-
1
-
-
0037423143
-
Cellular warriors at the battle of the bulge
-
Marx J (2003) Cellular warriors at the battle of the bulge. Science 299:846-849
-
(2003)
Science
, vol.299
, pp. 846-849
-
-
Marx, J.1
-
2
-
-
0842285784
-
-
Grundy SM, Hansen B, Smith SC Jr et al (2004) Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Circulation 109:551-556
-
Grundy SM, Hansen B, Smith SC Jr et al (2004) Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Circulation 109:551-556
-
-
-
-
3
-
-
0033180532
-
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
-
Elias CF, Aschkenasi C, Lee C et al (1999) Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23:775-786
-
(1999)
Neuron
, vol.23
, pp. 775-786
-
-
Elias, C.F.1
Aschkenasi, C.2
Lee, C.3
-
4
-
-
14444268971
-
Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat
-
Wang Q, Bing C, Al-Barazanji K et al (1997) Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat. Diabetes 46:335-341
-
(1997)
Diabetes
, vol.46
, pp. 335-341
-
-
Wang, Q.1
Bing, C.2
Al-Barazanji, K.3
-
6
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
Cowley MA, Smart JL, Rubinstein M et al (2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480-484
-
(2001)
Nature
, vol.411
, pp. 480-484
-
-
Cowley, M.A.1
Smart, J.L.2
Rubinstein, M.3
-
7
-
-
0037456519
-
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
-
Cowley MA, Smith RG, Diano S et al (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-661
-
(2003)
Neuron
, vol.37
, pp. 649-661
-
-
Cowley, M.A.1
Smith, R.G.2
Diano, S.3
-
8
-
-
0035143816
-
Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway
-
Shintani M, Ogawa Y, Ebihara K et al (2001) Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50:227-232
-
(2001)
Diabetes
, vol.50
, pp. 227-232
-
-
Shintani, M.1
Ogawa, Y.2
Ebihara, K.3
-
9
-
-
0014683812
-
Glucose and osmosensitive neurones of the rat hypothalamus
-
Oomura Y, Ono T, Ooyama H, Wayner MJ (1969) Glucose and osmosensitive neurones of the rat hypothalamus. Nature 222:282-284
-
(1969)
Nature
, vol.222
, pp. 282-284
-
-
Oomura, Y.1
Ono, T.2
Ooyama, H.3
Wayner, M.J.4
-
10
-
-
0016191102
-
Glucose inhibition of the glucose-sensitive neurone in the rat lateral hypothalamus
-
Oomura Y, Ooyama H, Sugimori M, Nakamura T, Yamada Y (1974) Glucose inhibition of the glucose-sensitive neurone in the rat lateral hypothalamus. Nature 247:284-286
-
(1974)
Nature
, vol.247
, pp. 284-286
-
-
Oomura, Y.1
Ooyama, H.2
Sugimori, M.3
Nakamura, T.4
Yamada, Y.5
-
12
-
-
0031440266
-
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
-
Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford ML (1997) Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390:521-525
-
(1997)
Nature
, vol.390
, pp. 521-525
-
-
Spanswick, D.1
Smith, M.A.2
Groppi, V.E.3
Logan, S.D.4
Ashford, M.L.5
-
13
-
-
0035650534
-
Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus
-
Song Z, Levin BE, McArdle JJ, Bakhos N, Routh VH (2001) Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 50:2673-2681
-
(2001)
Diabetes
, vol.50
, pp. 2673-2681
-
-
Song, Z.1
Levin, B.E.2
McArdle, J.J.3
Bakhos, N.4
Routh, V.H.5
-
14
-
-
0036303140
-
Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons
-
Dunn-Meynell AA, Routh VH, Kang L, Gaspers L, Levin BE (2002) Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons. Diabetes 51:2056-2065
-
(2002)
Diabetes
, vol.51
, pp. 2056-2065
-
-
Dunn-Meynell, A.A.1
Routh, V.H.2
Kang, L.3
Gaspers, L.4
Levin, B.E.5
-
15
-
-
1442276966
-
Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons
-
Kang L, Routh VH, Kuzhikandathil EV, Gaspers LD, Levin BE (2004) Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons. Diabetes 53:549-559
-
(2004)
Diabetes
, vol.53
, pp. 549-559
-
-
Kang, L.1
Routh, V.H.2
Kuzhikandathil, E.V.3
Gaspers, L.D.4
Levin, B.E.5
-
16
-
-
12144281012
-
Visualising insulin secretion. The Minkowski Lecture 2004
