Geldanamycin promotes nuclear localisation and clearance of PHOX2B misfolded proteins containing polyalanine expansions

International Journal of Biochemistry and Cell Biology

Volumn 39, Issue 2, 2007, Pages 327-339

  Bachetti, Tiziana ^a   Bocca, Paola ^a   Borghini, Silvia ^a   Matera, Ivana ^a   Prigione, Ignazia ^a   Ravazzolo, Roberto ^a,b   Ceccherini, Isabella ^a  

^a G GASLINI INSTITUTE   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Cellular toxicity; Geldanamycin; PHOX2B; Polyalanine aggregates

Indexed keywords

ALANINE; DOPAMINE BETA MONOOXYGENASE; GELDANAMYCIN; GREEN FLUORESCENT PROTEIN; HEAT SHOCK PROTEIN; POLYALANINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE REGULATION; CELL FATE; CELL NUCLEUS MEMBRANE; CELL STRAIN COS7; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; GENE; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; NONHUMAN; PAIRED LIKE HOMEOBOX 2 B GENE; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SYNTHESIS; TRANSACTIVATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; AUTOPHAGY; BENZOQUINONES; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; DOPAMINE BETA-HYDROXYLASE; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HOMEODOMAIN PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; PROTEIN TRANSPORT; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; TRINUCLEOTIDE REPEAT EXPANSION; UBIQUITIN;

EID: 33845212645     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2006.08.014     Document Type: Article

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