CH⋯O and CH⋯N hydrogen bonds in ligand design: A novel quinazolin-4-ylthiazol-2-ylamine protein kinase inhibitor

Journal of Medicinal Chemistry

Volumn 48, Issue 4, 2005, Pages 1278-1281

  Pierce, Albert C ^a   Ter Haar, Ernst ^a   Binch, Hayley M ^a   Kay, David P ^a   Patel, Sanjay R ^a   Li, Pan ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; LIGAND; PYRAZOL 3 YLQUINAZOLIN 4 YLAMINE INHIBITOR; QUINAZOLIN 4 YLTHIAZOL 2 YLAMINE PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; THIAZOLE DERIVATIVE;

ARTICLE; CONFORMATION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME BINDING; ENZYME STRUCTURE; HYDROGEN BOND; LIGAND BINDING; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ISOMERISM; SYNTHESIS;

DRUG DESIGN; GLYCOGEN SYNTHASE KINASE 3; HYDROGEN BONDING; ISOMERISM; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 13944252481     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0492249     Document Type: Article

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