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2
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12444299569
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Chloroplast genetic engineering
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Daniell H, Chase C Ed, Kluwer Academic Publishers, Dordrecht, The Netherlands
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Daniell H, Cohill P, Kumar S, Dufourmantel N, Chloroplast genetic engineering. In: Molecular Biology and Biotechnology of Plant Organelles. Daniell H, Chase C (Ed.). Kluwer Academic Publishers, Dordrecht, The Netherlands 443-490 (2004).
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(2004)
Molecular Biology and Biotechnology of Plant Organelles
, pp. 443-490
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Daniell, H.1
Cohill, P.2
Kumar, S.3
Dufourmantel, N.4
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3
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0035212386
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Medical molecular farming: Production of antibodies, biopharmaceuticals and edible vaccines in plants
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Daniell H, Streatfield SJ, Wycoff K. Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci. 6, 219-226 (2001).
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(2001)
Trends Plant Sci
, vol.6
, pp. 219-226
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Daniell, H.1
Streatfield, S.J.2
Wycoff, K.3
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4
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0036305744
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Edible plant vaccines: Applications for prophylactic and therapeutic molecular medicine
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Mason HS, Warzecha H, Mor T, Arntzen CJ. Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine. Trends Mol. Med. 8, 324-329 (2002).
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(2002)
Trends Mol. Med
, vol.8
, pp. 324-329
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Mason, H.S.1
Warzecha, H.2
Mor, T.3
Arntzen, C.J.4
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5
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0035925697
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The green revolution: Plants as heterologous expression vectors
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Koprowski H, Yusibov V. The green revolution: plants as heterologous expression vectors. Vaccine 19, 2735-2741 (2001).
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(2001)
Vaccine
, vol.19
, pp. 2735-2741
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Koprowski, H.1
Yusibov, V.2
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6
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0035162968
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De Cosa B, Moar W, Lee SB, Miller M, Daniell H. Overexpression of the Bt cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals. Nat. Biotechnol. 19, 71-74 (2001). •• Reports the highest expression level of any foreign protein ever expressed in tranasgenic plants and the first expression of a bacterial operon in plants, thereby facilitating expression of multivalent vaccines. Therefore, this article was featured on the cover of Nature Biotechnology.
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De Cosa B, Moar W, Lee SB, Miller M, Daniell H. Overexpression of the Bt cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals. Nat. Biotechnol. 19, 71-74 (2001). •• Reports the highest expression level of any foreign protein ever expressed in tranasgenic plants and the first expression of a bacterial operon in plants, thereby facilitating expression of multivalent vaccines. Therefore, this article was featured on the cover of Nature Biotechnology.
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7
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12444271778
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Chloroplast genetic engineering for enhanced agronomic traits and expression of proteins for medical/industrial applications
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Moller SG Ed, Blackwell Publishing
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Devine AL, Daniell H. Chloroplast genetic engineering for enhanced agronomic traits and expression of proteins for medical/industrial applications. In: Plastids. Moller SG (Ed.). Blackwell Publishing. 13, 283-323 (2004).
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(2004)
Plastids
, vol.13
, pp. 283-323
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Devine, A.L.1
Daniell, H.2
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8
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21344474571
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Chloroplast genetic engineering: Recent advances and future perspectives
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Grevich J, Daniell H. Chloroplast genetic engineering: recent advances and future perspectives. Crit. Rev. Plant Sci. 24, 83-108 (2005).
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(2005)
Crit. Rev. Plant Sci
, vol.24
, pp. 83-108
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Grevich, J.1
Daniell, H.2
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10
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0037283514
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Accumulation of trehalose within transgenic chloroplasts confers drought tolerance
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Lee SB, Kwon HB, Kwon SJ et al. Accumulation of trehalose within transgenic chloroplasts confers drought tolerance. Mol Breed. 11, 1-13 (2003).
