메뉴 건너뛰기




Volumn 21, Issue 1, 2007, Pages 81-88

Effect of α-asarone and a derivative on lipids, bile flow and Na +/K+-ATPase in ethinyl estradiol-induced cholestasis in the rat

Author keywords

Estrogens; Ethynylestradiol; K+ ATPase; Liver damage; Liver injury; N+

Indexed keywords

2 METHOXY 4 (2 PROPENYL)PHENOXYACETIC ACID; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALKALINE PHOSPHATASE; ALPHA ASARONE; ANTILIPEMIC AGENT; BILE ACID; ETHINYLESTRADIOL; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 33846192354     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2006.00453.x     Document Type: Article
Times cited : (8)

References (39)
  • 1
    • 0032558588 scopus 로고    scopus 로고
    • Molecular pathogenesis of cholestasis
    • Trauner M., Meier P.J., Boyer J.L. Molecular pathogenesis of cholestasis. N. Engl. J. Med. (1998) 339 1217-1227.
    • (1998) N. Engl. J. Med , vol.339 , pp. 1217-1227
    • Trauner, M.1    Meier, P.J.2    Boyer, J.L.3
  • 2
    • 0029893370 scopus 로고    scopus 로고
    • Sinusoidal (basolateral) bile salt uptake systems of hepatocytes
    • Hagenbuch B., Meier P.J. Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin. Liver Dis. (1996) 16 129-136.
    • (1996) Semin. Liver Dis , vol.16 , pp. 129-136
    • Hagenbuch, B.1    Meier, P.J.2
  • 3
    • 0020527459 scopus 로고
    • Estrogen-induced cholestasis: Clues to pathogenesis and treatment
    • Schreiber A., Simon F.R. Estrogen-induced cholestasis: clues to pathogenesis and treatment. Hepatology (1983) 3 607-613.
    • (1983) Hepatology , vol.3 , pp. 607-613
    • Schreiber, A.1    Simon, F.R.2
  • 4
    • 3042620358 scopus 로고    scopus 로고
    • Cholestasis: Human disease and experimental animal models
    • Rodríguez-Garay E.A. Cholestasis: human disease and experimental animal models. Ann. Hepatol. (2003) 2 150-158.
    • (2003) Ann. Hepatol , vol.2 , pp. 150-158
    • Rodríguez-Garay, E.A.1
  • 6
    • 0031032516 scopus 로고    scopus 로고
    • Hypolipidemic activity of α-asarone in mice
    • Garduño L., Salazar M., Salazar S. et al. Hypolipidemic activity of α-asarone in mice. J. Etnopharmacol. (1997) 55 161-163.
    • (1997) J. Etnopharmacol , vol.55 , pp. 161-163
    • Garduño, L.1    Salazar, M.2    Salazar, S.3
  • 7
    • 0027477170 scopus 로고
    • Inhibition of lipid synthesis and secretion in long-term cultures of adult rat hepatocytes by α-asarone
    • Hernández A., López M.L., Chamorro G., Mendoza-Figueroa T. Inhibition of lipid synthesis and secretion in long-term cultures of adult rat hepatocytes by α-asarone. Planta Med. (1993) 59 121-124.
    • (1993) Planta Med , vol.59 , pp. 121-124
    • Hernández, A.1    López, M.L.2    Chamorro, G.3    Mendoza-Figueroa, T.4
  • 8
    • 0034922662 scopus 로고    scopus 로고
    • Synthesis and hypolipidemic activity of modified side chain alpha-asarone homologues
    • Cruz A., Garduño L., Salazar M. et al. Synthesis and hypolipidemic activity of modified side chain alpha-asarone homologues. Arzneimittelforschung (2001) 51 535-544.
    • (2001) Arzneimittelforschung , vol.51 , pp. 535-544
    • Cruz, A.1    Garduño, L.2    Salazar, M.3
  • 9
    • 0033021868 scopus 로고    scopus 로고
    • Synthesis and hypolipidaemic evaluation of a series of a-asarone analogues related to clofibrate in mice
    • Labarrios F., Garduño L., Vidal M.R. et al. Synthesis and hypolipidaemic evaluation of a series of a-asarone analogues related to clofibrate in mice. J. Pharm. Pharmacol. (1999) 51 1-7.
