Repression of inducible nitric oxide synthase and cyclooxygenase-2 by prostaglandin E2 and other cyclic AMP stimulants in J774 macrophages

Biochemical Pharmacology

Volumn 53, Issue 4, 1997, Pages 493-500

  Pang, Linhua ^a,b   Hoult, J R S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

cAMP; cyclooxygenase 2; cytotoxicity; forskolin; inducible nitric oxide synthase; lipopolysaccharide; phosphodiesterase inhibitors; prostaglandin E2; Western blot

Indexed keywords

8 BROMO CYCLIC AMP; 8 BROMO CYCLIC GMP; ADENYLATE CYCLASE; ARACHIDONIC ACID; CYCLIC AMP; CYCLIC GMP; DEXAMETHASONE; FORSKOLIN; ILOPROST; ISOBUTYLMETHYLXANTHINE; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; PROSTACYCLIN; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; IN VITRO STUDY; MACROPHAGE ACTIVATION; NONHUMAN; PRIORITY JOURNAL;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; CELLS, CULTURED; CYCLIC AMP; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME REPRESSION; FORSKOLIN; ISOENZYMES; LIPOPOLYSACCHARIDES; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0031581844     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00737-X     Document Type: Article

References (57)

1. 1. Nathan C, Nitric oxide as a secretory product of mammalian cells, FASEB J 6: 3051-3064, 1992.
2. 2. Moncada S, Palmer RMJ and Higgs EA, Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43: 109-142, 1991.
3. 3. Xie QW, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T and Nathan C, Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256: 225-228, 1992.
4. 4. Weisz A, Oguchi A, Cicatiello L and Esumi H, Dual mechanism for the control of inducible-type NO synthase gene expression in macrophages during activation by interferon-γ and bacterial lipopolysaccharide. J Biol Chem 269: 8324-8333, 1994.
5. 5. Ding A, Nathan C and Stuehr DJ, Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J Immtmol 141: 2407-2412, 1988.
6. 6. Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG and Needleman P, Nitric oxide activates cyclo-oxygenase enzymes. Proc Natl Acad Sci USA 90: 7240-7244, 1993.
7. 7. Akarasereenont P, Mitchell JA, Bakhle YS, Thiemermann C and Vane JR, Comparison of the induction of cyclooxygenase and nitric oxide synthase by endotoxin in endothelial cells and macrophages. Eur J Pharmacol 273: 121-128, 1994.
8. 8. Masferrer JL, Zweifel BS, Seibert K and Needleman P, Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J Clin Invest 86: 1375-1379, 1990.
9. 9. Fu J-Y, Masferrer JL, Seibert K, Raz A and Needleman P, The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J Biol Chem 265: 16737-16740, 1990.
10. 10. Lee SH, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H, Liou S, Simmons D and Hwang D, Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 267: 25934-25938, 1992.
11. 11. O'Sullivan MG, Chilton FH, Huggins EM and McCall CE, Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase. J Biol Chem 267: 14547-14550, 1992.
12. 12. De Witt DL, Prostaglandin endoperoxide synthase: regulation of enzyme expression. Biochim Biophys Acta 1083: 121-134, 1991.
13. 13. Swierkosz TA, Mitchell JA, Warner TD, Botting RM and Vane JR, Co-induction of nitric oxide synthase and cyclooxygenase: interactions between nitric oxide and prostaglandins. Br J Pharmacol 114: 1335-1342, 1995.
14. 14. Marotta P, Sautebin L and Di Rosa M, Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774. Br J Pharmacol 107: 640-641, 1992.
