-
1
-
-
0028943870
-
Design, synthesis, and structure-activity relationship of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720
-
Adachi K, Kohara T, Nakao N. Design, synthesis, and structure-activity relationship of 2-substituted-2-amino-1,3-propanediols: discovery of a novel immunosuppressant, FTY720. Bioorg Med Chem Lett. 1995;5:853-856.
-
(1995)
Bioorg Med Chem Lett
, vol.5
, pp. 853-856
-
-
Adachi, K.1
Kohara, T.2
Nakao, N.3
-
2
-
-
0032525049
-
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing
-
Chiba K, Yanagawa Y, Masubuchi Y, et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J Immunol. 1998;160:5037-5044.
-
(1998)
J Immunol
, vol.160
, pp. 5037-5044
-
-
Chiba, K.1
Yanagawa, Y.2
Masubuchi, Y.3
-
3
-
-
0034120178
-
FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory
-
Pinschewer DD, Ochsenbein AF, Odermatt B, et al. FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. J Immunol. 2000;164:5761-5770.
-
(2000)
J Immunol
, vol.164
, pp. 5761-5770
-
-
Pinschewer, D.D.1
Ochsenbein, A.F.2
Odermatt, B.3
-
4
-
-
0029996293
-
FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin graft survival and synergistic effects in combination with cyclosporine in rats
-
Chiba K, Hoshino Y, Suzuki C, et al. FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin graft survival and synergistic effects in combination with cyclosporine in rats. Transplant Proc. 1996;28:1056-1059.
-
(1996)
Transplant Proc
, vol.28
, pp. 1056-1059
-
-
Chiba, K.1
Hoshino, Y.2
Suzuki, C.3
-
5
-
-
0029918395
-
FTY720, a novel immunosuppressant possessing unique mechanisms. II. Long-term graft survival induction in rat heterotopic cardiac allografts and synergistic effect in combination with cyclosporine A
-
Hoshino Y, Suzuki C, Ohtsuki M, et al. FTY720, a novel immunosuppressant possessing unique mechanisms. II. Long-term graft survival induction in rat heterotopic cardiac allografts and synergistic effect in combination with cyclosporine A. Transplant Proc. 1996;282:1060-1061.
-
(1996)
Transplant Proc
, vol.282
, pp. 1060-1061
-
-
Hoshino, Y.1
Suzuki, C.2
Ohtsuki, M.3
-
6
-
-
0033969361
-
Effect of FTY720, a novel immunosuppressant, on adjuvant-and collagen-induced arthritis in rats
-
Matsuura M, Imayoshi T, Okumoto T. Effect of FTY720, a novel immunosuppressant, on adjuvant-and collagen-induced arthritis in rats. Int J Immunol. 2000;22:323-331.
-
(2000)
Int J Immunol
, vol.22
, pp. 323-331
-
-
Matsuura, M.1
Imayoshi, T.2
Okumoto, T.3
-
7
-
-
0034002825
-
FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes
-
Kitabayashi H, Isobe M, Watanabe N, et al. FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. J Cardiovasc Pharmacol. 2000;35:410-416.
-
(2000)
J Cardiovasc Pharmacol
, vol.35
, pp. 410-416
-
-
Kitabayashi, H.1
Isobe, M.2
Watanabe, N.3
-
8
-
-
0036228891
-
Effects of FTY720 in MPL-lpr/lpr mice: therapeutic potential in systemic lupus erythematosus
-
Okazaki H, Hirata D, Kamimura T, et al. Effects of FTY720 in MPL-lpr/lpr mice: therapeutic potential in systemic lupus erythematosus. J Rheumatol. 2002;29:707-716.
-
(2002)
J Rheumatol
, vol.29
, pp. 707-716
-
-
Okazaki, H.1
Hirata, D.2
Kamimura, T.3
-
9
-
-
0037961801
-
The immune modulator FTY720 prevents autoimmune diabetes in nonobese diabetic mice
-
Yang Z, Chen M, Fialkow LB, et al. The immune modulator FTY720 prevents autoimmune diabetes in nonobese diabetic mice. Clin Immunol. 2003;107:30-35.
