Prostaglandin E2 is an Enhancer of Interleukin-1β-Induced Expression of Membrane-Associated Prostaglandin E Synthase in Rheumatoid Synovial Fibroblasts

Arthritis and Rheumatism

Volumn 48, Issue 10, 2003, Pages 2819-2828

  Kojima, Fumiaki ^a,b   Naraba, Hiroaki ^c   Sasaki, Yasuharu ^b   Beppu, Moroe ^a   Aoki, Haruhito ^a   Kawai, Shinichi ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; INTERLEUKIN 1BETA; MELOXICAM; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; ROFECOXIB; CYCLIC AMP; CYCLOOXYGENASE 2; EP4 RECEPTOR; FORSKOLIN; INTERLEUKIN 1; ISOENZYME; ISOMERASE; LACTONE; MEMBRANE PROTEIN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN EP2 RECEPTOR; PROSTAGLANDIN SYNTHASE; PTGS2 PROTEIN, HUMAN; SULFONE;

ARTHRITIS; ARTICLE; DRUG EFFECT; FIBROBLAST; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIUM; WESTERN BLOTTING; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG POTENTIATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; CYCLIC AMP; CYCLOOXYGENASE 2; DINOPROSTONE; FIBROBLASTS; FORSKOLIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERLEUKIN-1; INTRAMOLECULAR OXIDOREDUCTASES; ISOENZYMES; LACTONES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, PROSTAGLANDIN E; RNA, MESSENGER; SULFONES; SYNOVIAL MEMBRANE;

EID: 0142072321     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.11261     Document Type: Article

References (34)

1. Kudo I, Murakami M. Diverse functional coupling of prostanoid biosynthetic enzymes in various cell types. Adv Exp Med Biol 1999;469:29-35.
2. Urade Y, Watanabe K, Hayaishi O. Prostaglandin D, E, and F synthases. J Lipid Mediat Cell Signal 1995;12:257-73.
3. Jakobsson PJ, Thoren S, Morgenstern R, Samuelsson B. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci U S A 1999;96:7220-5.
4. 2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem 2000;275: 32783-92.
5. Filion F, Bouchard N, Goff AK, Lussier JG, Sirois J. Molecular cloning and induction of bovine prostaglandin E synthase by gonadotropins in ovarian follicles prior to ovulation in vivo. J Biol Chem 2001;276:34323-30.
6. 2 biosynthesis. J Biol Chem 2000;275:32775-82.
7. Kojima F, Naraba H, Sasaki Y, Okamoto R, Koshino T, Kawai S. Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells. J Rheumatol 2002;29:1836-42.
8. Crofford LJ, Wilder RL, Ristimaki AP, Sano H, Remmers EF, Epps HR, et al. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues: effects of interleukin-1β, phorbol ester, and corticosteroids. J Clin Invest 1994;93:1095-101.
9. Kawai S, Nishida S, Kato M, Furumaya Y, Okamoto R, Koshino T, et al. Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells. Eur J Pharmacol 1998;347:87-94.
10. Crofford LJ. COX-2 in synovial tissues. Osteoarthritis Cartilage 1999;7:406-8.
11. Kato M, Nishida S, Kitasato H, Sakata N, Kawai S. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal antiinflammatory drugs: investigation using human peripheral monocytes. J Pharm Pharmacol 2001;53:1679-85.
12. Kusunoki N, Yamazaki R, Kawai S. Induction of apoptosis in rheumatoid synovial fibroblasts by celecoxib, but not by other selective cyclooxygenase 2 inhibitors. Arthritis Rheum 2002;46:3159-67.
13. Ducharme Y, Gauthier J, Prasit P, Leblanc Y, Waug Z, Leger S, et al, inventors; Merck Frosst Canada, assignee. Phenylheterocycles as COX-2 inhibitors. US patent 5474995. 1995 Dec 12.
14. Chan CC, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, et al. Rofecoxib [Vioxx, MK-0966;4-(4′ -methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A potent and orally active cyclooxygenase-2 inhibitor: pharmacological and biochemical profiles. J Pharmacol Exp Ther 1999;290:551-60.
15. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
16. Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S. Nonsteroidal anti-inflammatory drugs induce apoptosis in association with activation of peroxisome proliferator-activated receptor γ in rheumatoid synovial cells. J Pharmacol Exp Ther 2002;302: 18-25.
17. 2 generation in immature mouse mast cells. J Biol Chem 1995;270:3239-46.
18. Funk CD, Furci L, FitzGerald GA, Grygorczyk R, Rochette C, Bayne MA, et al. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J Biol Chem 1993;268:26767-72.
19. Regan JW, Bailey TJ, Pepperl DJ, Pierce KL, Bogardus AM, Donello JE, et al. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol Pharmacol 1994;46:213-20.
20. 2. Biochem Biophys Res Commun 1994;198:999-1006.
21. Mori K, Tanaka I, Kotani M, Miyaoka F, Sando T, Muro S, et al. Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester. J Mol Med 1996;74:333-6.
22. 2 in lipopolysaccharide-stimulated rat peritoneal macrophages. Biochem Biophys Res Commun 1997;230:110-4.
23. Mancini JA, Blood K, Guay J, Gordon R, Claveau D, Chan CC, et al. Cloning, expression, and up-regulation of inducible rat prostaglandin E synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis. J Biol Chem 2001;276:4469-75.
24. Soler M, Camacho M, Escudero JR, Iniguez MA, Vila L. Human vascular smooth muscle cells but not endothelial cells express prostaglandin E synthase. Circ Res 2000;87:504-7.
25. Yamagata K, Matsumura K, Inoue W, Shiraki T, Suzuki K, Yasuda S, et al. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J Neurosci 2001;21:2669-77.
26. 2 synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J Immunol 2002; 168:5811-6.
27. Stichtenoth DO, Thoren S, Bian H, Peters-Golden M, Jakobsson PJ, Crofford LJ. Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. J Immunol 2001;167:469-74.
28. Kawai S. Cyclooxygenase selectivity and the risk of gastro-intestinal complications of various non-steroidal anti-inflammatory drugs: a clinical consideration. Inflamm Res 1998;47 Suppl 2:S102-6.
29. Suzawa T, Miyaura C, Inada M, Maruyama T, Sugimoto Y, Ushikubi F, et al. The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology 2000;141:1554-9.
30. 2 receptors, EP2 and EP4, differentially modulate TNF-α and IL-6 production induced by lipopolysaccharide in mouse peritoneal neutrophils. Biochem Biophys Res Commun 2000;278:224-8.
31. 2 in interleukin-1α-induced parathyroid hormone-related peptide production in synovial fibroblasts of patients with rheumatoid arthritis. J Clin Endocrinol Metab 2001;86:3272-8.
32. 2 of the production of interleukin-6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblasts. Br J Pharmacol 2002;136:287-95.
33. 2 synthase expression. J Biol Chem 2002;277:16355-64.
34. 2 regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1β-treated human synovial fibroblasts. J Biol Chem 2001;276:31720-31.