Synthesis and hypolipidaemic evaluation of a series of α-asarone analogues related to clofibrate in mice

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 1, 1999, Pages 1-7

  Labarrios, Fernando ^a   Garduño, Leticia ^a   Vidal, Maria Del Rosario ^a   Garcia, Raul ^a   Salazar, Maria ^a   Martinez, Elizdath ^a   Diaz, Francisco ^a   Chamorro, German ^a   Tamariz, Joaquin ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; ALPHA ASARONE; ANTILIPEMIC AGENT; CHOLESTEROL; CLOFIBRATE; DRUG ANALOG; ESTER DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HYPERLIPIDEMIA; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0033021868     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991772015     Document Type: Article

References (18)

1. Abraham, D. J., Kenedy, P. E., Mehanna, A. S., Patwa, D. C., Williams, F. L. (1984) Design, synthesis, and testing of potential antisicking agents. 4. Structure-activity relationships of benzyloxy and phenoxy acids. J. Med. Chem. 27: 967-978
2. Byington, R. P., Jukema, J. W., Salonen, J. J., Pitt, B., Bruschle, A. V., Hoen, H., Furberg, C. D., Manicni, J. (1995) Reduction in cardiovascular events during provastatin therapy. Circulation 92: 2419-2425
3. Chamorro, G., Garduño, L., Sánchez, A., Labarrios, F., Salazar, M., Martínez, E., Díaz, F., Tamariz, J. (1998) Hypolipidaemic activity of dimethoxy unconjugated side-chain analogues of α-asarone in mice. Drug. Dev. Res. 43: 105-108
4. Chapman, J. M., Sowell, J. W., Abdalla, G., Hall, J. H., Wong, O. T. (1989) Hypolipidemic activity of cyclic imido alkyl ethers, thioethers, sulfoxides, and sulfones. J. Pharm. Sci. 78: 903-909
5. Dart, A., Jerums, G., Nicholson, G., d'Emden, M., Hamilton-Craig, J. H., Tallis, G., Best, J., West, M., Sullivan, D., Bracs, P., Black, D. (1997) A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simbastatin in patients with hypercholesterolemia. Am. J. Cardiol. 80: 39-44
6. Díaz, F., Contreras, L., Flores, R., Tamariz, J., Labarrios, F., Chamorro, G., Muñoz, H. (1991) An efficient synthesis of α-asarone. Org. Prep. Proced. Int. 23: 133-138
7. Díaz, F., Muñoz, H., Labarrios, F., Chamorro, G., Salazar, M., Morelos, M. E., Tamariz, J. (1993) Synthesis and hypolipidemic activity of some α-asarone analogues. Med. Chem. Res. 3: 101-109
8. Garduño, L., Salazar, M., Salazar, S., Morelos, M. E., Labarrios, F., Tamariz, J., Chamorro, G. (1997) Hypolipidaemic activity of α-asarone in mice. J. Ethnopharmacol. 55: 161-163
9. Gómez, C., Chamorro, G., Chávez, M. A., Martínez, G., Salazar, M., Pages, N. (1987) Effet de l'α-asarone sur l'hypercholestérolemie et la cholélithiase expérimentales. Plantes Méd. Phytothér. 21: 279-284
10. Hall, J. H., Spielvogel, B. F., Sood, A., Amhed, F., Jafri, S. (1987) Hypolipidaemic activity of trimethylamine-carbomethoxyborane and related derivatives in rodents. J. Pharm. Sci. 76: 359-364
11. Hernández, A., López, M. L., Chamorro, G., Mendoza-Figueroa, T. (1993) Alpha-asarone inhibits lipids synthesis and secretion by long-term cultures of adult rat hepatocytes. Planta Med. 59: 121-124
12. Hughes, T. A., Elan, M. B., Applegate, W. B., Bond, M. G., Hughes, S. M., Wang, X., Tolley, E. A., Bittle, J. C., Stenz, F. B., Kang, E. S. (1995) Post-prandial lipoprotein responses in hypertriglyceridemic subjects with and without cardiovascular disease. Metabolism 44: 1082-1098
13. López, M. L., Hernández, A., Chamorro, G., Mendoza-Figueroa, T. (1993) α-asarone toxicity in long-term cultures of adult rat hepatocytes. Planta Med. 59: 115-120
14. Matsuda, H., Chisaka, T., Kubomura, Y., Yamahara, J., Sawada, J. T., Fujimura, H., Kimkura, H. (1986) Effects of crude drugs on experimental hypercholesterolemia. I. Tea and its active principles. J. Ethnopharmacol. 2: 213-224
15. Morales-Ramírez, P., Madrigal-Bujaidar, E., Mercader-Martínez, J., Cassani, M., González, G., Chamorro-Cevallos, G., Salazar-Jacobo, M. (1992) Sister-chromatide exchange induction produced by in vivo and in vitro exposure to alpha-asarone. Mutat. Res. 59: 269-273
16. Muñoz, H., Díaz, F., Sánchez, A., Barajas, M., Labarrios, F., Tamariz, J. (1993) Nueva ruta sintética para la preparación de agentes hipocolesterolemiantes potenciales análogos de α-asarona. Determinación del contenido E/Z en muestras sintéticas y naturales de α-asarona y de sus análogos. Act. Mex. Cien. Tecnol. 11: 51-62
17. Salazar, M., Salazar, S., Ulloa, V., Mendoza, T., Chamorro, G. (1992) Action tératogene de l'α-asarone chez la souris. J. Toxicol. Clin. Exp. 12: 149-154
18. Tallarida, R. J., Murray, R. B. (1987) Manual of Pharmacological Calculations, Springer, New York, pp 131-134.