Apoptosis: Its role in the development of malignancies and its potential as a novel therapeutic target

Annals of Pharmacotherapy

Volumn 31, Issue 1, 1997, Pages 76-82

  Dixon, Shannon C ^a   Soriano, Barbara J ^a   Lush, Richard M ^a   Borner, Markus M ^b   Figg, William D ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CANCER CELL; CARCINOGENESIS; CELL DAMAGE; CELL DEATH; GENE TARGETING; GENETIC REGULATION; HOMEOSTASIS; PRIORITY JOURNAL; REVIEW; TARGET CELL;

EID: 0031031293     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1177/106002809703100113     Document Type: Review

References (80)

1. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-58.
2. Fesus L, Davies PJA, Piacentini M. Apoptosis: molecular mechanisms in programmed cell death. Eur J Cell Bio 1991;56:170-7.
3. Rothenberg EV. The development of functionally responsive T cells. Adv Immunol 1992;51:85-214.
4. Young AR, The sunburn cell. Photodermatology 1987;4:127-34.
5. Danno K, Horio T. Formation of UV-induced apoptosis relates to the cell cycle. Br J Dermatol 1982;107:423-8.
6. Amos TA, Lewis JL, Grand FH, Gooding RP, Goldman JM, Gordon MY. Apoptosis in chronic myeloid leukaemia: normal responses by progenitor cells to growth factor deprivation, X-irradiation and glucocorticoids. Br J Haematol 1995;91:387-93.
7. Woloschak GE, Chang-Liu CM, Chung J, Libertin CR. Expression of enhanced spontaneous and gamma-ray-induced apoptosis by lymphocytes of the wasted mouse. Int J Radial Biol 1996;69:47-55.
8. Inouye M, Yamamura H, Nakano A. Lithium delays the radiation-induced apoptotic process in external granule cells of mouse cerebellum. J Radiat Res (Tokyo) 1995;36:203-8.
9. Harney JV, Seymour CB, Murphy DM, Mothersill C. Variation in the expression of p53, c-myc, and bcl-2 oncoproteins in individual patient cultures of normal urothelium exposed to cobalt 60 gamma-rays and N-nitrosodiethanolamine. Cancer Epidemiol Biomarkers Prev 1995;4:617-25.
10. Delic J, Magdelenat H, Barbaroux C, Chaillet MP, Dubray B, Gluckman E, et al. In vivo induction of apoptosis in human lymphocytes by therapeutic fractionated total body irradiation. Br J Radiol 1995;68:997-1003.
11. Vincent PC. Apoptosis and the assessment of radiation injury. Stem Cells (Dayt) 1995;13(suppl 1):153-64.
12. Sakaguchi Y, Stephens LC, Makino M, Kaneko T, Strebel FR, Danhauser LL, et al. Apoptosis in tumors and normal tissues induced by whole body hyperthermia in rats. Cancer Res 1995;55:5459-64.
13. Cregan SP, Boreham DR, Walker PR, Brown DL, Mitchel RE. Modification of radiation-induced apoptosis in radiation- or hyperthermia-adapted human lymphocytes. Biochem Cell Biol 1994;72:475-82.
14. Swanson PE, Carroll SB, Zhang XF, Mackey MA. Spontaneous premature chromosome condensation, micronucleus formation, and non-apoptotic cell death in heated HeLa S3 cells. Ultrastructural observations. Am J Pathol 1995;146:963-71.
15. Fairbairn JJ, Khan MW, Ward KJ, Loveridge BW, Fairbairn DW, O'Neill KL. Induction of apoptotic cell DNA fragmentation in human cells after treatment with hyperthermia. Cancer Lett 1995;89:183-8.
16. Fuller KJ, Issels RD, Slosman DO, Guillet JG, Soussi T, Polla BS. Cancer and the heat shock response. Eur J Cancer 1994;29A:1884-91.
17. Schepotin IB, Soldatenkov V, Buras RR, Nauta RJ, Shabahang M, Evans SR. Apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro induced by 5-fluorouracil, verapamil, and hyperthermia. Anticancer Res 1994;14:1027-31.
18. Lichtenstein A, Tu Y, Fady C, Vescio R, Berenson J. Interleukin-6 inhibits apoptosis of malignant plasma cells. Cell Immunol 1995;162:248-55.
19. Carson DA, Ribeiro JM. Apoptosis and disease. Lancet 1993;341:1251-4.
20. Hickman JA. Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 1992;11:121-39.
21. Kyprianou N, Isaacs JT. Activation of programmed cell death in the rat ventral prostate after castration. Endocrinology 1988;122:552-62.
