guanfacine for treatment of Attention-Deficit Hyperactivity Disorder in boys. J Child Adolesc Psychopharmacol. 5:1995;215-223.
104. Huang Y.H., Mass J.W. D-amphetamine at low doses suppresses noradrenergic functions. Eur J Pharmacol. 75:1981;187-195.
105. Hughes R.N., Greig A.M. Effects of caffeine, methamphetamine and methylphenidate on reactions to novelty and activity in rats. Neuropharmacology. 15:1976;673-676.
106. Hunt R.D. Treatment effects of oral and transdermal clonidine in relation to methylphenidate: An open pilot study in ADD-H. Psychopharmacol Bull. 23:1987;111-114.
107. Hunt G.E., Atrens D.M. Reward summation and the effects of pimozide, clonidine, and amphetamine on fixed-interval responding for brain stimulation. Pharmacol Biochem Behav. 42:1992;563-577.
108. Hunt R.D., Minderra R., Cohen D.J. Clonidine benefits children with attention deficit disorder: report of a double-blind crossover trial. J Am Acad Child Adolesc Psychiatry. 24:1985;617-629.
109. Hunt R.D., Arnsten A.F.T., Asbell M.D. An open trial of guanfacine in the treatment of attention deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 34:1995;50-54.
110. Hurst P.M., Radlow R., Chubb N.C., Bagley S.K. Effects of D-amphetamine on acquisition, persistence, and recall. Am J Psychol. 82:1969;307-319.
111. Hynd G.W., Semrud-Clikeman M., Lorys A.R., Novey E.S., Eliopulos D. Brain morphology in developmental dyslexia and attention deficit/hyperacitivy. Arch Neurol. 47:1990;919-926.
112. Iaboni F., Douglas V.I., Baker A.G. Effects of reward and response costs on inhibition in ADHD children. J Abnorm Psychol. 104:1995;232-240.
113. Inglis W.L., Dunbar J.S., Winn P. Outflow from the nucleus accumbens to the pedunculopontine tegmental nucleus: A dissociation between locomotor activity and the acquisition of responding for conditioned reinforcement stimulated by D-amphetamine. Neuroscience. 62:1994;51-64.
114. Johnson F.N., Waite K. Experientia. 27:1971;1316-1317.
115. Kamal L.A., Arbilla S., Langer S.Z. Presynaptic modulation of the release of dopamine from the rabbit caudate nucleus: differences between electrical stimulation, amphetamine and tyramine. J Pharmacol Exp Ther. 216:1981;592-598.
116. Katz J.L. Effects of drugs on stimulus control of behavior. III. Analysis of effects of pentobarbital and D-amphetamine. J Pharmacol Exp Ther. 246:1988;76-83.
117. Kelley A.E., Delfs J.M. Dopamine and conditioned reinforcment I. Differential effects of amphetamine microinjections into striatal subregions. Psychopharmacology. 103:1991;187-196.
118. Kempf E., Greilsamer J., Mack G., Mandel P. Correlation of behavioral differences in three strains of mice with differences in brain amines. Nature. 247:1974;483-485.
119. Kirouac G.J., Ganguly P.K. Up-regulation of dopamine receptors in the brain of the spontaneously hypertensive rat: an autoradiographic analysis. Neuroscience. 52:1993;135-141.
120. Klorman R. Cognitive event-related potentials in attention deficit disorder. J Learn Disabil. 24:1991;130-140.
121. Klorman R., Bauer L.O., Coons H.W., Lewis J.L., Peloquin L.J., Perlmutter R.A., Ryan R.M., Salzman L.F., Strauss J. Enhancing effects of methylphenidate on normal young adults' cognitive processes. Psychopharmacol Bull. 20:1984;3-9.
122. Klorman R., Brumaghim J.T., Salzman L.F., Strauss J., Borgstedt A.D., McBride M.C., Loeb L. Effects of methylphenidate on attention-deficit hyperactivity disorder with and without aggressive/noncompliant features. J Abnorm Psychol. 97:1988;413-422.
123. Klorman R., Brumaghim J.T., Fitzpatrick P.A., Borgstedt A. Methylphenidate speeds evaluation processes of attention deficit disorder adolescents during a continuous performance task. J Child Psychol Psychiatry. 19:1991;262-283.
124. Klorman R, Brumaghim J.T., Fitzpatrick P.A., Borgstedt A.D. Methylphenidate reduces abnormalities of stimulus classification in attention deficit disorder adolescents. J Abnorm Psychol. 101:1992;130-138.
125. Klorman R., Brumaghim J.T., Fitzpatrick P.A., Borgstedt A.D., Strauss J. Clinical and cognitive effects of methylphenidate on children with attention deficit disorder as a function of aggression/oppositionality and age. J Abnorm Psychol. 103:1994;206-221.
