Regulation of the RAP1/RAF-1/extracellularly regulated kinase-1/2 cascade and prolactin release by the phosphoinositide 3-kinase/AKT pathway in pituitary cells

Endocrinology

Volumn 147, Issue 12, 2006, Pages 6036-6045

  Romano, David ^a   Pertuit, Morgane ^a   Rasolonjanahary, Ramahefarizo ^a   Barnier, Jean Vianney ^b   Magalon, Karine ^a   Enjalbert, Alain ^a   Gerard, Corinne ^a  

^a CNRS   (France)

^b LABORATOIRE DE NEUROBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOMER; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROLACTIN; PROTEIN KINASE B; RAF PROTEIN; RAP1 PROTEIN; SERINE;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; GENETIC TRANSCRIPTION; HYPOPHYSIS CELL; NONHUMAN; PRIORITY JOURNAL; PROLACTIN RELEASE; PROMOTER REGION; RAT; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELLS, CULTURED; FEMALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PITUITARY GLAND; PROLACTIN; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; RAP1 GTP-BINDING PROTEINS; RAS PROTEINS; RATS; RATS, WISTAR; RECEPTOR CROSS-TALK; SIGNAL TRANSDUCTION; SOMATOTROPHS; TRANS-ACTIVATION (GENETICS);

EID: 33751503046     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-0325     Document Type: Article

References (59)

