Expression of Neuropilin-1 in High-grade Dysplasia, Invasive Cancer, and Metastases of the Human Gastrointestinal Tract

American Journal of Surgical Pathology

Volumn 28, Issue 3, 2004, Pages 347-356

  Hansel, Donna E ^a   Wilentz, Robert E ^a   Yeo, Charles J ^a   Schulick, Richard D ^a   Montgomery, Elizabeth ^a   Maitra, Anirban ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biliary; Colon; Esophagus; NRP 1; Pancreas; VEGF

Indexed keywords

NEUROPILIN 1;

ANTIBODY LABELING; ARTICLE; BARRETT ESOPHAGUS; CANCER CELL CULTURE; CANCER GRADING; CANCER GROWTH; CANCER INVASION; COLON; COLON MUCOSA; COLORECTAL ADENOMA; COLORECTAL TUMOR; CONTROLLED STUDY; CORRELATION ANALYSIS; DYSPLASIA; ENDOTHELIUM CELL; ESOPHAGUS; GALLBLADDER; GASTROINTESTINAL CARCINOMA; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LABELING INDEX; LIVER METASTASIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; METASTASIS; PANCREAS; PANCREAS CANCER; PANCREAS ISLET; PANCREAS ISLET CELL; PRECANCER; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; UPREGULATION; VATER PAPILLA; WESTERN BLOTTING;

ADENOCARCINOMA; CELL LINE, TUMOR; GASTROINTESTINAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM INVASIVENESS; NEUROPILIN-1; PANCREATIC NEOPLASMS; PRECANCEROUS CONDITIONS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 1442329388     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200403000-00007     Document Type: Article

References (37)

1. Akagi M, Kawaguchi M, Liu W, et al. Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells. Br J Cancer. 2003;88:796-802.
2. Bachelder RE, Wendt MA, Mercurio AM. Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res. 2002;62:7203-7206.
3. Booth C, Brady G, Potten CS. Crowd control in the crypt. Nat Med. 2002;8:1360-1361.
4. Brambilla E, Constantin B, Drabkin H, et al. Semaphorin SEMA3F localization in malignant human lung and cell lines: a suggested role in cell adhesion and cell migration. Am J Pathol. 2000;156:939-950.
5. Chedotal A, Del Rio JA, Ruiz M. C, et al. Semaphorins III and IV repel hippocampal axons via two distinct receptors. Development. 1998;125:4313-4323.
6. Chen H, He Z, Bagri A, et al. Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins. Neuron. 1998;21:1283-1290.
7. Cheung N, Wong MP, Yuen ST, et al. Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon. Hum Pathol. 1998;29:910-914.
8. Ding H, Wu X, Roncari L, et al. Expression and regulation of neuropilin-1 in human astrocytomas. Int J Cancer. 2000;88:584-592.
9. Fakhari M, Pullirsch D, Abraham D, et al. Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma. Cancer. 2002;94:258-263.
10. Fujimoto K, Hosotani R, Wada M, et al. Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in human pancreatic cancer, and its relationship to angiogenesis. Eur J Cancer. 1998;34:1439-1447.
11. Gagnon ML, Bielenberg DR, Gechtman Z, et al. Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity. Proc Natl Acad Sci USA. 2000;97:2573-2578.
12. Giger RJ, Urquhart ER, Gillespie SK, et al. Neuropilin-2 is a receptor for semaphorin W: insight into the structural basis of receptor function and specificity. Neuron. 1998;21:1079-1092.
13. He Z, Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell. 1997;90:739-751.
14. He Z, Wang KC, Koprivica V, et al. Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system. Sci STKE. 2002;219:1-10.
15. Itakura J, Ishiwata T, Shen B, et al. Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int J Cancer. 2000;85:27-34.
16. Karkkainen MJ, Petrova TV. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis. Oncogene. 2000;19:5598-5605.
17. Kawakami T, Tokunaga T, Hatanaka H, et al. Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma. Cancer. 2002;95:2196-2201.
18. Kikutani H, Kumanogoh A. Semaphorins in interactions between T cells and antigen-presenting cells. Nat Rev Immunol. 2003;3:159-167.
19. Kolodkin AL, Levengood DV, Rowe EG, et al. Neuropilin is a semaphorin III receptor. Cell. 1997;90:753-762.
20. Latil A, Bieche I, Pesche S, et al. VEGF overexpression in clinically localized prostate tumors and neuropilin-1 overexpression in metastatic forms. Int J Cancer. 2000;89:167-171.
21. Mamluk R, Gechtman Z, Kutcher ME, et al. Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain. J Biol Chem. 2002;277:24818-24825.
22. Miao HQ, Klagsbrun M. Neuropilin is a mediator of angiogenesis. Cancer Metastasis Rev. 2000;19:29-37.
23. Miao HQ, Soker S, Feiner L, et al. Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165. J Cell Biol. 1999;146:233-242.
24. Miyamoto Y, Maitra A, Ghosh B, et al. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell. 2003;3:565-576.
25. Nagata J, Kijima H, Hatanaka H, et al. Correlation between interleukin 10 and vascular endothelial growth factor expression in human esophageal cancer. Int J Mol Med. 2002;10:169-172.
26. Nakamura F, Tanaka M, Takahashi T, et al. Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse. Neuron. 1998;21:1093-1100.
27. Nakamura F, Kalb RG, Strittmatter SM. Molecular basis of semaphorin-mediated axon guidance. J Neurobiol. 2000;44:219-229.
28. Pasterkamp RJ, Kolodkin AL. Semaphorin junction: making tracks toward neural connectivity. Curr Opin Neurobiol. 2003;13:79-89.
29. Rossignol M, Gagnon ML, Klagsbrun M. Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms. Genomics. 2000;70:211-222.
30. Soker S. Neuropilin in the midst of cell migration and retraction. Int J Biochem Cell Biol. 2001;33:433-437.
31. Stephenson JM, Banerjee S, Saxena NK, et al. Neuropilin-1 is differentially expressed in myoepithelial cells and vascular smooth muscle cells in preneoplastic and neoplastic human breast: a possible marker for the progression of breast cancer. Int J Cancer. 2002;101:409-414.
32. Takahashi T, Fournier A, Nakamura F, et al. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell. 1999;99:59-69.
33. Tamagnone L, Artigiani S, Chen H, et al. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell. 1999;99:71-80.
34. Tomizawa Y, Sekido Y, Kondo M, et al. Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B. Proc Natl Acad Sci USA. 2001;98:13954-13959.
35. Trusolino L, Comoglio PM. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat Rev Cancer. 2002;2:289-300.
36. Warren RS, Yuan H, Matli MR, et al. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest. 1995;95:1789-1797.
37. Xiang RH, Hensel CH, Garcia DK, et al. Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer. Genomics. 1996;32:39-48.