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(2003)
Mol Breed
, vol.11
, pp. 1-13
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Lee, S.B.1
Kwon, H.B.2
Kwon, S.J.3
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11
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1942501588
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Enhanced translation of chloroplast-expressed RbcS gene restores small subunit levels and photosynthesis in nuclear antisense RbcS plants
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Dhingra A, Portis AR, Daniell H. Enhanced translation of chloroplast-expressed RbcS gene restores small subunit levels and photosynthesis in nuclear antisense RbcS plants. Proc. Natl Acad. Sci. USA 101, 6315-6320 (2004).
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(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 6315-6320
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Dhingra, A.1
Portis, A.R.2
Daniell, H.3
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12
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12444286371
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The sexual inheritance of plant organelles
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Daniell H, Chase C Ed, Springer Publishers, Dordrecht, The Netherlands
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Hagemann R. The sexual inheritance of plant organelles. In: Molecular Biology and Biotechnology of Plant Organelles. Daniell H, Chase C (Ed.). Springer Publishers, Dordrecht, The Netherlands 93-113 (2004).
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(2004)
Molecular Biology and Biotechnology of Plant Organelles
, pp. 93-113
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Hagemann, R.1
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13
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0035984717
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Molecular strategies for gene containment in transgenic crops
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Daniell H. Molecular strategies for gene containment in transgenic crops. Nat. Biotechnol. 20, 581-586 (2002).
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(2002)
Nat. Biotechnol
, vol.20
, pp. 581-586
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Daniell, H.1
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14
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27244443586
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Ruiz ON, Daniell H. Engineering cytoplasmic male sterility via the chloroplast genome by the expression of β-ketothiolase. Plant Physiol. 138, 1232-1246 (2005). •• Reports a novel method of engineering cytoplasmic male sterility in plants. In addition to maternal inheritance of chloroplast genomes, this is yet another failsafe method of containing trasngene escape via pollen. Therefore, this article was featured on the cover of Plant Physiology and highlighted in Nature and Trends in Plant Science.
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Ruiz ON, Daniell H. Engineering cytoplasmic male sterility via the chloroplast genome by the expression of β-ketothiolase. Plant Physiol. 138, 1232-1246 (2005). •• Reports a novel method of engineering cytoplasmic male sterility in plants. In addition to maternal inheritance of chloroplast genomes, this is yet another failsafe method of containing trasngene escape via pollen. Therefore, this article was featured on the cover of Plant Physiology and highlighted in Nature and Trends in Plant Science.
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15
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27244432790
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Characterization of heterologous multigene operons in transgenic chloroplasts: Transcription, processing, and translation
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Quesada-Vergas T, Ruiz ON, Daniell H. Characterization of heterologous multigene operons in transgenic chloroplasts: transcription, processing, and translation. Plant Physiol. 138, 1746-1762 (2005).
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(2005)
Plant Physiol
, vol.138
, pp. 1746-1762
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Quesada-Vergas, T.1
Ruiz, O.N.2
Daniell, H.3
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16
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0037700822
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Phytoremediation of organomercurial compounds via chloroplast genetic engineering
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Ruiz ON, Hussein HS, Terry N, Daniell H. Phytoremediation of organomercurial compounds via chloroplast genetic engineering. Plant Physiol. 132, 1344-1352 (2003).
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(2003)
Plant Physiol
, vol.132
, pp. 1344-1352
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Ruiz, O.N.1
Hussein, H.S.2
Terry, N.3
Daniell, H.4
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17
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84954192625
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Chloroplast-derived antibodies, biopharmaceuticals and eedible vaccines
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Schillberg S, Wiley VCH Ed, Verlag publishers, Germany
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Daniell H, Carmona-Sanchez O, Burns B. Chloroplast-derived antibodies, biopharmaceuticals and eedible vaccines. In: Molecular Farming. Schillberg S, Wiley VCH (Ed.). Verlag publishers, Germany 113-133 (2004).
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(2004)
Molecular Farming
, pp. 113-133
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Daniell, H.1
Carmona-Sanchez, O.2
Burns, B.3
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18
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85169106486
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A chloroplast transgenic approach to hyper-express and purify human serum albumin, a protein highly susceptible to proteolytic degradation
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Fernandez-San Millan A, Mingeo-Castel AM, Miller M, Daniell H. A chloroplast transgenic approach to hyper-express and purify human serum albumin, a protein highly susceptible to proteolytic degradation. Plant Biotechnol. 1, 71-79 (2003).
