Mesenchymal stem cell engineering and transplantation introduction

Genetic Engineering of Mesenchymal Stem Cells

Volumn , Issue , 2006, Pages 1-44

  Aerts, F ^a   Wagemaker, G ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33845992975     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/1-4020-3959-X_1     Document Type: Chapter

References (192)

1. Junquiera LC, Carneiro J, Kelley RO. Basic Histology. 7th ed., 1992.
2. Weiss L, Geduldig U. Barrier cells: stromal regulation of hematopoiesis and blood cell release in normal and stressed murine bone marrow. Blood. 1991;78:975-990.
3. Bianco P, Gehron Robey P. Marrow stromal stem cells. J Clin Invest. 2000;105(12):1663-1668.
4. Bianco P, Riminucci M, Kuznetsov S, Gehron Robey P. Multipotential cells in the bone marrow stroma: regulation in the context of organ physiology. Crit Rev Eukaryot Gene Expr. 1999;9:159-173.
5. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 1997;89:747-754.
6. Satomura K, Krebsbach P, Bianco P, Gehron Robey P. Osteogenic imprinting upstream of marrow stromal cell differentiation. J Cell Biochem. 2000;78(3):391-403.
7. Owen M. The marrow stromal cell system. In: Beresford JN, Owen ME, eds. Marrow stromal Cell Culture. Cambridge University Press; 1998: chap 1.
8. Bianco P, Riminucci M. The bone marrow stroma in vivo: ontogeny, structure, cellular composition and changes in disease. In: Beresford JN, Owen ME, eds. Marrow Stromal Cell Culture. United Kingdom: Cambridge University Press; 1998: chap 2.
9. Muller-Sieburg CE, Deryugina E. The stromal cells' guide to the stem cell universe. Stem Cells. 1995;13:477-486.
10. Dormady SP, Bashayan O, Dougherty R, Zhang XM, Basch RS. Immortalized multipotential mesenchymal cells and the hematopoietic microenvironment. J Hematother Stem Cell Res. 2001;10:125-140.
11. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143-147.
12. Friedenstein AJ, Chailakhyan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea pig bone marrow and spleen cells. Cell Tissue Kinet. 1970;3(4):393-403.
13. Piersma AH, Brockbank KG, Ploemacher RE, Van Vliet E, Brakel-van Peer KM, Visser PJ. Characterization of fibroblastic stromal cells from murine bone marrow. Exp Hematol. 1985;13:237-243.
14. Kuznetsov SA, Krebsbach PH, Satomura K, et al. Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J Bone Miner Res. 1997;12(9):1335-1347.
15. Kuznetsov SA, Friedenstein AJ, Gehron Robey P. Factors required for bone marrow stromal fibroblast colony formation in vitro. Br J Haematol. 1997;97:561-570.
16. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997;276:71-74.
17. Conget PA, Minguell JJ. Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells. J Cell Physiol. 1999;181:67-73.
18. Fuchs E, Segre J. Stem cells: a new lease on life. Cell. 2000;100:143-155.
19. Watt FM, Hogan B L M. Out of Eden: stem cells and their niches. Science. 2000;287:1427-1430.
20. Tavassoli M, Crosby WH. Transplantation of marrow to extramedullary sites. Science. 1968;161(836):54-6.
21. Fernandez M, Simon V, Herrera G, Cao C, Del Favero H, Minguell JJ. Detection of stromal cells in peripheral blood progenitor cell collections from breast cancer patients. Bone Marrow Transplant. 1997;20:265-271.
22. Erices A, Conget P, Minguell JJ. Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol. 2000;109:235-242.
23. Sukhikh GT, Malaitsev VV, Bogdanova IM, Dubrovina IV. Mesenchymal stem cells. Bull Exp Biol Med. 2002;133(2):103-109.
24. Shimizu N, Asai T, Hashimoto S, et al. Mobilization factors of peripheral blood stem cells in healthy donors. Ther Apher. 2002;6(6):413-418.
25. Menendez P, Caballero MD, Prosper F, et al. The composition of leukapheresis products impacts on the hematopoietic recovery after autologous transplantation independently of the mobilization regimen. Transfusion. 2002;42(9):1159-1172.