    • (1999) J. Pharm. Pharmacol , vol.51 , pp. 1-7
    • Labarrios, F.1    Garduño, L.2    Vidal, M.R.3
  • 10
    • 33846241402 scopus 로고    scopus 로고
    • Bergmeyer H.U., Grabl M., Walter H.E. Enzymes, in: Bergmeyer J., Grabl M. (Eds), Methods of enzymatic analysis, Verlag-Chemie, Weinheim, Germany 1983, pp. 269-270.
    • Bergmeyer H.U., Grabl M., Walter H.E. Enzymes, in: Bergmeyer J., Grabl M. (Eds), Methods of enzymatic analysis, Verlag-Chemie, Weinheim, Germany 1983, pp. 269-270.
  • 11
    • 0000869591 scopus 로고
    • The isolation of a cell membrane fraction from rat liver
    • Neville G.H., Jr. The isolation of a cell membrane fraction from rat liver. Biophys. Biochem. Cytol. (1960) 8 413-422.
    • (1960) Biophys. Biochem. Cytol , vol.8 , pp. 413-422
    • Neville Jr., G.H.1
  • 12
    • 0021349075 scopus 로고
    • Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver
    • Meier P.J., Sztul E.S., Reuben A., Boyer J.L. Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver. J. Cell Biol. (1984) 98 991-1000.
    • (1984) J. Cell Biol , vol.98 , pp. 991-1000
    • Meier, P.J.1    Sztul, E.S.2    Reuben, A.3    Boyer, J.L.4
  • 13
    • 0016612368 scopus 로고
    • Functional polarity of the rat hepatocyte surface membrane. Isolation and characterization of plasma-membrane subfractions from the blood-sinusoidal, bile-canalicular and contiguous surfaces of the hepatocyte
    • Wisher M.H., Evans W. Functional polarity of the rat hepatocyte surface membrane. Isolation and characterization of plasma-membrane subfractions from the blood-sinusoidal, bile-canalicular and contiguous surfaces of the hepatocyte. Biochem. J. (1975) 146 375-388.
    • (1975) Biochem. J , vol.146 , pp. 375-388
    • Wisher, M.H.1    Evans, W.2
  • 15
    • 0027225501 scopus 로고
    • Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver
    • Bossard R., Stieger B., O'Neill B., Fricker G., Meier P.J. Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver. J. Clin. Invest. (1993) 91 2714-2720.
    • (1993) J. Clin. Invest , vol.91 , pp. 2714-2720
    • Bossard, R.1    Stieger, B.2    O'Neill, B.3    Fricker, G.4    Meier, P.J.5
  • 16
    • 0025145898 scopus 로고
    • The role of membrane composition in ATPase activities of cirrhotic rat liver: Effect of silymarin
    • Muriel P., Mourelle M. The role of membrane composition in ATPase activities of cirrhotic rat liver: effect of silymarin. J. Appl. Toxicol. (1990) 10 281-284.
    • (1990) J. Appl. Toxicol , vol.10 , pp. 281-284
    • Muriel, P.1    Mourelle, M.2
  • 17
    • 0343879238 scopus 로고
    • Assay of inorganic phosphate, total phosphate and phosphatases
    • Ames B.N. Assay of inorganic phosphate, total phosphate and phosphatases. Methods Enzymol. (1966) 8 115-118.
    • (1966) Methods Enzymol , vol.8 , pp. 115-118
    • Ames, B.N.1
  • 18
    • 0017169220 scopus 로고
    • Investigations on the sodium dependence of bile acid fluxes in the isolated perfused rat liver
    • Dietmaier A., Gasser R., Graf J., Peterlik M. Investigations on the sodium dependence of bile acid fluxes in the isolated perfused rat liver. Biochim. Biophys. Acta (1976) 443 81-91.
    • (1976) Biochim. Biophys. Acta , vol.443 , pp. 81-91
    • Dietmaier, A.1    Gasser, R.2    Graf, J.3    Peterlik, M.4
  • 19
    • 0020086154 scopus 로고
    • Uptake of bile acids by isolated rat hepatocytes
    • Iga T., Klaassen C.D. Uptake of bile acids by isolated rat hepatocytes. Biochem. Pharmacol. (1982) 31 211-216.