-
Rutter GA (2004) Visualising insulin secretion. The Minkowski Lecture 2004. Diabetologia 47:1861-1872
-
(2004)
Diabetologia
, vol.47
, pp. 1861-1872
-
-
Rutter, G.A.1
-
17
-
-
0037107408
-
Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: Evidence for ATP-independent control of ATP-sensitive K(+) channels
-
Ainscow EK, Mirshamsi S, Tang T, Ashford ML, Rutter GA (2002) Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K(+) channels. J Physiol 544:429-445
-
(2002)
J Physiol
, vol.544
, pp. 429-445
-
-
Ainscow, E.K.1
Mirshamsi, S.2
Tang, T.3
Ashford, M.L.4
Rutter, G.A.5
-
18
-
-
0031717105
-
The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
-
Hardie DG, Carling D, Carlson M (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67:821-855
-
(1998)
Annu Rev Biochem
, vol.67
, pp. 821-855
-
-
Hardie, D.G.1
Carling, D.2
Carlson, M.3
-
19
-
-
0141905919
-
Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis
-
Rutter GA, da Silva Xavier G, Leclerc I (2003) Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem J 375:1-16
-
(2003)
Biochem J
, vol.375
, pp. 1-16
-
-
Rutter, G.A.1
da Silva Xavier, G.2
Leclerc, I.3
-
20
-
-
1842484296
-
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
-
Minokoshi Y, Alquier T, Furukawa N et al (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428:569-574
-
(2004)
Nature
, vol.428
, pp. 569-574
-
-
Minokoshi, Y.1
Alquier, T.2
Furukawa, N.3
-
21
-
-
1842582870
-
AMP-activated protein kinase plays a role in the control of food intake
-
Andersson U, Filipsson K, Abbott CR et al (2004) AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 279:12005-12008
-
(2004)
J Biol Chem
, vol.279
, pp. 12005-12008
-
-
Andersson, U.1
Filipsson, K.2
Abbott, C.R.3
-
23
-
-
0036109543
-
Adenoviral-mediated, high-level, cell-specific transgene expression: A SYN1-WPRE cassette mediates increased transgene expression with no loss of neuron specificity
-
Glover CPJ, Bienemann AS, Heywood DJ, Cosgrave AS, Uney JB (2002) Adenoviral-mediated, high-level, cell-specific transgene expression: a SYN1-WPRE cassette mediates increased transgene expression with no loss of neuron specificity. Mol Ther 5:509-516
-
(2002)
Mol Ther
, vol.5
, pp. 509-516
-
-
Glover, C.P.J.1
Bienemann, A.S.2
Heywood, D.J.3
Cosgrave, A.S.4
Uney, J.B.5
-
24
-
-
0032478271
-
A simplified system for generating recombinant adenoviruses
-
He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B (1998) A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95:2509-2514
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2509-2514
-
-
He, T.C.1
Zhou, S.2
da Costa, L.T.3
Yu, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
25
-
-
0032144010
-
Stimulation of neuropeptide Y gene expression by brain-derived neurotrophic factor requires both the phospholipase Cgamma and Shc binding sites on its receptor, TrkB
-
Williams AG, Hargreaves AC, Gunn-Moore FJ, Tavare JM (1998) Stimulation of neuropeptide Y gene expression by brain-derived neurotrophic factor requires both the phospholipase Cgamma and Shc binding sites on its receptor, TrkB. Biochem J 333:505-509
-
(1998)
Biochem J
, vol.333
, pp. 505-509
-
-
Williams, A.G.1
Hargreaves, A.C.2
Gunn-Moore, F.J.3
Tavare, J.M.4
-
26
-
-
0035864148
-
2+ oscillations and insulin secretion in pancreatic islets
-
2+ oscillations and insulin secretion in pancreatic islets. Biochem J 353:175-180
-
(2001)
Biochem J
, vol.353
, pp. 175-180
-
-
Ainscow, E.K.1
Rutter, G.A.2
-
27
-
-
0038584871
-
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression
-
da Silva Xavier G, Leclerc I, Varadi A, Tsuboi T, Moule SK, Rutter GA (2003) Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J 371:761-774
-
(2003)
Biochem J
, vol.371
, pp. 761-774
-
-
da Silva Xavier, G.1
Leclerc, I.2
Varadi, A.3
Tsuboi, T.4
Moule, S.K.5
Rutter, G.A.6
-
28
-
-
0036318475
-