22. Kyprianou N, English HF, Davidson NE, Isaacs JT. Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation. Cancer Res 1991;51:162-6.
23. Redding TW, Schally AV, Radulovic S, Milovanovic S, Szepeshazi K, Isaacs JT. Sustained release formulations of luteinizing hormone-releasing hormone antagonist SB-75 inhibit proliferation and enhance apoptotic cell death of human prostate carcinoma (PC-82) in male nude mice. Cancer Res 1991;52:2538-44.
24. Laster SM, Wood JG, Gooding LR. Tumor necrosis factor can induce both apoptotic and necrotic forms of cell lysis. J Immunol 1988;141:2629-34.
25. Heller RA, Song K, Fan N, Chang DJ. The p70 tumor necrosis factor receptor mediates cytotoxicity. Cell 1992;70:47-56.
26. Zheng L, Fisher G, Miller RE, Peschon J, Lynch DH, Lenardo MJ. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 1995;377:348-51.
27. Beyaert R, Vanhaesebroeck B, Declercq W, Van Lint J, Vandenabeele P, Agostinis P, et al. Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis. J Biol Chem 1995;270:23293-9.
28. Manabe A, Coustan-Smith E, Kumagai M, Behm FG, Raimondi SC, Pui CH, et al. Interleukin-4 induces programmed cell death (apoptosis) in cases of high-risk acute lymphoblastic leukemia. Blood 1994;83:1731-7.
29. Yonish-Rouach E, Resnitsky D, Lotem J, Sachs L, Kimchi A, Oren M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 1991;352:345-7.
30. Kerr JFR, Winterford CM, Harmon BV. Apoptosis: its significance in cancer and cancer therapy. Cancer 1994;73:2013-26.
31. Schwartz LM, Kosz L, Kay BK. Gene activation is required for developmentally programmed cell death. Proc Natl Acad Sci U S A 1990;87:6594-8.
32. Tata JR, Kawahara A, Baker BS. Prolactin inhibits both thyroid hormone-induced morphogenesis and cell death in cultured amphibian larval tissues. Dev Biol 1991;146:72-80.
33. Truman JW. Insect systems for the study of programmed neuronal death. Exp Gerontol 1992;27:17-28.
34. Weeks JC, Roberts WM, Trimble DL. Hormonal regulation and segmental specificity of motoneuron phenotype during metamorphosis of the tobacco hornworm, Manduca sexta. Dev Biol 1992;149:185-96.
35. Kimura KI, Truman JW. Postmetamorphic cell death in the nervous and muscular systems of Drosophila melanogaster. J Neurosci 1990;10:403-11.
36. Williams L, Bell L. Asynchronous development of the rat colon. Anat Embryol 1991;183:573-8.
37. Antalikova L, Kien V, Kasparek R, Bila V. Patterns of physiological cell death and mitoses in the apical ectodermal ridge in normodactylous and polydactylous rat limb buds. A quantitative evaluation. Folia Biol (Praha) 1989;35:339-46.
38. Lewinson D, Silbermann M. Chondroclasts and endothelial cells collaborate in the process of cartilage resorption. Anat Rec 1992;233:504-14.
39. Furtwangler JA, Hall SH, Koskinen-Moffett LK. Sutural morphogenesis in the mouse calvaria: the role of apoptosis. Acta Anat 1985;124:74-80.
40. Golstein P, Ojcius DM, Young JD. Cell death mechanisms and the immune system. Immunol Rev 1991;121:30-53.
41. Arends MJ, Wyllie AH. Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol 1991;32:223-54.
42. Wyllie AH. Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview. Cancer Metastasis Rev 1992;11:95-103.
43. Cohen JJ, Duke RC Apoptosis and programmed cell death in immunity. Ann Rev Immunol 1992;10:267-93.
44. Vaux DL. Toward an understanding of the molecular mechanisms of physiological cell death. Proc Natl Acad Sci U S A 1993;90:786-9.
45. Hacker G, Vaux DL. The medical significance of physiological cell death. Med Res Rev 1995;15:299-311.
46. Hopwood D, Levison DA. Atrophy and apoptosis in the cyclical human endometrium. J Pathol 1976;119:159-66.
47. Cornillie FJ, Lauweryn JM, Brosens IA. Normal human endometrium. An ultrastructural survey. Gynecol Obstet Invest 1985;20:113-29.
48. Parmley TH. Spontaneous cell death in the chorion laeve. Am J Obstet Gynecol 1990;162:1576-83.