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(2003)
Plant Biotechnol
, vol.1
, pp. 71-79
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Fernandez-San Millan, A.1
Mingeo-Castel, A.M.2
Miller, M.3
Daniell, H.4
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19
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0037283651
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Chloroplast expression of His-tagged GUS fusions: A general strategy to overproduce and purify foreign proteins using transplastomic plants as bioreactors
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Leelavathi S, Reddy VS. Chloroplast expression of His-tagged GUS fusions: a general strategy to overproduce and purify foreign proteins using transplastomic plants as bioreactors. Mol. breed. 11, 49-58 (2003).
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(2003)
Mol. breed
, vol.11
, pp. 49-58
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Leelavathi, S.1
Reddy, V.S.2
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20
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0034016818
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Staub JM, Garcia B, Graves J et al. High-yield production of a human therapeutic protein in tobacco chloroplasts. Nat. Biotechnol. 18, 333-338 (2000). •• Reports expression of a fully functional human blood protein in transgenic chloroplasts with proper folding and disulfide bonds.
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Staub JM, Garcia B, Graves J et al. High-yield production of a human therapeutic protein in tobacco chloroplasts. Nat. Biotechnol. 18, 333-338 (2000). •• Reports expression of a fully functional human blood protein in transgenic chloroplasts with proper folding and disulfide bonds.
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21
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14744286603
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Chloroplast-derived vaccine antigens and other therapeutic proteins
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Daniell H, Chebolu S, Kumar S, Singleton M, Falconer R. Chloroplast-derived vaccine antigens and other therapeutic proteins. Vaccine 23, 1779-1783 (2005).
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(2005)
Vaccine
, vol.23
, pp. 1779-1783
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Daniell, H.1
Chebolu, S.2
Kumar, S.3
Singleton, M.4
Falconer, R.5
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22
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18144428771
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Breakthrough in chloroplast genetic engineering of agronomically important crops
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Daniell H, Kumar S, Dufourmantel N. Breakthrough in chloroplast genetic engineering of agronomically important crops. Trends Biotechnol. 23, 238-245 (2005).
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(2005)
Trends Biotechnol
, vol.23
, pp. 238-245
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Daniell, H.1
Kumar, S.2
Dufourmantel, N.3
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23
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0035979785
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Expression of the native cholera toxin B subunit gene and assembly as functional oligomers in transgenic tobacco chloroplasts
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•• First report of a vaccine antigen expressed in transgenic chloroplasts. Formation of disulfide bonds and assembly of pentamers were demonstrated by polyacrylamide gel electrophoresis (PAGE) and GM1 binding assays
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Daniell H, Lee SB, Panchal T, Wiebe PO. Expression of the native cholera toxin B subunit gene and assembly as functional oligomers in transgenic tobacco chloroplasts. J. Mol. Biol. 311, 1001-1009 (2001). •• First report of a vaccine antigen expressed in transgenic chloroplasts. Formation of disulfide bonds and assembly of pentamers were demonstrated by polyacrylamide gel electrophoresis (PAGE) and GM1 binding assays.
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(2001)
J. Mol. Biol
, vol.311
, pp. 1001-1009
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Daniell, H.1
Lee, S.B.2
Panchal, T.3
Wiebe, P.O.4
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24
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0037145812
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Anthrax toxIn: A tripartite lethal combination
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Ascenzi P, Visca P, Ippolito G, Spallarossa A, Bolognesi M, Montecucco C. Anthrax toxIn: a tripartite lethal combination. FEBS Lett. 531, 384-388 (2002).
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FEBS Lett
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Ascenzi, P.1
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Ippolito, G.3
Spallarossa, A.4
Bolognesi, M.5
Montecucco, C.6
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27
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0036433129
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Expression of protective antigen in transgenic plants: A step towards edible vaccine against anthrax
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Aziz MA, Singh S, Kumar PA, Bhatnagar R. Expression of protective antigen in transgenic plants: a step towards edible vaccine against anthrax. Biochem. Biophys. Res. Commun. 299, 345-351 (2002).