-
(2003)
Clin Immunol
, vol.107
, pp. 30-35
-
-
Yang, Z.1
Chen, M.2
Fialkow, L.B.3
-
10
-
-
0037379202
-
Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment
-
Fujino M, Funeshima N, Kitazawa Y, et al. Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment. J Pharmacol Exp Ther. 2003;305:70-77.
-
(2003)
J Pharmacol Exp Ther
, vol.305
, pp. 70-77
-
-
Fujino, M.1
Funeshima, N.2
Kitazawa, Y.3
-
11
-
-
0033829476
-
Effect of FTY720, a novel immunosuppressant, on adjuvant-induced arthritis in rats
-
Matsuura M, Imayoshi T, Chiba K, et al. Effect of FTY720, a novel immunosuppressant, on adjuvant-induced arthritis in rats. Inflamm Res. 2000;49:404-410.
-
(2000)
Inflamm Res
, vol.49
, pp. 404-410
-
-
Matsuura, M.1
Imayoshi, T.2
Chiba, K.3
-
12
-
-
0034902982
-
Cytokine mRNA levels and lymphocyte infiltration in pancreatic tissue during experimental chronic pancreatitis induced by dibutylin dichloride
-
Sparmann G, Behrend S, Merkord J, et al. Cytokine mRNA levels and lymphocyte infiltration in pancreatic tissue during experimental chronic pancreatitis induced by dibutylin dichloride. Dig Dis Sci. 2001;46:1647-1656.
-
(2001)
Dig Dis Sci
, vol.46
, pp. 1647-1656
-
-
Sparmann, G.1
Behrend, S.2
Merkord, J.3
-
13
-
-
0034048657
-
Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response
-
Okazaki K, Uchida K, Ohana M, et al. Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response. Gastroenterology. 2000;118:573-581.
-
(2000)
Gastroenterology
, vol.118
, pp. 573-581
-
-
Okazaki, K.1
Uchida, K.2
Ohana, M.3
-
14
-
-
0000163034
-
A new diabetic strain of rat with exocrine pancreatic insufficiency
-
In: Tiengo A, Del Prato S, Alberti KG, et al, eds., Amsterdam: Elsevier
-
Mori Y, Yokoyama J, Nishimura M, et al. A new diabetic strain of rat with exocrine pancreatic insufficiency. In: Tiengo A, Del Prato S, Alberti KG, et al, eds. Diabetes Secondary to Pancreatopathy. Amsterdam: Elsevier; 1988:107-112.
-
(1988)
Diabetes Secondary to Pancreatopathy
, pp. 107-112
-
-
Mori, Y.1
Yokoyama, J.2
Nishimura, M.3
-
15
-
-
0025279310
-
WBN/Kob rats: A new spontaneously occurring model of chronic pancreatitis
-
Ohashi K, Kim J-H, Hara H, et al. WBN/Kob rats: a new spontaneously occurring model of chronic pancreatitis. Int J Pancreatol. 1989;6:231-247.
-
(1989)
Int J Pancreatol
, vol.6
, pp. 231-247
-
-
Ohashi, K.1
Kim, J.-H.2
Hara, H.3
-
16
-
-
0033803222
-
Apoptosis of acinar cells is involved in chronic pancreatitis in WBN/Kob rats: Role of glucocorticoids
-
Hashimoto T, Yamada T, Yokoi T, et al. Apoptosis of acinar cells is involved in chronic pancreatitis in WBN/Kob rats: role of glucocorticoids. Pancreas. 2000;21:296-304.