49. Tropea F, Troiano L, Monti D, Lovato E, Malorni W, Rainaldi G, et al. Sendai virus and herpes virus type 1 induce apoptosis in human peripheral blood mononuclear cells. Exp Cell Res 1995;218:63-70.
50. Esolen LM, Park SW, Hardwick JM, Griffin DE. Apoptosis as a cause of death in measles virus-infected cells. J Virol 1995;69:3955-8.
51. Shen Y, Shenk TE. Viruses and apoptosis. Curr Opin Genet Dev 1995;5:105-11.
52. Whyte M, Evan G. The last cut is the deepest. Nature 1995;376:17-8.
53. Petito CK, Roberts B. Evidence of apoptotic cell death in HIV encephalitis. Am J Pathol 1995;146:1121-30.
54. Ucker DS. Death by suicide: one way to go in mammalian cellular development? New Biol 1991;3:103-9.
55. Oberhammer F, Wilson JW, Dive C, Morris ID, Hickman JA, Wakeling AE, et al. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 1993;12:3679-84.
56. Wyllie AH. Cell death. Int Rev Cytol 1987;17(suppl):755-85.
57. Tenniswood MP, Guenette RS, Lakins J, Mooibroek M, Wong P, Welsh JE. Active cell death in hormone-dependent tissues. Can Metastasis Rev 1992;11:197-220.
58. McConkey DJ, Orrenius S, Jondal M. Cellular signalling in programmed cell death (apoptosis). Immunol Today 1990;11:120-1.
59. Cohen JJ, Duke RC. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J Immunol 1984;132:38-42.
60. Gaido ML, Cidlowski JA. Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes: NUC 18 is not histone H2B. J Biol Chem 1991;266:18580-5.
61. Barry MA, Eastman A. Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Arch Biochem Biophys 1993;300:440-50.
62. Sulston JE, Horvitz HR. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol 1977;56:110-56.
63. Korsmeyer SJ. Bcl-2: an antidote to programmed cell death. Cancer Sur 1992;15:105-18.
64. Yin XM, Oltvai ZN, Veis-Novack DJ, Linette GP, Korsmeyer SJ. Bcl-2 gene family and the regulation of programmed cell death. Cold Spring Harbor Symp Quant Biol 1994;59:387-93.
65. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992;69:119-28.
66. Carson DA, Lois A. Cancer progression and p53. Lancet 1995;346:1009-11.
67. Canman CE, Chen C-Y, Lee M-H, Kastan MB. DNA damage response: p53 induction, cell cycle perturbations and apoptosis. Cold Spring Harbor Symp Quant Biol 1994;59:277-86.
68. Evan GI, Brown L, Whyte M, Harrington E. Apoptosis and the cell cycle. Curr Opin Cell Biol 1995;7:825-34.
69. Boise LH, Gonzales-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, et al. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993;74:597-608.
70. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993;74:609-19.
71. Yin XM, Oltvai ZN, Korsmeyer SJ. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Box. Nature 1994;369:321-3.
72. Grand RJA, Milner AE, Mustoe T, Johnson GD, Owen D, Grant ML, et al. A novel protein expressed in mammalian cells undergoing apoptosis. Exp Cell Res 1995;218:439-51.
73. Nicholson DW, Ali A, Thornberry NA, Vaitlancourt JP, Ding CK, Gallant M, et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 1995;376:37-43.
74. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995;267:2000-3.
75. Stellar H. Mechanisms and genes of cellular suicide. Science 1995;267:1445-9.
76. Lazebnik YA, Takahasi A, Moir RD, Goldman RD, Poirier GG, Kaufman SH, et al. Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci USA 1995;92:9042-6.
77. Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, et al. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 1995;80:401-11.
78. Lazebnik Y, Cole S, Cooke C, Nelson W, Earnshaw W. Nuclear events of apoptosis in vitro in cell-free mitotic extracts - a model system for analysis of the active phase of apoptosis. J Cell Biol 1993;123:7-22.
79. Tewari M, Quan L, O'Rourke K, Desnoyers S, Zeng Z, Beidler D, et al. Yama/CPP32p, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell 1995;81:801-9.
80. Fisher DE. Apoptosis and cancer therapy: crossing the threshold. Cell 1994;78:539-42.