Shunting of prostanoid biosynthesis in microsomal prostaglandin E synthase-1 null embryo fibroblasts: Regulatory effects on inducible nitric oxide synthase expression and nitrite synthesis

FASEB Journal

Volumn 20, Issue 13, 2006, Pages

  Kapoor, Mohit ^a   Kojima, Fumiaki ^a   Qian, Min ^b   Yang, Lihua ^a   Crofford, Leslie J ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Arachidonic acid (AA); Cyclooxygenase (COX); L arginine

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ARACHIDONIC ACID; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MESSENGER RNA; NITRITE; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROSTANOID; ISOMERASE; PROSTAGLANDIN;

ANIMAL CELL; ARTICLE; CELL LINE; CELL LINEAGE; CELL STIMULATION; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; FATTY ACID SYNTHESIS; FIBROBLAST; GENE DELETION; HETEROZYGOSITY; MICROSOME; MOUSE; NONHUMAN; NULL CELL; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; SHUNTING; WILD TYPE; ANIMAL; BIOSYNTHESIS; DBA MOUSE; ENZYMOLOGY; GENETICS; METABOLISM; MOUSE MUTANT;

ANIMALS; INTRAMOLECULAR OXIDOREDUCTASES; MICE; MICE, INBRED DBA; MICE, KNOCKOUT; MICROSOMES; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PROSTAGLANDINS;

EID: 33845618517     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-6366fje     Document Type: Article

References (47)

