Molecular basis of interactions of cholinesterases with tight binding inhibitors

Chemico-Biological Interactions

Volumn 157-158, Issue , 2005, Pages 133-141

  Radić, Zoran ^a   Manetsch, Roman ^b   Krasiński, Antoni ^b   Raushel, Jessica ^b   Yamauchi, John ^a   Garcia, Cindy ^a   Kolb, Hartmuth ^b   Sharpless, K Barry ^b   Taylor, Palmer ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Acetylcholinesterase; Click chemistry; Conformational flexibility; Fasciculin; Femtomolar inhibitors; Interaction kinetics; Reversible inhibition; Tight binding; Triazole inhibitors; Trifluoroacetophenone

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; ACETOPHENONE DERIVATIVE; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; FASCICULIN; SERINE; SNAKE VENOM;

BINDING AFFINITY; COMPARATIVE STUDY; CONFERENCE PAPER; COVALENT BOND; DISSOCIATION; DRUG SELECTIVITY; DRUG STRUCTURE; ELECTROPHORUS; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; MOLECULAR SIZE; MOUSE; NONHUMAN; PHARMACOPHORE; PROTEIN INTERACTION;

ACETOPHENONES; AMINO ACID SEQUENCE; ANIMALS; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; CRYSTALLOGRAPHY, X-RAY; ELAPID VENOMS; FLUORIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; STEREOISOMERISM; TRIAZOLES;

ELECTROPHORUS;

EID: 28744458913     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2005.10.020     Document Type: Conference Paper

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