26. Dexter TM. Stromal cell associated haemopoiesis. J Cell Physiol Suppl. 1982;1:87-94.
27. Gartner S, Kaplan HS. Long-term culture of bone marrow cells. Proc Natl Acad Sci USA. 1980;77:4756-4759.
28. Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL. Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol. 1998;176:57-66.
29. Lodie TA, Blickarz CE, Devarakonda TJ, et al. Systematic analysis of reportedly distinct populations of multipotent bone marrow-derived stem cells reveals a lack of distinction. Tissue Eng. 2002;8(5):739-751.
30. Deans RJ, Moseley AB. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol. 2000;28:875-884.
31. Minguell JJ, Erices A, Conget P. Mesenchymal stem cells. Exp Biol Med. 2001;226(6):507-520.
32. Mareschi K, Biasin E, Piacibello W, Aglietta M, Madon E, Fagioli F. Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood. Haematologica. 2001;86(10):1099-1100.
33. Wexler SA, Donaldson C, Denning-Kendall P, Rice C, Bradley B, Hows JM. Adult bone marrow is a rich source of human mesenchymal "stem" cells but umbilical cord and mobilized adult blood are not. Br J Haematol. 2003;121:368-374.
34. Ye ZQ, Burkholder JK, Qiu P, Schultz JC, Shahidi NT, Yang NS. Establishment of an adherent cell feeder layer from human umbilical cord blood for support of long-term hematopoietic progenitor cell growth. Proc Natl Acad Sci USA. 1994;91:12140-12144.
35. Gutierrez-Rodriguez M, Reyes-Maldonado E, Mayani H. Characterization of the adherent cells developed in Dexter-type long-term cultures from human umbilical cord blood. Stem Cells. 2000;18:46-52.
36. Campagnoli C, Roberts IAG, Kumar S, Bennett PR, Bellantuono I, Fisk NM. Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood. 2001;98:2396-2402.
37. Suda T, Takahashi N, Martin J. Modulation of osteoclast differentiation. Endocr Rev. 1992;13:66-80.
38. Minguell JJ, Conget P, Erices A. Biology and clinical utilization of mesenchymal progenitor cells. Braz J Med Biol Res. 2000;33:881-887.
39. Romanov YA, Svintsitskaya VA, Smirnov VN. Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord blood. Stem Cells. 2003;21:105-110.
40. Lazarus HM, Haynesworth SE, Gerson SL, Caplan AI. Human bone marrow-derived mesenchymal (stromal) progenitor cells (MPCs) cannot be recovered from peripheral blood progenitor cell collections. J Hematother. 1997;6(5):447-455.
41. Ojeda-Uribe M, Brunot A, Lenat A, Legros M. Failure to detect spindle-shaped fibroblastoid cell progenitors in PBPC collections. Acta Haematol. 1993;90(3):139-143.
42. Purton LE, Mielcarek M, Torok-Storb B. Monocytes are the likely candidate "stromal" cell in G-CSF mobilized peripheral blood. Bone Marrow Transplant. 1998;21:1075-1076.
43. Zvaifler NJ, Marinova-Mutafchieva L, Adams G, et al. Mesenchymal precursors in the blood of normal individuals. Arthritis Res. 2000;2:477-488.
44. Piersma AH, Ploemacher RE, Brockbank KG, Nikkels PG, Ottenheim CP. Migration of fibroblastoid stromal cells in murine blood. Cell Tissue Kinet. 1985;18(6):589-595.
45. Kuznetsov SA, Mankani MH, Gronthos S, Satomura K, Bianco P, Gehron Robey P. Circulating skeletal stem cells. J Cell Biol. 2001;153(5):1133-1139.
46. Bianco P, Riminucci M, Gronthos S, Gehron Robey P. Bone marrow stromal stem cells: nature, biology and potential applications. Stem Cells. 2001;19:180-192.
47. Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211-228.
48. Rangappa S, Fen C, Lee EH, Bongso A, Wei E S K. Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. Ann Thor Surg. 2003;75:775-779.
49. Tholpady SS, Katz AJ, Ogle RC. Mesenchymal stem cells from rat visceral fat exhibit multipotential differentiation in vitro. Anat Rec. 2003;272a:398-402.