2+-ATPase (SERCA)-2 and ryanodine receptors
-
2+-ATPase (SERCA)-2 and ryanodine receptors. Diabetes 51:S190-S201
-
(2002)
Diabetes
, vol.51
-
-
Varadi, A.1
Rutter, G.A.2
-
29
-
-
0028101988
-
Extracellular glucose concentration in mammalian brain: Continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals
-
Silver I, Erecinska M (1994) Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals. J Neurosci 14:5068-5076
-
(1994)
J Neurosci
, vol.14
, pp. 5068-5076
-
-
Silver, I.1
Erecinska, M.2
-
30
-
-
0242268888
-
Extracellular glucose in rat ventromedial hypothalamus during acute and recurrent hypoglycemia
-
de Vries MG, Arseneau LM, Lawson ME, Beverly JL (2003) Extracellular glucose in rat ventromedial hypothalamus during acute and recurrent hypoglycemia. Diabetes 52:2767-2773
-
(2003)
Diabetes
, vol.52
, pp. 2767-2773
-
-
de Vries, M.G.1
Arseneau, L.M.2
Lawson, M.E.3
Beverly, J.L.4
-
31
-
-
7044253373
-
A new ATP-sensitive K+ channel-independent mechanism is involved in glucose-excited neurons of mouse arcuate nucleus
-
Fioramonti X, Lorsignol A, Taupignon A, Penicaud L (2004) A new ATP-sensitive K+ channel-independent mechanism is involved in glucose-excited neurons of mouse arcuate nucleus. Diabetes 53:2767-2775
-
(2004)
Diabetes
, vol.53
, pp. 2767-2775
-
-
Fioramonti, X.1
Lorsignol, A.2
Taupignon, A.3
Penicaud, L.4
-
32
-
-
0034790747
-
Brain glucose-sensing mechanisms: Ubiquitous silencing by aglycemia vs. hypothalamic neuroendocrine responses
-
Mobbs CV, Kow LM, Yang XJ (2001) Brain glucose-sensing mechanisms: ubiquitous silencing by aglycemia vs. hypothalamic neuroendocrine responses. Am J Physiol Endocrinol Metab 281:E649-E654
-
(2001)
Am J Physiol Endocrinol Metab
, vol.281
-
-
Mobbs, C.V.1
Kow, L.M.2
Yang, X.J.3
-
33
-
-
0033515710
-
Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y
-
Muroya S, Yada T, Shioda S, Takigawa M (1999) Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y. Neurosci Lett 264:113-116
-
(1999)
Neurosci Lett
, vol.264
, pp. 113-116
-
-
Muroya, S.1
Yada, T.2
Shioda, S.3
Takigawa, M.4
-
34
-
-
0032967165
-
Brain glucose sensing and body energy homeostasis: Role in obesity and diabetes
-
Levin BE, Dunn-Meynell AA, Routh VH (1999) Brain glucose sensing and body energy homeostasis: role in obesity and diabetes. Am J Physiol 276:R1223-R1231
-
(1999)
Am J Physiol
, vol.276
-
-
Levin, B.E.1
Dunn-Meynell, A.A.2
Routh, V.H.3
-
35
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G, Myers R, Li Y et al (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-1174
-
(2001)
J Clin Invest
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
-
36
-
-
2442631468
-
C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase
-
Kim EK, Miller I, Aja S et al (2004) C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. J Biol Chem 279:19970-19976
-
(2004)
J Biol Chem
, vol.279
, pp. 19970-19976
-
-
Kim, E.K.1
Miller, I.2
Aja, S.3
-
37
-
-
12144288387
-
2+ signaling in a reciprocal manner to leptin: Orexigenic neuronal pathways in the mediobasal hypothalamus
-
2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. Eur J Neurosci 19:1524-1534
-
(2004)
Eur J Neurosci
, vol.19
, pp. 1524-1534
-
-
Muroya, S.1
Funahashi, H.2
Yamanaka, A.3
-
38
-
-
3242765290
-
The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides
-
Wang R, Liu X, Hentges ST et al (2004) The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes 53:1959-1965
-
(2004)
Diabetes
, vol.53
, pp. 1959-1965
-
-
Wang, R.1
Liu, X.2
Hentges, S.T.3
-
40
-
-
14644396121
-
Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ
-
Burdakov D, Gerasimenko O, Verkhratsky A (2005) Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J Neurosci 25:2429-2433
-
(2005)
J Neurosci
, vol.25
, pp. 2429-2433
-
-
Burdakov, D.1
Gerasimenko, O.2
Verkhratsky, A.3
-
41
-
-
33644773627
-
Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing
-
Kang L, Dunn-Meynell AA, Routh VH et al (2006) Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing. Diabetes 55:412-420
-
(2006)
Diabetes
, vol.55
, pp. 412-420
-
-
Kang, L.1
Dunn-Meynell, A.A.2
Routh, V.H.3
-
42
-
-
0034104737
-
Circumventricular organs: Definition and role in the regulation of endocrine and autonomic function
-
Ganong WF (2000) Circumventricular organs: definition and role in the regulation of endocrine and autonomic function. Clin Exp Pharmacol Physiol 27:422-427
-
(2000)
Clin Exp Pharmacol Physiol
, vol.27
, pp. 422-427
-
-
Ganong, W.F.1
-
43
-
-
3142677140
-
Anti-obesity effects of [alpha]-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
-
Kim M-S, Park J-Y, Namkoong C et al (2004) Anti-obesity effects of [alpha]-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 10:727-733
-
(2004)
Nat Med
, vol.10
, pp. 727-733
-
-
Kim, M.-S.1
Park, J.-Y.2
Namkoong, C.3
-
44
-
-
3242811250
-
Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus
-
McCrimmon RJ, Fan X, Ding Y, Zhu W, Jacob RJ, Sherwin RS (2004) Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus. Diabetes 53:1953-1958
-
(2004)
Diabetes
, vol.53
, pp. 1953-1958
-
-
McCrimmon, R.J.1
Fan, X.2
Ding, Y.3
Zhu, W.4
Jacob, R.J.5
Sherwin, R.S.6
-
45
-
-
19944426367
-
Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats
-
Namkoong C, Kim MS, Jang PG et al (2005) Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats. Diabetes 54:63-68
-
(2005)
Diabetes
, vol.54
, pp. 63-68
-
-
Namkoong, C.1
Kim, M.S.2
Jang, P.G.3
-
46
-
-
10744230942
-
AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus
-
Gadalla AE, Pearson T, Currie AJ et al (2004) AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus. J Neurochem 88:1272-1282
-
(2004)
J Neurochem
, vol.88
, pp. 1272-1282
-
-
Gadalla, A.E.1
Pearson, T.2
Currie, A.J.3
-
47
-
-
0028346768
-
Activation of specific ATP receptors induces a rapid increase in intracellular calcium ions in rat hypothalamic neurons
-
Chen ZP, Levy A, Lightman SL (1994) Activation of specific ATP receptors induces a rapid increase in intracellular calcium ions in rat hypothalamic neurons. Brain Res 641:249-256
-
(1994)
Brain Res
, vol.641
, pp. 249-256
-
-
Chen, Z.P.1
Levy, A.2
Lightman, S.L.3
-
48
-
-
0031019855
-
Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression
-
Hardingham GE, Chawla S, Johnson CM, Bading H (1997) Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature 385:260-265
-
(1997)
Nature
, vol.385
, pp. 260-265
-
-
Hardingham, G.E.1
Chawla, S.2
Johnson, C.M.3
Bading, H.4
-
49
-
-
27144506185
-
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
-
Koo S-H, Flechner L, Qi L et al (2005) The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437:1109-1111
-
(2005)
Nature
, vol.437
, pp. 1109-1111
-
-
Koo, S.-H.1
Flechner, L.2
Qi, L.3
-
50
-
-
0032500529
-
Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA
-
Gribble FM, Proks P, Corkey BE, Ashcroft FM (1998) Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA. J Biol Chem 273:26383-26387
-
(1998)
J Biol Chem
, vol.273
, pp. 26383-26387
-
-
Gribble, F.M.1
Proks, P.2
Corkey, B.E.3
Ashcroft, F.M.4
-
51
-
-
0028031858
-
Fatty acyl-CoA esters induce calcium release from terminal cisternae of skeletal muscle
-
Fulceri R, Nori A, Gamberucci A, Volpe P, Giunti R, Benedetti A (1994) Fatty acyl-CoA esters induce calcium release from terminal cisternae of skeletal muscle. Cell Calcium 15:109-116
-
(1994)
Cell Calcium
, vol.15
, pp. 109-116
-
-
Fulceri, R.1
Nori, A.2
Gamberucci, A.3
Volpe, P.4
Giunti, R.5
Benedetti, A.6
-
52
-
-
0034733730
-
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
-
Loftus TM, Jaworsky DE, Frehywot GL et al (2000) Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288:2379-2381
-
(2000)
Science
, vol.288
, pp. 2379-2381
-
-
Loftus, T.M.1
Jaworsky, D.E.2
Frehywot, G.L.3
|