Extracellular Glucose in Rat Ventromedial Hypothalamus during Acute and Recurrent Hypoglycemia

Diabetes

Volumn 52, Issue 11, 2003, Pages 2767-2773

  De Vries, Martin G ^a   Arseneau, Linda M ^a   Lawson, Marcus E ^a   Beverly, Joseph Lee ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECURRENT DISEASE; STEADY STATE; ZONA INCERTA;

ANIMALS; BLOOD GLUCOSE; EXTRACELLULAR SPACE; FASTING; GLUCOSE; HYPOGLYCEMIA; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECURRENCE; REFERENCE VALUES; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 0242268888     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.11.2767     Document Type: Article

References (50)

1. Bolli GB, Fanelli CG: Physiology of glucose counterregulation to hypoglycemia. Endocrinol Metab Clin North Am 28:467-493, 1999
2. Biggers DW, Myers SR, Neal D, Stinson R, Cooper NB, Jaspan J-B, Williams PE, Cherrington AD, Frizzell RT: Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes 38:7-16, 1989
3. Beverly JL, De Vries MG, Bouman SD, Arseneau LM: Noradrenergic and GABAergic systems in the medial hypothalamus are activated during hypoglycemia. Am J Physiol Regul Integr Comp Physiol 280:R563-R569, 2001
4. Levin BE, Dunn-Meynell AA, Routh VH: Brain glucose sensing and body energy homeostasis: role in obesity and diabetes. Am J Physiol 276:R1223-R1231, 1999
5. Silver IA, Erecinska M: Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons. J Neurophys 79:1733-1745, 1998
6. Song Z, Levin BE, McArdle JJ, Bakhos N, Routh VH: Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 50:2673-2681, 2001
7. Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI: Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 44:180-184, 1995
8. Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI: Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J Clin Invest 99:361-365, 1997
9. Lee K, Dixon AK, Richardson PJ, Pinnock RD: Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits. J Physiol (Lond) 515:439-452, 1999
10. Miki T, Liss B, Minami K, Shiuchi T, Saraya A, Kashima Y, Horiuchi M, Ashcroft F, Minokoshi Y, Roeper J, Seino S: ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci 4:507-512, 2001
11. Lonnroth P, Jansson PA, Smith U: A microdialysis method allowing characterization of intercellular water space in humans. Am J Physiol 253:E228-E231, 1987
12. Fellows LK, Boutelle MG, Fillenz M: Extracellular brain glucose levels reflect local neuronal activity: a microdialysis study in awake, freely moving rats. J Neurochem 59:2141-2147, 1992
13. Fray AE, Boutelle M, Fillenz M: Extracellular glucose turnover in the striatum of unanaesthetized rats measured by quantitative microdialysis. J Physiol 504:721-726, 1997
14. McNay EC, Gold PE: Extracellular glucose concentrations in the rat hippocampus measured by zero-net-flux: effects of microdialysis flow rate, strain, and age [see comments]. J Neurochem 72:785-790, 1999
15. Ronne-Engstrom E, Carlson H, Liu Y, Ungerstedt U, Hillered L: Influence of perfusate glucose concentration on dialysate lactate, pyruvate, aspartate, and glutamate levels under basal and hypoxic conditions: a microdialysis study in rat brain. J Neurochem 65:257-262, 1995
16. Hu Y, Wilson GS: Rapid changes in local extracellular rat brain glucose observed with an in vivo glucose sensor. J Neurochem 68:1745-1752, 1997
17. Lowry JP, O'Neill RD, Boutelle MG, Fillenz M: Continuous monitoring of extracellular glucose concentrations in the striatum of freely moving rats with an implanted glucose biosensor. J Neurochem 70:391-396, 1998
18. Silver IA, Erecinska M: Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals. J Neurosci 14:5068-5076, 1994
19. Bequet F, Peres M, Gomez-Merino D, Berthelot M, Satabin P, Pierard C, Guezennec CY: Simultaneous NMR microdialysis study of brain glucose metabolism in relation to fasting or exercise in the rat. J Appl Physiol 88:1949-1954, 2000
20. Robinson PJ, Rapoport SI: Glucose transport and metabolism in the brain. Am J Physiol 250:R127-R136, 1986
21. Pardridge WM: Glucose transport and phosphorylation: which is rate limiting for brain glucose utilization? Ann Neurol 35:511-512, 1994
22. Baker D, Evans M, Cryer P, Sherwin R: Hypoglycaemia and glucose sensing. Diabetologia 40 (Suppl. 3):B83-B88, 1997
23. McNay EC, Fries TM, Gold PE: Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task. Proc Natl Acad Sci U S A 97:2881-2885, 2000