50. Gronthos S, Franklin DM, Leddy HA, Robey PG, Storms RW, Gimble JM. Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol. 2001;189(1):54-63.
51. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13(12):4279-4295.
52. Noth U, Osyczka AM, Tuli R, Hickok NJ, Danielson KG, Tuan RS. Multilineage mesenchymal differentiation potential of human trabecular bone-derived cells. J Orthop Res. 2002;20(5):1060-1069.
53. Zohar R, Sodek J, McCulloch C A G. Characterization of stromal progenitor cells enriched by flowcytometry. Blood. 1997;90(9):3471-3481.
54. Grigoriadis AE, Heersche JN, Aubin JE. Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone. J Cell Biol. 1988;106:2139-2151.
55. Gronthos S, Zannettino AC, Graves SE, Ohta S, Hay SJ, Simmons PJ. Differential cell surface expression of the STRO-1 and alkaline phosphatase antigens on discrete developmental stages in primary cultures of human bone cells. J Bone Miner Res. 1999;14:47-56.
56. Williams JT, Southerland SS, Souza J, Calcutt AF, Cartledge RG. Cells isolated from adult human skeletal muscle capable of differentiating into multiple mesodermal phenotypes. Am Surg. 1999;65(1):22-26.
57. Beauchamp JR, Morgan JE, PagelCN, Partridge TA. Dynamics ofmyoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as themyogenic source. J Cell Biol. 1999;144:1113-1122.
58. Lipton BH, Schultz E. Developmental fate of skeletal muscle satellite cells. Science. 1979;205:1292-1294.
59. Warejcka DJ, Harvey R, Taylor BJ, Young HE, Lucas PA. A population of cells isolated from rat heart capable of differentiating into several mesodermal phenotypes. J Surg Res. 1996;62:233-242.
60. Tallheden T, Dennis JE, Lennon DP, Sj̈ogren-Jansson, Caplan AI, Lindahl A. Phenotypic plasticity of human articular chondrocytes. J Bone Joint Surg. 2003;85 A, S2, 93-100.
61. Bernard-Beaubois K, Hecquet C, Houcine O, Hayem G, Adolphe M. Culture and characterization of juvenile rabbit tenocytes. Cell Biol Toxicol. 1997;13(2):103-113.
62. Charbord P, Oostendorp R, Pang W, et al. Compartative study of stromal cell lines derived from embryonic, fetal, and postnatal mouse blood-forming tissues. Exp Hematol. 2002;30:1202-1210.
63. Galmiche MC, Koteliansky VE, Briere J, Herve P, Charbord P. Stromal cells from human long-termmarrow cultures are mesenchymal cells that differentiate following a vascular smooth muscle differentiation pathway. Blood. 1993;82:66-76.
64. Gronthos S, Mankani M, Brahim J, Gehron Robey P, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA. 2000;97(25):13625-13630.
65. Almeida-Porada G, El Shabrawy D, Porada C, Zanjani ED. Differentiative potential of human metanephric mesenchymal cells. Exp Hematol. 2002;30:1454-1462.
66. Owen M, Friedenstein AJ. Stromal stem cells: marrow derived osteogenic precursors. Ciba Foundat Symp. 1988;136:42-60.
67. Friedenstein AJ, Chailakhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet. 1987;20(3):263-272.
68. Castro-Malaspina H, Gay RE, Resnick G, et al. Characterization of human bone marrow fibroblast colonyforming cells (CFU-F) and their progeny. Blood. 1980;56(2):289-301.
69. Friedenstein AJ, Deriglasova UF, Kulagina NN, et al. Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp Hematol. 1974;2(2):83-92.
70. Bruder SP, Jaiswal N, Haynesworth SE. Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem. 1997;64:278-294.
71. Phinney DG, Kopen G, Righter W, Webster S, Tremain N, Prockop DJ. Donor variation in the growth properties and osteogenic potential of human marrow stromal cells. J Cell Biochem. 1999;75:424-436.
72. Di Girolamo C, Stokes D, Colter D, Phinney DG, Class R, Prockop DJ. Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br J Haemat. 1999;107:275-281.
73. Ko̧c ON, Peters C, Aubourg P, et al. Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxismal storage diseases. Exp Hematol. 1999;27:1675-1681.