15. 15. Milano S, Arcoleo F, Dieli M, D'Agostino R, D'Agostino P, De Nucci G and Cillari E, Prostaglandin E2 regulates inducible nitric oxide synthase in the murine macrophage cell line J774. Prostaglandins 49: 105-115, 1995.
16. 16. Hoult JRS, Moroney MA and Payá M, Actions of flavonoids and coumarins on lipoxygenase and cyclooxygenase. Methods Enzymol 234: 443-454, 1994.
17. 17. Pang L, de las Heras B and Hoult JRS, A novel diterpenoid labdane from Sideritis javalambrensis inhibits eicosanoid generation but enhances arachidonate release. Biochem Pharmacol 51: 863-868, 1996.
18. 18. Bulut V, Severn A and Liew FY, Nitric oxide production by murine macrophages is inhibited by prolonged elevation of cyclic AMP. Biochem Biophys Res Commun 195: 1134-1138, 1993.
19. 19. Raddassi K, Petit JF and Lemaire G, LPS-induced activation of primed murine peritoneal macrophages is modulated by prostaglandins and cyclic nucleotides. Cell Immunol 149: 50-64, 1993.
20. 2 negatively modulates induction of nitric oxide synthase by interleukin 1. Proc Natl Acad Sci USA 91: 12168-12172, 1994.
21. 21. Radomski MW, Palmer RMJ and Moncada S, Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 87: 10043-10047, 1990.
22. 22. Oswald I, Gazzinelli RT, Sher A and James SL, IL-10 synergises with IL-4 and transforming growth factot-β to inhibit macrophage cytotoxic activity. J Immunol 148: 3578-3582, 1992.
23. 23. Cunha FQ, Moncada S and Liew FY, Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages. Biochem Biophys Res Commun 182: 1155-1159, 1992.
24. 24. Saura M, Martinez-Dalmau R, Minty A, Perez-Sala D and Lamas S, Interleukin-13 inhibits inducible nitric oxide synthase expression in human mesangial cells. Biochem J 313: 641-646, 1996.
25. 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-γ. J Immunol 145: 940-944, 1990.
26. 26. Schini VB, Durante W, Elizondo E, Scott-Burden T, Junquero DC, Schafer AI and Vanhoutte PM, The induction of nitric oxide synthase activity is inhibited by TGF-β1, PDGF-AB and PDGF-BB in vascular smooth muscle cells. Eur J Pharmacol 216: 379-383, 1992.
27. 27. Schini VB, Catovsky S, Scray-Utz B, Busse R and Vanhoutte PM, Insulin-like growth factor I inhibits induction of nitric oxide synthase in vascular smooth muscle cells. Circ Res 74: 24-32, 1994.
28. 28. Dong Z, Qi X, Xie K and Fidler IJ, Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages. J Immunol 151: 2717-2724, 1993.
29. 29. Akarasereenont P, Mitchell JA, Appleton I, Thiemermann C and Vane JR, Involvement of tyrosine kinase in the induction of cyclo-oxygenase and nitric oxide synthase by endotoxin in cultured cells. Br J Pharmacol 113: 1522-1528, 1994.
30. 30. Szabó C, Southan GJ, Thiemermann C and Vane JR, The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites. Br J Pharmacol 113: 755-766, 1994.
31. 31. Tschaikowsky K, Meisner M, Schönhuber F and Rügheimer E, Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br J Pharmacol 113: 664-668, 1994.
32. 32. Rogers NE and Ignarro LJ, Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine. Biochem Biophys Res Commun 189: 242-249, 1992.
33. 33. Assreuy J, Cunha FQ, Liew FY and Moncada S, Feedback inhibition of nitric oxide synthase activity by nitric oxide. Br J Pharmacol 108: 833-837, 1993.
34. 34. Morin C, Fessi H, Devissaguet JP, Puisieux F and Barrait G, Factors influencing macrophage activation by muramyl peptides: inhibition of NO synthase activity by high levels of NO. Biochim Biophys Acta 1224: 427-432, 1994.
35. 35. Mariotto S, Cuzzolin L, Adami A, Del Soldato P, Suzuki H and Benoni G, Inhibition by sodium nitroprusside of the expression of inducible nitric oxide synthase in rat neutrophils. Br J Pharmacol 114: 1105-1106, 1995.
