Synthesis, in vitro antiviral evaluation, and stability studies of novel α-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine

Journal of Medicinal Chemistry

Volumn 49, Issue 26, 2006, Pages 7799-7806

  Barral, Karine ^a   Priet, Stéphane ^b   Sire, Joséphine ^b   Neyts, Johan ^c   Balzarini, Jan ^c   Canard, Bruno ^a   Alvarez, Karine ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b Aix Marseille University IRD 190 Inserm 1207   (France)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

9 [2 (BORANOPHOSPHONOMETHOXY)PROPYL]ADENINE; 9 [2 (BORANOPHOSPHONOMETHOXYL)ETHYL]ADENINE; 9 [2 (HYDROXYPHOSPHINYLMETHOXY)ETHYL]ADENINE; 9 [2 (HYDROXYPHOSPHINYLMETHOXY)PROPYL]ADENINE; 9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE DERIVATIVE; 9 [2 (PHOSPHONOMETHOXY)PROPYL]ADENINE DERIVATIVE; ALPHA BORANO NUCLEOTIDE DERIVATIVE; NUCLEOTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG HALF LIFE; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; ENZYME STABILITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; NONHUMAN;

ADENINE; ANIMALS; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; BORANES; BORON COMPOUNDS; CERCOPITHECUS AETHIOPS; DNA VIRUSES; HIV-1; HUMANS; NUCLEOSIDES; PHOSPHATES; PHOSPHONIC ACIDS; RNA VIRUSES; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS; VIRUS REPLICATION;

EID: 33845947984     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060030y     Document Type: Article

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