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Volumn 22, Issue 1, 2007, Pages 5-13

Determination of genetic toxicity and potential carcinogenicity in vitro - Challenges post the Seventh Amendment to the European Cosmetics Directive

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; COSMETIC; REACTIVE OXYGEN METABOLITE;

EID: 33846071711     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gel052     Document Type: Review
Times cited : (34)

References (53)
  • 1
    • 21544473568 scopus 로고    scopus 로고
    • Evaluation of the ability of a battery of 3 in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. I. Sensitivity, specificity and relative predictivity
    • Kirkland,D., Aardema,M., Henderson,L. and Müller,L. (2005) Evaluation of the ability of a battery of 3 in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. I. Sensitivity, specificity and relative predictivity. Mutat. Res., 584, 1-256.
    • (2005) Mutat. Res , vol.584 , pp. 1-256
    • Kirkland, D.1    Aardema, M.2    Henderson, L.3    Müller, L.4
  • 2
    • 32544452551 scopus 로고    scopus 로고
    • An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints
    • Matthews,E.J., Kruhlak,N.L., Cimino,M.C., Benz,R.D. and Contrera,J.F. (2006) An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints. Regul. Toxicol. Pharmacol., 44, 83-96.
    • (2006) Regul. Toxicol. Pharmacol , vol.44 , pp. 83-96
    • Matthews, E.J.1    Kruhlak, N.L.2    Cimino, M.C.3    Benz, R.D.4    Contrera, J.F.5
  • 3
    • 33846104580 scopus 로고    scopus 로고
    • Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests. II. Identification of 'in vivo only' positive compounds in the bone marrow micronucleus test
    • in press
    • Tweats,D.J., Blakey,D., Heflich,R.H., Jacobs,A., Jacobsen,S.D., Morita,T., Nohmi,T., O'Donovan,M.R., Sasaki,Y.F., Sofuni,T. and Tice,R. (2006) Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests. II. Identification of 'in vivo only' positive compounds in the bone marrow micronucleus test. Mutat. Res., (in press).
    • (2006) Mutat. Res
    • Tweats, D.J.1    Blakey, D.2    Heflich, R.H.3    Jacobs, A.4    Jacobsen, S.D.5    Morita, T.6    Nohmi, T.7    O'Donovan, M.R.8    Sasaki, Y.F.9    Sofuni, T.10    Tice, R.11
  • 4
    • 24944588858 scopus 로고    scopus 로고
    • Historical perspective of the cancer bioassay
    • Pastoor,T. and Stevens,J. (2005) Historical perspective of the cancer bioassay. Scand. J. Work Environ. Health, 31, 119-122.
    • (2005) Scand. J. Work Environ. Health , vol.31 , pp. 119-122
    • Pastoor, T.1    Stevens, J.2
  • 5
    • 33846074495 scopus 로고    scopus 로고
    • How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop
    • in press
    • Kirkland,D., Pfuhler,S. and Tweats,D et al. (2006) How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: report of an ECVAM Workshop. Mutat. Res., (in press).
    • (2006) Mutat. Res
    • Kirkland, D.1    Pfuhler, S.2    Tweats, D.3
  • 6
    • 0037430971 scopus 로고    scopus 로고
    • Oxidative stress in cell culture: An under-appreciated problem?
    • Halliwell,B. (2003) Oxidative stress in cell culture: an under-appreciated problem? FEBS Lett., 540, 3-6.
    • (2003) FEBS Lett , vol.540 , pp. 3-6
    • Halliwell, B.1
  • 7
    • 0142125716 scopus 로고    scopus 로고
    • Factors affecting the ascorbate- and phenolic-dependent generation of hydrogen peroxide in Dulbecco's modified Eagles medium
    • Wee,L.M., Long,L.H., Whitemen,M. and Halliwell,B. (2003) Factors affecting the ascorbate- and phenolic-dependent generation of hydrogen peroxide in Dulbecco's modified Eagles medium. Free Radic. Res., 37, 1123-1130.