1. Meade, E. A., Smith, W. L., and DeWitt, D. L. (1993) Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 268, 6610-6614
2. Crofford, L. J. (2002) Specific cyclooxygenase-2 inhibitors: what have we learned since they came into widespread clinical use? Curr. Opin. Rheumatol. 14, 225-230
3. Crofford, L. J. (2003) COX-2: Where are we in 2003? - Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease. Arthritis Res. Ther. 5, 25-27
4. Solomon, S. D., McMurray, J. J., Pfeffer, M. A., Wittes, J., Fowler, R., Finn, P., Anderson, W. F., Zauber, A., Hawk, E., and Bertagnolli, M. (2005) Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N. Engl. J. Med. 352, 1071-1080
5. White, W. B., Faich, G., Borer, J. S., and Makuch, R. W. (2003) Cardiovascular thrombotic events in arthritis trials of the cyclooxygenase-2 inhibitor celecoxib. Am. J. Cardiol. 92, 411-418
6. Bresalier, R. S., Sandler, R. S., Quan, H., Bolognese, J. A., Oxenius, B., Horgan, K., Lines, C., Riddell, R., Morton, D., and Lanas, A. et al. (2005) Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N. Engl. J. Med. 352, 1092-1102
7. Kawai, S. (1998) Cyclooxygenase selectivity and the risk of gastro-intestinal complications of various non-steroidal antiinflammatory drugs: a clinical consideration. Inflamm. Res. 47 Suppl. 2, S102-106
8. Simon, L. S., Weaver, A. L., Graham, D. Y., Kivitz, A. J., Lipsky, P. E., Hubbard, R. C., Isakson, P. C., Verburg, K. M., Yu, S. S., Zhao, W. W., and Geis, G. S. (1999) Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial. JAMA 282, 1921-1928
9. Jakobsson, P. J., Thoren, S., Morgenstern, R., and Samuelsson, B. (1999) Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. U. S. A. 96, 7220-7225
10. Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh, S., and Kudo, I. (2000) Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. J. Biol. Chem. 275, 32783-32792
11. Tanioka, T., Nakatani, Y., Semmyo, N., Murakami, M., and Kudo, I. (2000) Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J. Biol. Chem. 275, 32775-32782
12. Tanikawa, N., Ohmiya, Y., Ohkubo, H., Hashimoto, K., Kangawa, K., Kojima, M., Ito, S., and Watanabe, K. (2002) Identifi-cation and characterization of a novel type of membraneassociated prostaglandin E synthase. Biochem. Biophys. Res. Commun. 291, 884-889
13. Murakami, M., Nakashima, K., Kamei, D., Masuda, S., Ishikawa, Y., Ishii, T., Ohmiya, Y., Watanabe, K., and Kudo, I. (2003) Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. J. Biol. Chem. 278, 37937-37947
14. Kojima, F., Naraba, H., Sasaki, Y., Okamoto, R., Koshino, T., and Kawai, S. (2002) Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells. J. Rheumatol. 29, 1836-1842
15. Stichtenoth, D. O., Thoren, S., Bian, H., Peters-Golden, M., Jakobsson, P. J., and Crofford, L. J. (2001) Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. J. Immunol. 167, 469-474
16. Kamei, D., Yamakawa, K., Takegoshi, Y., Mikami-Nakanishi, M., Nakatani, Y., Oh-Ishi, S., Yasui, H., Azuma, Y., Hirasawa, N., and Ohuchi, K. et al. (2004) Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1. J. Biol. Chem. 279, 33684-33695
17. Trebino, C. E., Stock, J. L., Gibbons, C. P., Naiman, B. M., Wachtmann, T. S., Umland, J. P., Pandher, K., Lapointe, J. M., Saha, S., and Roach, M. L. et al. (2003) Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc. Natl. Acad. Sci. U. S. A. 100, 9044-9049
18. Saha, S., Engstrom, L., Mackerlova, L., Jakobsson, P. J., and Blomqvist, A. (2005) Impaired febrile responses to immune challenge in mice deficient in microsomal prostaglandin E synthase-1. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R1100-1107
19. Kamei, D., Murakami, M., Nakatani, Y., Ishikawa, Y., Ishii, T., and Kudo, I. (2003) Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. J. Biol. Chem. 278, 19396-19405
20. Kojima, F., Naraba, H., Miyamoto, S., Beppu, M., Aoki, H., and Kawai, S. (2004) Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis. Arthritis Res. Ther. 6, R355-365
21. Kojima, F., Naraba, H., Sasaki, Y., Beppu, M., Aoki, H., and Kawai, S. (2003) Prostaglandin E2 is an enhancer of interleukin-1beta-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts. Arthritis Rheum. 48, 2819-2828
22. Morham, S. G., Langenbach, R., Loftin, C. D., Tiano, H. F., Vouloumanos, N., Jennette, J. C., Mahler, J. F., Kluckman, K. D., Ledford, A., Lee, C. A., and Smithies, O. (1995) Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 83, 473-482
23. Pelletier, J. P., Fernandes, J. C., Jovanovic, D. V., Reboul, P., and Martel-Pelletier, J. (2001) Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase. J. Rheumatol. 28, 2509-2519
