Hepatic iron metabolism gene expression profiles in HFE associated Hereditary Hemochromatosis

Blood Cells, Molecules, and Diseases

Volumn 38, Issue 1, 2007, Pages 37-44

  Gleeson, Ferga ^a   Ryan, Eleanor ^a   Barrett, Sharon ^a   Russell, Jennifer ^a   Crowe, John ^a  

^a MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Ferroportin; Hemojuvelin; Hepcidin; HFE; TfR2

Indexed keywords

FERRITIN; FERROPORTIN 1; HEMOJUVELIN; HEPCIDIN; INTERLEUKIN 6; IRON; MESSENGER RNA; TRANSFERRIN RECEPTOR 2;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; DISEASE ASSOCIATION; FEMALE; FERRITIN BLOOD LEVEL; GENE; GENE EXPRESSION PROFILING; GENE MUTATION; HEMOCHROMATOSIS; HFE GENE; HOMOZYGOTE; HUMAN; HUMAN TISSUE; IRON BALANCE; IRON METABOLISM; IRON OVERLOAD; MALE; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STAINING;

ADULT; AGED; FEMALE; GENE EXPRESSION PROFILING; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IRON; LIVER; MALE; MEMBRANE PROTEINS; MIDDLE AGED;

EID: 33845608857     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2006.09.008     Document Type: Article

References (30)

1. Feder J.N., Gnirke A., Thomas W., et al. A novel MHC class I-like gene is mutated in patients with Hereditary Hemochromatosis. Nat. Genet. 13 (1996) 399-408
2. Donovan A., Brownlie A., Zhou Y., et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403 (2000) 776-781
3. Nicolas G., Bennoun M., Devaux I., et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 8160-8162
4. Papanikolaou G., Samuels M., Ludwig E., et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat. Genet. 36 (2004) 77-82
5. Kawabata H., Yang R., Hirama T., et al. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J. Biol. Chem. 30 (1999) 20826-20832
6. Gunshin H., Mackenzie B., Berger U.V., et al. Cloning and characterization of a mammalian proton-coupled metal ion transporter. Nature 388 (1997) 482-488
7. McKie A.T., Marciani P., Rolks A., et al. A novel duodenal iron-regulated transporter, IREG1 implicated in the basolateral transfer of iron to the circulation. Mol. Cell 2 (2000) 299-309
8. Vulpe C.D., Kuo Y.M., Murphy T.L., et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat. Genet. 2 (1999) 195-199
9. Roy CN., and Enns C.A. Iron homeostasis: new tales from the crypt. Blood 96 (2000) 4020-4027
10. Camaschella C. Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders. Blood 106 (2005) 3710-3717
11. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102 (2003) 783-788
12. Nemeth E., Tuttle M.S., Powelson J., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalisation. Science 306 (2004) 2090-2093
13. Bridle K., Frazer D., Wilkins S., et al. Disrupted hepcidin regulation in HFE associated Hemochromatosis and the liver as a regulatory of body iron homeostasis. Lancet 361 (2003) 673-699
14. Gehrke S., Kulaksiz H., Hermann T., et al. Expression of hepcidin in hereditary Hemochromatosis evidence for a regulation in response to the serum transferrin saturation and to non transferrin bound iron. Blood 102 (2003) 371-376
15. Nemeth E., Roetto A., Garozzo G., et al. Hepcidin is decreased in TFR2 hemochromatosis. Blood 105 (2005) 1803-1806
16. Beutler E. Cell biology. "Pumping" iron: the proteins. Science 306 (2004) 2051-2053
17. Wallace D.F., Summerville L., Lusby P.E., et al. First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut 54 (2005) 980-986
18. Huang F.W., Pinkus J.L., Pinkus G.S., et al. A mouse model of juvenile hemochromatosis. J. Clin. Invest. 115 (2005) 2187-2191
19. Sharma N., Butterworth J., Cooper B., Tselepis C., and Iqbal T. The emerging role of the liver in iron metabolism. Am. J. Gastroenterol. 100 (2005) 201-206
20. Lee P., Peng H., Gelbart T., Wang L., and Beutler E. Regulation of hepcidin transcription by interleukin 1 and interleukin 6. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 1906-1910
21. Nemeth E., Rivera S., Gabayan V., et al. IL-6 mediated hypoferremia of inflammation by inducing synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 113 (2004) 1271-1276
22. Ahmad K.A., Ahmann J.R., Migas M.C., et al. Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cells, Mol. Dis. 29 (2002) 361-366
23. Lanzara C., Roetto A., Darario F., et al. The spectrum of hemojuvelin gene mutations in 1q linked juvenile hemochromatosis. Blood 103 (2004) 4317-4321
24. Ludwiczek S., Theurl I., Bahram S., et al. Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis. J. Cell. Physiol. 204 (2005) 489-499
25. Gehrke S.G., Herrmann T., Kulaksiz H., Merle U., Bents K., Kaiser I., Riedel H.-D., and Stremmel W. Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway. Digestion 72 (2005) 25-32
26. Muckenthaler M., Roy C.N., Custodio A.O., et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat. Genet. 34 1 (2003 May) 102-107
27. Bondi A., Valentino P., Daraio F., et al. Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload. Haematologica 90 (2005) 1161-1167
28. Lou D.Q., Lesbordes J.C., Nicolas G., et al. Iron and not inflammation induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo. Hepatology 41 (2005) 1056-1064
29. Frazer D.M., Wilkins S.J., Becker E.M., et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 123 (2002) 835-844
30. Kelleher T., Ryan E., Barrett S., et al. Increased DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary haemochromatosis. Gut 53 (2004) 1174-1179