Tropisetron modulation of the glycine receptor: Femtomolar potentiation and a molecular determinant of inhibition

Journal of Neurochemistry

Volumn 100, Issue 3, 2007, Pages 758-769

  Yang, Zhe ^a   Ney, Agnieszka ^a   Cromer, Brett A ^b   Ng, Hooi Ling ^b   Parker, Michael W ^b   Lynch, Joseph W ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

5 HT3 receptor antagonist; Binding site; Cys loop receptor; Femtomolar; Ligand gated ion channel; Molecular structure and function; Tropeine

Indexed keywords

3 INDOLECARBOXYLIC ACID 2 (1 PIPERIDINYL)ETHYL ESTER; ANTIEMETIC AGENT; ATROPINE; CHLORIDE CHANNEL; GLYCINE RECEPTOR; NITROGEN; SEROTONIN 3 ANTAGONIST; TROPANE DERIVATIVE; TROPISETRON;

ALPHA CHAIN; ARTICLE; BETA CHAIN; BINDING SITE; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; DRUG BINDING; DRUG INHIBITION; DRUG POTENCY; DRUG POTENTIATION; GENE MUTATION; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; MOLECULAR INTERACTION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CELL LINE; CELL MEMBRANE; CHLORIDE CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GLYCINE; HUMANS; INDOLES; ION CHANNEL GATING; LIGANDS; MODELS, MOLECULAR; MUTATION; NEURAL INHIBITION; NITROGEN; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, GLYCINE; SEROTONIN ANTAGONISTS;

EID: 33846198278     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04242.x     Document Type: Article

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