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Biochem. Biophys. Res. Commun
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Aziz, M.A.1
Singh, S.2
Kumar, P.A.3
Bhatnagar, R.4
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28
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24644461525
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Transformation of an edible crop with the pagA gene of Bacillus anthracis
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Aziz MA, Sikriwal D, Singh S, Jarugula S, Kumar PA, Bhatnagar R. Transformation of an edible crop with the pagA gene of Bacillus anthracis. FASEB J. 19, 1501-1503 (2005).
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Aziz, M.A.1
Sikriwal, D.2
Singh, S.3
Jarugula, S.4
Kumar, P.A.5
Bhatnagar, R.6
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29
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4944224143
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Watson J, Koya V, leppla SH, Daniell H. Expression of Bacillus anthracis protective antigen in transgenic chloroplasts of tobacco, a non-feed/feed crop. Vaccine 22(31-32), 4374-4384 (2004). •• First report of a functional vaccine antigen against a pathogen used in bioterrorism. Reports high expression levels of anthrax protective antigen, confirms its biological functionality in in vitro assays and also shows the intactness and stability of full length PA protein within chloroplasts.
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Watson J, Koya V, leppla SH, Daniell H. Expression of Bacillus anthracis protective antigen in transgenic chloroplasts of tobacco, a non-feed/feed crop. Vaccine 22(31-32), 4374-4384 (2004). •• First report of a functional vaccine antigen against a pathogen used in bioterrorism. Reports high expression levels of anthrax protective antigen, confirms its biological functionality in in vitro assays and also shows the intactness and stability of full length PA protein within chloroplasts.
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30
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28444439874
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Koya V, Moayeri M, Leppla SH, Daniell H. Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge. Infect. Immun. 73(12), 8266-8274 (2005). •• Reports exceptionally high expression levels of chloroplast-derived anthrax protective antigen and immunogenic and immunoprotective properties in immunized mice. This article has been highlighted by numerous articles in the public press and broadcasting stations, including the Discovery channel and scientific journals.
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Koya V, Moayeri M, Leppla SH, Daniell H. Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge. Infect. Immun. 73(12), 8266-8274 (2005). •• Reports exceptionally high expression levels of chloroplast-derived anthrax protective antigen and immunogenic and immunoprotective properties in immunized mice. This article has been highlighted by numerous articles in the public press and broadcasting stations, including the Discovery channel and scientific journals.
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31
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21644475277
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Synthesis and assembly of anthrax lethal factor-cholera toxin B-subunit fusion protein in transgenic potato
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Kim TG, Galloway DR, Langridge WH. Synthesis and assembly of anthrax lethal factor-cholera toxin B-subunit fusion protein in transgenic potato. Mol. Biotechnol. 28, 175-183 (2004).
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Kim, T.G.1
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32
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29644440579
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Bacterial and plant enterotoxin B subunit-autoantigen fusion proteins suppress diabetes insulitis
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Arkawa T, Yu J, Chong DK, Hough J, Engen PC, Langridge WH. A plant-based cholera toxin B subunit-insulin fusion protein against the development of autoimmune diabetes. Nat. Biotechnol. 16, 934-938 (1998). •• First report of oral tolerance from a plant-derived autoantigen.
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Arkawa T, Yu J, Chong DK, Hough J, Engen PC, Langridge WH. A plant-based cholera toxin B subunit-insulin fusion protein against the development of autoimmune diabetes. Nat. Biotechnol. 16, 934-938 (1998). •• First report of oral tolerance from a plant-derived autoantigen.
