The preserved expression of neuropilin (NRP) 1 contributes to a better prognosis in colon cancer

Oncology Reports

Volumn 15, Issue 2, 2006, Pages 369-373

  Kamiya, Takashi ^a   Kawakami, Tsutomu ^a   Abe, Yoshiyuki ^a   Nishi, Masatake ^a   Onoda, Noboru ^b   Miyazaki, Noriyuki ^a   Oida, Yasuhisa ^a   Yamazaki, Hitoshi ^a   Ueyama, Yoshito ^a,c   Nakamura, Masato ^a,c  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Yamato Municipal Hospital   (Japan)

^c CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

Author keywords

Colon cancer; Neuropilin; Prognosis

Indexed keywords

NEUROPILIN 1; NEUROPILIN 2; TUMOR MARKER; VASCULAR ENDOTHELIAL GROWTH FACTOR A, HUMAN; VASCULOTROPIN A;

ADENOCARCINOMA; ARTICLE; BIOSYNTHESIS; COLON TUMOR; GENE EXPRESSION; HUMAN; METABOLISM; MORTALITY; PATHOLOGY; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL;

ADENOCARCINOMA; COLONIC NEOPLASMS; GENE EXPRESSION; HUMANS; NEUROPILIN-1; NEUROPILIN-2; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33744474889     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.15.2.369     Document Type: Article

References (28)

1. Risau W: Mechanisms of angiogenesis. Nature 386: 671-674, 1997.
2. Soker S, Takashima S, Miao HQ, Neufeld G and Klagsbrun M: Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92: 735-745, 1998. (Pubitemid 28155313)
3. Whitaker GB, Limberg BJ and Rosenbaum JS: Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121). J Biol Chem 276: 25520-25531, 2001.
4. Chen H, Chedotal A, He Z, Goodman CS and Tessier-Lavigne M: Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron 19: 547-559, 1997. (Pubitemid 27430744)
5. He Z and Tessier-Lavigne M: Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 90: 739-751, 1997. (Pubitemid 27357965)
6. Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ and Ginty DD: Neuropilin is a semaphorin III receptor. Cell 90: 753-762, 1997. (Pubitemid 27357966)
7. Kawakami A, Kitsukawa T, Takagi S and Fujisawa H: Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system. J Neurobiol 29: 1-17, 1996. (Pubitemid 26021768)
8. Takagi S, Kasuya Y, Shimizu M, et al : Expression of a cell adhesion molecule, neuropilin, in the developing chick nervous system. Dev Biol 170: 207-222, 1995.
9. Chen H, Chedotal A, He Z, Goodman CS and Tessier-Lavigne M: Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron 19: 547-559, 1997. (Pubitemid 27430744)
10. Takahashi T, Namura F, Jin Z, Kalb RG and Strittmatter SM: Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors. Nat Neurosci 1: 487-493, 1998.
11. Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD and Kolodkin AL: Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. Neuron 21: 1079-1092, 1998. (Pubitemid 29018077)
12. Rossignol M, Beggs AH, Pierce EA and Klagsbrun M: Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively. Genomics 57: 459-460, 1999. (Pubitemid 29239238)
13. Miao HQ, Lee P, Lin H, Soker S and Klagsbrun M: Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression. FASEB J 14: 2532-2539, 2000.
14. Handa A, Tokunaga T, Tsuchida T, et al: Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. Int J Oncol 17: 291-295, 2000.
15. Kawakami T, Tokunaga T, Hatanaka H, et al: Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma. Cancer 95: 2196-2201, 2002. (Pubitemid 35253382)
16. Osada H, Tokunaga T, Nishi M, et al: Overexpression of the neuropilin 1 (NRP1) gene correlated with poor prognosis in human glioma. Anticancer Res 24: 547-552, 2004. (Pubitemid 38624988)
17. Fujimori S, Abe Y, Nishi M, et al: The subunits of glutamate cysteine ligase (GCL) enhance cisplatin resistance in human nonsmall cell lung cancer xenografts in vivo. Int J Oncol 25: 413-418, 2004.
18. Hamamoto A, Abe Y, Nishi M, et al: Aberrant expression of the gastric mucin MUC6 in human pulmonary adenocarcinoma xenografts. Int J Oncol 26: 891-896, 2005.
19. Nishi M, Abe Y, Tomii Y, et al : Cell binding isoforms of vascular endothelial growth factor-A (VEGF189) contribute to blood flow-distant metastasis of pulmonary adenocarcinoma. Int J Oncol 26: 1517-1524, 2005.
20. Ferrara N, Chen H, Davis-Smyth T, et al: Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat Med 4: 336-340, 1998. (Pubitemid 28144094)
21. Gerber HP, Kowalski J, Sherman D, Eberhard DA and Ferrara N: Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor. Cancer Res 60: 6253-6258, 2000.
22. Holash J, Davis S, Papadopoulos N, et al: VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 99: 11393-11398, 2002. (Pubitemid 34920936)
23. Shaheen RM, Ahmad SA, Liu W, et al : Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors. Br J Cancer 85: 584-589, 2001. (Pubitemid 32808285)
24. Iqbal S and Lenz HJ: Angiogenesis inhibitors in the treatment of colorectal cancer. Semin Oncol 31 (suppl 17): 10-16, 2004. (Pubitemid 40193371)
25. Byrne AT, Ross L, Holash J, et al: Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res 9: 5721-5728, 2003. (Pubitemid 37499496)
26. Parikh AA, Liu WB, Fan F, et al: Expression and regulation of the novel vascular endothelial growth factor receptor neuropilin-1 by epidermal growth factor in human pancreatic carcinoma. Cancer 98: 720-729, 2003. (Pubitemid 36959267)
27. Tokunaga T, Oshika Y, Abe Y, et al : Vascular endothelial growth factor (VEGF) mRNA isoform expression pattern is correlated with liver metastasis and poor prognosis in colon cancer. Br J Cancer 77: 998-1002, 1998. (Pubitemid 28101792)
28. Akagi M, Kawaguchi M, Liu W, et al: Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells. Br J Cancer 88: 796-802, 2003. (Pubitemid 36411462)