36. 36. Mariotto S, Cuzzolin L, Adami A, Del Soldato P, Suzuki H and Benoni G, Effect of a new non-steroidal anti-inflammatory drug, nitroflurbiprofen, on the expression of inducible nitric oxide synthase in rat neutrophils. Br J Pharmacol 115: 225-226, 1995.
37. G-monomethyl-L-arginine. Biochem J 316: 209-215, 1996.
38. 38. Muhl H, Kunz D and Pfeilschifter J, Expression of nitric oxide synthase in rat glomerular mesangial cells mediated by cyclic AMP. Br J Pharmacol 112, 1-8, 1994.
39. 39. Koide M, Kawahara Y, Nakayama I, Tsuda T and Yokoyama M, Cyclic AMP-elevating agents induce an inducible type of nitric oxide synthase in cultured vascular smooth muscle cells. Synergism with the induction elicited by inflammatory cytokines. J Biol Chem 268: 24959-24966, 1994.
40. 2 and agents that raise cAMP levels on macrophage activation induced by IFN-γ and TNF-α. J Leukocyte Biol 58: 217-224, 1995.
41. 2 on the induction of nitric oxide-and prostanoid-forming pathways in cultured rat mesangial cells. Biochem J 313: 617-623, 1996.
42. 42. Raz A, Wyche A and Needleman P, Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases. Proc Natl Acad Sci USA 86: 1657-1661, 1989.
43. 43. O'Banion K, Winn VD and Young DA, cDNA cloning and functional activity of glucocorticoid-regulated inflammatory cyclo-oxygenase. Proc Natl Acad Sci USA 89: 4888-4992, 1992.
44. v-src-transformed 3T3 fibroblasts. Proc Natl Acad Sci USA 87: 3373-3377, 1990.
45. 45. Mitchell JA, Belvisi MG, Akarasereenont P, Robbins RA, Kwon O-J, Croxtall J, Barnes PJ and Vane JR, Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br J Pharmacol 113: 1008-1014, 1994.
46. 46. Hunt NH and Evans T, RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations. Biochim Biophys Acta 613: 499-506, 1980.
47. 47. Inoue H, Nanayama T, Hara S, Yokoyama C and Tanabe T, The cyclic AMP response element plays an essential role in the expression of the human prostaglandin-endoperoxide synthase 2 gene in differentiated U937 monocytic cells. FEBS Lett 350: 51-54, 1994.
48. 48. Trends in Pharmacological Sciences: Receptor and Ion Channel Nomenclature Supplement (1996) 54-56, 1996.
49. 49. Taffet SM and Russell SW, Macrophage-mediated tumor cell killing: regulation of expression of cytolytic activity by prostaglandin E. J Immunol 126: 424-427, 1981.
50. 2 and cyclic nucleotides. J Immunol 141: 2388-2393, 1988.
51. 51. Marcinkiewicz J, In vitro cytokine release by activated murine peritoneal macrophages: role of prostaglandins in the differential regulation of tumor necrosis factor alpha, interleukin-1 and interleukin-6. Cytokine 3: 327-332, 1991.
52. 52. Bonta I and Parnham MJ, Immunomodulatory-antiinflammatory functions of E-type prostaglandins. Minireview with emphasis on macrophage-mediated effects. Int J Immunopharmacol 4: 103-109, 1982.
53. 53. Ninnemann JL, Prostaglandins, Leukotrienes and the Immune Response. Cambridge University Press, Cambridge, 1988.
54. 2 regulates macrophage-derived tumor necrosis factor gene expression. J Biol Chem 263: 5380-5384, 1988.
55. 2-induced suppression. J Immunol 142: 4346-4350, 1989.
56. 56. Turner NC, Wood LJ, Burns FM, Gueremy T and Souness JE, The effect of cyclic AMP and cyclic GMP phosphodiesterase inhibitors on the superoxide burst of guinea-pig peritoneal macrophages. Br J Pharmacol 108: 876-883, 1993.
57. 57. Sinha B, Semmler J, Eisenhut T, Eigler A and Endres S, Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids. Eur J Immunol 25: 147-153, 1995.