    • (1982) Biochem. Pharmacol , vol.31 , pp. 211-216
    • Iga, T.1    Klaassen, C.D.2
  • 20
    • 0033980287 scopus 로고    scopus 로고
    • Expression of the bile salt export pump is maintained after chronic cholestasis in the rat
    • Lee J., Trauner M., Soroka C.J., Stieger B., Meier P.J., Boyer J.L. Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology (2000) 118 163-172.
    • (2000) Gastroenterology , vol.118 , pp. 163-172
    • Lee, J.1    Trauner, M.2    Soroka, C.J.3    Stieger, B.4    Meier, P.J.5    Boyer, J.L.6
  • 21
    • 0030470648 scopus 로고    scopus 로고
    • Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters
    • Simon F.R., Fortune J., Iwahashi M., Gartung C., Wolkoff A., Sutherland E. Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters. Am. J. Physiol. (1996) 271 G1043-G1052.
    • (1996) Am. J. Physiol , vol.271
    • Simon, F.R.1    Fortune, J.2    Iwahashi, M.3    Gartung, C.4    Wolkoff, A.5    Sutherland, E.6
  • 22
    • 0032589850 scopus 로고    scopus 로고
    • Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat
    • Koopen N. R., Post S.M., Wolters H. et al. Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat. J. Lipid Res. (1999) 40 100-108.
    • (1999) J. Lipid Res , vol.40 , pp. 100-108
    • Koopen, N.R.1    Post, S.M.2    Wolters, H.3
  • 23
    • 0036623233 scopus 로고    scopus 로고
    • Nuclear receptor regulation of hepatic function
    • Karpen S.J. Nuclear receptor regulation of hepatic function. J. Hepatol. (2002) 36 832-850.
    • (2002) J. Hepatol , vol.36 , pp. 832-850
    • Karpen, S.J.1
  • 25
    • 0242665373 scopus 로고    scopus 로고
    • Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity
    • Guo G., Lambert G., Negishi M. et al. Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J. Biol. Chem. (2003) 278 45062-45071.
    • (2003) J. Biol. Chem , vol.278 , pp. 45062-45071
    • Guo, G.1    Lambert, G.2    Negishi, M.3
  • 26
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal C.J., Tohkin M., Miyata M., Ward J.M., Lambert G., Gonzalez F.J. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell (2000) 102 731-744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 27
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • Goodwin B., Jones S.A., Price R.R. et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol. Cell (2000) 6 517-526.
    • (2000) Mol. Cell , vol.6 , pp. 517-526
    • Goodwin, B.1    Jones, S.A.2    Price, R.R.3
  • 28
    • 0033636789 scopus 로고    scopus 로고
    • Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
    • Lu T.T., Makishima M., Repa J.J. et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol. Cell (2000) 6 507-515.
    • (2000) Mol. Cell , vol.6 , pp. 507-515
    • Lu, T.T.1    Makishima, M.2    Repa, J.J.3
  • 29
    • 0035800772 scopus 로고    scopus 로고
    • Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
    • Ananthanarayan M., Balasudramanian N., Makishima M., Mangelsdorf D.J., Suchy F.J. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J. Biol. Chem. (2001) 276 28857-28865.
    • (2001) J. Biol. Chem , vol.276 , pp. 28857-28865
    • Ananthanarayan, M.1    Balasudramanian, N.2    Makishima, M.3    Mangelsdorf, D.J.4    Suchy, F.J.5
  • 30
    • 33745187361 scopus 로고    scopus 로고
    • Estrogen receptor a mediates 17α-ethynylestradiol causing hepatotoxicity
    • Yamamoto Y., Moore R., Hess H.A. et al. Estrogen receptor a mediates 17α-ethynylestradiol causing hepatotoxicity. J. Biol. Chem. (2006) 281 16625-16631.