24. Widom B, Simonson DC: Intermittent hypoglycemia impairs glucose counterregulation, Diabetes 41:1597-1602, 1992
25. Cryer PE: Symptoms of hypoglycemia, thresholds for their occurrence, and hypoglycemia unawareness. Diabetologia 28:495-500, 1999
26. Cryer PE: Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM: a vicious cycle. Diabetes 41:255-260, 1992
27. Boyle PJ, Nagy RJ, O'Connor AM, Kempers SF, Yeo RA, Qualls C: Adaptation in brain glucose uptake following recurrent hypoglycemia. Proc Natl Acad Sci U S A 91:9352-9356, 1994
28. Jones TW, Borg WP, Borg MA, Boulware SD, McCarthy G, Silver D, Tamborlane WV, Sherwin RS: Resistance to neuroglycopenia: an adaptive response during intensive insulin treatment of diabetes. J Clin Endocrinol Metab 82:1713-1718, 1997
29. McCall AL, Fixman LB, Fleming N, Tornheim K, Chick W, Ruderman NB: Chronic hypoglycemia increases brain glucose transport. Am J Physiol 251:E442-E447, 1986
30. Pelligrino DA, Segil LJ, Albrecht RF: Brain glucose utilization and transport and cortical function in chronic vs. acute hypoglycemia. Am J Physiol 259:E729-E735, 1990
31. Jacob RJ, Dziura J, Blumberg M, Morgen JP, Sherwin RS: Effects of recurrent hypoglycemia on brainstem function in diabetic BB rats: protective adaptation during acute hypoglycemia. Diabetes 48:141-145, 1999
32. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates. Sydney; Orlando, Academic Press, 1986
33. Fray AE, Forsyth RJ, Boutelle MG, Fillenz M: The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: a microdialysis study. J Physiol 496:49-57, 1996
34. Eckert B, Ryding E, Agardh C-D: Sustained elevation of cerebral blood flow after hypoglycaemia in normal man. Diabetes Res Clin Pract 40:91-100, 1998
35. Wahren J, Ekberg K, Fernqvist-Forbes E, Nair S: Brain substrate utilisation during acute hypoglycaemia. Diabetologia 42:812-818, 1999
36. Fülenz, Lowry, Boutelle, Fray: The role of astrocytes and noradrenaline in neuronal glucose metabolism. Acta Physiol Scand 167:275-284, 1999
37. Segel SA, Fanelli CG, Dence CS, Markham J, Videen TO, Paramore DS, Powers WJ, Cryer PE: Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia. Diabetes 50:1911-1917, 2001
38. Boyle PJ: Alteration in brain glucose metabolism induced by hypoglycaemia in man. Diabetologia 40 (Suppl. 2):S69-S74, 1997
39. Duelli R, Staudt R, Duembgen L, Kuschinsky W: Increase in glucose transporter densities of Glut3 and decrease of glucose utilization in rat brain after one week of hypoglycemia. Brain Res 831:254-262, 1999
40. Simpson IA, Appel NM, Hokari M, Oki J, Holman GD, Maher F, Koehler-Stec EM, Vannucci SJ, Smith QR: Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited. J Neurochem 72:238-247, 1999
41. Kumagai AK: Glucose transport in brain and retina: implications in the management and complications of diabetes. Diabete Metab Res Rev 15:261-273, 1999
42. Boado RJ, Pardridge WM: Glucose deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis-acting regulatory element. J Neurochem 80:552-554, 2002
43. Choi IY, Seaquist ER, Gruetter R: Effect of hypoglycemia on brain glycogen metabolism in vivo. J Neurosci Res 72:25-32, 2003
44. Forsyth RJ: Astrocytes and the delivery of glucose from plasma to neurons. Neurochem Int 28:231-241, 1996
45. Borg WP, During MJ, Sherwin RS, Borg MA, Brines ML, Shulman GI: Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. J Clin Invest 93:1677-1682, 1994
46. Scheurink AJ, Steffens AB, Gaykema RP: Hypothalamic adrenoceptors mediate sympathoadrenal activity in exercising rats. Am J Physiol 259: R470-R477, 1990
47. Yoshimatsu H, Niijima A, Oomura Y, Katafuchi T: Lateral and ventromedial hypothalamic influences on hepatic autonomic nerve activity in the rat. Brain Res Bull 21:239-244, 1988
48. Takahashi A, Ishimaru H, Ikarashi Y, Kishi E, Maruyama Y: Effects of ventromedial hypothalamus stimulation on glycogenolysis in rat liver using in vivo microdialysis. Metabolism 46:897-901, 1997
49. Ruffin M, Nicolaidis S: Electrical stimulation of the ventromedial hypothalamus enhances both fat utilization and metabolic rate that precede and parallel the inhibition of feeding behavior. Brain Res 846:23-29, 1999
50. Yoshimatsu H, Oomura Y, Katafuchi T, Niijima A: Effects of hypothalamic stimulation and lesion on adrenal nerve activity. Am J Physiol 253:R418-R424, 1987