74. Murphy JM, Dixon K, Beck S, Fabian D, Feldman A, Barry F. Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis. Arthr Rheum. 2002;46(3):704-713.
75. Galotto M, Berisso G, Delfino L, et al. Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients. Exp Hematol. 1999;27:1460-1466.
76. Satomura K, Derubeis AR, Fedarko NS, et al. Receptor tyrosine kinase expression in human bone marrow stromal cells. J Cell Physiol. 1998;177(3):426-438.
77. Gronthos S, Simmons PJ. The Growth factor requirements of STRO-1-positive human bone marrowstromal precursors under serum-deprived conditions in vitro. Blood. 1995;85(4):929-940.
78. Lennon DP, Haynesworth SE, Young RG, Dennis JE, Caplan AI. A chemically defined medium supports in vitro proliferation and maintains the osteochondral potential of rat marrow-derived mesenchymal stem cells. Exp Cell Res. 1995;219:211-222.
79. Dartsch PC, Weiss HD, Betz E. Human vascular smooth muscle cells in culture: growth characteristics and protein pattern by use of serum-free media supplements. Eur J Cell Biol. 1990;51(2):285-294.
80. Sekiya I, Larson BL, Smith JR, Pochampally R, Cui JG, Prockop DJ. Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells. 2002;6:530-541.
81. Gronthos S, Graves SE, Simmons PJ. Isolation, purification and in vitro manipulation of human bone marrow stromal precursor cells. In: Beresford JN and Owen ME, eds. Marrow Stromal Cell Culture. United Kingdom: Cambridge University Press; 1998: chap 3.
82. Pereira RF, Halford KW, O'Hara MD, et al. Cultured adherent cells from marrow serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc Natl Acad Sci USA. 1995;92:4857-4861.
83. Horwitz EM, Gordon PL, Koo WKK, et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci USA. 2002;99(13):8932-8937.
84. Majumdar MK, Banks V, Peluso DP, Morris EA. Isolation, characterization, and chondrogenic potential of human bone marrow-derived multipotential stromal cells. J Cell Physiol. 2000;185:98-106.
85. Young RG, Butler DL, Weber W, Caplan AI, Gordon SL, Fink DJ. Use of mesenchymal stem cells in a collagen matrix for Achilles tendon repair. J Ortho Res. 1998;16:406-413.
86. Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA. 1999;96:10711-10716.
87. Azizi SA, Stokes D, Augelli BJ, Di Girolamo C, Prockop DJ. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats-similarities to astrocyte grafts. Proc Natl Acad Sci USA. 1998;95:3908-3913.
88. Dezawa M, Takahashi I, Esaka M, Takano M, Sawada H. Sciatic nerve regeneration inh rats induced by transplantation of in vitro differentiated bone-marrowstromal cells. Eur J Neurosci. 2001;14:1771-1776.
89. Woodbury D, Reynolds K, Black IB. Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis. J Neurosci Res. 2002;96:908-917.
90. Ferrari G, Cusella-De Angelis G, Coletta M, et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science. 1998;279:1528-1530.
91. Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation. 2002;105:93-98.
92. Shake JG, Gruber PJ, Baumgartner WA, et al. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann Thorac Surg. 2002;73:1919-1926.
93. Hakuno D, Fukuda K, Makino S, et al. Bone marrow-derived regenerated cardiomyocytes (CMG cells) express functional adrenergic and muscarinic receptors. Circulation. 2002;105:380-386.
94. Wang JS, Shum-Tim D, Galipeau J, Chedrawy E, Eliopoulos N, Chiu RC. Marrow stromal cells for cellular cardiomyoplasty: feasibility and potential clinical advantages. J Thorac Cardiovasc Surg. 2000;120(5):999-1005.
95. Jaiswal N, Haynesworth SE, Caplan AI, Bruder SP. Osteogenic differentiation potential of purified, cultureexpanded human mesenchymal stem cells in vitro. J Cell Biochem. 1997;64:295.
96. Muraglia A, Cancedda R, Quarto R. Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model. J Cell Sci. 2000;113:1161-1166.
97. Gronthos S, Graves SE, Ohta S, Simmons PJ. The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors. Blood. 1994;84(12):4164-4173.
