Borano-nucleotides: New analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 419-422

  Alvarez, Karine ^a   Deval, Jérôme ^a   Selmi, Boulbaba ^a   Barral, Karine ^a   Boretto, Joelle ^a   Guerreiro, Catherine ^b   Mulard, Laurence ^b   Sarfati, Robert ^b   Canard, Bruno ^a  

^a CNRS   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; ALPHA BORANOPHOSPHATE DERIVATIVE; BORANE DERIVATIVE; BORANONUCLEOTIDE DERIVATIVE; DNA; LAMIVUDINE; NUCLEOSIDE; NUCLEOTIDE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; STAVUDINE; UNCLASSIFIED DRUG; ZIDOVUDINE;

AMINO ACID SUBSTITUTION; CATALYSIS; CONFERENCE PAPER; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; NUCLEOTIDE METABOLISM; VIRUS RESISTANCE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 26644475653     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200059951     Document Type: Conference Paper

References (10)

1. De Clercq, E. Antiviral drugs: current state of the art. J. Clin. Virol. 2001, 22(1), 73-89.
2. Arion, D.; Kaushik, N.; McCormick, S.; Borkow, G.; Pamiak, M.A. Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′- deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Biochemistry 1998, 37(45), 15908-15917.
3. Selmi, B.; Boretto, J.; Sarfati, S.R.; Guerreiro, C.; Canard, B. Mechanism-based suppression of dideoxynucleotide resistance by K65R human immunodeficiency virus reverse transcriptase using an α-boranophosphate nucleoside analogue. J. Biol. Chem. 2001, 276(51), 48466-48472.
4. Meyer, P.R.; Matsuura, S.E.; Mian, A.M.; So, A.G.; Scott, W.A. A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase. Mol. Cell. 1999, 4, 35-43.
5. Shaw, B.R.; Sergueev, D.; He, K.; Porter, K.; Summers, J.; Sergueeva, Z.; Rait, V. Boranophosphate backbone: a mimic of phosphodiesters, phosphorothioates, and methyl phosphonates. Methods Enzymol. 2000, 313, 226-257.
6. Barth, R.F.; Soloway, A.H.; Fairchild, R.G.; Brugger, R.M. Boron neutron capture therapy for cancer, realities and prospects. Cancer 1992, 70, 2995-3007.
7. Meyer, P.; Schneider, B.; Sarfati, S.; Deville-Bonne, D.; Guerreiro, C.; Boretto, J.; Janin, J.; Veron, M.; Canard, B. Structural basis for activation of α-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase. EMBO J. 2000, 19(14), 3520-3529.
8. Deval, J.; Selmi, B.; Boretto, J.; Egloff, M.P.; Guerreiro, C.; Sarfati, S.; Canard, B. The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using α-boranophosphate nucleotide analogues. J. Biol. Chem. 2002, 277(44), 42097-42104.
9. Deval, J.; White, K.L.; Miller, M.D.; Parkin, N.T.; Courcambeck, J.; Halfon, P.; Selmi, B.; Boretto, J.; Canard, B. Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations. J. Biol. Chem. 2004, 279(1), 509-516.
10. Deval, J.; Alvarez, K.; Selmi, B.; Bermond, M.; Boretto, J.; Guerreiro, C.; Mulard, L.; Canard, B. Mechanistic insights into the suppression of drug-resistance by human immunodeficiency virus type-1 reverse transcriptase using α-boranophosphate nucleoside analogues. J. Biol. Chem. 2005, in press.