126. Kornetsky C. Effects of meprobamate, phenobarbital, and dextro-amphetamine on reaction time and learning in man. J Pharmacol. 123:1958;216-219.
127. Kostowski W. Noradrenergic interactions among central neurotransmitters. Essran W.B. Neurotransmitters, Receptors and Drug Action. 1980;SP Medical and Scientific Books, New York.
128. Krivanek J., McGaugh J.L. Agents Actions. 1:1969;36-42.
129. Krusch D.A., Klorman R., Brumaghim J.T., Fitzpatrick P.A., Borgstedt A.D., Strauss J. Methylphenidate slows reactions of children with Attention Deficit Disorder during and after an error. J Abnorm Child Psychol. 24:1996;633-650.
130. Kuczenski R., Segal D. Concomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis. J Neurosci. 9:1989;2051-2065.
131. Kuczenski R., Segal D.S., Leith N.J., Applegate C.D. Effects of amphetamine, methylphenidate, and apomorphine on regional brain 5-HT and 5-hydroxyindole acetic acid. Psychopharmacology. 93:1987;329-335.
132. LaHoste G.J., Swanson J.M., Wigal S.B. et al. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol Psychiatry. 1:1996;121-124.
133. Lacroix D., Ferron A. Electrophysiological effects of methylphenidate on the coeruleo-cortical noradrenergic system in the rat. Eur J Pharmacol. 149:1988;277-285.
134. Layer R.T., Uretsky N.J., Wallace L.J. Effect of serotonergic agonists in the nucleus accumbens on D-amphetamine-stimulated locomotion. Life Sci. 50:1992;813-820.
135. Le Moal M. Mesocorticolimbic dopaminergic neurons: Functional and regulatory roles. Bloom F.E., Kupfer D.J. Psychopharmacology: The Fourth Generation of Progress. 1996;283-294 Raven Press, New York.
136. Le Moal M., Simon H. Mesocorticolimbic dopaminergic network: functional and regulatory roles. Physiol Rev. 71:1991;155-234.
137. Levy F., Hobbes G. The action of stimulant medication in attention deficit disorder with hyperactivity: Dopaminergic, noradrenergic, or both? J Am Acad Child Adolesc Psychiatry. 27:1988;802-805.
138. Livingstone R.L., Dykman R.A., Ackerman P.T. Psychiatric comorbidity and response to two doses of methylphenidate in children with attention deficit disorder. J Child Adolesc Psychopharmacol. 2:1992;115-122.
139. Ljunberg T., Enquist M. Disruptive effects of low doses of D-amphetamine on the ability of rats to organize behavior into functional sequences. Psychopharmacology. 93:1987;146-151.
140. Loiselle D.L., Stamm J.S., Maitinsky S., Whipple S.C. Evoked potential and behavioral signs of attentive dysfunction in hyperactive boys. Psychophysiology. 17:1980;193-201.
141. Losier B.J., McGrath P.J., Klein R.M. Error patterns on the continuous performance test in non-medicated and medicated samples of children with and without ADHD: A meta-analytic review. J Child Psychol Psychiatry. 37:1996;971-987.
142. Lou H.C., Henriksen L., Bruhn P. Focal cerebral hypoperfusion in children with dysphasia and/or attention deficit disorder. Arch Neurol. 41:1984;825-829.
143. Lou H.C., Henriksen L., Bruhn P., Borner H., Nielsen J.B. Striatal dysfunction in attention deficit and hyperkinetic disorder. Arch Neurol. 46:1989;48-52.
144. Luthman J., Fredriksson A.T.L., Jonsson G., Archer T. Effects of D-amphetamine and methylphenidate on hyperactivity produced by neonatal 6-hydroxydopamine treatment. Psychopharmacology. 99:1989;550-557.
145. Lyness W.H., Friedle N.M., Moore K.E. Destruction of dopaminergic nerve terminals in nucleus accumbens: effects of amphetamine self-stimulation. Pharmacol Biochem Behav. 11:1979;553-556.
146. Lyon M., Robbins T.W. The action of central nervous stimulant drugs: a general theory concerning amphetamine effects. Essman W., Valzelli L. Current Developments in Psychopharmacology. 1975;79-163 Spectrum, New York.
147. Mathieu J.-F., Ferron A., Dewar K.M. Acute and chronic effects of methylphenidate on cortical adrenoceptors in the rat. Eur J Pharmacol. 162:1989;173-178.
148. Matochik J.A., Nordahl T.E., Gross M., Semple W.E., King A.C., Cohen R.M., Zametkin A.J. Effects of acute stimulant medication on cerebral metabolism in adults with hyperactivity. Neuropsychopharmacology. 8:1993;377-386.
149. Matochik J.A., Liebenauer L.L., King A.C., Szymanski H.V., Cohen R.M., Zametkin A.J. Cerebral glucose metabolism in adults with attention deficit hyperactivity disorder after chronic stimulant treatment. Am J Psychiatry. 151:1994;658-664.