98. Dennis JE, Carbillet JP, Caplan AI, Charbord P. The STRO-1+ marrow cell population is multipotential. Cells Tissues Organs. 2002;170:73-82.
99. Simmons PJ, Torok-Storb B. Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood. 1991;78(1):55-62.
100. Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991;9(5):641-650.
101. Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU. In vitro chondrogenesis of bone marrow derived mesenchymal progenitor cells. Exp Cell Res. 1998;238:265-272.
102. Petersen BE, Bowen WC, Patrene KD, et al. Bone marrow as a potential source of hepatic oval cells. Science. 1999;284:1168-1170.
103. Theise ND, Badve S, Saxena R, et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology. 2000;31:235-240.
104. Theise ND, Nimmakayalu M, Gardner R, et al. Liver from bone marrow in humans. Hepatology. 2000;32:11-16.
105. Brazelton TR, Rossi FMV, Keshet GI, Blau HM. From marrowto brain: expression of neuronal phenotypes in adult mice. Science. 2000;290:1775-1779.
106. Mezey ́ E, Chandross KJ, Harta G, Maki RA, McKercher SR. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science. 2000;290:1779-1782.
107. Bjornson CRR, Rietze RL, Reynolds BA, Magli MC, Vescovi AL. Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science. 1999;283:534-537.
108. Dennis JE, Charbord P. Origin and differentiation of human and murine stroma. Stem Cells. 2002;20:205-214.
109. Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res. 2000;61:364-370.
110. Hu M, Krause D, Greaves M, et al. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 1997;774-785.
111. Cross MA, Enver T. The lineage commitment of haemapoietic progenitor cells. Curr Opin Genet Dev. 1997;7:609-613.
112. Seshi B, Kumar S, Sellers D. Human bone marrow stromal cell, coexpression of markers specific for multiple mesenchymal cell lineages. Blood Cell Mol Dis. 2000;26:234-246.
113. Tagami M, Ichinose S, Yamagata K, et al. Genetic and ultrastructural demonstration of strong reversibility in human mesenchymal stem cell. Cell Tissue Res. 2003;312:31-40.
114. Sanchez-Ramos J, Song S, Cardozo-Pelaez F, et al. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol. 2000;164(2):247-56.
115. Zhao LR, Duan WM, Reyes M, Keene CD, Verfaillie CM, Low WC. Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp Neurol. 2002;174(1):11-20.
116. Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve. 1995;18:1417-1426.
117. Makino S, Fukuda K, Miyoshi S, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest. 1999;103(5):697-705.
118. Tomita S, Li R, Weisel R, et al. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation. 1999;100: II247-II256.
119. Fukuda K. Reprogramming of bone marrow mesenchymal stem cells into cardiomyocytes. Crit Rev Biol. 2002;325(10):1027-1038.
120. Reyes M, Lund T, Lenvik T, Aguiar D, Koodie L, Verfaillie CM. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood. 2001;98:2615-2625.
121. Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002, advance online publication.
122. Colter DC, Sekiya I, Prockop DJ. Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells. Proc Natl Acad Sci USA. 2001;98(4):7841-7845.
123. Colter DC, Class R, Di Girolamo CM, Prockop DJ. Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci. 2000;97(7):3213-3218.
124. Simmons PJ, Torok-Storb B. CD34 expression by stromal precursors in normal human adult bone marrow. Blood. 1991;78:2848.
125. Haynesworth SE, Baber MA, Caplan AI. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone. 1992;13(1):69-80.
126. Barry FP, Boynton RE, Haynesworth S, Murphy JM, Zaia J. The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105). Biochem Biophys Res Commun. 1999;265:134-139.
127. Barry F, Boynton RE, Murphy M, Zaia J. The SH-3 and SH-4 antibodies recognize distinct epitopes on CD73 from human mesenchymal stem cells. Biochem Biophys Res Commun. 2001;289:519-524.
128. Seventh International Workshop on Human Leukocyte Differentiation Antigens. 2003.
129. Bruder SP, Ricalton NS, Boynton RE, et al. Mesenchymal stem cell surface antigen SB-10 corresponds to activated leukocyte-cell adhesion molecule and is involved in osteogenic differentiation. J Bone Miner Res. 1998;13(4):655-663.
