Epidermal Growth Factor Receptor (EGFR) antibody down-regulates mutant receptors and inhibits tumors expressing EGFR mutations

Journal of Biological Chemistry

Volumn 281, Issue 52, 2006, Pages 40183-40192

  Perez Torres, Marianela ^a   Guix, Marta ^a   Gonzalez, Adriana ^a   Arteaga, Carlos L ^a,b  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CELLS; MOLECULES; TUMORS;

CANCER CELLS; EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) ANTIBODY; HEMATOPOIETIC CELLS;

BIOCHEMISTRY;

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; ERLOTINIB; GEFITINIB; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DIMERIZATION; DOSE RESPONSE; DOWN REGULATION; DRUG BLOOD LEVEL; DRUG MECHANISM; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; LUNG CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; XENOGRAFT;

ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BINDING SITES, ANTIBODY; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL SURVIVAL; DOWN-REGULATION; FEMALE; GROWTH INHIBITORS; HUMANS; LIGANDS; LUNG NEOPLASMS; MICE; MICE, NUDE; MUTAGENESIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 33845973029     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607958200     Document Type: Article

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