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Volumn 72, Issue 1, 2005, Pages 25-32

Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway

Author keywords

Hemochromatosis gene, HFE; Hemojuvelin; Hepcidin; Hereditary hemochromatosis; Iron metabolism; Transferrin receptor 2

Indexed keywords

HEPCIDIN; IRON; TRANSFERRIN RECEPTOR;

EID: 24344462594     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000087400     Document Type: Article
Times cited : (32)

References (43)
  • 1
    • 0033599057 scopus 로고    scopus 로고
    • Disorders of iron metabolism
    • Andrews NC: Disorders of iron metabolism. N Engl J Med 1999;341:1986-1995.
    • (1999) N Engl J Med , vol.341 , pp. 1986-1995
    • Andrews, N.C.1
  • 2
    • 2542560427 scopus 로고    scopus 로고
    • Hereditary hemochromatosis - A new look at an old disease
    • Pietrangelo A: Hereditary hemochromatosis - a new look at an old disease. N Engl J Med 2004;350:2383-2397.
    • (2004) N Engl J Med , vol.350 , pp. 2383-2397
    • Pietrangelo, A.1
  • 3
    • 0036196205 scopus 로고    scopus 로고
    • Mechanisms of iron accumulation in hereditary hemochromatosis
    • Fleming RE, Sly WS: Mechanisms of iron accumulation in hereditary hemochromatosis. Annu Rev Physiol 2002;64:663-680.
    • (2002) Annu Rev Physiol , vol.64 , pp. 663-680
    • Fleming, R.E.1    Sly, W.S.2
  • 4
    • 0035049419 scopus 로고    scopus 로고
    • Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload
    • Zoller H, Koch RO, Theurl I, Obrist P, Pietrangelo A, Montosi G, Haile DJ, Vogel W, Weiss G: Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload. Gastroenterology 2001;120:1412-1419.
    • (2001) Gastroenterology , vol.120 , pp. 1412-1419
    • Zoller, H.1    Koch, R.O.2    Theurl, I.3    Obrist, P.4    Pietrangelo, A.5    Montosi, G.6    Haile, D.J.7    Vogel, W.8    Weiss, G.9
  • 9
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T: Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003,101:2461-2463.
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 10
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O: A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-7819.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6    Loreal, O.7
  • 13
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 2001;98:8780-8785.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3    Beaumont, C.4    Grandchamp, B.5    Kahn, A.6    Vaulont, S.7
  • 15
    • 0037111732 scopus 로고    scopus 로고
    • Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
    • Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC: Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 2002;100:3776-3781.
    • (2002) Blood , vol.100 , pp. 3776-3781
    • Weinstein, D.A.1    Roy, C.N.2    Fleming, M.D.3    Loda, M.F.4    Wolfsdorf, J.I.5    Andrews, N.C.6
  • 16
    • 0036727925 scopus 로고    scopus 로고
    • Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
    • Frazer DM, Wilkins SJ, Becker EM, Vulpe CD, McKie AT, Trinder D, Anderson GJ: Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 2002;123:835-844.
    • (2002) Gastroenterology , vol.123 , pp. 835-844
    • Frazer, D.M.1    Wilkins, S.J.2    Becker, E.M.3    Vulpe, C.D.4    McKie, A.T.5    Trinder, D.6    Anderson, G.J.7
  • 21
    • 0037564038 scopus 로고    scopus 로고
    • Expression of hepcidin in hereditary hemochromatosis: Evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
    • Gehrke SG, Kulaksiz H, Herrmann T, Riedel HD, Bents K, Veltkamp C, Stremmel W: Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood 2003,102:371-376.
    • (2003) Blood , vol.102 , pp. 371-376
    • Gehrke, S.G.1    Kulaksiz, H.2    Herrmann, T.3    Riedel, H.D.4    Bents, K.5    Veltkamp, C.6    Stremmel, W.7
  • 25
    • 2342422913 scopus 로고    scopus 로고
    • Prohepcidin: Expression and cell specific localisation in the liver and its regulation in hereditary hemochromatosis, chronic renal insufficiency, and renal anemia
