Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate

Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2003, Pages 1538-1545

  Meltzer, Peter C ^a   Wang, Pinglang ^a   Blundell, Paul ^a   Madras, Bertha K ^b  

^a ORGANIX INC   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3,4 DICHLOROPHENYL) 2 (TETRAHYDROPYRAN 2 YL)ACETIC ACID METHYL ESTER; 3,4 DICHLOROPHENYLOXAMETHYLPHENIDATE DERIVATIVE; ACETIC ACID DERIVATIVE; BRAIN MONOAMINE; COCAINE; DOPAMINE TRANSPORTER; DOPAMINE UPTAKE INHIBITOR; METHYLPHENIDATE; NITROGEN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN TISSUE; CHEMICAL INTERACTION; COCAINE DEPENDENCE; CONTROLLED STUDY; DOPAMINE UPTAKE; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERANCE; ENANTIOMER; ENANTIOSELECTIVITY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MACACA; MALE; NONHUMAN; PROTEIN DETERMINATION; SEROTONIN UPTAKE; STEREOCHEMISTRY;

ANIMALS; BINDING, COMPETITIVE; CARRIER PROTEINS; CAUDATE NUCLEUS; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; FEMALE; MACACA FASCICULARIS; MACACA MULATTA; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT MODULATORS; MEMBRANE TRANSPORT PROTEINS; METHYLPHENIDATE; NERVE TISSUE PROTEINS; PHENYLACETATES; PUTAMEN; PYRANS; RADIOLIGAND ASSAY; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037431381     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0205292     Document Type: Article

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