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34
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0032146489
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Edible vaccine protects mice against E. coli heat-labile enterotoxin (LT): Potatoes expressing a synthetic LT-B gene
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Mason HS, Haq TA, Clements JD, Arntzen CA. Edible vaccine protects mice against E. coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene. Vaccine 16, 1336-1343
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Mason, H.S.1
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0031863854
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Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nat. Med. 4, 607-609
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••
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Tacket CO, Mason HS, Losonsky G, Clements JD, Levine MM, Arntzen CJ. Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nat. Med. 4, 607-609. •• First report of human clinical trials conducted using a plant-derived vaccine antigen.
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First report of human clinical trials conducted using a plant-derived vaccine antigen
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Tacket, C.O.1
Mason, H.S.2
Losonsky, G.3
Clements, J.D.4
Levine, M.M.5
Arntzen, C.J.6
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36
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2442708551
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Immunogenisity of recombinant LT-B delivered orally to human in transgenic corn
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Tacket CO, Pasetti MF, Edelman R, Howard JA, Streatfield SJ. Immunogenisity of recombinant LT-B delivered orally to human in transgenic corn.Vaccine 22, 4385-4389 (2004)
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Tacket, C.O.1
Pasetti, M.F.2
Edelman, R.3
Howard, J.A.4
Streatfield, S.J.5
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37
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4944264765
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Molina A, Hervás-Stubbs S, Daniell H, Mingo-Castel AM, Veramendi A. High-yield expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts. Plant Biotechnol. J. 2(2), 141-153 (2004). •• First report of animal vaccine via the chloroplast genome, confirming expression and immunogenic properties in mice.
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Molina A, Hervás-Stubbs S, Daniell H, Mingo-Castel AM, Veramendi A. High-yield expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts. Plant Biotechnol. J. 2(2), 141-153 (2004). •• First report of animal vaccine via the chloroplast genome, confirming expression and immunogenic properties in mice.
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38
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33845650824
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Limaye A, Koya V, Mohtashem S, Daniell H. Receptor-mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system. FASEB J. 20(7), 959-961 (2006). •• First demonstration of the transmucosal activity of plant-derived CTB in delivering a foreign protein to target tissues via the circulatory system in orally fed mice and confirmation of protection of recombinant proteins from proteases/pepdidases by bioencapsulation within plant cells.
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Limaye A, Koya V, Mohtashem S, Daniell H. Receptor-mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system. FASEB J. 20(7), 959-961 (2006). •• First demonstration of the transmucosal activity of plant-derived CTB in delivering a foreign protein to target tissues via the circulatory system in orally fed mice and confirmation of protection of recombinant proteins from proteases/pepdidases by bioencapsulation within plant cells.
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39
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0347693160
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Expression of the B subunit of E. coli heat-labile enterotoxin in the chloroplasts of plants and its characterization
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Kang TJ, Loc NH, Jang MO et al. Expression of the B subunit of E. coli heat-labile enterotoxin in the chloroplasts of plants and its characterization. Transgenic Res. 12(6), 683-691 (2003).
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Kang, T.J.1
Loc, N.H.2
Jang, M.O.3
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40
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4444336532
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Plastid-expressed betaine aldehyde dehydrogenase gene in carrot cultured cells, roots and leaves confers enhanced salt tolerance
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•• First chloroplast transformation via somatic embryogenesis using nongreen tissues for the expression of recombinant proteins
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Kumar S, Dhingra A, Daniell H. Plastid-expressed betaine aldehyde dehydrogenase gene in carrot cultured cells, roots and leaves confers enhanced salt tolerance. Plant Physiol. 136, 2843-2854 (2004) •• First chloroplast transformation via somatic embryogenesis using nongreen tissues for the expression of recombinant proteins.
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(2004)
Plant Physiol
, vol.136
, pp. 2843-2854
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Kumar, S.1
Dhingra, A.2
Daniell, H.3
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41
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33645679058
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Efficient and stable transformation of Lactuca sativa L.cv. Cisco (lettuce) Plastids
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Kanamoto H, Yamashita A, Asao H et al., Efficient and stable transformation of Lactuca sativa L.cv. Cisco (lettuce) Plastids. Transgenic Res. 15, 205-217 (2006).
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Stable Plastid Transformation in Lettuce (Lactuca sativa L.)
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Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system
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