    • Kulaksiz H, Gehrke SG, Janetzko A, Rost D, Bruckner T, Kallinowski B, Stremmel W: Prohepcidin: expression and cell specific localisation in the liver and its regulation in hereditary hemochromatosis, chronic renal insufficiency, and renal anemia. Gut 2004;53:734-742.
    • (2004) Gut , vol.53 , pp. 734-742
    • Kulaksiz, H.1    Gehrke, S.G.2    Janetzko, A.3    Rost, D.4    Bruckner, T.5    Kallinowski, B.6    Stremmel, W.7
  • 30
    • 2942619988 scopus 로고    scopus 로고
    • Genetic abnormalities and juvenile hemochromatosis: Mutations of the HJV gene encoding hemojuvelin
    • Lee PL, Beutler E, Rao SV, Barton JC: Genetic abnormalities and juvenile hemochromatosis: mutations of the HJV gene encoding hemojuvelin. Blood 2004;103:4669-4671.
    • (2004) Blood , vol.103 , pp. 4669-4671
    • Lee, P.L.1    Beutler, E.2    Rao, S.V.3    Barton, J.C.4
  • 32
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • Ganz T: Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003;102:783-788.
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1
  • 33
    • 0037962795 scopus 로고    scopus 로고
    • The orchestration of body iron intake: How and where do enterocytes receive their cues?
    • Frazer DM, Anderson GJ: The orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cells Mol Dis 2003;30:288-297.
    • (2003) Blood Cells Mol Dis , vol.30 , pp. 288-297
    • Frazer, D.M.1    Anderson, G.J.2
  • 34
    • 1642394686 scopus 로고    scopus 로고
    • Intestinal absorption of iron in HFE-1 hemochromatosis: Local or systemic process?
    • Brissot P, Troadec MB, Loreal O: Intestinal absorption of iron in HFE-1 hemochromatosis: local or systemic process? J Hepatol 2004;40:702-709.
    • (2004) J Hepatol , vol.40 , pp. 702-709
    • Brissot, P.1    Troadec, M.B.2    Loreal, O.3
  • 36
    • 3042636759 scopus 로고    scopus 로고
    • The IL-6-and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes
    • Lee P, Peng H, Gelbart T, Beutler E: The IL-6-and lipopolysaccharide- induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes. Proc Natl Acad Sci USA 2004;101:9263-9265.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9263-9265
    • Lee, P.1    Peng, H.2    Gelbart, T.3    Beutler, E.4
  • 37
    • 3442875926 scopus 로고    scopus 로고
    • Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE
    • Frazer DM, Wilkins SJ, Millard KN, McKie AT, Vulpe CD, Anderson GJ: Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE. Br J Haematol 2004;126:434-436.
    • (2004) Br J Haematol , vol.126 , pp. 434-436
    • Frazer, D.M.1    Wilkins, S.J.2    Millard, K.N.3    McKie, A.T.4    Vulpe, C.D.5    Anderson, G.J.6
  • 38
    • 0015142989 scopus 로고
    • Iron absorption in hemochromatosis before and after phlebotomy therapy
    • Sargent T, Saito H, Winchell HS: Iron absorption in hemochromatosis before and after phlebotomy therapy. J Nucl Med 1971;12:660-667.
    • (1971) J Nucl Med , vol.12 , pp. 660-667
    • Sargent, T.1    Saito, H.2    Winchell, H.S.3
  • 39
    • 0037103357 scopus 로고    scopus 로고
    • Regulation of iron absorption in Hfe mutant mice
    • Ajioka RS, Levy JE, Andrews NC, Kushner JP: Regulation of iron absorption in Hfe mutant mice. Blood 2002;100:1465-1469.
    • (2002) Blood , vol.100 , pp. 1465-1469
    • Ajioka, R.S.1    Levy, J.E.2    Andrews, N.C.3    Kushner, J.P.4
  • 42
    • 4544314123 scopus 로고    scopus 로고
    • The recently identified type 2A juvenile haemochromatosis gene (HJV), a second candidate modifier of the C282Y homozygous phenotype
    • Le Gac G, Scotet V, Ka C, Gourlaouen I, Bryckaert L, Jacolot S, Mura C, Ferec C: The recently identified type 2A juvenile haemochromatosis gene (HJV), a second candidate modifier of the C282Y homozygous phenotype. Hum Mol Genet 2004;13:1913-1918.
    • (2004) Hum Mol Genet , vol.13 , pp. 1913-1918
    • Le Gac, G.1    Scotet, V.2    Ka, C.3    Gourlaouen, I.4    Bryckaert, L.5    Jacolot, S.6    Mura, C.7    Ferec, C.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.