    • (2003) Free Radic. Res , vol.37 , pp. 1123-1130
    • Wee, L.M.1    Long, L.H.2    Whitemen, M.3    Halliwell, B.4
  • 8
    • 33846085159 scopus 로고
    • Cell culture and mutagenicity assessment
    • Tweats,D.J. (1992) Cell culture and mutagenicity assessment. Analyt. Proc., 29, 476-481.
    • (1992) Analyt. Proc , vol.29 , pp. 476-481
    • Tweats, D.J.1
  • 9
    • 0025279377 scopus 로고
    • A comparison of chromosome aberration induction by 25 compounds tested by two Chinese hamster cell (CHL and CHO) systems in culture
    • Sofuni,T., Matsuoka,A., Sawada,M., Ishidate,M.,Jr, Zeiger,E. and Shelby,M.D. (1990) A comparison of chromosome aberration induction by 25 compounds tested by two Chinese hamster cell (CHL and CHO) systems in culture. Mutat. Res., 241, 175-213.
    • (1990) Mutat. Res , vol.241 , pp. 175-213
    • Sofuni, T.1    Matsuoka, A.2    Sawada, M.3    Ishidate Jr, M.4    Zeiger, E.5    Shelby, M.D.6
  • 10
    • 33746460874 scopus 로고    scopus 로고
    • Relationship between p53 status and 5-fluorouracil sensitivity in 3 cell lines
    • Oka,H., Ikeda,K., Yoshimura,H., Ohuchida,A. and Honma,M. (2006) Relationship between p53 status and 5-fluorouracil sensitivity in 3 cell lines. Mutat. Res., 606, 52-60.
    • (2006) Mutat. Res , vol.606 , pp. 52-60
    • Oka, H.1    Ikeda, K.2    Yoshimura, H.3    Ohuchida, A.4    Honma, M.5
  • 11
    • 0030751965 scopus 로고    scopus 로고
    • The p53 status of Chinese hamster V79 cells frequently used for studies of DNA damage and DNA repair
    • Chaung,W., Mi,L.-J. and Boorstein,R.J. (1997) The p53 status of Chinese hamster V79 cells frequently used for studies of DNA damage and DNA repair. Nucleic Acid Res., 25, 992-994.
    • (1997) Nucleic Acid Res , vol.25 , pp. 992-994
    • Chaung, W.1    Mi, L.-J.2    Boorstein, R.J.3
  • 12
    • 0026718955 scopus 로고
    • Chromosomal aberration tests in vitro: Problems with protocol design and interpretation of results
    • Kirkland,D. (1992) Chromosomal aberration tests in vitro: problems with protocol design and interpretation of results. Mutagenesis, 7, 95-106.
    • (1992) Mutagenesis , vol.7 , pp. 95-106
    • Kirkland, D.1
  • 14
    • 0842309805 scopus 로고    scopus 로고
    • Population doubling: A simple and more accurate estimation of cell growth suppression in the in vitro assay for chromosomal aberrations that reduces irrelevant positive results
    • Greenwood,S.K., Hill,R.B., Sun,J.T., Armstrong,M.J., Johnson,T.E., Gara,J.P. and Galloway,S.M. (2004) Population doubling: a simple and more accurate estimation of cell growth suppression in the in vitro assay for chromosomal aberrations that reduces irrelevant positive results. Environ. Mol. Mutagen., 43, 36-44.
    • (2004) Environ. Mol. Mutagen , vol.43 , pp. 36-44
    • Greenwood, S.K.1    Hill, R.B.2    Sun, J.T.3    Armstrong, M.J.4    Johnson, T.E.5    Gara, J.P.6    Galloway, S.M.7
  • 15
    • 0036301269 scopus 로고    scopus 로고
    • Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: Molecular mechanisms that determine lower expression in cultured cells
    • Rodriguez-Antona,C., Donato,M.T., Boobis,A., Edwards,R.J., Watts,P.S., Castell,J.V. and Gomez-Lechon,M.J. (2002) Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells. Xenobiotica, 32, 505-520.