130. Chichester CO, Fernandez M, Minguell JJ. Extracellular matrix gene expression by human bone marrow stroma and by marrow fibroblasts. Cell Adhes Commun. 1993;1(2):93-99.
131. Andrades JA, Nimni ME, Han B, Ertl DC, Hall FL, Becerra J. Type I collagen combined with a recombinant TGF-beta serves as a scaffold for mesenchymal stem cells. Int J Dev Biol. 1996; S1:1073.
132. Robledo MM, Hidalgo A, Lastres P, et al. Characterization of TGF-beta 1-binding proteins in human bone marrow stromal cells. Br J Haematol. 1996;93(3):507-514.
133. Gordon EM, Skotzko M, Kundu RK, et al. Capture and expansion of bone marrow-derived mesenchymal progenitor cells with a transforming growth factor-beta1-von Willebrand's factor fusion protein for retrovirus-mediated delivery of coagulation factor IX. Hum Gene Ther. 1997;8(11):1385-1394.
134. Quirici N, Soligo D, Bossolasco P, Servida F, Lumini C, Lambertenghi Deliliers G. Isolation of bone marrowmesenchymal stem cells by anti-nerve growth factor receptor antibodies. Exp Hematol. 2002;30:783-791.
135. Guerriero A, Worford L, Holland HK, Guo GR, Sheehan K, Waller EK. Thrombopoietin is synthesized by bone marrow stromal cells. Blood. 1997;90(9):3444-3455.
136. Simmons PJ, Gronthos S, Zannettino A C W. The development of stromal cells. In: Son L, ed. Hematopoiesis: A developmental approach. New York: Oxford University Press; 2001:718-726.
137. Deschaseaux F, Charbord P. Human marrow stromal precursors are alpha1 integrin subunit-positive. J Cell Physiol. 2000;184:319-325.
138. Filshie RJA, Zannettino ACW, Makrynikola V. MUC18, a member of the immunoglobulin superfamily, is expressed on bone marrow fibroblasts and a subset of haematological malignancies. Leukemia. 1998;12:414-421.
139. Simmons PJ, Gronthos S, Zannettino A, Ohta S, Graves S. Isolation, characterization and functional activity of human marrow stromal progenitors in hemopoiesis. Prog Clin Biol Res. 1994;389:271-280.
140. Gronthos S, Franklin DM, Leddy HA, Gehron-Robey P, Storms RW, Gimble JM. Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol. 2001;189:54-63.
141. Wineman J, Moore K, Lemischka I, Muller-Sieburg C. Functional heterogeneity of the hematopoietic microenvironment: rare stromal elements maintain long-termrepopulating cells. Blood. 1996;87(10):4082-4090.
142. Gualtieri RJ, Liang CM, Shadduck RK, Waheed A, Banks J. Identification of the hematopoietic growth factors elaborated by bone marrow stromal cells using antibody neutralization analysis. Exp Hematol. 1987;15:883-889.
143. Majumdar MK, Thiede MA, Haynesworth SE, Bruder SP, Gerson SL. Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res. 2000;9(6):841-848.
144. Haynesworth SE, Baber MA, Caplan AI. Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha. J Cell Physiol. 1996;166(3):585-592.
145. Thalmeier K, Meissner P, Reisbach G, et al. Constitutive and modulated cytokine expression in two permanent human bone marrow stromal cell lines. Exp Hematol. 1996;24(1):1-10.
146. Brouard N, Chapel A, Thierry D, Charbord P, Peault B. Transplantation of gene-modified human bone marrow stromal cells into mouse-human bone chimeras. J Hematother Stem Cell Res. 2000;9(2):175-181.
147. Ding L, Lu S, Batchu R, III RS, Munshi N. Bone marrow stromal cells as a vehicle for gene transfer. Gene Ther. 1999;6(9):1611-1616.
148. Caplan AI, Bruder SP. Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol Med. 2001;7(6):259-264.
149. Li KJ, Dilber MS, Abedi MR, et al. Retroviral-mediated gene transfer into human bone marrow stromal cells: studies of efficiency and in vivo survival in SCID mice. Eur J Haematol. 1995;55(5):302-306.