-
(2000)
Pancreas
, vol.21
, pp. 296-304
-
-
Hashimoto, T.1
Yamada, T.2
Yokoi, T.3
-
17
-
-
0035662128
-
Involvement of T cells in development of chronic pancreatitis in male Wistar Bonn/Kobori rats: Protective effects of tacrolimus
-
Yamada T, Hashimoto T, Sogawa M, et al. Involvement of T cells in development of chronic pancreatitis in male Wistar Bonn/Kobori rats: protective effects of tacrolimus. Am J Physiol. 2001;281:G1397-G1404.
-
(2001)
Am J Physiol
, vol.281
-
-
Yamada, T.1
Hashimoto, T.2
Sogawa, M.3
-
18
-
-
0023245677
-
FK-506, a novel immunosuppressant isolated for a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics
-
Kino T, Hatanaka H, Hashimoto M, et al. FK-506, a novel immunosuppressant isolated for a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1987;40:1256-1265.
-
(1987)
J Antibiot (Tokyo)
, vol.40
, pp. 1256-1265
-
-
Kino, T.1
Hatanaka, H.2
Hashimoto, M.3
-
19
-
-
0028676623
-
Nephrotoxicity after orthotopic liver transplantation in cyclosporin A and FK 506-treated patients
-
Platz KP, Mueller AR, Blumhardt G, et al. Nephrotoxicity after orthotopic liver transplantation in cyclosporin A and FK 506-treated patients. Transpl Int. 1994;7:S52-S57.
-
(1994)
Transpl Int
, vol.7
-
-
Platz, K.P.1
Mueller, A.R.2
Blumhardt, G.3
-
20
-
-
0033023568
-
FK506 nephrotoxicity
-
Finn WF. FK506 nephrotoxicity. Ren Fail. 1999;21:319-329.
-
(1999)
Ren Fail
, vol.21
, pp. 319-329
-
-
Finn, W.F.1
-
21
-
-
0033949793
-
Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation
-
Nieto Y, Russ P, Everson G, et al. Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation. Bone Marrow Transplant. 2000;261:109-111.
-
(2000)
Bone Marrow Transplant
, vol.261
, pp. 109-111
-
-
Nieto, Y.1
Russ, P.2
Everson, G.3
-
22
-
-
1942506088
-
Acute pancreatitis due to tacrolimus in a case of allogeneic bone marrow transplantation
-
Sastry J, Young S, Shaw PJ. Acute pancreatitis due to tacrolimus in a case of allogeneic bone marrow transplantation. Bone Marrow Transplant. 2004;33:867-868.
-
(2004)
Bone Marrow Transplant
, vol.33
, pp. 867-868
-
-
Sastry, J.1
Young, S.2
Shaw, P.J.3
-
23
-
-
0030013720
-
Drug-induced pancreatitis
-
Wilmink T, Frick TW. Drug-induced pancreatitis. Drug Saf. 1996;14:406-423.
-
(1996)
Drug Saf
, vol.14
, pp. 406-423
-
-
Wilmink, T.1
Frick, T.W.2
-
24
-
-
3042552573
-
Vitamin E attenuates biochemical and morphological features with development of chronic pancreatitis
-
Gomez JA, Molero X, Vaquero E, et al. Vitamin E attenuates biochemical and morphological features with development of chronic pancreatitis. Am J Physiol. 2004;287:162-169.
-
(2004)
Am J Physiol
, vol.287
, pp. 162-169
-
-
Gomez, J.A.1
Molero, X.2
Vaquero, E.3
-
25
-
-
0030049234
-
A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation
-
Suzuki S, Enosawa S, Kakefuda T, et al. A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. Transplantation. 1996;61:200-205.
-
(1996)
Transplantation
, vol.61
, pp. 200-205
-
-
Suzuki, S.1
Enosawa, S.2
Kakefuda, T.3
-
26
-
-
0037381733
-
Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats
-
Kuno A, Yamada T, Masuda K, et al. Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats. Gastroenterology. 2003;124:1010-1019.
-
(2003)
Gastroenterology
, vol.124
, pp. 1010-1019
-
-
Kuno, A.1
Yamada, T.2
Masuda, K.3
-
27
-
-
0141630677
-
Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats
-
Yamada T, Kuno A, Masuda K, et al. Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats. J Pharmacol Exp Ther. 2003;307:17-23.