    • (2002) Xenobiotica , vol.32 , pp. 505-520
    • Rodriguez-Antona, C.1    Donato, M.T.2    Boobis, A.3    Edwards, R.J.4    Watts, P.S.5    Castell, J.V.6    Gomez-Lechon, M.J.7
  • 16
    • 0026096161 scopus 로고
    • A metabolically competent human cell line expressing 5 cDNAs encoding procarcinogen-activating enzymes: Application to mutagenicity testing
    • Crespi,C.L., Gonzalez,F.J., Steimel,D.T., Turner,T.R., Gelboin,H.V., Penman,B.W. and Langenbach,R. (1991) A metabolically competent human cell line expressing 5 cDNAs encoding procarcinogen-activating enzymes: Application to mutagenicity testing. Chem. Res. Toxicol., 4, 566-572.
    • (1991) Chem. Res. Toxicol , vol.4 , pp. 566-572
    • Crespi, C.L.1    Gonzalez, F.J.2    Steimel, D.T.3    Turner, T.R.4    Gelboin, H.V.5    Penman, B.W.6    Langenbach, R.7
  • 17
    • 0029880271 scopus 로고    scopus 로고
    • An investigationinto the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells
    • Doherty,A.T., Ellard,S., Parry,E.M. and Parry,J.M. (1996) An investigationinto the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells. Mutagenesis, 11, 247-274.
    • (1996) Mutagenesis , vol.11 , pp. 247-274
    • Doherty, A.T.1    Ellard, S.2    Parry, E.M.3    Parry, J.M.4
  • 18
    • 30744463522 scopus 로고    scopus 로고
    • Computational toxicology: Heading toward more relevance in drug discovery and development
    • Johnson,D.E. and Rodgers,A.D. (2006) Computational toxicology: heading toward more relevance in drug discovery and development. Curr. Opin. Drug Discov. Dev., 9, 29-37.
    • (2006) Curr. Opin. Drug Discov. Dev , vol.9 , pp. 29-37
    • Johnson, D.E.1    Rodgers, A.D.2
  • 19
    • 33746309471 scopus 로고    scopus 로고
    • High-specificity and highsensitivity genotoxicity assessment in a human cell line: Validation of the GreenScreen HC GADD45a-GFP genotoxicity assay
    • Hastwell,P.W., Chai,L.L., Roberts,K.J., Webster,T.W., Harvey,J.S., Rees,R.W. and Walmsley,R.M. (2006) High-specificity and highsensitivity genotoxicity assessment in a human cell line: validation of the GreenScreen HC GADD45a-GFP genotoxicity assay. Mutat. Res., 607, 160-175.
    • (2006) Mutat. Res , vol.607 , pp. 160-175
    • Hastwell, P.W.1    Chai, L.L.2    Roberts, K.J.3    Webster, T.W.4    Harvey, J.S.5    Rees, R.W.6    Walmsley, R.M.7
  • 20
    • 0031667426 scopus 로고    scopus 로고
    • UV-A1 cytotoxicity and antioxidant defence in keratinocytes and fibroblasts
    • Leccia,M.T., Richard,M.J., Joanny-Crisci,F. and Beani,J.C. (1998) UV-A1 cytotoxicity and antioxidant defence in keratinocytes and fibroblasts. Eur. J. Dermatol., 8, 478-482.
    • (1998) Eur. J. Dermatol , vol.8 , pp. 478-482
    • Leccia, M.T.1    Richard, M.J.2    Joanny-Crisci, F.3    Beani, J.C.4
  • 21
    • 33846050087 scopus 로고    scopus 로고
    • Development of a human keratinocyte cell line that is up-regulated for the expression of superoxide dismutase 1 (SOD1)
    • in press
    • Maskell,S.,Malcomber,S.,Windebank,S., Carmichael,P. and Scott,A. (2006) Development of a human keratinocyte cell line that is up-regulated for the expression of superoxide dismutase 1 (SOD1). Toxicology, (in press).
    • (2006) Toxicology
    • Maskell, S.1    Malcomber, S.2    Windebank, S.3    Carmichael, P.4    Scott, A.5
  • 22
    • 33644870082 scopus 로고    scopus 로고
    • Metabolism: A bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54
    • Coecke,S., Ahr,H. and Blaauboer,B.J. et al. (2006) Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54. Altern Lab Anim., 34, 49-84.