150. Mattay V.S., Berman K.F., Ostrem J.L., Esposito G., Van Horn J.D., Bigelow L.B., Weinberger D.R. Dextroamphetamine enhances 'neural network-specific' physiological signals: a positron-emission tomography rCBF study. J Neurosci. 16:1996;4816-4822.
151. Mazurski E.J., Beninger R.J. The effects of (+)-amphetamine and apomorphine on responding for a conditioned reinforcer. Psychopharmacology. 90:1986;239-243.
152. McCracken J.T. A two part model of stimulant action on attention-deficit hyperactivity disorder in children. J Neuropsychiatry Clin Neurosci. 3:1991;201-209.
153. McGaugh J.L. Drug facilitation of learning and memory. Annu Rev Pharmacol. 13:1973;229-241.
154. McKeon T.W., Hendley E.D. Brain monoamines and metabolites in hypertensive and hyperactive rat strains. Clin Exp Hypertens. 10:1988;971-994.
155. McNamara C.G., Davidson E.S., Schenk S. A comparison of the motor-activating effects of acute and chronic exposure to amphetamine and methylphenidate. Pharmacol Biochem Behav. 45:1993;729-732.
156. Meador-Woodruff J.H., Damask S.P., Watson S.J. Jr. Differential expression of autoreceptors in the ascending dopamine systems of the human brain. Proc Natl Acad Sci USA. 91:1994;8297-8301.
157. Mefford I.N., Potter W.Z. A neuroanatomical and biochemical basis for attention deficit disorder with hyperactivity in children: a defect in tonic adrenaline mediated inhibition of locus coeruleus stimulation. Med Hypotheses. 29:1989;33-42.
158. Michael R.L., Klorman R., Salzman L.F., Borgstedt A.D., Dainer K. Normalizing effects of methylphenidate on hyperactive children's vigilance performance and evoked potentials. Psychophysiology. 18:1981;665-677.
159. Milberger S., Biederman J., Faraone S.V., Murphy J., Tsuang M.T. Attention deficit hyperactivity disorder and comorbid disoders: issues of overlapping symptoms. Am J Psychiatry. 152:1995;1793-1799.
160. Mithani S., Martin-Iverson M.T., Phillips A.G., Fibiger H.C. The effects of haloperidol on amphetamine- and methylphenidate-induced conditioned place preferences and locomotor activity. Psychopharmacology. 90:1986;247-252.
161. Naylor H., Halliday R., Callaway E. The effect of methylphenidate on information processing. Psychopharmacology. 86:1985;90-95.
162. Newman R.P., Weingartner H., Smallberg S.A., Calne D. Effortful and automatic memory: Effects of dopamine. Neurology. 34:1984;805-807.
163. Novak G.P., Solanto M., Abikoff H. Spatial orienting and focused attention in attention deficit hyperactivity disorder. Psychophysiology. 32:1995;546-559.
164. O'Dougherty M.O., Nuechterlein K.H., Drew B. Hyperactive and hypoxic children: Signal detection, sustained attention, and behavior. J Abnorm Psychol. 93:1984;178-191.
165. Oken B.S., Kishiyama S.S., Salinsky M.C. Pharmacologically induced changes in arousal: effects on behavioral and electrophysiologic measures of alertness and attention. Electroencephalogr Clin Neurophysiol. 95:1995;359-371.
166. Olmstead M.C., Franklin K.B.J. Lesions of the pedunculopontine tegmental nucleus block drug-induced reinforcement, but not amphetamine-induced locomotion. Brain Res. 638:1994;29-35.
167. Olpe H.-R., Steinmann M.W., Jones R.S.G. Locus coeruleus as a target for psychogeriatric agents. Ann NY Acad Sci. 444:1985;394-405.
168. Packard M.G., White N.M. Memory facilitation produced by dopamine agonists: Role of receptor subtype and mnemonic requirements. Pharmacol Biochem Behav. 33:1989;511-518.
169. Patrick S.L., Thompson T.L., Walker J.M., Patrick R.L. Concomitant sensitization of amphetamine-induced behavioral stimulation and in vivo dopamine release from rat caudate nucleus. Brain Res. 2:1991;343-346.
170. Peeke S., Halliday R., Callaway E., Prael R., Reus V. Effects of two doses of methylphenidate on verbal information processing in hyperactive children. J Clin Psychopharmacol. 4:1984;82-88.
171. Pelham W.E., Milich R., Walker J.L. Effects of continuous and partial reinforcement and methylphenidate on learning in children with attention deficit disorder. J Abnorm Psychol. 95:1986;319-325.
172. Peloquin L.J., Klorman R. Effects of methylphenidate on normal children's mood, event-related potentials, and performance in memory scanning and vigilance. J Abnorm Psychol. 95:1986;88-98.
