Mechanism of formation of novel covalent drug·DNA interstrand cross- links and monoadducts by enediyne antitumor antibiotics

Biochemistry

Volumn 36, Issue 48, 1997, Pages 14975-14984

  Xu, Yong Jie ^a,b   Xi, Zhen ^a   Zhen, Yong Su ^b   Goldberg, Irving H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC C 1027; ANTINEOPLASTIC ANTIBIOTIC; DNA; DNA FRAGMENT; NUCLEOTIDE;

ARTICLE; COVALENT BOND; CYTOTOXICITY; DNA CROSS LINKING; DNA DAMAGE; DRUG DNA INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL;

AMINOGLYCOSIDES; ANAEROBIOSIS; ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; CROSS-LINKING REAGENTS; DNA ADDUCTS; DNA DAMAGE; ENEDIYNES; FREE RADICALS; MISONIDAZOLE; NUCLEOTIDES; RIBOSE; ZINOSTATIN;

EID: 0030734671     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972101o     Document Type: Article

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