Apoptosis in C3H-10T1/2 cells: Roles of intracellular pH, protein kinase C, and the Na+/H+ antiporter

Journal of Cellular Biochemistry

Volumn 67, Issue 2, 1997, Pages 231-240

  Boyle, Kathleen M ^a,b   Irwin, James P ^a   Humes, Brandi R ^a   Runge, Steven W ^a  

^a UNIVERSITY OF CENTRAL ARKANSAS   (United States)

^b ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

12 O tetradecanoylphorbol 13 acetate (TPA); 5 (N,N hexamethylene) amiloride (HMA); Chelerythrine; Internucleosomal DNA cleavage; Protein kinase C (PKC); Serum withdrawal

Indexed keywords

ENDONUCLEASE; PROTEIN KINASE C;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LEVEL; CELL PH; DNA CLEAVAGE; ENZYME ACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE;

ANIMALS; APOPTOSIS; CELL LINE; CULTURE MEDIA; DNA; DNA FRAGMENTATION; EMBRYO; FIBROBLASTS; HYDROGEN-ION CONCENTRATION; MICE; PROTEIN KINASE C; SODIUM-HYDROGEN ANTIPORTER; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA; FORMICIDAE;

EID: 0030954791     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19971101)67:2<231::AID-JCB8>3.0.CO;2-Y     Document Type: Article

References (29)

1. Afanas'ev V, Korol B, Mantsygin YA, Nelipovich PA, Umansky SR (1986): Flow cytometry and biochemical analysis of DNA degradation characteristic of two types of cell death. FEBS Lett 194:347-350.
2. Arends MJ, Wyllie AH (1991): Apoptosis: Mechanisms and roles in pathology. Int Rev Exp Pathol 32:223-254.
3. Barry MA, Eastman A (1993): Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Arch Biochem Biophys. 300:440-450.
4. Barry MA, Reynolds JE, Eastman A (1993): Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification. Cancer Res 53:2349-2357.
5. Chmura SJ, Nodzenski E, Weichselbaum RR, Quintas J (1996): Protein kinase C inhibition induces apoptosis and ceramide production through activation of a neutral sphingomyelinase. Cancer Res 56:2711-2714.
6. Collins RJ, Harmon BV, Gobé GC, Kerr JFR (1992): Internucleosomal DNA cleavage should not be the sole criterion for the identifying apoptosis. J Radiat Biol 61:451-453.
7. Dekker LV, Parker PJ (1994): Protein kinase C - A question of specificity. TIBS 19:73-77.
8. + antiport. J Biol Chem 270:3203-3211.
9. Gottlieb RA, Nordberg J, Skowronski E, Babior BM (1996): Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc Natl Acad Sci USA 93:654-658.
10. + exchange: Contrasting effects of thrombin and PMA. J Cell Physiol 146:290-297.
11. Jarvis WD, Turner AJ, Povirk LF, Traylor RS, Grant S (1994): Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemic cells by pharmacological inhibitors of protein kinase C. Cancer Res 54:1707-1714.
12. Kerr JFR, Harmon BV (1991): Definition and incidence of apoptosis: An historical perspective. In Tomei LD, Cope FO (eds): "Apoptosis: The Molecular Basis of Cell Death." Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp 5-29.
13. Kikkawa U, Kishimot A, Nishizuka Y (1989): The protein kinase C family: Heterogeneity and its implications. Annu Rev Biochem 58:31-44.
14. + exchanger is phosphorylated in human platelets in response to activating agents. FEBS Lett 284:219-222.
15. Madshus IH (1988): Regulation of intracellular pH in eukaryotic cells. Biochem J 250:1-8.
16. McCabe MJ Jr, Orrenius S (1994): Protein kinase C: A key enzyme determining cell fate and apoptosis? In Kuo JF (ed): "Protein Kinase C." New York: Oxford University Press, pp 290-304.
17. + exchanger isoforms. Am J Physiol 268 (Cell Physiol 37): C283-C296.
18. + antiporter in chinese hamster embryo fibroblasts. J Cell Physiol 132: 311-317.
19. Oberhammer J, Fritsch G, Schmied M, Pavelka M, Printz D, Purchio T. Lassmann H, Schulte-Hermann R (1993): Condensation of the chromatin at the membrane of an apoptotic nucleus is not associated with activation of an endonuclease. J Cell Sci 104:317-326.
20. Ostad M, Shu WP, Kong L, Liu BC (1996): Ha-ras oncogene expression abrogates a pH dependent endonuclease activity of apoptosis in normal rat kidney cells. Cancer Lett 98:175-182.
21. Pérez-Sala D, Collado-Escobar D, Mollinedo F (1995): Intracellular alkalinization suppresses lovstatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. J Biol Chem 270:6235-6242.
22. + antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3. J Biol Chem 267:9980-9987.
23. Schulze-Osthoff K, Walczak H, Droege W, Krammer PH (1994): Cell nucleus and DNA fragmentation are not required for apoptosis. J Cell Biol 127:15-20.
24. Steller H (1995): Mechanisms and genes of cell suicide. Science 267:1445-1449.
25. Tomei LD, Shapiro JP (1993): Apoptosis in C3H-10T1/2 mouse embryonic cells: Evidence for internucleosomal DNA modification in the absence of double-strand cleavage. Proc Natl Acad Sci USA 90:853-857.
26. Tomei LD, Cheney JC, Wenner CE (1981): The effect of phorbol esters on the proliferation of C3H-10T1/2 mouse fibroblasts: Consideration of both stimulatory and inhibitory effects. J Cell Physiol 107:385-389.
27. Umansky SR, Beletsky IP, Korol BA, Lichtenstein AV, Nelipovich PA (1988): Molecular mechanisms of DNA degradation in dying rodent thymocytes. Mol Cell Biol 7:221-228.
28. Wyllie AH, Kerr JFR, Currie AR (1980): Cell death: The significance of apoptosis. Int Rev Cytol 68:251-306.
29. Wyllie AH, Arends MJ, Morris RG, Walker SW, Evan G (1992): The apoptosis endonuclease and its regulation. Semin Immunol 4:389-397.