173. Phillips G.D., Robbins T.W., Everitt B.J. Bilateral intra-accumbens self-administration of D-amphetamine: antagonism with intra-accumbens SCH-23390 and sulpiride. Psychopharmacology. 114:1994;477-485.
174. Pieters J.P.M. Reaction time analysis of simple mental tasks: A general approach. Acta Psychol. 59:1985;227-269.
175. Pliszka S.R. Tricyclic antidepressants in the treatment of children with attention deficit disorder. J Am Acad Child Adolesc Psychiatry. 26:1987;127-132.
176. Pliszka S.R. Effect of anxiety on cognition, behavior, and stimulant response in ADHD. J Am Acad Child Adolesc Psychiatry. 28:1989;882-887.
177. Pliszka S.R., McCracken J.T., Maas J.W. Catecholamines in
178. Porrino L.J., Goldman-Rakic P.S. Brainstem innervation of prefrontal and anterior cingulate cortex in the rhesus monkey revealed by retrograde transport of HRP. J Comp Neurol. 205:1982;63-76.
179. Porrino L.J., Lucignani G. Different patterns of local brain energy metabolism associated with high and low doses of methylphenidate: Relevance to its action in hyperactive children. Biol Psychiatry. 22:1987;126-138.
180. Pribram K.H., McGuinness D. Arousal, activation, and effort in the control of attention. Psychol Rev. 82:1975;116-149.
181. Porrino L.J., Rapoport J.L., Behar D., Ismond D.R., Bunney W.E. A naturalistic assessment of the motor activity of hyperactive boys II. Stimulant drug effects. Arch Gen Psychiatry. 40:1983;688-693.
182. Porrino L.J., Rapoport J.L., Behar D., Sceery W., Ismond D.R., Bunney W.E. A naturalistic assessment of the motor activity of hyperactive boys I. Comparison with normal controls. Arch Gen Psychiatry. 40:1983;681-687.
183. Porrino L., Lucignani G., Dow-Edwards D., Sokoloff L. Correlation of dose-dependent effects of acute amphetamine administration on behavior and local cerebral metabolism in rats. Brain Res. 307:1984;311-320.
184. Quartermain D., Judge M.E., Jung H. Amphetamine enhances retrieval following diverse sources of forgetting. Physiol Behav. 43:1988;239-241.
185. Rajkowski J., Kubiak P., Aston-Jones G. Locus coeruleus activity in monkey: phasic and tonic changes are associated with altered vigilance. Brain Res Bull. 35:1994;607-616.
186. Rajkowski J, Kubiak P, Ivanova S, Aston-Jones G. State-related activity and reactivity of locus coeruleus neurons in behaving monkeys. Adv Pharmacol 1997, in press.
187. Rapoport J.L., Buchsbaum M.S., Weingartner H., Zahn T.P., Ludlow C. Dextroamphetamine: Cognitive and behavioral effects in normal prepubertal boys. Science. 199:1978;560.
188. Rapoport J.L., Buchsbaum M.S., Weingartner H., Zahn T.P., Ludlow C. Dextroamphetamine: Cognitive and behavioral effects in normal and hyperactive boys and normal men. Arch Gen Psychiatry. 37:1980;933.
189. Rapoport J.L., Zametkin A., Donnelly M., Ismond D. New drug trials in attention deficit disorder. Psychopharmacol Bull. 21:1985;232-236.
190. Rapport M.D., Kelly K.L. Psychostimulant effects on learning and cognitive function: Findings and implications for children with attention deficit hyperactivity disorder. Clin Psychol Rev. 11:1991;61-92.
191. Rapport M.D., DuPaul G.J., Smith N.F. Rate-dependency and hyperactivity: Methylphenidate effects on operant responding. Pharmacol Biochem Behav. 23:1985;77-83.
192. Rapport M.D., Stoner G., DuPaul G.J., Birmingham B.K., Tucker S. Methylphenidate in hyperactive children: Differential effects of dose on academic, learning, and social behavior. J Abnorm Child Psychol. 13:1985;227-244.
193. Rapport M.D., Stoner G., DuPaul G.J., Kelly K.L., Tucker S.B., Schoeler T. Attention deficit disorder and methylphenidate: A multilevel analysis of dose-response effects on children's impulsivity across settings. J Am Acad Child Adolesc Psychiatry. 27:1988;60-69.
194. Rapport M.D., Quinn S.O., DuPaul G.J., Quinn E.P., Kelly K.L. Attention deficit disorder with hyperactivity and methylphenidate: The effects of dose and mastery level on children's learning performance. J Abnorm Child Psychol. 17:1989;669-689.
195. Rapport M.D., Carlson G.A., Kelly K.L., Pataki C. Methylphenidate and desipramine in hospitalized children: I. Separate and combined effects on cognitive function. J Am Acad Child Adolesc Psychiatry. 32:1993;333-342.
