Paired-like homeodomain proteins Phox2a/Arix and Phox2b/NBPhox have similar genetic organization and independently regulate dopamine β-hydroxylase gene transcription

DNA and Cell Biology

Volumn 19, Issue 9, 2000, Pages 539-554

  Adachi, M ^a   Browne, D ^a   Lewis, E J ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE BETA MONOOXYGENASE; HOMEODOMAIN PROTEIN; PROTEIN ARIX; PROTEIN NBPHOX; PROTEIN PHOX2A; PROTEIN PHOX2B; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL SPECIFICITY; CHROMOSOMAL LOCALIZATION; CONCENTRATION RESPONSE; GENE STRUCTURE; GENETIC LINKAGE; GENETIC ORGANIZATION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; NORADRENERGIC NERVE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATOR GENE; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; DNA PRIMERS; DOPAMINE BETA-HYDROXYLASE; EXONS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOMEODOMAIN PROTEINS; HUMANS; INTRONS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PROMOTER REGIONS (GENETICS); RATS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0033819080     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/104454900439773     Document Type: Article

References (41)

1. Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1
2. Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm
3. Human/mouse homology relationships
4. Linkage studies with the pirouette gene
5. The HER-2/neu receptor tyrosine kinase gene encodes a secreted auto inhibitor
6. Characterization and mutation analysis of goosecoid-like (GSCL), a homeodomain-containing gene that maps to the critical regions for VDFS/DGS on 22q11
7. Homeodomain proteins
8. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells
9. A new technique for the assay of infectivity of human adenovirus 5 DNA
10. Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor
11. Mapping of the Arix homeodomain gene to mouse chromosome 7 and human chromosome 11q13
12. Noradrenergic-specific transcription of dopamine β-hydroxylase gene requires synergy of multiple cis-acting elements including at least Phox2a-binding sites
13. The T protein encoded by Brachyury is a tissue-specific transcription factor
14. Genetic, functional and morphological analysis of pirouette, a mouse neuroepithelial deafness mutant
15. Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations
16. Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells
17. Evidence for genetic linkage to alcohol dependence on chromosome 4 and 11 from autosome-wide scan in an American Indian population
18. Both isoforms of the cAMP-dependent protein kinase catalytic subunit can activate transcription of the prolactin gene
19. Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a
20. Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13
21. Zebrafish Pax9 encodes two protein with distinct C-terminal transactivating domains of different potency negatively regulated by adjacent N-terminal sequences
22. Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
23. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
24. Physical and genetic interactions between Alx4 and Cart1
25. Maps from two interspecific back-cross DNA panels available as a community genetic mapping resource
26. A bifunctional genetic regulatory element of the rat dopamine beta-hydroxylase gene influences cell type and second messenger-mediated transcription
27. Nested expression domains of four homeobox genes in developing rostral brain
28. Protein and DNA contact surfaces that mediate the selective action of the Phox1 homeodomain at the c-fos serum response element
29. The Phox2 homeodomain proteins are sufficient to promote the development of sympathetic neurons
30. The homeo-domain protein Arix promotes PKA-dependent activation of the dopamine β-hydroxylase promoter through multiple elements and interaction with the coactivator CBP
31. The homeo-domain protein Arix interacts synergistically with cyclic AMP to regulate expression of neurotransmitter biosynthetic genes
32. AP1 proteins mediate the cAMP response of the dopamine β-hydroxylase gene
33. The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system
34. Site-specific heterodimerization by paired class homeodomain proteins mediates selective transcriptional responses
35. The mouse homeodomain protein Phox2 regulates N-Cam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype
36. Cooperative dimerization of paired class homeodomains on DNA
37. Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine β-hydroxylase gene
38. Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles
39. Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation
40. A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neuro-transmitter biosynthetic genes