Synthesis and NMR-driven conformational analysis of Taxol analogues conformationally constrained on the C13 side chain

Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2001, Pages 1576-1587

  Barboni, L ^a   Lambertucci, C ^a   Appendino, G ^b   Vander Velde, D G ^c   Himes, R H ^c   Bombardelli, E ^d   Wang, M ^e   Snyder, J P ^e  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^c UNIVERSITY OF KANSAS   (United States)

^d INDENA S P A   (Italy)

^e EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',2'' METHYLENEDOCETAXEL; 2',2'' METHYLENEPACLITAXEL; BETA TUBULIN; PACLITAXEL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; PACLITAXEL; TAXOIDS; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0035837071     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001103v     Document Type: Article

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