-
(2003)
J Pharmacol Exp Ther
, vol.307
, pp. 17-23
-
-
Yamada, T.1
Kuno, A.2
Masuda, K.3
-
29
-
-
0024999311
-
Assessment of leukocyte involvement during ischemia and perfusion of intestine
-
Grisham MB, Benoit JN, Granger DN. Assessment of leukocyte involvement during ischemia and perfusion of intestine. Methods Enzymol. 1990;186:729-741.
-
(1990)
Methods Enzymol
, vol.186
, pp. 729-741
-
-
Grisham, M.B.1
Benoit, J.N.2
Granger, D.N.3
-
30
-
-
0015886195
-
A quick and specific assay for hydroxyproline
-
Blumenkrantz N, Asobe-Hansen G. A quick and specific assay for hydroxyproline. Anal Biochem. 1973;55:288-291.
-
(1973)
Anal Biochem
, vol.55
, pp. 288-291
-
-
Blumenkrantz, N.1
Asobe-Hansen, G.2
-
31
-
-
0031765615
-
Immunosuppressive effect of FTY 720 on autoimmune diabetes models
-
Yan H, Suzuki K, Li XK, et al. Immunosuppressive effect of FTY 720 on autoimmune diabetes models. Transplant Proc. 1998;30:3436-3437.
-
(1998)
Transplant Proc
, vol.30
, pp. 3436-3437
-
-
Yan, H.1
Suzuki, K.2
Li, X.K.3
-
32
-
-
0034002825
-
FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes
-
Kitabayashi H, Isobe M, Watanabe N, et al. FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. J Cardiovasc Pharmacol. 2000;35:410-416.
-
(2000)
J Cardiovasc Pharmacol
, vol.35
, pp. 410-416
-
-
Kitabayashi, H.1
Isobe, M.2
Watanabe, N.3
-
33
-
-
0030017757
-
Cytokine mRNA expression in the liver of patients with primary biliary cirrhosis (PBC) and chronic hepatitis B (CHB)
-
Shindo M, Mullin GE, Braun-Elwert L, et al. Cytokine mRNA expression in the liver of patients with primary biliary cirrhosis (PBC) and chronic hepatitis B (CHB). Clin Exp Immunol. 1996;105:254-259.
-
(1996)
Clin Exp Immunol
, vol.105
, pp. 254-259
-
-
Shindo, M.1
Mullin, G.E.2
Braun-Elwert, L.3
-
34
-
-
0028989087
-
IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice
-
Rabinovitch A, Suarez-Pinzon WL, Sorensen O, et al. IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J Immunol. 1995;154:4874-4882.
-
(1995)
J Immunol
, vol.154
, pp. 4874-4882
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.L.2
Sorensen, O.3
-
35
-
-
0032531099
-
IFN-γ action on pancreatic β cells causes class I MHC upregulation but not diabetes
-
Thomas HE, Parker JL, Schreiber RD, et al. IFN-γ action on pancreatic β cells causes class I MHC upregulation but not diabetes. J Clin Invest. 1998;15:1249-1257.
-
(1998)
J Clin Invest
, vol.15
, pp. 1249-1257
-
-
Thomas, H.E.1
Parker, J.L.2
Schreiber, R.D.3
-
36
-
-
0037442021
-
Th1 and Th2 pancreatic inflammation differentially affects homing of islet-reactive CD4 cells in nonobese diabetic mice
-
Hill NJ, Van Gunst K, Sarvetnick N. Th1 and Th2 pancreatic inflammation differentially affects homing of islet-reactive CD4 cells in nonobese diabetic mice. J Immunol. 2003;170:1649-1658.