196. Rapport M.D., Denney C., DuPaul G.J., Gardner M.J. Attention deficit disorder and methylphenidate: Normalization rates, clinical effectiveness, and response prediction in 76 children. J Am Acad Child Adolesc Psychiatry. 33:1994;882-893.
197. Rebec G.V., Curtis S.D. Reciprocal changes in the firing rate of neostriatal and dorsal raphe neurons following local infusions or systemic injections of D-amphetamine. Evidence for neostriatal heterogeneity. J Neurosci. 3:1983;2240-2250.
198. Reid M.K., Borkowski J.G. Effects of methylphenidate (Ritalin) on information processing in hyperactive children. J Abnorm Child Psychol. 12:1984;169-186.
199. Ritz M.C., Kuhar M.J. Relationship between self-administration of amphetamine and monoamine receptors in brain: Comparison with cocaine. J Pharmacol Exp Ther. 248:1989;1010-1017.
200. Robbins T.W., Everitt B.J. Central norepinephrine neurons and behavior. Bloom F.E., Kupfer D.J. Psychopharmacology: The Fourth Generation of Progress. 1996;363-372 Raven Press, New York.
201. Robbins T.W., Sahakian B.J. Paradoxical effects of psychomotor stimulant drugs in hyperactive children from the standpoint of behavioural pharmacology. Neuropharmacology. 18:1979;931-950.
202. Robbins T.W., Roberts D.C.S., Koob G.F. Effects of D-amphetamine and apomorphine upon behaviour and schedule-induced licking in rats with 6-hydroxydopamine-induced lesions of the nucleus accumbens. J Pharmacol Exp Ther. 222:1983;662-673.
203. Robbins T.W., Evender J.L., Ksir C., Reading P., Wood S., Carli M. The effects of D-amphetamine, alpha-flupenthixol and mesolimbic dopamine depletion on a test of attentional switching in the rat. Psychopharmacology. 90:1986;72-78.
204. Robinson T.E. Behavioral sensitization: characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats. Psychopharmacology. 84:1984;466-475.
205. Robinson T.E., Becker J.B. Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis. Brain Res Rev. 11:1986;157-198.
206. Roth R.H., Elsworth J.D. Biochemical pharmacology of midbrain dopamine neurons. Bloom F.E., Kupfer D.J. Psychopharmacology: The Fourth Generation of Progress. 1996;227-243 Raven Press, New York.
207. Russell V., de Villiers A., Sagvolden T., Lamm M., Taljaard J. Altered dopaminergic function in the prefrontal cortex, nucleus accumbens and caudate-putamen of an animal model of Attention-Deficit Hyperactivity Disorder - the spontaneously hyperactive rat. Brain Res. 676:1995;343-351.
208. Sadile A.G., Lamberti C., Siegfried B., Welzl H. Circadian activity, nociceptive thresholds, nigrostriatal and mesolimbic dopaminergic activity in the Naples High- and Low-Excitability rat lines. Behav Brain Res. 55:1993;17-27.
209. Sadile AG, Aspide R, Sagvolden T, Sergeant J. Novelty-induced rearing duation in two animal models of attention deficit hyperactivity disorder. In: Annual Meeting of the Society for Neuroscience, San Diego, CA, 1995.
210. Sagvolden T., Slåtta K., Arntzen E. Low doses of methylphenidate (Ritalin) may alter the delay-of-reinforcement gradient. Psychopharmacology. 95:1988;303-312.
211. Sagvolden T., Metzger M.A., SchiÝrbeck H.K., Rugland A.-L., Spinnangr I., Sagvolden G. The Spontaneously Hypertensive Rat as an animal model of childhood hyperactivity (ADHD): Changed reactivity to reinforcers and to psychomotor stimulants. Behav Neural Biol. 58:1992;103-112.
212. Sagvolden T., Metzger M.A., Sagvolden G. Frequent reward eliminates differences in activity between hyperkinetic rats and controls. Behav Neural Biol. 59:1993;225-229.
213. Sagvolden T., Pettersen M.B., Larsen M.C. Spontaneously hypertensive rats (SHR) as a putative animal model of childhood hyperkinesis: SHR behavior compared to four other rat strains. Behav Neural Biol. 54:1993;1047-1055.
214. Sallee F. Dopamine systems and attentional functioning. In: Annual Meeting of the American Academy of Child Adolescent Psychiatry, Philadelphia, 1996.
215. Sanders A.V. Towards a model of stress and human performance. Acta Psychol. 53:1983;61-97.
216. Sara S.J., Deweer B. Memory retrieval enhanced by amphetamine after a long retention interval. Behav Neural Biol. 36:1982;146-160.
217. Schachar R., Logan G.D. Are hyperactive children deficient in attentional capacity? J Abnorm Child Psychol. 18:1990;493-513.
