Brain glucose-sensing mechanisms: Ubiquitous silencing by aglycemia vs. hypothalamic neuroendocrine responses

American Journal of Physiology - Endocrinology and Metabolism

Volumn 281, Issue 4 44-4, 2001, Pages

  Mobbs, Charles V ^a   Kow, Lee Ming ^b   Yang, Xue Jun ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Adenosine triphosphate dependent potassium channel; Glucokinase; Hypoglycemia; Obesity; Ventromedial hypothalamus

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOKINASE; GLUCOSE; LACTIC ACID; POTASSIUM CHANNEL; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

CELL METABOLISM; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; HUMAN; HYPERPOLARIZATION; HYPOGLYCEMIA; HYPOTHALAMUS; NERVE CELL; NEUROENDOCRINE SYSTEM; OBESITY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; ZONA INCERTA;

EID: 0034790747     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2001.281.4.e649     Document Type: Review

References (39)

1. Glucose action "beyond ionic events" in the pancreatic beta cell
2. Tolbutamide excites rat glucoreceptive ventromedial hypothalamic neurones by indirect inhibition of ATP-K+ channels
3. Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels
4. Hypoglycaemia: Brain neurochemistry and neuropathology
5. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats
6. Gold thioglucose obesity syndrome
7. Intracarotid glucose selectively increases Fos-like immunoreactivity in paraventricular, ventromedial and dorsomedial nuclei neurons
8. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion
9. Anorexia induced in rat by D-glucosamine deoxidized at C-1
10. Counterregulatory responses to hypoglycemia in patients with glucokinase gene mutations
11. Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices
12. Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut
13. Brain glucose sensing and body energy homeostasis: Role in obesity and diabetes
14. The temporal response of the brain after eating revealed by functional MRI
15. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
16. Localization of glucokinase gene expression in the rat brain
17. Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion
18. Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting
19. Pharmacological identification of the K(+) currents mediating the hypoglycemic hyperpolarization of rat midbrain dopaminergic neurones
20. Pancreatic beta-cell glucokinase: Closing the gap between theoretical concepts and experimental realities
21. Activation of stimulus-secretion coupling in pancreatic beta-cells by specific products of glucose metabolism. Evidence for privileged signaling by glycolysis
22. ATP-sensitive K+ channels in the hypothalamus are essential for the maintainance of glucose homeostasis
23. Central glucoprivation evoked by administration of 2-deoxy-D-glucose induces expression of the c-fos gene in a subpopulation of neuropeptide Y neurons in the rat hypothalamus
24. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and in ob/ob and db/db mice, but is stimulated by leptin
25. Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin
26. A glucokinase/AP-1 glucose transduction mechanism in the ventromedial hypothalamic satiety center
27. Glucoresponsive neurons in rat ventromedial hypothalamic tissue slices in vitro
28. Feeding- and chemical-related activity of ventromedial hypothalamic neurones in freely behaving rats
29. Signal transduction mechanisms in nutrient-induced insulin secretion
30. Hypoglycemic and hypoxic modulation of cortical micro-EEG activity in rat brain slices
31. Inhibition of hypothalamic neuropeptide Y gene expression by insulin
32. Leptin effects on feeding-related hypothalamic and peripheral neuronal activities in normal and obese rats
33. Extracellular glucose concentration in mammalian brain: Continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals
34. Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons
35. The brain as a chemical machine
36. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
37. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
38. Glucose depletion hyperpolarizes guinea pig hippocampal neurons by an increase in potassium conductance
39. Hypothalamic glucose sensor: Similarities to and differences from pancreatic beta-cell mechanisms