    • (2006) J. Biol. Chem , vol.281 , pp. 16625-16631
    • Yamamoto, Y.1    Moore, R.2    Hess, H.A.3
  • 31
    • 0022356933 scopus 로고
    • Cryptic adenosine triphosphatase activities in plasma membranes of CCl4-cirrhotic rats. Its modulation by changes in cholesterol/phospholipids ratios
    • Yahuaca P., Amaya A., Rojkind M., Mourelle M. Cryptic adenosine triphosphatase activities in plasma membranes of CCl4-cirrhotic rats. Its modulation by changes in cholesterol/phospholipids ratios. Lab. Invest. (1985) 53 541-545.
    • (1985) Lab. Invest , vol.53 , pp. 541-545
    • Yahuaca, P.1    Amaya, A.2    Rojkind, M.3    Mourelle, M.4
  • 32
    • 0024550129 scopus 로고
    • Overview of epithelial polarity
    • Handler J.S. Overview of epithelial polarity. Ann. Rev. Physiol. (1989) 51 729-740.
    • (1989) Ann. Rev. Physiol , vol.51 , pp. 729-740
    • Handler, J.S.1
  • 33
    • 0000010561 scopus 로고
    • Intrahepatic cholestasis
    • Schiff L, Schiff E.R, Eds, J.B. Lippincott Co, Philadelphia, PA
    • Fallon M.B., Anderson J.M., Boyer J.L., Intrahepatic cholestasis, in: Schiff L., Schiff E.R. (Eds), Diseases of the liver, J.B. Lippincott Co., Philadelphia, PA, 1993, pp. 343-361.
    • (1993) Diseases of the liver , pp. 343-361
    • Fallon, M.B.1    Anderson, J.M.2    Boyer, J.L.3
  • 34
    • 0002966509 scopus 로고
    • Bile flow
    • Arias I.M, Boyer J.L, Fausto N, Jakoby W.B, Schachter D, Shafritz D.A, Eds, Raven Press, New York
    • Erlinger S. Bile flow, in: Arias I.M., Boyer J.L., Fausto N., Jakoby W.B., Schachter D., Shafritz D.A. (Eds), The liver biology and pathobiology, Raven Press, New York, 1994, pp. 769-786.
    • (1994) The liver biology and pathobiology , pp. 769-786
    • Erlinger, S.1
  • 35
    • 0025333328 scopus 로고
    • Isolation and characterization of the canalicular membrane bile acid transport protein of rat liver
    • Sippel C.J., Anantharayanan M., Suchy F.J. Isolation and characterization of the canalicular membrane bile acid transport protein of rat liver. Am. J. Physiol. (1990) 258 G728-G737.
    • (1990) Am. J. Physiol , vol.258
    • Sippel, C.J.1    Anantharayanan, M.2    Suchy, F.J.3
  • 36
    • 0027366353 scopus 로고
    • Intrahepatic cholestasis of pregnancy: An estrogen-related disease
    • Reyes H., Simon F.R. Intrahepatic cholestasis of pregnancy: an estrogen-related disease. Semin. Liver Dis. (1993) 13 289-301.
    • (1993) Semin. Liver Dis , vol.13 , pp. 289-301
    • Reyes, H.1    Simon, F.R.2
  • 38
    • 0029991949 scopus 로고    scopus 로고
    • Current concepts of hepatic uptake, intracellular transport and biliary secretion of bile acids: Physiological basis and pathophysiological changes in cholestatic liver dysfunction
    • Azer S.A., Stacey N.H. Current concepts of hepatic uptake, intracellular transport and biliary secretion of bile acids: physiological basis and pathophysiological changes in cholestatic liver dysfunction. J. Gastroenterol. Hepatol. (1996) 11 396-407.
    • (1996) J. Gastroenterol. Hepatol , vol.11 , pp. 396-407
    • Azer, S.A.1    Stacey, N.H.2
  • 39
    • 0020694640 scopus 로고
    • +-ATPase, membrane fluidity, and bile flow in rats with ethinyl estradiol-induced cholestasis
    • +-ATPase, membrane fluidity, and bile flow in rats with ethinyl estradiol-induced cholestasis. Hepatology (1983) 3 12-17.
    • (1983) Hepatology , vol.3 , pp. 12-17
    • Boelsterli, U.A.1    Rakhit, G.2    Balazs, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.