Bidirectional allosteric modulation of strychnine-sensitive glycine receptors by tropeines and 5-HT3 serotonin receptor ligands

Neuropharmacology

Volumn 37, Issue 12, 1998, Pages 1633-1641

  Maksay, Gábor ^a  

^a CHEMICAL RESEARCH CENTER   (Hungary)

Author keywords

5 HT3 receptor ligands; Allosteric modulation; Dissociation of strychnine; Glycine receptor ionophore complex; Strychnine binding; Tropeines

Indexed keywords

1 (3 CHLOROPHENYL)BIGUANIDE; 4 AMINO 1 (6 CHLORO 2 PYRIDYL)PIPERIDINE; BEMESETRON; GLYCINE; GLYCINE RECEPTOR; GRANISETRON; IONOPHORE; METOCLOPRAMIDE; SEROTONIN; STRYCHNINE; ZATOSETRON;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISSOCIATION; DRUG BINDING; LIGAND BINDING; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT;

ALLOSTERIC REGULATION; ANIMALS; BENZOFURANS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; GLYCINE; GRANISETRON; INDOLES; LIGANDS; MALE; MEDULLA OBLONGATA; ONDANSETRON; PONS; RATS; RATS, WISTAR; RECEPTORS, GLYCINE; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SPINAL CORD; STRYCHNINE; TROPANES; TUBOCURARINE;

EID: 0032404064     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00127-0     Document Type: Article

References (28)

1. 3 receptors in vitro and in vivo. Eur. J. Pharmacol. 237:1993;299-309.
2. Betz H., Becker C.M. The mammalian glycine receptor: biology and structure of a neuronal chloride channel protein. Neurochem. Int. 13:1988;137-146.
3. Bradford M.M. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
4. 3 antagonists in rat spinal neurones. Br. J. Pharmacol. 118:1996;2115-2125.
5. 3H]strychnine binding sites in rat spinal cord and brainstem. Eur. J. Pharmacol. 318:1996;201-204.
6. Flynn D.D., Vaishnav A.A., Mash D.C. Interactions of cocaine with primary and secondary recognition sites on muscarinic receptors. Mol. Pharmacol. 41:1992;736-742.
7. 3 receptors modulate spinal nociceptive reflexes. Brain Res. 510:1990;12-16.
8. 3 receptor antagonists. Drugs. 53:1997;20-39.
9. Grenningloh G., Rienitz A., Schmitt B. et al. The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature. 328:1987;215-220.
10. 3 receptors: pharmacologic and therapeutic aspects. J. Clin. Pharmacol. 35:1995;845-855.
11. A and glycine receptors by chlormethiazole. Eur. J. Pharmacol. 210:1992;239-246.
12. 3 recognition sites in membranes of cat and rabbit vagus nerve and superior cervical ganglion, Naunyn-Schmiedeberg's Arch. Pharmacol. 340:1989;396-402.
13. A receptors. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 268:1994;237-246.
14. Kostenis E., Mohr K. Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation. TIPS. 17:1996;280-283.
15. Lynch J.W., Rajendra S., Barry P.H., Schofield P.R. Mutations affecting the glycine agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator. J. Biol. Chem. 270:1995;13799-13806.
16. A and glycine receptors, respectively, suggests similar cooperative interactions. J. Neurochem. 54:1990;1961-1966.
17. Maksay G. Kinetic cooperative effect of glycine receptor agonists and antagonists on the dissociation of strychnine binding. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 245:1993;183-185.
18. A receptor binding to ionophore function. Neurochem. Int. 29:1996;361-370.
19. 3H]granisetron binding. J. Neurochem. 67:1996;407-412.
20. 3H]strychnine binding by monovalent anions reveals similarities between γ-aminobutyric acid- and glycine-gated chloride channels. J. Neurochem. 50:1988;1632-1639.
21. 3H]strychnine binding to glycine-gated chloride channels is explained by the presence of two anion binding sites. Mol. Pharmacol. 34:1988;806-813.
22. O'Connor V., Phelan P.P., Fry J.P. Interactions of glycine and strychnine with their receptor recognition sites in mouse spinal cord. Neurochem. Int. 29:1996;423-434.
23. 7 nicotinic receptor converts 5-hydroxytryptamine from antagonist to agonist. Proc. Natl. Acad. Sci. USA. 93:1996;11231-11235.
24. Schmieden V., Jezequel S., Betz H. Novel antagonists of the inhibitory glycine receptor derived from quinolinic acid compounds. Mol. Pharmacol. 50:1996;1200-1206.
25. Wakamori M., Ikemoto Y., Akaike N. Effects of two volatile anaesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the rat. J. Neurophysiol. 66:1991;2014-2021.
26. Wu F.S., Gibbs T.T., Farb D.H. Inverse modulation of γ-aminobutyric acid- and glycine-induced currents by progesterone. Mol. Pharmacol. 37:1990;597-602.
27. Wu F.S., Chen S.C., Tsai J.J. Competitive inhibition of the glycine-induced current by pregnenolone sulfate in cultured chick spinal cord neurons. Brain Res. 750:1997;318-320.
28. Young A.B., Zukin S.R., Snyder S.H. Interaction of benzodiazepines with central nervous glycine receptors: possible mechanism of action. Proc. Natl. Acad. Sci. USA. 71:1974;2246-2250.