1. O'Neill E, Kolch W 2004 Conferring specificity on the ubiquitous Raf/MEK signalling pathway. Br J Cancer 90:283-288
2. Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH 2001 Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22:153-183
3. Downward J 2003 Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 3:11-22
4. Zwartkruis FJ, Bos JL 1999 Ras and Rap1: two highly related small GTPases with distinct function. Exp Cell Res 253:157-165
5. Kerkhoff E, Rapp UR 2001 The Ras-Raf relationship: an unfinished puzzle. Adv Enzyme Regul 41:261-267
6. Wellbrock C, Karasarides M, Marais R 2004 The RAF proteins take centre stage. Nat Rev Mol Cell Biol 5:875-885
7. Vivanco I, Sawyers CL 2002 The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2:489-501
8. Yang ZZ, Tschopp O, Baudry A, Dummler B, Hynx D, Hemmings BA 2004 Physiological functions of protein kinase B/Akt. Biochem Soc Trans 32:350-354
9. Vanhaesebroeck B, Ali K, Bilancio A, Geering B, Foukas LC 2005 Signalling by PI3K isoforms: insights from gene-targeted mice. Trends Biochem Sci 30:194-204
10. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA 1996 Mechanism of activation of protein kinase B by insulin and IGF-I. EMBO J 15:6541-6551
11. Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes AB, McCormick F, Hawkins PT 1997 Dual role of phosphatidylinositol-3,4,5- trisphosphate in the activation of protein kinase B. Science 277:567-570
12. Duckworth BC, Cantley LC 1997 Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength. J Biol Chem 272:27665-27670
13. Versteeg HH, Evertzen MW, van Deventer SJ, Peppelenbosch MP 2000 The role of phosphatidylinositide-3-kinase in basal mitogen-activated protein kinase activity and cell survival. FEBS Lett 465:69-73
14. Wennstrom S, Downward J 1999 Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor. Mol Cell Biol 19:4279-4288
15. Kim SE, Cho JY, Kim KS, Lee SJ, Lee KH, Choi KY 2004 Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells. Cell Signal 16:1309-1317
16. Schmidt EK, Fichelson S, Feller SM 2004 PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors. BMC Biol 2:7
17. Yart A, Laffargue M, Mayeux P, Chretien S, Peres C, Tonks N, Roche S, Payrastre B, Chap H, Raynal P 2001 A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor. J Biol Chem 276:8856-8864
18. Choi WS, Sung CK 2004 Inhibition of phosphatidylinositol-3-kinase enhances insulin stimulation of insulin receptor substrate 1 tyrosine phosphorylation and extracellular signal-regulated kinases in mouse R-fibroblasts. J Recept Signal Transduct Res 24:67-83
19. Laprise P, Langlois MJ, Boucher MJ, Jobin C, Rivard N 2004 Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells. J Cell Physiol 199:32-39
20. van der Heide LP, Hoekman MF, Biessels GJ, Gispen WH 2003 Insulin inhibits extracellular regulated kinase 1/2 phosphorylation in a phosphatidylinositol 3-kinase (PI3) kinase-dependent manner in Neuro2a cells. J Neurochem 86:86-91
21. Chaudhary A, King WG, Mattaliano MD, Frost JA, Diaz B, Morrison DK, Cobb MH, Marshall MS, Brugge JS 2000 Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr Biol 10:551-554
22. Sun H, King AJ, Diaz HB, Marshall MS 2000 Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak. Curr Biol 10:281-284
23. Zimmermann S, Moelling K 1999 Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 286:1741-1744
24. Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M 2002 Regulation of Raf-Akt cross-talk. J Biol Chem 277:31099-31106
25. Guan KL, Figueroa C, Brtva TR, Zhu T, Taylor J, Barber TD, Vojtek AB 2000 Negative regulation of the serine/threonine kinase B-Raf by Akt. J Biol Chem 275:27354-27359
26. Bondeva T, Pirola L, Bulgarelli-Leva G, Rubio I, Wetzker R, Wymann MP 1998 Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PKB and MAPK. Science 282:293-296
27. Reusch HP, Zimmermann S, Schaefer M, Paul M, Moelling K 2001 Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells. J Biol Chem 276:33630-33637
28. Rommel C, Clarke BA, Zimmermann S, Nunez L, Rossman R, Reid K, Moelling K, Yancopoulos GD, Glass DJ 1999 Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science 286:1738-1741
29. Romano D, Magalon K, Ciampini A, Talet C, Enjalbert A, Gerard C 2003 Differential involvement of the Ras and Rap1 small GTPases in vasoactive intestinal and pituitary adenylyl cyclase activating polypeptides control of the prolactin gene. J Biol Chem 278:51386-51394
30. Castillo AI, Tolon RM, Aranda A 1998 Insulin-like growth factor-1 stimulates rat prolactin gene expression by a Ras, ETS and phosphatidylinositol 3-kinase dependent mechanism. Oncogene 16:1981-1991
31. Fernandez M, Sanchez-Franco F, Palacios N, Sanchez I, Fernandez C, Cacicedo L 2004 IGF-I inhibits apoptosis through the activation of the phosphatidylinositol 3-kinase/Akt pathway in pituitary cells. J Mol Endocrinol 33:155-163
32. Fruchtman S, Gift B, Howes B, Borski R 2001 Insulin-like growth factor-I augments prolactin and inhibits growth hormone release through distinct as well as overlapping cellular signaling pathways. Comp Biochem Physiol B Biochem Mol Biol 129:237-242