    • (2006) Altern Lab Anim , vol.34 , pp. 49-84
    • Coecke, S.1    Ahr, H.2    Blaauboer, B.J.3
  • 23
    • 12744258127 scopus 로고    scopus 로고
    • V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals
    • Glatt,H., Schneider,H. and Liu,Y. (2005) V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals. Mutat. Res., 580, 41-52.
    • (2005) Mutat. Res , vol.580 , pp. 41-52
    • Glatt, H.1    Schneider, H.2    Liu, Y.3
  • 26
    • 0242500447 scopus 로고    scopus 로고
    • Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro
    • Marek,C.J., Cameron,G.A., Elrick,L.J., Hawksworth,G.M. and Wright,M.C. (2003) Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro. Biochem. J., 370, 763-769.
    • (2003) Biochem. J , vol.370 , pp. 763-769
    • Marek, C.J.1    Cameron, G.A.2    Elrick, L.J.3    Hawksworth, G.M.4    Wright, M.C.5
  • 27
    • 28444440251 scopus 로고    scopus 로고
    • Characterization of liver function in transdifferentiated hepatocytes
    • Burke,Z.D., Shen,C.N., Ralphs,K.L. and Tosh,D. (2006) Characterization of liver function in transdifferentiated hepatocytes. J. Cell. Physiol., 206, 147-159.
    • (2006) J. Cell. Physiol , vol.206 , pp. 147-159
    • Burke, Z.D.1    Shen, C.N.2    Ralphs, K.L.3    Tosh, D.4
  • 28
    • 21444432708 scopus 로고    scopus 로고
    • Gene expression profile analysis: An emerging approach to investigate mechanisms of genotoxicity
    • Aubrecht,J. and Caba,E. (2005) Gene expression profile analysis: an emerging approach to investigate mechanisms of genotoxicity. Pharmacogenomics, 6, 419-428.
    • (2005) Pharmacogenomics , vol.6 , pp. 419-428
    • Aubrecht, J.1    Caba, E.2
  • 30
    • 0033573938 scopus 로고    scopus 로고
    • Global response of Saccharomyces cerevisiae to an alkylating agent
    • Jelinsky,S .A. and Samson,L.D. (1999) Global response of Saccharomyces cerevisiae to an alkylating agent. Proc. Natl Acad. Sci. USA, 96, 1486-1491.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 1486-1491
    • Jelinsky, S.A.1    Samson, L.D.2
  • 31
    • 0033772765 scopus 로고    scopus 로고
    • Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: Rpn4 links base excision repair with proteasomes
    • Jelinsky,S.A., Estep,P., Church,G.M. and Samson,L.A. (2000) Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: Rpn4 links base excision repair with proteasomes. Mol. Cell. Biol., 20, 8157-8167.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 8157-8167
    • Jelinsky, S.A.1    Estep, P.2    Church, G.M.3    Samson, L.A.4
  • 33
    • 1542271923 scopus 로고    scopus 로고
    • The utility of DNA microarrays for characterizing genotoxicity
    • Newton,R.K., Aardema,M. and Aubrecht,J. (2004) The utility of DNA microarrays for characterizing genotoxicity. Environ. Health Perspect., 112, 420-422.
    • (2004) Environ. Health Perspect , vol.112 , pp. 420-422
    • Newton, R.K.1    Aardema, M.2    Aubrecht, J.3
  • 34
    • 17444385654 scopus 로고    scopus 로고
    • Proteome analysis of antiproliferative mechanism of 12-O-tetradecanoylphorbol 13-acetate on cultured nasopharyngeal carcinoma CNE2 cells
    • Jiang,P., Gan,M., Huang,H., Shen,X., Wang,S. and Yao,K. (2005) Proteome analysis of antiproliferative mechanism of 12-O-tetradecanoylphorbol 13-acetate on cultured nasopharyngeal carcinoma CNE2 cells. J. Proteome Res., 4, 599-605.