218. Schachar R., Logan G., Wachsmuth R., Chajczyk D. Attaining and maintaining preparation: A comparison of attention in hyperactive, normal, and disturbed control children. J Abnorm Child Psychol. 16:1988;361-378.
219. Scheel-Krüger J. Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain. Eur J Pharmacol. 14:1971;47-59.
220. Schroeder S.R., Mann-Koepke K., Gualtieri C.T., Eckerman D.A., Breese G.R. Methylphenidate affects strategic choice behavior in normal adult humans. Pharmacol Biochem Behav. 28:1987;213-217.
221. Schultz W. Behavior-related activity of primate dopamine neurons. Rev Neurol. 150:1994;634-639.
222. Seidel W.T., Joschko M. Evidence of difficulties in sustained attention in children with ADDH. J Abnorm Child Psychol. 18:1990;217-229.
223. Sergeant J.A., van der Meere J.J. Additive factor method applied to psychopathology with special reference to childhood hyperactivity. Acta Psychol. 74:1990;277-296.
224. 2-autoreceptor agonists, with special reference to indolybutylamines. Drugs Future. 8:1990;819-832.
225. Shaywitz B.A., Yager R.D., Klopper J.H. An experimental model of minimal brain dysfunction (MBD) in developing rats. Science. 191:1976;305-308.
226. Shaywitz B.A., Klopper J.H., Gordon J.W. Methylphenidate in 6-hydroxydopamine-treated developing rat pups: Effects on activity and maze performance. Arch Neurol. 35:1978;463-469.
227. Shenker A. The mechanism of action of drugs used to treat attention deficit hyperactivity disorder: focus on catecholamine receptor pharmacology. Adv Pediatr. 39:1992;337-382.
228. Silverstone P.H., Oldman D., Johnson B., Cowen P.J. Ondansetron, a 5-HT3 receptor anatagonist, partially attenuates the effects of amphetamine: a pilot study in healthy volunteers. Int Clin Psychopharmacol. 7:1992;37-43.
229. Skirboll L.R., Grace A.A., Bunney B.S. Dopamine auto- and postsynaptic receptors: Electrophysiological evidence for differential sensitivity to dopamine agonists. Science. 206:1979;80-82.
230. Soetens E., Casaer S., D'Hooge R., Hueting J. Effect of amphetamine on long-term retention of verbal material. Psychopharmacology. 119:1995;155-162.
231. Solanto M.V. Neuropharmacological basis of stimulant drug action in attention deficit disorder with hyperactivity: A review and synthesis. Psychol Bull. 95:1984;387-409.
232. Solanto M.V. Behavioral effects of low-dose methylphenidate in childhood attention deficit disorder: Implications for a mechanism of stimulant drug action. J Am Acad Child Adolesc Psychiatry. 25:1986;96-101.
233. Solanto M.V. Dosage effects of Ritalin on cognition. Greenhill L.L., Osman B.B. Ritalin: Theory and Patient Management. 1991;Mary Ann Lieber, New York.
234. Solanto M.V., Conners C.K. A dose-response and time-action analysis of autonomic and behavioral effects of methylphenidate in attention deficit disorder with hyperactivity. Psychophysiology. 19:1982;658-667.
235. Solanto M.V., Wender E.H. Does methylphenidate constrict cognitive functioning? J Am Acad Child Adolesc Psychiatry. 26:1989;897-902.
236. Solanto MV, Wender EH, Bartell SS. Effects of methylphenidate and behavioral contingencies on vigilance in AD/HD: A test of the reward dysfunction hypothesis. J Child Adolesc Psychopharmacol 1997, in press.
237. Sonders M.S., Zhu S.-J., Zahniser N.R., Kavanaugh M.P., Amara S.G. Multiple ionic conductances of the human dopamine transporter: The actions of dopamine and psychostimulants. J Neurosci. 17:1997;960-974.
238. Sostek A.J., Buchsbaum M.S., Rapoport J.L. Effects of amphetamine on vigilance performance in normal and hyperactive children. J Abnorm Child Psychol. 8:1980;491-500.
239. Sprague R.L., Sleator E.K. Methylphenidate in hyperkinetic children: differences in dose effects on learning and social behavior. Science. 198:1977;1274-1276.
240. Spyraki C., Fibiger H.C., Phillips A.G. Dopaminergic substrates of amphetamine-induced place-preference conditioning. Brain Res. 253:1982;185-193.
241. Sternberg S. Discovery of processing stages: Extensions of Donders' method. Acta Psychol. 8:1969;276-315.
242. Strauss J., Lewis J.L., Klorman R., Peloquin L.J., Perlmutter R.A., Salzman L.F. Effects of methylphenidate on young adults' performance and event-related potentials in a vigilance and a paired-associates learning test. Psychophysiology. 21:1984;609-621.