33. Ohmichi M, Sawada T, Kanda Y, Koike K, Hirota K, Miyake A, Saltiel AR 1994 Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation. J Biol Chem 269:3783-3788
34. Kievit P, Lauten JD, Maurer RA 2001 Analysis of the role of the mitogen-activated protein kinase in mediating cyclic-adenosine 3′,5′-monophosphate effects on prolactin promoter activity. Mol Endocrinol 15:614-624
35. Rasolonjanahary R, Gerard C, Dufour MN, Homburger V, Enjalbert A, Guillon G 2002 Evidence for a direct negative coupling between dopamine-D2 receptors and PLC by heterotrimeric Gi1/2 proteins in rat anterior pituitary cell membranes. Endocrinology 143:747-754
36. Meloche S, Pages G, Pouyssegur J 1992 Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk. Mol Biol Cell 3:63-71
37. Morrison DK 1995 Activation of Raf-1 by Ras in intact cells. Methods Enzymol 255:301-310
38. Papin C, Eychene A, Brunet A, Pages G, Pouyssegur J, Calothy G, Barnier JV 1995 B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222. Oncogene 10:1647-1651
39. Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K, Vande Woude GF, Ahn NG 1994 Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265:966-970
40. de Rooij J, Bos JL 1997 Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 14:623-625
41. Franke B, Akkerman JW, Bos JL 1997 Rapid Ca2+-mediated activation of Rap1 in human platelets. EMBO J 16:252-259
42. Niswender GD, Chen CL, Midgley Jr AR, Meites J, Ellis S 1969 Radioimmunoassay for rat prolactin. Proc Soc Exp Biol Med 130:793-797
43. Hu Y, Qiao L, Wang S, Rong SB, Meuillet EJ, Berggren M, Gallegos A, Powis G, Kozikowski AP 2000 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth. J Med Chem 43:3045-3051
44. Castillo SS, Brognard J, Petukhov PA, Zhang C, Tsurutani J, Granville CA, Li M, Jung M, West KA, Gills JG, Kozikowski AP, Dennis PA 2004 Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues. Cancer Res 64:2782-2792
45. Diaz B, Barnard D, Filson A, MacDonald S, King A, Marshall M 1997 Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling. Mol Cell Biol 17:4509-4516
46. York RD, Molliver DC, Grewal SS, Stenberg PE, McCleskey EW, Stork PJ 2000 Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1. Mol Cell Biol 20:8069-8083
47. Herrmann C, Horn G, Spaargaren M, Wittinghofer A 1996 Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor. J Biol Chem 271:6794-6800
48. Lara JI, Lorenzo MJ, Cacicedo L, Tolon RM, Balsa JA, Lopez-Fernandez J, Sanchez-Franco F 1994 Induction of vasoactive intestinal peptide gene expression and prolactin secretion by insulin-like growth factor I in rat pituitary cells: evidence for an autoparacrine regulatory system. Endocrinology 135:2526-2532
49. Le Pechon-Vallee C, Magalon K, Rasolonjanahary R, Enjalbert A, Gerard C 2000 Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptides stimulate mitogen-activated protein kinase in the pituitary cell line GH4C1 by a 3′,5′-cyclic adenosine monophosphate pathway. Neuroendocrinology 72:46-56
50. Jun T, Gjoerup O, Roberts TM 1999 Tangled webs: evidence of cross-talk between c-Raf-1 and Akt. Sci STKE 1999:PE1
51. Ikenoue T, Kanai F, Hikiba Y, Tanaka Y, Imamura J, Ohta M, Jazag A, Guleng B, Asaoka Y, Tateishi K, Kawakami T, Matsumura M, Kawabe T, Omata M 2005 Functional consequences of mutations in a putative Akt phosphorylation motif of B-raf in human cancers. Mol Carcinog 43:59-63
52. Fernandez M, Sanchez-Franco F, Palacios N, Sanchez I, Cacicedo L 2005 IGF-I and vasoactive intestinal peptide (VIP) regulate cAMP-response element-binding protein (CREB)-dependent transcription via the mitogen-activated protein kinase (MAPK) pathway in pituitary cells: requirement of Rap1. J Mol Endocrinol 34:699-712
53. Liu L, Xie Y, Lou L 2006 PI3K is required for insulin-stimulated but not EGF-stimulated ERK1/2 activation. Eur J Cell Biol 85:367-374
54. Lou L, Urbani J, Ribeiro-Neto F, Altschuler DL 2002 cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b. J Biol Chem 277:32799-32806
55. Hu CD, Kariya K, Okada T, Qi X, Song C, Kataoka T 1999 Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation. J Biol Chem 274:48-51
56. Quilliam LA, Rebhun JF, Castro AF 2002 A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases. Prog Nucleic Acids Res Mol Biol 71:391-444
57. Fruchtman S, Jackson L, Borski R 2000 Insulin-like growth factor I disparately regulates prolactin and growth hormone synthesis and secretion: studies using the teleost pituitary model. Endocrinology 141:2886-2894
58. Kajimura S, Uchida K, Yada T, Hirano T, Aida K, Gordon Grau E 2002 Effects of insulin-like growth factors (IGF-I and -II) on growth hormone and prolactin release and gene expression in euryhaline tilapia, Oreochromis mossambicus. Gen Comp Endocrinol 127:223-231
59. Atkin SL, Landolt AM, Foy P, Jeffreys RV, Hipkin L, White MC 1994 Effects of insulin-like growth factor-I on growth hormone and prolactin secretion and cell proliferation of human somatotrophinomas and prolactinomas in vitro. Clin Endocrinol (Oxf) 41:503-509