    • (2005) J. Proteome Res , vol.4 , pp. 599-605
    • Jiang, P.1    Gan, M.2    Huang, H.3    Shen, X.4    Wang, S.5    Yao, K.6
  • 35
    • 0034752076 scopus 로고    scopus 로고
    • The Syrian hamster embryo (SHE) cell transformation assay; a review of the methods and results
    • Mauthe,M.J., Gibson,D.P., Bunch,R.T. and Custer,L. (2001) The Syrian hamster embryo (SHE) cell transformation assay; a review of the methods and results. Toxicol. Pathol., 29 (Suppl.), 138-146.
    • (2001) Toxicol. Pathol , vol.29 , Issue.SUPPL. , pp. 138-146
    • Mauthe, M.J.1    Gibson, D.P.2    Bunch, R.T.3    Custer, L.4
  • 36
    • 33646166308 scopus 로고    scopus 로고
    • Infrared spectroscopy with multivariate analysis potentially facilitates the segregation of different types of prostate cell
    • German,M.J., Hammiche,A. and Ragavan,N. et al. (2006) Infrared spectroscopy with multivariate analysis potentially facilitates the segregation of different types of prostate cell. Biophys. J., 90, 1-13.
    • (2006) Biophys. J , vol.90 , pp. 1-13
    • German, M.J.1    Hammiche, A.2    Ragavan, N.3
  • 39
    • 22844434663 scopus 로고    scopus 로고
    • Genotoxicity and mutagenicity
    • Maurici,D., Aardema,M. and Corvi,R. et al. (2005) Genotoxicity and mutagenicity. Altern. Lab. Anim., 33 (Suppl. 1), 117-130.
    • (2005) Altern. Lab. Anim , vol.33 , Issue.SUPPL. 1 , pp. 117-130
    • Maurici, D.1    Aardema, M.2    Corvi, R.3
  • 40
    • 33746279142 scopus 로고    scopus 로고
    • Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm™)
    • Curren,R.D., Mun,G.C., Gibson,D.P. and Aardema,M.J. (2006) Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm™). Mutat. Res., 607, 192-204.
    • (2006) Mutat. Res , vol.607 , pp. 192-204
    • Curren, R.D.1    Mun, G.C.2    Gibson, D.P.3    Aardema, M.J.4
  • 41
    • 33646875263 scopus 로고    scopus 로고
    • Development of genotoxicity test procedures with Episkin®, a reconstructed human skin model: Towards new tools for in vitro risk assessment of dermally applied compounds?
    • Flamand,N., Marrot,L., Belaidi,J.P., Bourouf,L., Dourille,E., Feltes,M. and Meunier,J.R. (2006) Development of genotoxicity test procedures with Episkin®, a reconstructed human skin model: towards new tools for in vitro risk assessment of dermally applied compounds? Mutat. Res., 606, 39-51.
    • (2006) Mutat. Res , vol.606 , pp. 39-51
    • Flamand, N.1    Marrot, L.2    Belaidi, J.P.3    Bourouf, L.4    Dourille, E.5    Feltes, M.6    Meunier, J.R.7
  • 42
    • 0344011659 scopus 로고    scopus 로고
    • Biochemical and functional changes of rat liver spheroids during spheroid formation and maintenance in culture: II. nitric oxide synthesis and related changes
    • Xu,J., Ma,M. and Purcell,W.M. (2003) Biochemical and functional changes of rat liver spheroids during spheroid formation and maintenance in culture: II. nitric oxide synthesis and related changes. J. Cell. Biochem., 90, 1176-1185.
    • (2003) J. Cell. Biochem , vol.90 , pp. 1176-1185
    • Xu, J.1    Ma, M.2    Purcell, W.M.3
  • 43
    • 33744544354 scopus 로고    scopus 로고
    • Toward refinement of the colony-forming unit-granulocyte/macrophage clonogenic assay: Inclusion of a metabolic system
    • Dal Negro,G., Vandin,L., Bonato,M. and Sciuscio,D. (2006) Toward refinement of the colony-forming unit-granulocyte/macrophage clonogenic assay: inclusion of a metabolic system. Toxicol. In Vitro, 20, 743-749.