243. Stromberg Differences between (+) and (-) amphetamine in effects on locomotor activity and L-Dopa potentiating action in mice. Naunyn-Schmiedberg's Arch Pharmacol. 287:1975;171-179.
244. Strombom U. Catecholamine receptor agonists: Effects on motor activity and rate of tyrosine hydroxylation in mouse brain. Naunyn-Schmiedeberg's Arch Pharmacol. 292:1976;167-176.
245. Strupp B.J., Bunsey M., Levitsky D., Kesler M. Time-dependent effects of post-trial amphetamine treatment in rats: Evidence for enhanced storage of representational memory. Behav Neural Biol. 56:1991;62-76.
246. Svenssen T.H., Bunney B.S., Aghajanian G.K. Inhibition of both noradrenergic and serotonergic neurons in the brain by the alpha-adrenergic agonist clonidine. Brain Res. 92:1975;291-306.
247. Swanson J.M., Kinsbourne M.K., Roberts W., Zucker K. Time response analysis of the effect of stimulant medication on learning ability of children referred for hyperactivity. Pediatrics. 61:1978;21-29.
248. Swanson J.M., Posner M., Potkin S., Bonforte S., Youpa D., Fiore C., Cantwell D., Crinella F. Activating tasks for the study of visual-spatial attention in ADHD children: A cognitive anatomic approach. J Child Neurol. 6(Suppl):1991;S117-S127.
249. Swanson J.M., Kennedy M., Barr C. Molecular Genetics of ADHD. 1997;International Society for Research in Child and Adolescent Psychopathology, Paris, France.
250. Sykes D.H., Douglas V.I., Morgenstern G. The effect of methylphenidate (Ritalin) on sustained attention in hyperactive children. Psychopharmacology. 25:1972;262-274.
251. Sykes D.H., Douglas V.I., Morgenstern G. Sustained attention in hyperactive children. J Child Psychol Psychiatry. 14:1973;213-220.
252. Talmaciu R.K., Hofmann I.S., Cubeddu L.X. Dopamine autoreceptors modulate dopamine release from the prefrontal cortex. J Neurochem. 47:1986;865-870.
253. Tannock R., Schachar R.J. Methylphenidate and cognitive perseveration in hyperactive children. J Am Acad Child Adolesc Psychiatry. 33:1992;1217-1228.
254. Tannock R., Schachar R.J., Carr R.P., Chajczyk D., Logan D. Effects of methylphenidate on inhibitory control in hyperactive children. J Abnorm Child Psychol. 17:1989;473-491.
255. Tannock R., Ickowiz A., Schachar R. Differential effects of methylphenidate on working memory in ADHD children with and without comorbid anxiety. J Am Acad Child Adolesc Psychiatry. 34:1995;886-896.
256. Tannock R., Schachar R., Logan G. Methylphenidate and cognitive flexibility: dissociated dose effects in hyperactive children. J Abnorm Child Psychol. 23:1995;235-266.
257. Taylor M.J., Voros J.G., Logan W.J., Malone M.A. Changes in event-related potentials with stimulant medication in children with attention deficit hyperactivity disorder. Biol Psychol. 36:1993;139-156.
258. Taylor J.R., Robbins T.W. 6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens D-amphetamine. Psychopharmacology. 90:1986;390-397.
259. Thierry A., Mantz J., Glowinski J. Influence of dopaminergic and noradrenergic afferents on their target cells in the rat medial prefrontal cortex. Adv Neurol. 57:1992;545-554.
260. Thurmond J.B., Freeman G.B., Soblosky J.S., Ieni J.R., Brown J.W. Effects of dietary tyrosine on L-dopa-and amphetamine-induced changes in locomotor activity and neurochemistry in miceActivating tasks for the study of visual-spatial attention in ADHD children: A cognitive anatomic approach. Pharmacol Biochem Behav. 37:1990;259-266.
261. Trommer B.L., Hoeppner J.B., Zecker S.G. The go-no go test in attention deficit disorder is sensitive to methylphenidate. J Child Neurol. 6:1991;126-129.
262. Trujillo K.A., Belluzzi J.D., Stein L. Naloxone blockade of amphetamine place preference conditioning. Psychopharmacology. 104:1991;265-274.
263. Tsai S.J., Huang Y.H., Chang L.S., Yang Y.C., Sim C.B. Alterations in local cerebral glucose utilization in rats after chronic amphetamine administration without subsequent challenge. Psychiatry Res. 57:1995;65-73.
264. Tucker D.M., Williamson P.A. Asymmetric neural control systems in human self-regulation. Psychol Rev. 91:1984;185-215.
265. Ungerstedt U. Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol Scand. 367:1971;1-48.
266. Van den Buuse M., Jones C.R., Wagner J. Brain dopamine D-2 receptor mechanisms in spontaneously hypertensive rats. Brain Res Bull. 28:1992;289-297.
