Lipopolysaccharide-dependent prostaglandin E2 production is regulated by the glutathione-dependent prostaglandin E2 synthase gene induced by the toll-like receptor 4/MyD88/NF-IL6 pathway

Journal of Immunology

Volumn 168, Issue 11, 2002, Pages 5811-5816

  Uematsu, Satoshi ^a   Matsumoto, Makoto ^a   Takeda, Kiyoshi ^a   Akira, Shizuo ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; GLUTATHIONE; INTERLEUKIN 12; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NUCLEAR FACTOR; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE CONTROL; GENE INDUCTION; IMMUNE RESPONSE; IMMUNOMODULATION; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SIGNAL TRANSDUCTION;

EID: 0036604215     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.11.5811     Document Type: Article

References (32)

1. Prostanoid receptors structures, properties, and functions
2. 2 enzymes in eicosanoid generation
3. Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin H synthase-1 and -2
4. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2
5. Two types of microsomal prostaglandin E synthase: Glutathione-dependent and -independent prostaglandin E synthases
6. 2 biosynthesis
7. 2, cyclooxygenases, and terminal prostanoid synthases in different phases of prostanoid biosynthesis in rat peritoneal macrophages
8. 2 production in murine macrophages
9. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
10. Common structural features of MAPEG: A widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism
11. 2 synthase that acts in concert with cyclooxygenase-2
12. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
13. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the LPS gene product
14. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
15. A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages
16. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IKB kinases
17. NF-IL6 and NF-κB in cytokine gene regulation
18. A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages
19. Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages
20. Redundancy in the signaling pathways and promoter elements regulating cyclooxygenase-2 gene expression in endotoxin-treated macrophage/monocytic cells
21. The expression of prostaglandin E receptors EP2 and EP4 and their different regulation by lipopolysaccharide in C3H/HeN peritoneal macrophages
22. Unresponsiveness of MyD88-deficient mice to endotoxin
23. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
24. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family
25. Glucocorticoid-mediated suppression of the promoter activity of the cyclooxygenase-2 gene is modulated by expression of its receptor in vascular endothelial cells
26. The transcription factor C/EBP is essential for inducible expression of the cox-2 gene in macrophages but not in fibroblasts
27. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells: Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element
28. Transcriptional roles of nuclear factor κ B and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-El cells
29. The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancerbinding protein β (C/EBPβ) and C/EBPδ transcription factors
30. Prostaglandin synthase gene disruption in mice reduce arachidonic acidinduced inflammation and indomethacin-induced gastric ulceration
31. Interactions between cytokines and eicosanoids: A study using human peritoneal macrophages
32. 2