    • (2006) Toxicol. In Vitro , vol.20 , pp. 743-749
    • Dal Negro, G.1    Vandin, L.2    Bonato, M.3    Sciuscio, D.4
  • 44
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones,P.A. and Baylin,P.A. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet., 3, 415-428.
    • (2002) Nat. Rev. Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, P.A.2
  • 45
    • 33646123093 scopus 로고    scopus 로고
    • Gene promoter hypermethylation in mouse lung tumours
    • Vuillemenot,B.R., Hutt,J.A. and Belinsky,S.A. (2006) Gene promoter hypermethylation in mouse lung tumours. Mol.Cancer Res., 4, 267-273.
    • (2006) Mol.Cancer Res , vol.4 , pp. 267-273
    • Vuillemenot, B.R.1    Hutt, J.A.2    Belinsky, S.A.3
  • 46
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan,D. and Weinberg,R.A. (2000) The hallmarks of cancer. Cell, 100, 57-70.
    • (2000) Cel , vol.50 , Issue.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 47
    • 4444334026 scopus 로고    scopus 로고
    • Epidemiology and molecular pathology at crossroads to establish causation: Molecular mechanisms of malignant transformation
    • Bocchetta,M. and Carbone,M. (2004) Epidemiology and molecular pathology at crossroads to establish causation: molecular mechanisms of malignant transformation. Oncogene, 23, 6484-6491.
    • (2004) Oncogene , vol.23 , pp. 6484-6491
    • Bocchetta, M.1    Carbone, M.2
  • 48
    • 33746074049 scopus 로고    scopus 로고
    • Stem cells:the real culprits in cancer?
    • Clarke,M.F. and Becker,M.F. (2006) Stem cells:the real culprits in cancer? Sci. Amer., 295, 52-59.
    • (2006) Sci. Amer , vol.295 , pp. 52-59
    • Clarke, M.F.1    Becker, M.F.2
  • 49
    • 14944382346 scopus 로고    scopus 로고
    • Ignored hallmarks of carcinogenesis: Stem cells and cell-cell communication
    • Trosko,J.E., Chang,C.C., Upham,B.L. and Tai Mh,H. (2004) Ignored hallmarks of carcinogenesis: stem cells and cell-cell communication. Ann. NY Acad. Sci., 1028, 192-201.
    • (2004) Ann. NY Acad. Sci , vol.1028 , pp. 192-201
    • Trosko, J.E.1    Chang, C.C.2    Upham, B.L.3    Tai Mh, H.4
  • 50
    • 18344386028 scopus 로고    scopus 로고
    • The emperor wears no clothes in the field of carcinogen risk assessment
    • Trosko,J.E. and Upham,B.L. (2005) The emperor wears no clothes in the field of carcinogen risk assessment. Mutagenesis, 20, 81-97.
    • (2005) Mutagenesis , vol.20 , pp. 81-97
    • Trosko, J.E.1    Upham, B.L.2
  • 51
    • 0036923370 scopus 로고    scopus 로고
    • Damage recovery pathways in Saccaromyces cerevisiae revealed by genomic phenotyping and interactome mapping
    • Begley,T.J., Rosenbach,A.S., Ideker,T. and Samson,L.D. (2002) Damage recovery pathways in Saccaromyces cerevisiae revealed by genomic phenotyping and interactome mapping. Mol. Cancer Res., 1, 103-112.
    • (2002) Mol. Cancer Res , vol.1 , pp. 103-112
    • Begley, T.J.1    Rosenbach, A.S.2    Ideker, T.3    Samson, L.D.4
  • 52
    • 0000801240 scopus 로고    scopus 로고
    • Discovering regulatory and signalling circuits in molecular interaction networks
    • Ideker,T., Ozier,O., Schwikowski,B. and Siegel,A. (2002) Discovering regulatory and signalling circuits in molecular interaction networks. Bioinformatics, 18, 233-240.
    • (2002) Bioinformatics , vol.18 , pp. 233-240
    • Ideker, T.1    Ozier, O.2    Schwikowski, B.3    Siegel, A.4


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