267. van der Meere J.J. The role of attention. Sandberg S. Monographs on Child and Adolescent Psychiatry: Hyperactivity Disorders. 1996;109-145 Cambridge University Press, Cambridge.
268. van der Meere J., Sergeant J. Controlled processing and vigilance in hyperactivity: Time will tell. J Abnorm Child Psychol. 16:1988;641-655.
269. van der Meere J., Stemerdink N. Effects of presentation rate of stimuli on response inhibition in ADHD children with and without tics. Percept Mot Skills. 81:1995;259-262.
270. van der Meere J.J., van Baal M., Sergeant J.A. The additive factor method: a differential diagnostic tool in hyperactive and learning disability. J Abnorm Child Psychol. 33:1989;409-422.
271. van der Meere J.J., Shalev R.S., Burger N., Gross-Tsur V. Sustained attention, activation, and MPH in ADHD. J Child Psychol Psychiatry. 36:1995;697-703.
272. Versteeg D.H.G., Palkovits M., Van den Gugten J., Wijnen H.L.J.M., Smeets G.W.M., De Jong W. Catecholamine content of individual brain regions of spontaneously hypetensive rats (SH-rats). Brain Res. 112:1976;429-434.
273. Voeller K.K.S., Heilman K.M. Attention deficit disorder in children: A neglect syndrome? Neurology. 38:1988;806-808.
274. Volkow N.D., Ding Y.S., Fowler J.S., Wang G.J., Logan J., Gatley J.S., Dewey S., Ashby C., Lieberman J., Hitzemann R., Wolf A.P. Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain. Arch Gen Psychiatry. 52:1995;456-463.
275. Vyse S.A., Rapport M.D. The effect of methylphenidate in children with ADDH: The stimulus equivalence paradigm. J Consult Clin Psychol. 57:1989;425-435.
276. Waldman I.D., Rowe D.C., Abramowitz A., Kozel S., Mohr J., Sherman S.L., Cleveland H.H., Sanders M.L., Stever C. Association of dopamine transporter gene (DAT1) and attention deficit hyperactivity disorder in children. Am J Hum Genet. 59:1997;25.
277. Weber K. Methylphenidate: Rate-dependent drug effects in hyperactive children. Psychopharmacology. 85:1985;231-235.
278. Weiss B., Laties V.G. Enhancement of human performance by caffeine and the amphetamines. Pharmacol Rev. 14:1962;1-35.
279. Weitzner M. Manifest anxiety, amphetamine, and performance. J Psychol. 60:1965;71-79.
280. Weizman A., Weitz R., Szekely G.A. et al. Combination of neuroleptic and stimulant treatment in attention deficit disorder with hyperactivity. J Am Acad Child Adolesc Psychiatry. 23:1984;295-298.
281. Werry J.S., Aman M.G. Methylphenidate and haloperidol in children. Arch Gen Psychiatry. 32:1975;790-795.
282. Wetzel C.D., Squire L.R., Janowsky D.S. Methylphenidate impairs learning and memory in normal adults. Behav Neural Biol. 31:1981;413-424.
283. White F.J., Wang R.Y. Electrophysiological evidence for A10 dopamine autoreceptor subsensitivity following chronic D-amphetamine treatment. Brain Res. 309:1984;283-292.
284. Wise R.A., Munn E. Effects of repeated amphetamine injections on lateral hypothalamic brain stimulation reward and subsequent locomotion. Behav Brain Res. 55:1993;195-201.
285. Wilkison P.C., Kircher J.C., McMahon W.M., Sloane H.N. Effects of methylphenidate on reward strength in boys with attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 34:1995;897-901.
286. Yerkes R.M., Dodson J.D. The relation of stimulus strength to rapidity of habit formation. J Comp Neurol Psychol. 18:1908;459-482.
287. Zametkin A., Rapoport J.L., Murphy D., Linnoila M., Ismond D. Treatment of hyperactive children with monoamine oxidase inhibitors. Arch Gen Psychiatry. 42:1985;962-966.
288. Zametkin A.J., Rapoport J.L. Neurobiology of attention deficit disorder with hyperactivity: where have we come in 50 years? J Am Acad Child Adolesc Psychiatry. 26:1987;676-686.
289. Zametkin A.J., Nordahl T.E., Gross M., King A.C., Semple W.E., Rumsey J., Hamburger S., Cohen R.M. Cerebral glucose metabolism in adults with hyperactivity of childhood onset. New Engl J Med. 323:1990;1361-1366.
290. Zametkin A.J., Liebenauer L.L., Fitzgerald G.A., King A.C., Minkunas D.V., Herscovitch P., Yamada E.M., Cohen R.M. Brain metabolism in teenagers with attention deficit hyperactivity disorder. Arch Gen Psychiatry. 50:1993;333-340.