150. Nolta JA, Hanley MB, Kohn DB. Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3: analysis of gene transduction of long-lived progenitors. Blood. 1994;83(10):3041-3051.
151. Mosca JD, Hendricks JK, Buyaner D, et al. Mesenchymal stem cells as vehicles for gene delivery. Clin Orthop Rel Res. 2000;379 S: S71-S90.
152. Allay JA, Dennis JE, Haynesworth SE, et al. LacZ and IL-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors. Hum Gene Ther. 1997;8(12):1417-1427.
153. Lee K, Wang G, Buyaner D. Retroviral transduced human mesenchymal stem cells: maintenance of expression and efficacy during expansion and lineage differentiation. Exp Hematol. 1999;27:53.
154. Marx JC, Allay JA, Persons DA, et al. High-efficiency transduction and long-term gene expression with a murine stem cell retroviral vector encoding the green fluorescent protein in human marrow stromal cells. Hum Gene Ther. 1999;10(7):1163-1173.
155. Lee K, Majumdar MK, Buyaner D, Hendricks JK, Pittenger MF, Mosca JD. Human mesenchymal stem cells maintain transgene expression during expansion and differentiation. Mol Ther. 2001;3(6):857-866.
156. Oyama M, Tatlock A, Fukuta S, et al. Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging. Gene Ther. 1999;6(3):321-329.
157. Bulabois CE, Yerly-Motta V, Mortensen BT, et al. Retroviral-mediated marker gene transfer in hematopoiesis-supportive marrow stromal cells. J Hematother. 1998;7(3):225-239.
158. Suzuki K, Oyama M, Faulcon L, Robbins PD, Niyibizi C. In vivo expression of human growth hormone by genetically modified murine bone marrowstromal cells and its effect on the cells in vitro. Cell Transplant. 2000;9(3):319-327.
159. Bartholomew A, Patil S, Mackay A, et al. Baboon mesenchymal stem cells can be genetically modified to secrete human erythropoietin in vivo. Hum Gene Ther. 2001;12(12):1527-1541.
160. Dao MA, Pepper KA, Nolta JA. Long-term cytokine production from engineered primary human stromal cells influences human hematopoiesis in an in vivo xenograft model. Stem Cells. 1997;15:443-454.
161. Conget PA, Minguell JJ. Adenoviral-mediated gene transfer into ex vivo expanded human bone marrow mesenchymal progenitor cells. Exp Hematol. 2000;28(4):382-390.
162. Gazit D, Turgeman G, Kelley P, et al. Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. J Gene Med. 1999;1(2):121-133.
163. Cancedda R, Dozin B, Giannoni P, Quarto R. Tissue engineering and cell therapy of cartilage and bone. Matrix Biol. 2003;22:81-91.
164. Tuan RS, Boland G, Tuli R. Adult mesenchymal stem cells and cell-based tissue engineering. Arthr Res Ther. 2002;5(1):32-45.
165. Pereira RF, O'Hara MD, Laptev AV, et al. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci USA. 1998;95:1142-1147.
166. Horwitz EM, Prockop DJ, Fitzpatrick LA, et al. Transplantability and therapeutic effects of bone marrowderived mesenchymal cells in children with osteogenesis imperfecta. Nat Med. 1999;5(3):309-313.
167. Saito T, Dennis JE, Lennon DP, Young RG, Caplan AI. Myogenic expression of mesenchymal stem cells within myotubes of mdx mice in vitro and in vivo. Tissue Eng. 1996;1:327-344.
168. Keating A, Guinn B, Laraya P, Wang XH. Human marrow stromal cells electrotransfected with human factor IX (FIX) cDNA engraft in SCID mouse marrow and transcribe human FIX. Exp Hematol. 1996;24(9):S180.
169. Hurwitz DR, Kirchgesser M, Merrill W, et al. Systemic delivery of human growth hormone or human factor IX in dogs by reintroduced genetically modified autologous bone marrow stromal cells. Hum Gene Ther. 1997;8(2):137-156.
170. Chuah MK, Van Damme A, Zwinnen H, et al. Long-term persistence of human bone marrow stromal cells transduced with factor VIII-retroviral vectors and transient production of therapeutic levels of human factor VIII in nonmyeloablated immunodeficient mice. Hum Gene Ther. 2000;11(5):729-738.