24. Kojima, F., Kato, S., and Kawai, S. (2005) Prostaglandin E synthase in the pathophysiology of arthritis. Fundam. Clin. Pharmacol. 19, 255-261
25. Westman, M., Korotkova, M., af Klint, E., Stark, A., Audoly, L. P., Klareskog, L., Ulfgren, A. K., and Jakobsson, P. J. (2004) Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium. Arthritis Rheum. 50, 1774-1780
26. Trebino, C. E., Eskra, J. D., Wachtmann, T. S., Perez, J. R., Carty, T. J., and Audoly, L. P. (2005) Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages. J. Biol. Chem. 280, 16579-16585
27. Boulet, L., Ouellet, M., Bateman, K. P., Ethier, D., Percival, M. D., Riendeau, D., Mancini, J. A., and Methot, N. (2004) Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile. J. Biol. Chem. 279, 23229-23237
28. Uematsu, S., Matsumoto, M., Takeda, K., and Akira, S. (2002) Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J. Immunol. 168, 5811-5816
29. Ikeda-Matsuo, Y., Ikegaya, Y., Matsuki, N., Uematsu, S., Akira, S., and Sasaki, Y. (2005) Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production. J Neurochem. 94, 1546-1558
30. Nussler, A. K., and Billiar, T. R. (1993) Inflammation, immunoregulation, and inducible nitric oxide synthase. J. Leukoc. Biol. 54, 171-178
31. Moncada, S., Palmer, R. M., and Higgs, E. A. (1989) The biological significance of nitric oxide formation from L-arginine. Biochem. Soc. Trans. 17, 642-644
32. Gibbons, G. H. (1997) Endothelial function as a determinant of vascular function and structure: a new therapeutic target. Am. J. Cardiol. 79, 3-8
33. Prast, H., and Philippu, A. (2001) Nitric oxide as modulator of neuronal function. Prog. Neurobiol. 64, 51-68
34. Stewart, A. G., Phan, L. H., and Grigoriadis, G. (1994) Physiological and pathophysiological roles of nitric oxide. Microsurgery 15, 693-702
35. Patel, R., Attur, M. G., Dave, M., Abramson, S. B., and Amin, A. R. (1999) Regulation of cytosolic COX-2 and prostaglandin E2 production by nitric oxide in activated murine macrophages. J. Immunol. 162, 4191-4197
36. Griffon, B., Cillard, J., Chevanne, M., Morel, I., Cillard, P., and Sergent, O. (1998) Macrophage-induced inhibition of nitric oxide production in primary rat hepatocyte cultures via prostaglandin E2 release. Hepatology 28, 1300-1308
37. Pang, L., and Hoult, J. R. (1997) Repression of inducible nitric oxide synthase and cyclooxygenase-2 by prostaglandin E2 and other cyclic AMP stimulants in J774 macrophages. Biochem. Pharmacol. 53, 493-500
38. Gomez-Hernandez, A., Sanchez-Galan, E., Martin-Ventura, J. L., Vidal, C., Blanco-Colio, L. M., Ortego, M., Vega, M., Serrano, J., Ortega, L., and Hernandez, G. et al. (2006) Atorvastatin reduces the expression of prostaglandin e2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. J. Cardiovasc. Pharmacol. 47, 60-69
39. Satoh, K., Nagano, Y., Shimomura, C., Suzuki, N., Saeki, Y., and Yokota, H. (2000) Expression of prostaglandin E synthase mRNA is induced in beta-amyloid treated rat astrocytes. Neurosci. Lett. 283, 221-223
40. Kino, Y., Kojima, F., Kiguchi, K., Igarashi, R., Ishizuka, B., and Kawai, S. (2005) Prostaglandin E2 production in ovarian cancer cell lines is regulated by cyclooxygenase-1, not cyclooxygenase-2. Prostaglandins Leukot. Essent. Fatty Acids. 73, 103-111
41. McAdam, B. F., Catella-Lawson, F., Mardini, I. A., Kapoor, S., Lawson, J. A., and FitzGerald, G. A. (1999) Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc. Natl. Acad. Sci. U. S. A. 96, 272-277
42. Bunting, S., Moncada, S., and Vane, J. R. (1983) The prostacyclin- thromboxane A2 balance: pathophysiological and therapeutic implications. Br. Med. Bull. 39, 271-276
43. Moncada, S., and Vane, J. R. (1979) Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. N. Engl. J. Med. 300, 1142-1147
44. Olschewski, H., Walmrath, D., Schermuly, R., Ghofrani, A., Grimminger, F., and Seeger, W. (1996) Aerosolized prostacyclin and iloprost in severe pulmonary hypertension. Ann. Intern. Med. 124, 820-824
45. Murata, T., Ushikubi, F., Matsuoka, T., Hirata, M., Yamasaki, A., Sugimoto, Y., Ichikawa, A., Aze, Y., Tanaka, T., and Yoshida, N. et al. (1997) Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 388, 678-682
46. Cuzzocrea, S., Chatterjee, P. K., Mazzon, E., McDonald, M. C., Dugo, L., Di Paola, R., Serraino, I., Britti, D., Caputi, A. P., and Thiemermann, C. (2002) Beneficial effects of GW274150, a novel, potent and selective inhibitor of iNOS activity, in a rodent model of collagen-induced arthritis. Eur. J. Pharmacol. 453, 119-129
47. Honda, T., Segi-Nishida, E., Miyachi, Y., and Narumiya, S. (2006) Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis. J. Exp. Med. 203, 325-335