Overexpression of truncated IκBα induces TNF-α-dependent apoptosis in human vascular smooth muscle cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 20, Issue 10, 2000, Pages 2198-2204

  Obara, Hideaki ^a   Takayanagi, Atsushi ^a   Hirahashi, Junichi ^a   Tanaka, Katsunori ^a   Wakabayashi, Go ^a   Matsumoto, Kenji ^a   Shimazu, Motohide ^a   Shimizu, Nobuyoshi ^a   Kitajima, Masaki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Inhibitory Ba; Nuclear factor B; Tumor necrosis factor ; Vascular smooth muscle cells

Indexed keywords

CASPASE 2; CASPASE 3; CASPASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; INHIBITOR PROTEIN I KAPPA B ALPHA; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CASP3 PROTEIN, HUMAN; CASPASE; DNA BINDING PROTEIN; DNA FRAGMENT; I KAPPA B; INTERLEUKIN 1; LUCIFERASE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; REPRESSOR PROTEIN;

ADENOVIRUS; APOPTOSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; GENE TRANSFER; HUMAN; HUMAN CELL; INFLAMMATION; INTIMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; AORTA; ARTERIOSCLEROSIS; BIOSYNTHESIS; CELL CULTURE; COMPARATIVE STUDY; DRUG ANTAGONISM; ELECTROPHORESIS; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; METABOLISM; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ADENOVIRIDAE; AORTA; APOPTOSIS; ARTERIOSCLEROSIS; BLOTTING, WESTERN; CASPASE 2; CASPASE 3; CASPASES; CELLS, CULTURED; DNA FRAGMENTATION; DNA-BINDING PROTEINS; ELECTROPHORESIS; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENE THERAPY; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-1; LUCIFERASES; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; REPRESSOR PROTEINS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033623317     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.10.2198     Document Type: Article

References (38)

1. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model
2. Evidence for apoptosis in advanced human atheroma: Colocalization with interleukin-lβ-converting enzyme
3. Apoptosis in human atherosclerosis and restenosis
4. Apoptosis is abundant in human athero-sclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability
5. Apoptosis participates in cellularity regulation during rat aortic intimal thickening
6. Vein graft intimal hyperplasia: Leukocytes and cytokine gene expression
7. Smooth muscle cells express Ia antigens during arterial response to injury
8. Human interleukin-1 induces interleukin-1 gene expression in human vascular smooth muscle cells
9. Interleukin-l: A mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids
10. Human vascular smooth muscle cells: Target for and source of tumor necrosis factor
11. Detection and localization of tumor necrosis factor in human atheroma
12. Tumor necrosis factor-a can modulate the phenotype of aortic smooth muscle cells
13. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-y, tumor necrosis factor-α, and interleukin-lβ
14. Activated transcription factor nuclear factor-κB is present in the atherosclerotic lesion
15. The nuclear factor κB signaling pathway participates in dysregulation of vascular smooth muscle cells in vitro and in human atherosclerosis
16. Activation of the NF-κB and IκB system in smooth muscle cells after rat arterial injury
17. Coupling of a signal response domain in IκBα to multiple pathways for NF-κB activation
18. Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation
19. Phosphorylation of human IκB-α on serines 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli
20. NF-κB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
21. Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IκBα over-expression
22. Overexpression of truncated IκBα potentiates TNF-α-induced apoptosis in mesangial cells
23. Efficient generation of recombinant adenoviruses using adenovims DNA-terminal protein complex and a cosmid bearing the full-length virus genome
24. A simple and efficient method for purification of infectious recombinant adenovirus
25. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase
26. Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer in vitro and in vivo
27. Liposomal delivery of purified inhibitory-κBα inhibits tumor necrosis factor-α-induced human vascular smooth muscle proliferation
28. Polycations increase the efficiency of adenovirus-mediated gene transfer to epithelial and endothelial cells in vitro
29. Adenovirus enhancement of polyethylenimine-mediated transfer of regulated genes in differentiated cells
30. An essential role for NF-κB in preventing TNF-α-induced cell death
31. TNF- and cancer therapy-induced apoptosis potentiation by inhibition of NF-κB
32. Suppression of TNF-α-induced apoptosis by NF-κB
33. X-linked IAP is a direct inhibitor of cell-death proteases
34. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1β-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-1ike proteases
35. Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response
36. HMG CoA reductase inhibitors: In vivo effects on carotid intimal thickening in normocholesterolemic rabbits
37. Nuclear factor-κB regulates induction of apoptosis and inhibitor of apoptosis protein-I expression in vascular smooth muscle cells
38. The unstable atheroma