171. Turgeman G, Pittman DD, Muller R, et al. Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy. J Gene Med. 2001;3(3):240-251.
172. Campagnoli C, Bellantuono I, Kumar S, Fairbairn LJ, Roberts I, Fisk NM. High transduction efficiency of circulating first trimester fetal mesenchymal stem cells: potential targets for in utero ex vivo gene therapy. BJOG. 2002;109(8):952-954.
173. Van Damme A, Vanden Driessche T, Collen D, Chuah MK. Bone marrow stromal cells as targets for gene therapy. Curr Gene Ther. 2002;2(2):195-209.
174. Laver J, Jhanwar SC, O'Reilly RJ, Castro-Malaspina H. Host origin of the human hematopoietic microenvironment following allogeneic bone marrow transplantation. Blood. 1987;70(6):1966-1968.
175. Simmons PJ, Przepiorka D, Donnall Thomas E, Torok-Storb B. Host origin of marrow stromal cells following allogeneic bone marrow transplantation. Nature. 1987;328:429-432.
176. Agematsu K, Nakahori Y. Recipient origin of bone-marrow-derived fibroblastic stromal cells during all periods following bone marrow transplantation in humans. Br J Haematol. 1991;79:359-365.
177. Santucci MA, Trabetti E, Martinelli G, et al. Host origin of bone marrow fibroblasts following allogeneic bone marrow transplantation for chronic myeloid leukemia. Bone Marrow Transplant. 1992;10:255-259.
178. Awaya N, Rupert K, Bryant E, Torok-Storb B. Failure of adult marrow-derived stem cells to generate marrow stroma after successful hematopoietic stem cell transplantation. Exp Hematol. 2002;30:937-942.
179. Galotto M, Berisso G, Delfino L, et al. Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients. Exp Hematol. 1999;27:1460-1466.
180. Lazarus HM, Haynesworth SE, Gerson SL, Rosenthal NS, Caplan AI. Ex vivo
181. Ko̧c ON, Gerson SL, Cooper BW, et al. Rapid hematopoietic recovery after coinfusion of autologousblood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol. 2000;18:307-316.
182. Gao J, Dennis JE, Muzic RF, Lundberg M, Caplan AI. The dynamic in vivo distribution of bone marrowderived mesenchymal stem cells after infusion. Cells Tissues Organs. 2001;169(1):12-20.
183. Devine S, Bartholomew AM, Mahmud N, et al. Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion. Exp Hematol. 2001;29:244-255.
184. Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol. 2002;30:42-48.
185. Di Nicola M, Carlo-Stella C, Magni M, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular on nonspecific mitogenic stimuli. Blood. 2002;99:3838-3843.
186. Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringd́en O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol. 2003;57(1):11-20.
187. Jorgensen C, Djouad F, Apparailly F, Nöel D. Engineering mesenchymal stem cells for immunotherapy. Gene therapy. 2003;10:928-931.
188. Ko̧c ON, Day J, Nieder M, Gerson SL, Lazarus HM, Krivit W. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant. 2002;30:215-222.
189. Lee ST, Jang JH, Cheong JW, et al. Treatment of high risk acute myelogenous leukaemia by myeloablative chemoradiotherapy followed by co-infusion of T-cell depleted haematopoietic stem cells and cultureexpanded marrow mesenchymal stem cells from a related donor with one fully mismatched human leukocyte antigen haplotype. Br J Haematol. 2002;118:1128-1131.
190. Fu SC, Wong YP, Chan BP, et al. The roles of bone morphogenetic protein (BMP) 12 in stimulating the proliferation and matrix production of human patellar tendon fibroblasts. Life Sci. 2003;72(26):2965-2974.
191. Phinney DG, Kopen G, Isaacson RI, Prockop DJ. Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: variations in yield, growth, and differentiation. J Cell Biochem. 1999;72:570-585.
192. Bianchi G, Muraglia A, Daga A, Corte G, Cancedda R, Quarto R. Microenvironment and stem properties of bone marrow-derived mesenchymal cells. Wound Rep Reg. 2001;9:460-466