-
(2003)
J Immunol
, vol.170
, pp. 1649-1658
-
-
Hill, N.J.1
Van Gunst, K.2
Sarvetnick, N.3
-
37
-
-
0035030341
-
Expression of tumor necrosis factor-α, interleukin-6, and interferon-γ in spontaneous chronic pancreatitis in the WBN/Kob rat
-
Xie MJ, Motoo Y, Su SB, et al. Expression of tumor necrosis factor-α, interleukin-6, and interferon-γ in spontaneous chronic pancreatitis in the WBN/Kob rat. Pancreas. 2001;22:400-408.
-
(2001)
Pancreas
, vol.22
, pp. 400-408
-
-
Xie, M.J.1
Motoo, Y.2
Su, S.B.3
-
38
-
-
0029051316
-
Localization of transforming growth factor-β1 expression and its binding protein in human chronic pancreatitis
-
Van Laethem JL, Deviere J, Resibois A, et al. Localization of transforming growth factor-β1 expression and its binding protein in human chronic pancreatitis. Gastroenterology. 1995;108:1873-1881.
-
(1995)
Gastroenterology
, vol.108
, pp. 1873-1881
-
-
Van Laethem, J.L.1
Deviere, J.2
Resibois, A.3
-
39
-
-
0030063574
-
Transforming growth factor-β promotes development of fibrosis after repeated courses of acute pancreatitis in mice
-
Van Laethem JL, Robberecht P, Resibois A, et al. Transforming growth factor-β promotes development of fibrosis after repeated courses of acute pancreatitis in mice. Gastroenterology. 1996;110:576-582.
-
(1996)
Gastroenterology
, vol.110
, pp. 576-582
-
-
Van Laethem, J.L.1
Robberecht, P.2
Resibois, A.3
-
40
-
-
0029017902
-
Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-β1
-
Lee M-S, Gu D, Feng D, et al. Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-β1. Am J Pathol. 1995;147:42-52.
-
(1995)
Am J Pathol
, vol.147
, pp. 42-52
-
-
Lee, M.-S.1
Gu, D.2
Feng, D.3
-
41
-
-
0034870206
-
Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells
-
Schneider E, Schmid-Kotsas A, Zhao J, et al. Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells. Am J Physiol. 2001;281:C532-C543.
-
(2001)
Am J Physiol
, vol.281
-
-
Schneider, E.1
Schmid-Kotsas, A.2
Zhao, J.3
-
42
-
-
0032954505
-
Pancreatic stellate cells are activated by proinflammatory cytokines: Implications for pancreatic fibrogenesis
-
Apte MV, Haber PS, Darby SJ, et al. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut. 1999;44:534-541.
-
(1999)
Gut
, vol.44
, pp. 534-541
-
-
Apte, M.V.1
Haber, P.S.2
Darby, S.J.3
-
43
-
-
0032829703
-
Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis
-
Haber PS, Keogh QW, Apte MV, et al. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol. 1999;155:1087-1095.
-
(1999)
Am J Pathol
, vol.155
, pp. 1087-1095
-
-
Haber, P.S.1
Keogh, Q.W.2
Apte, M.V.3
-
44
-
-
0031010387
-
Extracellular matrix protein is reduced by inhibition of TGF-β1 in pancreatitis in the rat
-
Menke A, Yamaguchi H, Gress TM, et al. Extracellular matrix protein is reduced by inhibition of TGF-β1 in pancreatitis in the rat. Gastroenterology. 1997;113:295-303.
-
(1997)
Gastroenterology
, vol.113
, pp. 295-303
-
-
Menke, A.1
Yamaguchi, H.2
Gress, T.M.3
-
45
-
-
0033993681
-
Expression of transforming growth factor-β in spontaneous chronic pancreatitis in the WBN/Kob rat
-
Su SB, Motoo Y, Xie MJ, et al. Expression of transforming growth factor-β in spontaneous chronic pancreatitis in the WBN/Kob rat. Dig Dis Sci. 2000;45:151-159.
-
(2000)
Dig Dis Sci
, vol.45
, pp. 151-159
-
-
Su, S.B.1
Motoo, Y.2
Xie, M.J.3
|